cancellous bone


Summary: A type of osseous tissue which makes up the inner part of bone. It has a spongy, honeycomb-like structure with struts or trabecula and contains the BONE MARROW. It has higher rate of BONE REMODELING turnover than CORTICAL BONE.

Top Publications

  1. Joffre T, Isaksson P, Procter P, Persson C. Trabecular deformations during screw pull-out: a micro-CT study of lapine bone. Biomech Model Mechanobiol. 2017;16:1349-1359 pubmed publisher
    ..Tensile strains were somewhat smaller. Strain concentrations and the location of trabecular failures provide experimental information that could be used in the development of new screw designs and/or to validate numerical simulations. ..
  2. Jiang H, Wang J, Chen M, Liu D. Biological activity evaluation of magnesium fluoride coated Mg-Zn-Zr alloy in vivo. Mater Sci Eng C Mater Biol Appl. 2017;75:1068-1074 pubmed publisher
    ..Low-density regions occurred around the cancellous bone, and the regions gradually expanded during the 12weeks after implantation...
  3. Schamel M, Groll J, Gbureck U. Simultaneous formation and mineralization of star-P(EO-stat-PO) hydrogels. Mater Sci Eng C Mater Biol Appl. 2017;75:471-477 pubmed publisher
    ..This study aimed to synthesize highly mineralized hydrogels to mimic the mechanical properties of cancellous bone. A six armed star molecule functionalized with isocyanate groups as reactive termini (NCO-sP(EO-stat-PO)) was ..
  4. Hulley P, Bishop T, Vernet A, Schneider J, Edwards J, Athanasou N, et al. Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2. J Pathol. 2017;242:322-333 pubmed publisher
    ..2017 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland. ..
  5. Verroken C, Pieters W, Beddeleem L, Goemaere S, Zmierczak H, Shadid S, et al. Cortical Bone Size Deficit in Adult Patients With Type 1 Diabetes Mellitus. J Clin Endocrinol Metab. 2017;102:2887-2895 pubmed publisher
    ..This deficit is mainly situated at the endosteal envelope, suggesting imbalanced remodeling rather than compromised modeling processes as the underlying mechanism. ..
  6. Smith A, Kortebein S, Eid A, BOUGHTER J, Cary N, Brooks J, et al. Comparing Cancellous Bone Volume of the Manubrium to Iliac Crest in Fresh Cadavers. Otolaryngol Head Neck Surg. 2017;157:36-41 pubmed publisher
    Objective The iliac crest is the gold standard for cancellous bone grafting. This site is distant from head and neck reconstruction and may lead to significant postoperative morbidity...
  7. Xiao L, Du E, Homer Bouthiette C, Hurley M. Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice. Endocrinology. 2017;158:3629-3646 pubmed publisher
    ..NVP-BGJ398 improved femur cancellous bone, cortical bone structure, growth plate, and double labeling in cortical bone and also increased femur ..
  8. Ye T, Cao P, Qi J, Zhou Q, Rao D, Qiu S. Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats. PLoS ONE. 2017;12:e0186012 pubmed publisher
    ..staining, osteoclast activity by TRAP staining and bone volume by micro-CT scanning in lumbar vertebral cancellous bone. Both low and high dose RIS significantly reduced caspase-3 positive osteocytes, empty lacunae and TRAP ..
  9. Wang Y, Liu Z, Wang Q, Feng Q, Chen W. Early Detection of Tibial Cartilage Degradation and Cancellous Bone Loss in an Ovariectomized Rat Model. Biomed Res Int. 2017;2017:9654056 pubmed publisher
    This study aimed to investigate degradation of the articular cartilage and loss of the cancellous bone in an ovariectomized (OVX) rat model simulating early human menopausal stage...

More Information


  1. Chen Y, Wang C, Huang Y, Feng T, Zou H, Fan Y. Biomechanical evaluation of the natural abutment teeth in combined tooth-implant-supported telescopic prostheses: a three-dimensional finite element analysis. Comput Methods Biomech Biomed Engin. 2017;20:967-979 pubmed publisher
  2. Cormier J, Cone K, Lanpher J, Kinens A, Henderson T, Liaw L, et al. Exercise reverses pain-related weight asymmetry and differentially modulates trabecular bone microarchitecture in a rat model of osteoarthritis. Life Sci. 2017;180:51-59 pubmed publisher
    ..Results indicate that voluntary exercise may protect against OA pain, the effect varies as a function of prior exercise duration, and is associated with distinct trabecular bone modifications. ..
  3. Tsegai Z, Skinner M, Gee A, Pahr D, Treece G, Hublin J, et al. Trabecular and cortical bone structure of the talus and distal tibia in Pan and Homo. Am J Phys Anthropol. 2017;163:784-805 pubmed publisher
    ..Cortical and trabecular bone distributions correlate with habitual joint positions adopted by each species, and thus have potential for interpreting joint position in fossil hominoids. ..
  4. Milovanovic P, Djonic D, Hahn M, Amling M, Busse B, Djuric M. Region-dependent patterns of trabecular bone growth in the human proximal femur: A study of 3D bone microarchitecture from early postnatal to late childhood period. Am J Phys Anthropol. 2017;164:281-291 pubmed publisher
  5. Wang W, Gordon J, Philbrick K, Yang X, Branscum A, LOHR C, et al. Low calcium diet increases 4T1 mammary tumor carcinoma cell burden and bone pathology in mice. PLoS ONE. 2017;12:e0180886 pubmed publisher
    ..The findings suggest that high bone turnover due to Ca insufficiency results in greater local mammary tumor cell growth, cortical osteolysis, woven bone formation, and invasion to muscle in mice. ..
  6. Krause A, Speacht T, Zhang Y, Lang C, Donahue H. Simulated space radiation sensitizes bone but not muscle to the catabolic effects of mechanical unloading. PLoS ONE. 2017;12:e0182403 pubmed publisher
    ..Our results suggest that combining simulated space radiation with HLS results in additional bone loss that may not be experienced by muscle. ..
  7. Farr J, Xu M, Weivoda M, Monroe D, Fraser D, Onken J, et al. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017;23:1072-1079 pubmed publisher