bone matrix

Summary

Summary: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.

Top Publications

  1. Thouverey C, Malinowska A, Balcerzak M, Strzelecka Kiliszek A, Buchet R, Dadlez M, et al. Proteomic characterization of biogenesis and functions of matrix vesicles released from mineralizing human osteoblast-like cells. J Proteomics. 2011;74:1123-34 pubmed publisher
  2. Kheir E, Stapleton T, Shaw D, Jin Z, Fisher J, Ingham E. Development and characterization of an acellular porcine cartilage bone matrix for use in tissue engineering. J Biomed Mater Res A. 2011;99:283-94 pubmed publisher
    ..In conclusion, this study has generated data on the production of an acellular cartilage bone matrix scaffold for use in osteochondral defect repair...
  3. Alcantara E, Shin M, Sohn H, Park Y, Kim T, Lim J, et al. Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. J Nutr Biochem. 2011;22:1055-63 pubmed publisher
    ..The medium and cellular levels of Type 1 collagen and alkaline phosphatase (ALP), both of which are major bone matrix proteins, increased within the low range of diosgenin concentration (>0-3 ?M), and this pattern was further ..
  4. Hofstaetter J, Roetzer K, Krepler P, Nawrot Wawrzyniak K, Schwarzbraun T, Klaushofer K, et al. Altered bone matrix mineralization in a patient with Rett syndrome. Bone. 2010;47:701-5 pubmed publisher
    ..However, very little is known if bone matrix mineralization is altered in RTT...
  5. Eleftheriadis E, Leventis M, Tosios K, Faratzis G, Titsinidis S, Eleftheriadi I, et al. Osteogenic activity of ?-tricalcium phosphate in a hydroxyl sulphate matrix and demineralized bone matrix: a histological study in rabbit mandible. J Oral Sci. 2010;52:377-84 pubmed
    ..potential of synthetic ?-tricalcium phosphate in a hydroxyl sulphate matrix (?-TCP/HS) and human demineralized bone matrix (DBM) putty. Sixteen New Zealand White rabbits were used...
  6. Helbig L, Simank H, Kroeber M, Schmidmaier G, Grützner P, Guehring T. Core decompression combined with implantation of a demineralised bone matrix for non-traumatic osteonecrosis of the femoral head. Arch Orthop Trauma Surg. 2012;132:1095-103 pubmed publisher
    ..This study evaluated patients after core decompression combined with an augmentation by a demineralised bone matrix, and particularly aimed to report long-term conversion rates to total hip replacement (THR).
  7. Irinakis T. Efficacy of injectable demineralized bone matrix as graft material during sinus elevation surgery with simultaneous implant placement in the posterior maxilla: clinical evaluation of 49 sinuses. J Oral Maxillofac Surg. 2011;69:134-41 pubmed publisher
    ..success of single implants placed simultaneously during direct sinus lifts with allograft forms of bone and to investigate the effect demineralized bone matrix paste has on time management and membrane integrity during these procedures.
  8. Lee J, Lee K, Baek H, Jang S, Lee J, Ryu H. Combined effects of porous hydroxyapatite and demineralized bone matrix on bone induction: in vitro and in vivo study using a nude rat model. Biomed Mater. 2011;6:015008 pubmed publisher
    Hydroxyapatite (HA) is an osteoconductive material used as a bone graft extender and demineralized bone matrix (DBM) has been used as a source of osteoinductive factors...
  9. Wang L, Wang J, Yang D, Yang C, Xia B, Wang J, et al. [Inhibitory effect of bone sialoprotein silencing on the adhesion ability of breast cancer cells to bone matrix]. Sheng Wu Gong Cheng Xue Bao. 2011;27:233-9 pubmed
    ..research mainly to explore the effect of bone sialoprotein (BSP) silence by siRNA on the adhesion ability to bone matrix of bone-seeking breast cancer cells (MDA-MB-231BO)...

More Information

Publications62

  1. Kim J, Oh J, Han I, Kim H, Chung S. Grafting using injectable calcium sulfate in bone tumor surgery: comparison with demineralized bone matrix-based grafting. Clin Orthop Surg. 2011;3:191-201 pubmed publisher
    ..of this study was to validate the clinical outcomes of injectable calcium sulfate (ICS) grafts as compared with those of a demineralized bone matrix (DBM)-based graft for filling in contained bony defects created by tumor surgery.
