prepulse inhibition


Summary: A neurophysiological phenomenon in which the response to a startling stimulus (pulse) is decreased when a weaker prestimulus (prepulse) precedes it closely in time. It is used as an operational measure of sensorimotor gating.

Top Publications

  1. del Pino I, Brotons Mas J, Marques Smith A, Marighetto A, Frick A, Marin O, et al. Abnormal wiring of CCK+ basket cells disrupts spatial information coding. Nat Neurosci. 2017;20:784-792 pubmed publisher
    ..These results suggest that normal integration of CCK+ basket cells in cortical networks is key to support spatial coding in the hippocampus. ..
  2. Barnes S, Sawiak S, Caprioli D, Jupp B, Buonincontri G, Mar A, et al. Impaired limbic cortico-striatal structure and sustained visual attention in a rodent model of schizophrenia. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..Furthermore, PCP exposure resulted in dissociable impairments in attentional function. ..
  3. Yang N, Tian Q, Fan Y, Bo Q, Zhang L, Li L, et al. Deficits of perceived spatial separation induced prepulse inhibition in patients with schizophrenia: relationships to symptoms and neurocognition. BMC Psychiatry. 2017;17:135 pubmed publisher
    b>Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia...
  4. Mereu M, Contarini G, Buonaguro E, Latte G, Managò F, Iasevoli F, et al. Dopamine transporter (DAT) genetic hypofunction in mice produces alterations consistent with ADHD but not schizophrenia or bipolar disorder. Neuropharmacology. 2017;121:179-194 pubmed publisher
    ..These behavioral and molecular phenotypes indicate that a genetic-driven DAT hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders. ..
  5. Chen L, Chen D, Tang L, Ren J, Chen J, Zhen X, et al. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors. Bioorg Med Chem. 2017;25:3315-3329 pubmed publisher
    ..And after further PDE enzymatic selectivity study, metabolic stability assay and in vivo pharmacological tests we identified two inhibitors as interesting lead compounds with the potential for further PDE10A lead optimizatioin. ..
  6. Takeuchi N, Sugiyama S, Inui K, Kanemoto K, Nishihara M. New paradigm for auditory paired pulse suppression. PLoS ONE. 2017;12:e0177747 pubmed publisher
    ..of sensory processing used to prevent an overflow of irrelevant information, with some indexes, such as prepulse inhibition (PPI) and P50 suppression, often utilized for its evaluation...