central nervous system sensitization
Summary: An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).
- Nijs J, Loggia M, Polli A, Moens M, Huysmans E, Goudman L, et al. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?. Expert Opin Ther Targets. 2017;21:817-826 pubmed publisher..Before translating these findings from basic science to clinical settings, more human studies exploring the outlined mechanisms in chronic pain patients are needed. ..
- Fox P, Hentges S. Differential Desensitization Observed at Multiple Effectors of Somatic Î¼-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci. 2017;37:8667-8677 pubmed publisher..Thus, in these cells, the cellular consequence of MOR desensitization cannot be defined by the activity of a single effector system. ..
- Follansbee T, Gjelsvik K, Brann C, McParland A, Longhurst C, Galko M, et al. Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. J Neurosci. 2017;37:8524-8533 pubmed publisher..2012). Because nociceptive sensitization is associated with chronic pain, these findings indicate that human BMP pathway components may represent targets for novel pain-relieving drugs. ..