  2. Poundarik A, Diab T, Sroga G, Ural A, Boskey A, Gundberg C, et al. Dilatational band formation in bone. Proc Natl Acad Sci U S A. 2012;109:19178-83 pubmed publisher
    ..OC(-/-), OPN(-/-), OC-OPN(-/-;-/-)) confirm that these two proteins regulate dilatational band formation and bone matrix toughness...
  3. Khan M, Donos N, Salih V, Brett P. The enhanced modulation of key bone matrix components by modified Titanium implant surfaces. Bone. 2012;50:1-8 pubmed publisher
    ..05). These findings suggest that modified Ti surfaces induce an enhancement in osteogenic commitment and differentiation, which likely underlie the deposition of more stable bone matrix early in the healing process in vivo.
  4. Fujisawa R, Tamura M. Acidic bone matrix proteins and their roles in calcification. Front Biosci (Landmark Ed). 2012;17:1891-903 pubmed
    ..Some of these acidic matrix proteins are immobilized on the collagen fibrils and induce nucleation of hydroxyapatite crystals. They can also modulate crystal shape by adsorption on a specific face of the crystals...
  5. Rodriguez I, Uceda M, Lobato R, Aniceto G. Postraumatic frontal sinus obliteration with calvarial bone dust and demineralized bone matrix: a long term prospective study and literature review. Int J Oral Maxillofac Surg. 2013;42:71-6 pubmed publisher
    ..Many efforts have been made to overcome these drawbacks, and an ideal bone substitute sought. Demineralized Bone Matrix (DBX; Musculoskeletal Transplant Foundation, Edison, NJ, USA) is a commercially available product composed of ..
  6. Supronowicz P, Gill E, Trujillo A, Thula T, Zhukauskas R, Ramos T, et al. Human adipose-derived side population stem cells cultured on demineralized bone matrix for bone tissue engineering. Tissue Eng Part A. 2011;17:789-98 pubmed publisher
    ..Natural scaffolds, such as demineralized bone matrix (DBM), contain collagenous networks with growth factors such as bone morphogenetic protein-2...
  7. Betz R, Lavelle W, Mulcahey M, Samdani A. Histology of a fusion mass augmented with demineralized bone matrix for congenital scoliosis. J Pediatr Orthop B. 2011;20:37-40 pubmed publisher
    ..Demineralized bone matrix (DBM) may be a cost effective, safe, and clinically effective alternative bone graft material...
  8. Kim H, Ji Y, Rhee S, Dhong E, Park S, Yoon E. Enhancement of bone regeneration using osteogenic-induced adipose-derived stem cells combined with demineralized bone matrix in a rat critically-sized calvarial defect model. Curr Stem Cell Res Ther. 2012;7:165-72 pubmed
    ..The present study examined whether osteogenic induced adipose-derived stem cells (ASCs) could enhance the osteogenic capacity of demineralized bone matrix and accelerate bone formation in a rat critically-sized calvarial defect model.
  9. Yang B, Yin Z, Cao J, Shi Z, Zhang Z, Song H, et al. In vitro cartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffold. Biomed Mater. 2010;5:045003 pubmed publisher
    In this study, we constructed tissue-engineered cartilage using allogeneic cancellous bone matrix gelatin (BMG) as a scaffold. Allogeneic BMG was prepared by sequential defatting, demineralization and denaturation...
  10. Lovric V, Chen D, Yu Y, Oliver R, Genin F, Walsh W. Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent model. Am J Sports Med. 2012;40:2365-74 pubmed
    Techniques to improve and accelerate tendon-bone healing could be advantageous in anterior cruciate ligament (ACL) reconstruction. Effects of demineralized bone matrix (DBM) on intra-articular tendon-bone healing have not been examined.
  11. Zhang J, Lazarenko O, Blackburn M, Badger T, Ronis M, Chen J. Blueberry consumption prevents loss of collagen in bone matrix and inhibits senescence pathways in osteoblastic cells. Age (Dordr). 2013;35:807-20 pubmed publisher
    Ovariectomy (OVX)-induced bone loss has been linked to increased bone turnover and higher bone matrix collagen degradation as the result of osteoclast activation...
