cell migration inhibition


Summary: Phenomenon of cell-mediated immunity measured by in vitro inhibition of the migration or phagocytosis of antigen-stimulated LEUKOCYTES or MACROPHAGES. Specific CELL MIGRATION ASSAYS have been developed to estimate levels of migration inhibitory factors, immune reactivity against tumor-associated antigens, and immunosuppressive effects of infectious microorganisms.

Top Publications

  1. Kivisakk P, Healy B, Viglietta V, Quintana F, Hootstein M, Weiner H, et al. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 2009;72:1922-30 pubmed publisher
    ..Natalizumab treatment increases the percentage of activated leukocytes producing proinflammatory cytokines in blood, presumably due to sequestration of activated cells in the peripheral circulation. ..
  2. Matsui H, Verghese M, Kesimer M, Schwab U, Randell S, Sheehan J, et al. Reduced three-dimensional motility in dehydrated airway mucus prevents neutrophil capture and killing bacteria on airway epithelial surfaces. J Immunol. 2005;175:1090-9 pubmed
    ..We conclude that concentrated ("thick") mucus inhibits neutrophil migration and killing and is a key component in the failure of defense against chronic airways infection in CF. ..
  3. Guo M, Hu L, Wang Y, Chen P, Huang J, Lu N, et al. miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. Med Oncol. 2013;30:542 pubmed publisher
    ..The findings of this study contribute to current understanding of the functions of miR-22 in gastric cancer. ..
  4. Gehad A, Al Banna N, Vaci M, Issekutz A, Mohan K, Latta M, et al. Differing requirements for CCR4, E-selectin, and ?4?1 for the migration of memory CD4 and activated T cells to dermal inflammation. J Immunol. 2012;189:337-46 pubmed publisher
    ..The differentiation from activated to memory CD4 cells increases the dependence on CCR4 for skin homing and decreases the requirement for ESL. ..
  5. Wu L, Wang X, Liu Q, Wingnang Leung A, Wang P, Xu C. Sinoporphyrin sodium mediated photodynamic therapy inhibits the migration associated with collapse of F-actin filaments cytoskeleton in MDA-MB-231 cells. Photodiagnosis Photodyn Ther. 2016;13:58-65 pubmed publisher
    ..However, details regarding the mechanism of cell migration inhibition remain unclear...
  6. Sacerdote P, Martucci C, Vaccani A, Bariselli F, Panerai A, Colombo A, et al. The nonpsychoactive component of marijuana cannabidiol modulates chemotaxis and IL-10 and IL-12 production of murine macrophages both in vivo and in vitro. J Neuroimmunol. 2005;159:97-105 pubmed
    ..Cannabidiol dose-dependently decreased fMLP-induced chemotaxis of macrophages, and the CB2 receptor antagonist prevented this decrease. ..
  7. Zabel B, Wang Y, Lewén S, Berahovich R, Penfold M, Zhang P, et al. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J Immunol. 2009;183:3204-11 pubmed publisher
    ..CXCR7 ligands, such as the chemokine CXCL11 and the newly described synthetic molecule CCX771, may represent novel therapeutic opportunities for the control of such cells. ..
  8. Papp K, Caro I, Leung H, Garovoy M, Mease P. Efalizumab for the treatment of psoriatic arthritis. J Cutan Med Surg. 2007;11:57-66 pubmed
    ..Efalizumab was not effective in treating PsA; efalizumab therapy did not worsen PsA. The efalizumab safety profile does not appear to be altered with the concomitant use of methotrexate therapy. ..
  9. Brunasso A, Salvini C, Massone C. Efalizumab for severe palmo-plantar psoriasis: an open-label pilot trial in five patients. J Eur Acad Dermatol Venereol. 2009;23:415-9 pubmed publisher
    ..Efalizumab therapy was well tolerated and effective in five patients with severe PPP, allowing a significant improvement in quality of life. ..

More Information


  1. Hyun Y, Chung H, McGrath J, Waugh R, Kim M. Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1. J Immunol. 2009;183:359-69 pubmed publisher
    ..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1. ..
  2. Huang K, Walker A. Long term increased expression of the short form 1b prolactin receptor in PC-3 human prostate cancer cells decreases cell growth and migration, and causes multiple changes in gene expression consistent with reduced invasive capacity. Prostate. 2010;70:37-47 pubmed publisher
  3. Serhan C, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003;171:6856-65 pubmed
    ..Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features. ..
