neuronal outgrowth


Summary: Formation of neuronal processes (AXONS; NEURITES) toward a target cell.

Top Publications

  1. Kempf A, Boda E, Kwok J, Fritz R, Grande V, Kaelin A, et al. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017;43:24-34.e5 pubmed publisher
    ..We thereby identify the HSPG family members syndecan-3 and syndecan-4 as functional receptors for Nogo-A-?20. Finally, we show in explant cultures ex vivo that Nogo-A-?20 promotes the migration of neuroblasts via HSPGs but not S1PR2. ..
  2. Florica R, Hipolito V, Bautista S, Anvari H, Rapp C, El Rass S, et al. The ENU-3 protein family members function in the Wnt pathway parallel to UNC-6/Netrin to promote motor neuron axon outgrowth in C. elegans. Dev Biol. 2017;430:249-261 pubmed publisher
    ..We conclude that the ENU-3 family proteins function in a pathway parallel to the UNC-6/Netrin pathway for motor neuron axon outgrowth, most likely in the Wnt pathway. ..
  3. Norsworthy M, Bei F, Kawaguchi R, Wang Q, Tran N, Li Y, et al. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017;94:1112-1120.e4 pubmed publisher
    ..We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types. ..
  4. Han H, Liang X, Wang J, Zhao Q, Yang M, Rong W, et al. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation. Brain Res. 2017;1663:132-140 pubmed publisher
    ..This finding may provide a new therapeutic target for patients with endometriosis. ..
  5. Gomez Sanchez J, Pilch K, van der Lans M, Fazal S, Benito C, Wagstaff L, et al. After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination. J Neurosci. 2017;37:9086-9099 pubmed publisher
    ..We also provide evidence for direct lineage relationships between: (1) repair cells and myelin and Remak cells of uninjured nerves and (2) remyelinating cells in regenerated nerves. ..
  6. Ivanova E, Mau Them F, Riazuddin S, Kahrizi K, Laugel V, Schaefer E, et al. Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development. Am J Hum Genet. 2017;101:428-440 pubmed publisher
    ..We propose that mutations in TBC1D23 are responsible for a form of PCH with small, normally proportioned cerebellum and should be screened in individuals with syndromic pontocereballar hypoplasia. ..
  7. Loers G, Astafiev S, Hapiak Y, Saini V, Mishra B, Gul S, et al. The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C. J Neurochem. 2017;142:392-406 pubmed publisher
  8. Chaudhry N, Bachelin C, Zujovic V, Hilaire M, Baldwin K, Follis R, et al. Myelin-Associated Glycoprotein Inhibits Schwann Cell Migration and Induces Their Death. J Neurosci. 2017;37:5885-5899 pubmed publisher
    ..Blockade of p75 cleavage using a specific inhibitor significantly improves migration and survival of the transplanted Schwann cells in vivo. ..
  9. Förster T, López Tosco S, Ziegler S, Antonchick A, Waldmann H. Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity. Chembiochem. 2017;18:1098-1108 pubmed publisher
    ..Evaluation of the different subcollections of secoyohimbanes for modulation of neurite outgrowth in the SH-SY5Y human cell line led to the discovery of new compounds that promote neurite outgrowth. ..

More Information


  1. Oguchi M, Noguchi K, Fukuda M. TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells. PLoS ONE. 2017;12:e0174883 pubmed publisher
    ..These findings indicated that TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells. ..
  2. Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, et al. Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS ONE. 2017;12:e0178182 pubmed publisher
    ..HBO treatment did not influence (increase / reduce) this effect. Secretome analysis showed that HBO treatment altered the protein expression pattern in MSCs. ..
  3. Al Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, et al. The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury. J Neurosci. 2017;37:7079-7095 pubmed publisher
    ..We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation. ..
  4. Motti D, Lerch J, Danzi M, Gans J, Kuo F, Slepak T, et al. Identification of miRNAs involved in DRG neurite outgrowth and their putative targets. FEBS Lett. 2017;591:2091-2105 pubmed publisher
    ..MiR-298, let-7a, and let-7f enhance neurite growth and target the majority of isoforms in the differentially expressed network. ..
  5. Shao Q, Yang T, Huang H, Alarmanazi F, Liu G. Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J Neurosci. 2017;37:5620-5633 pubmed publisher
  6. Wang J, Pavlyk I, Vedula P, Sterling S, Leu N, Dong D, et al. Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development. Dev Biol. 2017;430:41-51 pubmed publisher
    ..We propose that zipcode-mediated co-targeting of Ate1 and ?-actin mRNA leads to localized co-translational arginylation of ?-actin that drives the growth cone migration and neurite outgrowth. ..
  7. Gu T, Zhao T, Kohli U, Hewes R. The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila. Dev Biol. 2017;431:226-238 pubmed publisher
    ..We propose that SPEN and NITO function additively or synergistically in the CCAP/bursicon neurons to regulate multiple aspects of neurite outgrowth during metamorphic remodeling. ..
  8. Lu L, Zhou H, Pan B, Li X, Fu Z, Liu J, et al. c-Jun Amino-Terminal Kinase is Involved in Valproic Acid-Mediated Neuronal Differentiation of Mouse Embryonic NSCs and Neurite Outgrowth of NSC-Derived Neurons. Neurochem Res. 2017;42:1254-1266 pubmed publisher
    ..Taken together, these results suggest that VPA promotes neuronal differentiation of mouse embryonic NSCs and neurite outgrowth of NSC-derived neurons. Moreover, JNK activation is involved in the effects of VPA stimulation. ..