  12. Borel O, Gineyts E, Bertholon C, Garnero P. Cathepsin K preferentially solubilizes matured bone matrix. Calcif Tissue Int. 2012;91:32-9 pubmed publisher
    ..These results suggest that the collagenolytic activity of cathepsin K may be increased toward more matured bone collagen...
  13. GRUSKIN E, Doll B, Futrell F, Schmitz J, Hollinger J. Demineralized bone matrix in bone repair: history and use. Adv Drug Deliv Rev. 2012;64:1063-77 pubmed publisher
    Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms...
  14. Di Bella C, Dozza B, Frisoni T, Cevolani L, Donati D. Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst. Clin Orthop Relat Res. 2010;468:3047-55 pubmed publisher
    ..Various treatments have been proposed but there is no consensus regarding the best procedure...
  15. Cho H, Seo S, Park S, Park J, Shin D, Park I. Minimal invasive surgery for unicameral bone cyst using demineralized bone matrix: a case series. BMC Musculoskelet Disord. 2012;13:134 pubmed publisher
    ..Recent concern focuses on the effectiveness of closed methods. This study evaluated the effectiveness of demineralized bone matrix as a graft material after intramedullary decompression for the treatment of unicameral bone cysts.
  16. Servin Trujillo M, Reyes Esparza J, Garrido Fariña G, Flores Gazca E, Osuna Martínez U, Rodriguez Fragoso L. Use of a graft of demineralized bone matrix along with TGF-?1 leads to an early bone repair in dogs. J Vet Med Sci. 2011;73:1151-61 pubmed
    ..In present study, we investigate the effect of local application of a graft demineralized bone matrix (DBM) along with TGF-?1 in a model of open osteotomy induced experimentally in dogs...
  17. Dong X, Qin A, Xu J, Wang X. In situ accumulation of advanced glycation endproducts (AGEs) in bone matrix and its correlation with osteoclastic bone resorption. Bone. 2011;49:174-83 pubmed publisher
    ..and elderly (76±4years old) groups were examined to determine the spatial-temporal distribution of AGEs in bone matrix and its effect on bone resorption activities by directly culturing osteoclastic cells on bone slices...
  18. Macisaac Z, Rottgers S, Davit A, Ford M, Losee J, Kumar A. Alveolar reconstruction in cleft patients: decreased morbidity and improved outcomes with supplemental demineralized bone matrix and cancellous allograft. Plast Reconstr Surg. 2012;130:625-32 pubmed publisher
    ..The authors report the safety and efficacy of supplemental demineralized bone matrix and cancellous allograft with iliac crest bone autograft in cleft alveolar bone defects.
  19. Cox R, Jenkinson A, Pohl K, O Brien F, Morgan M. Osteomimicry of mammary adenocarcinoma cells in vitro; increased expression of bone matrix proteins and proliferation within a 3D collagen environment. PLoS ONE. 2012;7:e41679 pubmed publisher
    ..The expression of several bone matrix proteins were monitored throughout the process of mineralization and increased expression of collagen type 1 ..
  20. Hatzokos I, Stavridis S, Iosifidou E, Karataglis D, Christodoulou A. Autologous bone marrow grafting combined with demineralized bone matrix improves consolidation of docking site after distraction osteogenesis. J Bone Joint Surg Am. 2011;93:671-8 pubmed publisher
    ..We further sought to clarify whether the application of autologous bone marrow cells combined with demineralized bone matrix would substantially improve docking site consolidation.
  21. Crotti T, O Sullivan R, Shen Z, Flannery M, Fajardo R, Ross F, et al. Bone matrix regulates osteoclast differentiation and annexin A8 gene expression. J Cell Physiol. 2011;226:3413-21 pubmed publisher
  22. Sroga G, Vashishth D. Effects of bone matrix proteins on fracture and fragility in osteoporosis. Curr Osteoporos Rep. 2012;10:141-50 pubmed publisher
    ..Therefore, other factors including the quality of organic bone matrix components and their interactions may be of crucial importance to understanding of fragility fractures...
  23. Chen L, Jiang W, Huang J, He B, Zuo G, Zhang W, et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res. 2010;25:2447-59 pubmed publisher
    ..Taken together, our findings suggest that a combination of BMP-9 and IGF-2 may be explored as an effective bone-regeneration agent to treat large segmental bony defects, nonunion fracture, and/or osteoporotic fracture...