  4. Guan H, Zu G, Xie Y, Tang H, Johnson M, Xu X, et al. Neuronal repellent Slit2 inhibits dendritic cell migration and the development of immune responses. J Immunol. 2003;171:6519-26 pubmed
    ..These findings provide insights into a novel mechanism by which Slit2 functions as an anti-inflammatory factor for the initiation of immune responses. ..
  5. Curnock A, Sotsios Y, Wright K, Ward S. Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class IA and IB phosphoinositide 3-kinases. J Immunol. 2003;170:4021-30 pubmed
    ..Together, these results demonstrate that optimal chemotactic response of leukemic T cells to SDF-1 requires the activation of both class IA and class IB PI 3-kinases. ..
  6. Mirenda V, Millington O, Lechler R, Scott D, Hernandez Fuentes M, Read J, et al. Tolerant T cells display impaired trafficking ability. Eur J Immunol. 2005;35:2146-56 pubmed
    ..In physiological terms, this effect is likely to render immunoregulation a more efficient and controllable event. ..
  7. Hsieh M, Lai S, Chen J, Sung J, Lin Y, Wu Hsieh B, et al. Both CXCR3 and CXCL10/IFN-inducible protein 10 are required for resistance to primary infection by dengue virus. J Immunol. 2006;177:1855-63 pubmed
    ..Our results suggest that both CXCR3 and CXCL10/IP-10 contribute to resistance against primary dengue virus infection and that chemokines that are indistinguishable in in vitro assays differ in their activities in vivo. ..
  8. Mangashetti L, Khapli S, Wani M. IL-4 inhibits bone-resorbing activity of mature osteoclasts by affecting NF-kappa B and Ca2+ signaling. J Immunol. 2005;175:917-25 pubmed
    ..Furthermore, IL-4 inhibits bone resorption and actin ring formation by human mature osteoclasts. Thus, we reveal that IL-4 acts directly on mature osteoclasts and inhibits bone resorption by inhibiting NF-kappaB and Ca(2+) signaling. ..
  9. Abdul Hafeez M, Akhtar M, Hussain I. Protective effect of egg-propagated Eimeria tenella (local isolates) gametocytes as vaccine(s) against mixed species of coccidia in chickens. Parasitol Res. 2006;98:539-44 pubmed
    ..Modified splenic cell migration inhibition test and enzyme-linked immunosorbant assay were used to assess the cellular and humoral responses, ..
  10. Itoh R, Miura S, Takimoto A, Kondo S, Sano H, Hiraki Y. Stimulatory actions of lysophosphatidic acid on mouse ATDC5 chondroprogenitor cells. J Bone Miner Metab. 2010;28:659-71 pubmed publisher
    ..These results indicate that LPA plays an important role in the activation of chondroprogenitor cells. ..
  11. Chacko M, Weinberg J. Efalizumab. Dermatol Ther. 2007;20:265-9 pubmed
    ..In addition, several off-label applications of efalizumab will be reviewed. ..
  12. Sharma K, Mediratta P, Reeta K, Mahajan P. Effect of L-arginine on restraint stress induced modulation of immune responses in rats and mice. Pharmacol Res. 2004;49:455-60 pubmed
    ..Thus, NO appears to play an important role in RS-induced immunomodulation and these effects are different from its effect on immune responsiveness in non-stressed animals. ..
  13. Boucher I, Rich C, Lee A, Marcincin M, Trinkaus Randall V. The P2Y2 receptor mediates the epithelial injury response and cell migration. Am J Physiol Cell Physiol. 2010;299:C411-21 pubmed publisher
    ..This downregulation resulted also in an attenuation in phosphorylation of Src and ERK. Together, these data indicate that the P2Y(2) receptor plays a major biological role in the corneal injury response and repair mechanisms. ..
  14. Lahat N, Bitterman H, Engelmayer Goren M, Rosenzweig D, Weiss Cerem L, Rahat M. Reduced TIMP-2 in hypoxia enhances angiogenesis. Am J Physiol Cell Physiol. 2011;300:C557-66 pubmed publisher
    ..Thus we conclude that reduced TIMP-2 levels secreted from both hypoxic monocytes and endothelial cells are proangiogenic. ..
