axon guidance


Summary: The mechanism by which a neuronal process outgrows toward a target led by the GROWTH CONE. Local guidance cues are provided by cell surface proteins that act on the growing axon.

Top Publications

  1. Varadarajan S, Kong J, Phan K, Kao T, Panaitof S, Cardin J, et al. Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord. Neuron. 2017;94:790-799.e3 pubmed publisher
    ..Thus, netrin1 does not act as a long-range secreted chemoattractant for commissural spinal axons but instead promotes ventrally directed axon outgrowth by haptotaxis, i.e., directed growth along an adhesive surface. ..
  2. Dominici C, Moreno Bravo J, Puiggros S, Rappeneau Q, Rama N, Vieugué P, et al. Floor-plate-derived netrin-1 is dispensable for commissural axon guidance. Nature. 2017;545:350-354 pubmed publisher
    Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in axon guidance at the central nervous system midline...
  3. Miyake A, Mekata Y, Fujibayashi H, Nakanishi K, Konishi M, Itoh N. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain. PLoS ONE. 2017;12:e0176036 pubmed publisher
    ..In addition, brorin was required for axon guidance in the forebrain...
  4. Hand R, Kolodkin A. Netrin-Mediated Axon Guidance to the CNS Midline Revisited. Neuron. 2017;94:691-693 pubmed publisher
    ..2017)-in this issue of Neuron-and Dominici et al. (2017)-published online at Nature-independently show that floor plate-derived netrin-1 is dispensable for commissural neuron axon guidance to the CNS midline during development.
  5. Katori S, Noguchi Katori Y, Itohara S, Iwasato T. Spinal RacGAP ?-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance. J Neurosci. 2017;37:7682-7699 pubmed publisher
    ..comprises guidance molecule-expressing midline glial somata and processes, plays a pivotal role in midline axon guidance. Accumulating evidence has revealed the molecular mechanisms by which the midline barrier ensures proper ..
  6. Rajman M, Schratt G. MicroRNAs in neural development: from master regulators to fine-tuners. Development. 2017;144:2310-2322 pubmed publisher
  7. Lei H, Yan Z, Sun X, Zhang Y, Wang J, Ma C, et al. Axon guidance pathways served as common targets for human speech/language evolution and related disorders. Brain Lang. 2017;174:1-8 pubmed publisher
    ..trait was suggested to be associated with significant genomic convergence and best manifested at the ROBO-SLIT axon guidance pathway...
  8. Suter T, DeLoughery Z, Jaworski A. Meninges-derived cues control axon guidance. Dev Biol. 2017;430:1-10 pubmed publisher
    ..The full repertoire of axon guidance cues and receptors and the identity of the tissues producing these cues remain to be elucidated...
  9. Kaczmarek L, Zhang Y. Kv3 Channels: Enablers of Rapid Firing, Neurotransmitter Release, and Neuronal Endurance. Physiol Rev. 2017;97:1431-1468 pubmed publisher

More Information


  1. Sundaresan V, Lin V, Liang F, Kaye F, Kawabata Iwakawa R, Shiraishi K, et al. Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis. Cancer Genet. 2017;216-217:20-28 pubmed publisher
    ..Our results also indicated mutations in genes involved in the axon guidance pathways likely play an important role in SCLC progression...
  2. Shao Q, Yang T, Huang H, Alarmanazi F, Liu G. Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J Neurosci. 2017;37:5620-5633 pubmed publisher
    ..STATEMENT Proper regulation of microtubule (MT) dynamics in the growth cone plays an important role in axon guidance. However, whether guidance cues modulate MT dynamics directly or indirectly is unclear...
  3. Yoon J, Kim S, Ahmed G, Shay J, Terman J. Amplification of F-Actin Disassembly and Cellular Repulsion by Growth Factor Signaling. Dev Cell. 2017;42:117-129.e8 pubmed publisher
    ..repellents to combinatorially increase Mical-mediated F-actin disassembly, cellular remodeling, and repulsive axon guidance. Similar roles for Mical in growth factor/Abl-related cancer cell behaviors further revealed contexts in which ..
  4. Rapti G, Li C, Shan A, Lu Y, Shaham S. Glia initiate brain assembly through noncanonical Chimaerin-Furin axon guidance in C. elegans. Nat Neurosci. 2017;20:1350-1360 pubmed publisher
    ..neurons, with unique growth properties, anatomy, and innervation, cooperate with glia to mediate follower-axon guidance. We further identify a Chimaerin (CHIN-1)- Furin (KPC-1) double-mutant that severely disrupts assembly...
  5. Justice E, Barnum S, Kidd T. The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene. PLoS Genet. 2017;13:e1006865 pubmed publisher
    ..Comm intercepts the Robo axon guidance receptor in the ER/Golgi and targets Robo for degradation, allowing commissural axons to cross the CNS midline...
  6. Gujar M, Stricker A, Lundquist E. Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. PLoS Genet. 2017;13:e1006998 pubmed publisher
    The guidance cue UNC-6/Netrin regulates both attractive and repulsive axon guidance. Our previous work showed that in C...