  24. Kapinas K, Lowther K, Kessler C, Tilbury K, Lieberman J, Tirnauer J, et al. Bone matrix osteonectin limits prostate cancer cell growth and survival. Matrix Biol. 2012;31:299-307 pubmed publisher
    ..To determine how bone matrix osteonectin affects the behavior of prostate cancer cells, we modeled prostate cancer cell-bone interactions ..
  25. Fortunati D, Reppe S, Fjeldheim A, Nielsen M, Gautvik V, Gautvik K. Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone. Matrix Biol. 2010;29:594-601 pubmed publisher
    ..In conclusion, the present study provides novel observations related to the expression, distribution and regulation of periostin in bone cells and extracellular matrix...
  26. Sun X, McLamore E, Kishore V, Fites K, Slipchenko M, Porterfield D, et al. Mechanical stretch induced calcium efflux from bone matrix stimulates osteoblasts. Bone. 2012;50:581-91 pubmed publisher
    ..924±0.742 pmol cm(-2)s(-1)) from regions of devitalized bone matrix undergoing post-yield strains, induced by a stress concentrator...
  27. Baas J, Jakobsen T, Elmengaard B, Bechtold J, Soballe K. The effect of adding an equine bone matrix protein lyophilisate on fixation and osseointegration of HA-coated Ti implants. J Biomed Mater Res A. 2012;100:188-94 pubmed publisher
    ..the fixation of orthopedic implants could be improved by adding an osteoinductive extract of lyophilized equine bone matrix proteins (Colloss E, Ossacur AG, Germany), between the implant and the surrounding bone...
  28. Vanleene M, Porter A, Guillot P, Boyde A, Oyen M, Shefelbine S. Ultra-structural defects cause low bone matrix stiffness despite high mineralization in osteogenesis imperfecta mice. Bone. 2012;50:1317-23 pubmed publisher
    ..Using a composite framework, we interpret the lower oim bone matrix elasticity observed as the result of a change in the aspect ratio of apatite crystals and a disruption of the ..
  29. Stancoven B, Lee J, Dixon D, McPherson J, Bisch F, Wikesjö U, et al. Effect of bone morphogenetic protein-2, demineralized bone matrix and systemic parathyroid hormone (1-34) on local bone formation in a rat calvaria critical-size defect model. J Periodontal Res. 2013;48:243-51 pubmed publisher
    ..to an absorbable collagen sponge (ACS) to induce local bone formation compared with the clinical reference demineralized bone matrix (DBM) and to investigate potential additive/synergistic effects of exogenous parathyroid hormone (PTH).
  30. Leventis M, Eleftheriadis E, Oikonomopoulou P, Vavouraki H, Khaldi L, Tosios K, et al. Experimental study of the effect of autologous platelet-rich plasma on the early phases of osteoinduction by allogenic demineralized bone matrix. Implant Dent. 2012;21:399-405 pubmed
    To evaluate the effect of autologous platelet-rich plasma (PRP) on the early phases of osteoinduction by allogenic demineralized bone matrix (DBM) in rabbit intramuscular positions.
  31. Trebacz H, Zdunek A. Anisotropy of demineralized bone matrix under compressive load. Acta Bioeng Biomech. 2011;13:71-6 pubmed
    ..Both secant modulus of elasticity and AE parameters were significantly higher in T direction than in L direction, which is attributed to shifting and separation of lamellae of collagen fibrils and lamellae in bone matrix.
  32. Lim L, Bobyn J, Bobyn K, Lefebvre L, Tanzer M. The Otto Aufranc Award: Demineralized bone matrix around porous implants promotes rapid gap healing and bone ingrowth. Clin Orthop Relat Res. 2012;470:357-65 pubmed publisher
    ..Demineralized bone matrix has osteoinductive properties and therefore the potential to enhance gap healing and porous implant fixation.
  33. Sun X, Peng W, Yang Z, Ren M, Zhang S, Zhang W, et al. Heparin-chitosan-coated acellular bone matrix enhances perfusion of blood and vascularization in bone tissue engineering scaffolds. Tissue Eng Part A. 2011;17:2369-78 pubmed publisher
    ..a biomacromolecular layer-by-layer coating process of chitosan/heparin onto a decellularized extracellular bone matrix was designed to accelerate the blood perfusion and re-endothelialization process...