  15. Basta M, Van Goor F, Luccioli S, Billings E, Vortmeyer A, Baranyi L, et al. F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins. Nat Med. 2003;9:431-8 pubmed
    ..This binding could interfere with the role of C3a and C5a in inflammation. ..
  16. Sandy A, Stoolman J, Malott K, Pongtornpipat P, Segal B, Maillard I. Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol. 2013;191:1606-13 pubmed publisher
  17. Sun Y, Oh S, Uddin J, Yang R, Gotlinger K, Campbell E, et al. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007;282:9323-34 pubmed
    ..These results may contribute to the beneficial actions of aspirin and omega-3 fish oils in humans. ..
  18. Martinez L, Oliveira M, Miguel A, Rastelli V, Walber J, Cruz M, et al. Enalapril interferes with the effect of diclofenac on leucocyte-endothelium interaction in hypertensive rats. J Cardiovasc Pharmacol. 2004;43:258-65 pubmed
    ..The anti-inflammatory properties of a nonsteroidal anti-inflammatory drug could therefore be attenuated in hypertensive patients receiving an angiotensin-converting enzyme inhibitor. ..
  19. Kholmanskikh S, Dobrin J, Wynshaw Boris A, Letourneau P, Ross M. Disregulated RhoGTPases and actin cytoskeleton contribute to the migration defect in Lis1-deficient neurons. J Neurosci. 2003;23:8673-81 pubmed
    ..This effect of Lis1 on GTPases does not appear to occur through direct Lis1 binding of Rho, but could involve Lis1 effects on Rho modulatory proteins or on microtubule dynamics. ..
  20. Das A, Vaddi K, Solomon K, Krauthauser C, Jiang X, McIntyre K, et al. Selective inhibition of eosinophil influx into the lung by small molecule CC chemokine receptor 3 antagonists in mouse models of allergic inflammation. J Pharmacol Exp Ther. 2006;318:411-7 pubmed
    ..We conclude that small molecule CCR3 antagonists reduce pulmonary eosinophilic inflammation elicited by chemokine or allergenic challenge. ..
  21. Dong C, Chua A, Ganguly B, Krensky A, Clayberger C. Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity. J Immunol Methods. 2005;302:136-44 pubmed
    ..Comparison of this material with that expressed in E. coli reveals that glycosylation significantly increases the biologic activity of XCL1. ..
  22. Nick J, Young S, Arndt P, Lieber J, Suratt B, Poch K, et al. Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol. 2002;169:5260-9 pubmed
    ..These findings support the feasibility of p38 MAPK inhibition as a selective intervention to reduce neutrophilic inflammation. ..
  23. Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel J, et al. Determinants of human B cell migration across brain endothelial cells. J Immunol. 2003;170:4497-505 pubmed
  24. Huber Lang M, Sarma J, McGuire S, Lu K, Padgaonkar V, Younkin E, et al. Structure-function relationships of human C5a and C5aR. J Immunol. 2003;170:6115-24 pubmed
    ..Although previous data have suggested that there are two separate sites on C5a reactive with C5aR, the current data suggest that C5a interacts with C5aR in a manner that engages three discontinuous regions of C5a. ..
  25. Jones K, Korb E, Kundel M, Kochanek A, Kabraji S, McEvoy M, et al. CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia. 2008;56:1401-13 pubmed publisher
    ..These findings demonstrate a role for CPEB1-mediated protein synthesis in the localization of beta-catenin protein to the leading edge of migrating astrocytes and in regulating directed cell motility. ..
  26. Staquet M, Piccardi N, Piccirilli A, Vincent C, Schmitt D, Msika P. Novel protein kinase C and matrix metalloproteinase inhibitors of vegetable origin as potential modulators of Langerhans cell migration following hapten-induced sensitization. Int Arch Allergy Immunol. 2004;133:348-56 pubmed
    ..They underscore the role of PKC and MMPs inhibitors and suggest they may be of relevance for therapeutically regulating epidermal dendritic cell migration in inflammatory dermatoses. ..
