inhibitory postsynaptic potentials


Summary: Hyperpolarization of membrane potentials at the SYNAPTIC MEMBRANES of target neurons during NEUROTRANSMISSION. They are local changes which diminish responsiveness to excitatory signals.

Top Publications

  1. Koren D, Grove J, Wei W. Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity. Neuron. 2017;95:914-927.e4 pubmed publisher
    ..Therefore, our results directly link modulation of dendritic compartmentalization to circuit-level encoding of motion direction in the retina. ..
  2. de Luca E, Ravasenga T, Petrini E, Polenghi A, Nieus T, Guazzi S, et al. Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents. Neuron. 2017;95:63-69.e5 pubmed publisher
    ..Glutamatergic activity limits this inter-synaptic diffusion by trapping GABAARs at excitatory synapses. This novel form of activity-dependent hetero-synaptic interplay is likely to modulate dendritic synaptic signaling. ..
  3. Librizzi L, Losi G, Marcon I, Sessolo M, Scalmani P, Carmignoto G, et al. Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices. J Neurosci. 2017;37:10398-10407 pubmed publisher
    ..Our new findings reinforce and add a new piece of evidence to the proposal that limbic seizures can be supported by GABAergic hyperactivity. ..
  4. Arnson H, Strowbridge B. Spatial Structure of Synchronized Inhibition in the Olfactory Bulb. J Neurosci. 2017;37:10468-10480 pubmed publisher
  5. Bardóczi Z, Pál B, KÅ‘szeghy Ã, Wilheim T, Watanabe M, Záborszky L, et al. Glycinergic Input to the Mouse Basal Forebrain Cholinergic Neurons. J Neurosci. 2017;37:9534-9549 pubmed publisher
    ..The effect of glycine on BFC neurons was demonstrated by bicuculline-resistant, strychnine-sensitive spontaneous IPSCs recorded in whole-cell conditions. ..
  6. Casalia M, Howard M, Baraban S. Persistent seizure control in epileptic mice transplanted with gamma-aminobutyric acid progenitors. Ann Neurol. 2017;82:530-542 pubmed publisher
    ..Ann Neurol 2017;82:530-542. ..
  7. Drexel M, Romanov R, Wood J, Weger S, Heilbronn R, Wulff P, et al. Selective Silencing of Hippocampal Parvalbumin Interneurons Induces Development of Recurrent Spontaneous Limbic Seizures in Mice. J Neurosci. 2017;37:8166-8179 pubmed publisher
    ..The experiments highlight the importance of the potent inhibitory action mediated by parvalbumin cells in the hippocampus and identify a potential mechanism in the development of TLE. ..
  8. Taketo M, Matsuda H. Short-term inhibition of GABAergic IPSCs induced by association of pre- and postsynaptic activation in the neonatal hippocampus. Neuropharmacology. 2017;121:39-48 pubmed publisher
    ..This inhibition is mediated by a mechanism involving mGluRs, mAChRs, and CB1 receptors, and potentiated by NMDA receptor activation. ..
  9. Crunelli V, Di Giovanni G. Differential Control by 5-HT and 5-HT1A, 2A, 2C Receptors of Phasic and Tonic GABAA Inhibition in the Visual Thalamus. CNS Neurosci Ther. 2015;21:967-70 pubmed publisher

More Information


  1. Uchida T, Lossin C, Ihara Y, Deshimaru M, Yanagawa Y, Koyama S, et al. Abnormal ?-aminobutyric acid neurotransmission in a Kcnq2 model of early onset epilepsy. Epilepsia. 2017;58:1430-1439 pubmed publisher
    ..We conclude that excitatory GABA contributes to the phenotype in these animals, which raises the question of whether this special type of neurotransmission has broader importance in neonatal epilepsy than is currently recognized. ..
  2. Huang X, Zhou C, Tian M, Kang J, Shen W, Verdier K, et al. Overexpressing wild-type ?2 subunits rescued the seizure phenotype in Gabrg2+/Q390X Dravet syndrome mice. Epilepsia. 2017;58:1451-1461 pubmed publisher
    ..Based on these results we suggest that seizures in a genetic epilepsy syndrome caused by epilepsy mutant ?2(Q390X) subunits with dominant negative effects could be rescued potentially by overexpression of wild-type ?2 subunits. ..
  3. Imbrosci B, Wang Y, Arckens L, Mittmann T. Neuronal mechanisms underlying transhemispheric diaschisis following focal cortical injuries. Brain Struct Funct. 2015;220:1649-64 pubmed
    ..Our findings constitute an important step toward the understanding of transhemispheric diaschisis on the cellular level. ..
  4. Chen Z, Liu R, Yang S, Dillon G, Huang R. Methylene blue inhibits GABAA receptors by interaction with GABA binding site. Neuropharmacology. 2017;119:100-110 pubmed publisher
    ..We demonstrate that MB directly inhibits GABAA receptor function, which may underlie some of the effects of MB on the CNS. ..
  5. Bittner S, Williamson R, Snyder A, Litwin Kumar A, Doiron B, Chase S, et al. Population activity structure of excitatory and inhibitory neurons. PLoS ONE. 2017;12:e0181773 pubmed publisher
    ..These results imply that knowledge of neuron type is important, and allows for stronger statistical tests, when interpreting population activity structure. ..
  6. Maurer A, Burke S, Diba K, Barnes C. Attenuated Activity across Multiple Cell Types and Reduced Monosynaptic Connectivity in the Aged Perirhinal Cortex. J Neurosci. 2017;37:8965-8974 pubmed publisher
    ..The reduced inhibition in the perirhinal cortex reported here could contribute to this circuit imbalance, and may be a key point to consider for therapeutic interventions aimed at restoring network function to optimize cognition. ..
  7. Hirono M, Nagao S, Yanagawa Y, Konishi S. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells. Neuropharmacology. 2017;118:79-89 pubmed publisher
    ..Monoaminergic modulation of the neural connections between globular cells and PCs could play a role in cerebellar motor coordination. ..
  8. Currie S, Luz L, Booker S, Wyllie D, Kind P, Daw M. Reduced local input to fast-spiking interneurons in the somatosensory cortex in the GABAA ?2 R43Q mouse model of absence epilepsy. Epilepsia. 2017;58:597-607 pubmed publisher
    ..This reduction leads to altered inhibition during bursts of cortical activity. This altered inhibition demonstrates that alterations in cortical circuitry precede the onset of seizures by more than a week. ..
  9. Hernandez C, Kong W, Hu N, Zhang Y, Shen W, Jackson L, et al. Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome. Eneuro. 2017;4: pubmed publisher