  34. Zimmermann G, Moghaddam A. Allograft bone matrix versus synthetic bone graft substitutes. Injury. 2011;42 Suppl 2:S16-21 pubmed publisher
    ..Alternatives have included allografts and in recent years also demineralized bone matrix. The growing availability of good synthetic bone grafts and their advantages in safety and avoiding donor-site ..
  35. Cavusoglu T, Yazici I, Vargel I, Karakaya E. Reconstruction of coup de sabre deformity (linear localized scleroderma) by using galeal frontalis muscle flap and demineralized bone matrix combination. J Craniofac Surg. 2011;22:257-8 pubmed publisher
    In this clinical report, we are presenting the combination of demineralized bone matrix combined with bilateral galea frontalis flaps...
  36. Nistala H, Lee Arteaga S, Smaldone S, Siciliano G, Carta L, Ono R, et al. Fibrillin-1 and -2 differentially modulate endogenous TGF-? and BMP bioavailability during bone formation. J Cell Biol. 2010;190:1107-21 pubmed publisher
    ..Together, these findings identify the extracellular microfibrils as critical regulators of bone formation through the modulation of endogenous TGF-? and BMP signaling...
  37. Innes J, Myint P. Demineralised bone matrix in veterinary orthopaedics: a review. Vet Comp Orthop Traumatol. 2010;23:393-9 pubmed publisher
    Demineralised bone matrix (DBM) is commonly used in human orthopaedics as an allograft prepared from cortical bone...
  38. Rhee S, Ji Y, Gharibjanian N, Dhong E, Park S, Yoon E. In vivo evaluation of mixtures of uncultured freshly isolated adipose-derived stem cells and demineralized bone matrix for bone regeneration in a rat critically sized calvarial defect model. Stem Cells Dev. 2011;20:233-42 pubmed publisher
    ..We implanted uncultured freshly isolated adipose-derived stem cells combined with demineralized bone matrix (DBM) to induce bone regeneration in a critically sized rat calvarial defect model...
  39. Eryilmaz T, Ozmen S, Lortlar N, Omeroglu S, Ayhan S, Celebi C. Feasibility of demineralized bone matrix for craniomaxillofacial contour restoration. J Craniofac Surg. 2011;22:1888-92 pubmed publisher
    Demineralized bone matrix (DBM) could be a good alternative for craniomaxillofacial contour restoration, especially in perialar, malar, temporal, and frontal regions...
  40. Balooch G, Balooch M, Nalla R, Schilling S, Filvaroff E, Marshall G, et al. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci U S A. 2005;102:18813-8 pubmed
    The characteristic toughness and strength of bone result from the nature of bone matrix, the mineralized extracellular matrix produced by osteoblasts...
  41. Krugliakov P, Sokolova I, Zin kova N, Viĭde S, Cherednichenko N, Kisliakova T, et al. [The influence of mesenchymal stem cells on bone tissue regeneration upon implantation of demineralized bone matrix]. Tsitologiia. 2005;47:466-77 pubmed
    ..The implantation of rat's DBM with MSC led to the formation of a full value bone. MSC suppressed inflammation, when transplantation of hen's DBM was carried out. The application of MSC always improved bone tissue regeneration...
  42. Liu Y, Ahmad S, Shu X, Sanders R, Kopesec S, Prestwich G. Accelerated repair of cortical bone defects using a synthetic extracellular matrix to deliver human demineralized bone matrix. J Orthop Res. 2006;24:1454-62 pubmed
    ..of Carbylan-GSX, a crosslinked synthetic extracellular matrix (ECM), were used to deliver human demineralized bone matrix (DBM) in a rat femoral defect model...
  43. Acarturk T, Hollinger J. Commercially available demineralized bone matrix compositions to regenerate calvarial critical-sized bone defects. Plast Reconstr Surg. 2006;118:862-73 pubmed
    Demineralized bone matrix products are often used by surgeons to regenerate bone. Several different types of carriers have been combined with demineralized bone matrix to improve clinical handling and surgical outcome...