  27. Parameswaran N, Matsui K, Gupta N. Conformational switching in ezrin regulates morphological and cytoskeletal changes required for B cell chemotaxis. J Immunol. 2011;186:4088-97 pubmed publisher
  28. Sheppard G, Kawai M, Craig R, Davidson D, Majest S, Bell R, et al. Lysyl 4-aminobenzoic acid derivatives as potent small molecule mimetics of plasminogen kringle 5. Bioorg Med Chem Lett. 2004;14:965-6 pubmed
    ..Molecules displaying the required recognition groups on this core show similar in vitro properties to kringle 5, and are able to displace radiolabeled protein from a high affinity binding site on endothelial cells. ..
  29. Laan M, Bozinovski S, Anderson G. Cigarette smoke inhibits lipopolysaccharide-induced production of inflammatory cytokines by suppressing the activation of activator protein-1 in bronchial epithelial cells. J Immunol. 2004;173:4164-70 pubmed
    ..Hence, this study suggests a novel mechanism by which cigarette smoke may contribute to chronic colonization and chronic obstructive pulmonary disease in smokers. ..
  30. Le Y, Honczarenko M, Glodek A, Ho D, Silberstein L. CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells. J Immunol. 2005;174:2582-90 pubmed
    ..We conclude that the recruitment of signaling molecules to specific membrane domains plays an important role in CXCL12/CXCR4-induced cellular responses. ..
  31. Schreibelt G, Musters R, Reijerkerk A, de Groot L, van der Pol S, Hendrikx E, et al. Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity. J Immunol. 2006;177:2630-7 pubmed
  32. Christenson K, Björkman L, Karlsson J, Sundqvist M, Movitz C, Speert D, et al. In vivo-transmigrated human neutrophils are resistant to antiapoptotic stimulation. J Leukoc Biol. 2011;90:1055-63 pubmed publisher
    ..We describe a novel, functional alteration that takes place during in vivo transmigration and highlights the fact that life and death of neutrophils may be regulated differently in blood and tissue. ..
  33. Liu Y, O Connor M, Mandell K, Zen K, Ullrich A, Buhring H, et al. Peptide-mediated inhibition of neutrophil transmigration by blocking CD47 interactions with signal regulatory protein alpha. J Immunol. 2004;172:2578-85 pubmed
    ..Such peptide reagents may be useful for studies on experimental models of inflammation and provide a template for the design of anti-inflammatory agents. ..
  34. Gronert K, Kantarci A, Levy B, Clish C, Odparlik S, Hasturk H, et al. A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage. J Immunol. 2004;172:1856-61 pubmed
    ..Moreover, they identify a potential molecular lesion in PMN signal transduction that may account for their aberrant responses and tissue destruction in this disease. ..
  35. Fechner P. Inhibition of lens epithelial cell migration by contact pressure. J Cataract Refract Surg. 2005;31:1856 pubmed
  36. Jalocha L, Wojtuń S, Dyrla P, Błaszak A, Wojtkowiak M, Zysko B, et al. [Perspectives in inflammatory bowel diseases treatment]. Pol Merkur Lekarski. 2009;26:556-8 pubmed
    ..Those drug are under development or in various clinical trials phases and are the future of inflammatory bowel diseases treatment. ..
  37. Tennis M, Van Scoyk M, Freeman S, Vandervest K, Nemenoff R, Winn R. Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. Mol Cancer Res. 2010;8:833-43 pubmed publisher
    ..These data present previously undescribed targets of Spry4 and suggest that Spry4 is a downstream target of Wnt7A/Fzd 9 signaling. Spry4 may have efficacy in the treatment of NSCLC. ..
  38. Monpara J, Kanthou C, Tozer G, Vavia P. Rational Design of Cholesterol Derivative for Improved Stability of Paclitaxel Cationic Liposomes. Pharm Res. 2018;35:90 pubmed publisher
    ..liposomes showed slightly improved cytotoxicity in three different cell lines and improved endothelial cell migration inhibition compared to conventional liposomes...
  39. Hart A, Ng S, Mann E, Al Hassi H, Bernardo D, Knight S. Homing of immune cells: role in homeostasis and intestinal inflammation. Inflamm Bowel Dis. 2010;16:1969-77 pubmed publisher
    ..Unraveling the mechanisms underlying the immune post-code system would assist in achieving the goal of tissue-specific immunotherapy. ..
