central nervous system sensitization


Summary: An increased response to stimulation that is mediated by amplification of signaling in the CENTRAL NERVOUS SYSTEM (CNS).

Top Publications

  1. Hansson P. Translational aspects of central sensitization induced by primary afferent activity: what it is and what it is not. Pain. 2014;155:1932-4 pubmed publisher
  2. Woolf C. What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain?. Pain. 2014;155:1911-2 pubmed publisher
  3. Bennett E, Walsh K, Thompson N, Krishnaney A. Central Sensitization Inventory as a Predictor of Worse Quality of Life Measures and Increased Length of Stay Following Spinal Fusion. World Neurosurg. 2017;104:594-600 pubmed publisher
    ..CSI may be an additional measure in evaluating patients preoperatively to better predict successful spinal fusion outcomes. ..
  4. Keller J, McGovern A, Mazzone S. Translating Cough Mechanisms Into Better Cough Suppressants. Chest. 2017;152:833-841 pubmed publisher
  5. Wei J, Liu C, Ouyang H, Ma C, Xie M, Liu M, et al. Activation of RAGE/STAT3 pathway by methylglyoxal contributes to spinal central sensitization and persistent pain induced by bortezomib. Exp Neurol. 2017;296:74-82 pubmed publisher
    ..Our results suggest that accumulation of methylglyoxal may activate the RAGE/STAT3 signaling pathway in dorsal horn, and contributes to the spinal central sensitization and persistent pain induced by bortezomib treatment. ..
  6. Schäfer A, Joos L, Roggemann K, Waldvogel Röcker K, Pfingsten M, Petzke F. Pain experiences of patients with musculoskeletal pain + central sensitization: A comparative Group Delphi Study. PLoS ONE. 2017;12:e0182207 pubmed publisher
    ..Patients with MSP+CS reported distinct features in relation to their pain that were not captured with current questionnaires. Insight in patient's pain experience may help to choose and develop appropriate diagnostic instruments. ..
  7. Walters J, Baxter K, Chapman H, Jackson T, Sethuramachandran A, Couldridge M, et al. Chronic Pain and Associated Factors in India and Nepal: A Pilot Study of the Vanderbilt Global Pain Survey. Anesth Analg. 2017;125:1616-1626 pubmed publisher
    ..International expert consensus is needed. ..
  8. Akhter R, Benson J, Svensson P, Nicholas M, Peck C, Murray G. Experimental jaw muscle pain increases pain scores and jaw movement variability in higher pain catastrophizers. J Oral Facial Pain Headache. 2014;28:191-204 pubmed publisher
  9. Masala I, Caso F, Sarzi Puttini P, Salaffi F, Atzeni F. Acute and chronic pain in orthopaedic and rheumatologic diseases: mechanisms and characteristics. Clin Exp Rheumatol. 2017;35 Suppl 105:127-131 pubmed
    ..Consequently, its pharmacological and non-pharmacological treatment should be based on its specific characteristics, other disease-related factors, the ability of patients to cope with it, and the way in which they live their lives. ..

More Information


  1. Nijs J, Loggia M, Polli A, Moens M, Huysmans E, Goudman L, et al. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients?. Expert Opin Ther Targets. 2017;21:817-826 pubmed publisher
    ..Before translating these findings from basic science to clinical settings, more human studies exploring the outlined mechanisms in chronic pain patients are needed. ..
  2. Fox P, Hentges S. Differential Desensitization Observed at Multiple Effectors of Somatic μ-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity. J Neurosci. 2017;37:8667-8677 pubmed publisher
    ..Thus, in these cells, the cellular consequence of MOR desensitization cannot be defined by the activity of a single effector system. ..
  3. Follansbee T, Gjelsvik K, Brann C, McParland A, Longhurst C, Galko M, et al. Drosophila Nociceptive Sensitization Requires BMP Signaling via the Canonical SMAD Pathway. J Neurosci. 2017;37:8524-8533 pubmed publisher
    ..2012). Because nociceptive sensitization is associated with chronic pain, these findings indicate that human BMP pathway components may represent targets for novel pain-relieving drugs. ..