  44. Chen B, Lin H, Zhao Y, Wang B, Zhao Y, Liu Y, et al. Activation of demineralized bone matrix by genetically engineered human bone morphogenetic protein-2 with a collagen binding domain derived from von Willebrand factor propolypeptide. J Biomed Mater Res A. 2007;80:428-34 pubmed
    ..Bone filling materials are important in bone tissue restoration. In this study, the demineralized bone matrix (DBM) was activated with the engineering human bone morphogenetic protein-2 (BMP-2)...
  45. Lorenz Depiereux B, Bastepe M, Benet Pages A, Amyere M, Wagenstaller J, Müller Barth U, et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet. 2006;38:1248-50 pubmed
    ..4q21 and identified homozygous mutations in DMP1 (dentin matrix protein 1), which encodes a non-collagenous bone matrix protein expressed in osteoblasts and osteocytes...
  46. Miller E, Delos D, Baldini T, Wright T, Pleshko Camacho N. Abnormal mineral-matrix interactions are a significant contributor to fragility in oim/oim bone. Calcif Tissue Int. 2007;81:206-14 pubmed
    ..To investigate the bone matrix properties, tensile tests combined with geometric analyses were conducted on demineralized femora...
  47. Chen L, He Z, Chen B, Yang M, Zhao Y, Sun W, et al. Loading of VEGF to the heparin cross-linked demineralized bone matrix improves vascularization of the scaffold. J Mater Sci Mater Med. 2010;21:309-17 pubmed publisher
    ..The results demonstrated that heparin cross-linked DBM binding VEGF could be a useful strategy to stimulate cells and blood vessels invasion into the scaffolds...
  48. Arenaz Búa J, Luaces Rey R, Sironvalle Soliva S, Otero Rico A, Charro Huerga E, Patiño Seijas B, et al. A comparative study of platelet-rich plasma, hydroxyapatite, demineralized bone matrix and autologous bone to promote bone regeneration after mandibular impacted third molar extraction. Med Oral Patol Oral Cir Bucal. 2010;15:e483-9 pubmed
    ..autologous bone, platelet-rich plasma and two biomaterials (synthetic calcium hydroxyapatite, and demineralized bone matrix), and thus establish the potential benefits of these biomaterials in the regeneration of postextraction ..
  49. Leite F, Ramalho L. Bone regeneration after demineralized bone matrix and castor oil (Ricinus communis) polyurethane implantation. J Appl Oral Sci. 2008;16:122-6 pubmed
    ..This study compared connective tissue and bone reaction when exposed to demineralized bovine bone matrix and a polyurethane resin derived from castor bean (Ricinus communis)...
  50. McNamara L, Majeska R, Weinbaum S, Friedrich V, Schaffler M. Attachment of osteocyte cell processes to the bone matrix. Anat Rec (Hoboken). 2009;292:355-63 pubmed publisher
    ..To date the nature of this attachment is not understood. Osteocytes are embedded in mineralized bone matrix, but maintain a pericellular space (50-80 nm) to facilitate fluid flow and transport of metabolites...
  51. Lammens J, Nijs J, Schepers E, Ectors N, Lismont D, Verduyckt B. The effect of bone morphogenetic protein-7 (OP-1) and demineralized bone matrix (DBM) in the rabbit tibial distraction model. Acta Orthop Belg. 2009;75:103-9 pubmed
    ..They indicate that further studies are warranted to understand the process of bone formation and the working mechanisms of substances that potentially trigger bone healing...
  52. Jan A, Sandor G, Brkovic B, Peel S, Kim Y, Xiao W, et al. Effect of hyperbaric oxygen on demineralized bone matrix and biphasic calcium phosphate bone substitutes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:59-66 pubmed publisher
    ..effect of hyperbaric oxygen (HBO) on the healing of critical-sized defects that were grafted with demineralized bone matrix (DBM) combined with Pluronic F127 (F127) to form a gel or putty, or a commercially available biphasic calcium ..
  53. Viguet Carrin S, Garnero P, Delmas P. The role of collagen in bone strength. Osteoporos Int. 2006;17:319-36 pubmed
    ..To illustrate the role of the crosslinking process of collagen in bone strength, clinical disorders associated with bone collagen abnormalities and bone fragility, such as osteogenesis imperfecta and osteoporosis, are described...