  40. Partida Sanchez S, Iribarren P, Moreno Garcia M, Gao J, Murphy P, Oppenheimer N, et al. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose. J Immunol. 2004;172:1896-906 pubmed
  41. Frow E, Reckless J, Grainger D. Tools for anti-inflammatory drug design: in vitro models of leukocyte migration. Med Res Rev. 2004;24:276-98 pubmed
    ..While being more resource intensive than surrogate measures such as calcium flux, functional approaches nevertheless provide superior correlations with anti-inflammatory activity in vivo. ..
  42. Kamimura Y, Iwai H, Piao J, Hashiguchi M, Azuma M. The glucocorticoid-induced TNF receptor-related protein (GITR)-GITR ligand pathway acts as a mediator of cutaneous dendritic cell migration and promotes T cell-mediated acquired immunity. J Immunol. 2009;182:2708-16 pubmed publisher
    ..Our findings provide important implications for understanding the molecular bases of KC-LC interactions and for developing new therapeutic strategies in skin disease. ..
  43. Sroka J, Włosiak P, Wilk A, Antonik J, Czyz J, Madeja Z. The effect of tributyltin on human eosinophilic [correction of eosinophylic] leukemia EoL-1 cells. Cell Mol Biol Lett. 2008;13:67-73 pubmed
  44. Williamson M, Shuttleworth A, Canfield A, Black R, Kielty C. The role of endothelial cell attachment to elastic fibre molecules in the enhancement of monolayer formation and retention, and the inhibition of smooth muscle cell recruitment. Biomaterials. 2007;28:5307-18 pubmed
    ..These findings have important implications for the design of vascular graft scaffolds, the clinical performance of which may be enhanced by exploiting natural cell-matrix biology to regulate cell attachment and function. ..
  45. Huang J, Cheng Y, Lin Y, Lin H, Su C, Juliano R, et al. Extracellular matrix of glioblastoma inhibits polarization and transmigration of T cells: the role of tenascin-C in immune suppression. J Immunol. 2010;185:1450-9 pubmed publisher
    ..In summary, glioma cells can actively paralyze T cell migration by the expression of tenascin-C, representing a novel immune suppressive mechanism achieved through tumor ECM. ..
  46. Nath N, Giri S, Prasad R, Singh A, Singh I. Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy. J Immunol. 2004;172:1273-86 pubmed
    ..Together, these findings reveal that lovastatin may have possible therapeutic value involving new targets (in both APCs and T cells) for the treatment of multiple sclerosis and other inflammatory diseases. ..
  47. Zanotti C, Chiarini M, Serana F, Sottini A, Garrafa E, Torri F, et al. Peripheral accumulation of newly produced T and B lymphocytes in natalizumab-treated multiple sclerosis patients. Clin Immunol. 2012;145:19-26 pubmed publisher
    ..In some patients this resulted in an enlargement of T-cell heterogeneity. Because new lymphocyte production ensures the integrity of immune surveillance, its quantification could be used to monitor natalizumab therapy safety. ..
  48. Kong D, Zhang F, Zhang Z, Lu Y, Zheng S. Clearance of activated stellate cells for hepatic fibrosis regression: molecular basis and translational potential. Biomed Pharmacother. 2013;67:246-50 pubmed publisher
    ..In this review, we will discuss the mechanisms of clearance of activated HSCs and their potential in resolution of hepatic fibrosis. ..
  49. Mohan K, Pinto D, Issekutz T. Identification of tissue transglutaminase as a novel molecule involved in human CD8+ T cell transendothelial migration. J Immunol. 2003;171:3179-86 pubmed
    ..Thus, 6B9 is a new blocking mAb to human tTG, which demonstrates that tTG may have a novel role in mediating CD8(+) T cell migration across cytokine-activated endothelium and infiltration of tissues during inflammation. ..
  50. Seledtsov V, Rabinovich S, Kashchenko E, Fel de M, Banul N, Poveshchenko O, et al. Immunological and clinical aspects of cell therapy in the treatment of aftereffects of craniocerebral injury. Bull Exp Biol Med. 2006;141:121-3 pubmed
    ..No serious complications of this treatment modality were observed. Presumably, cell therapy is a safe method which can be used in the treatment of craniocerebral injury aftereffects. ..
  51. Tury A, Mairet Coello G, Dicicco Bloom E. The cyclin-dependent kinase inhibitor p57Kip2 regulates cell cycle exit, differentiation, and migration of embryonic cerebral cortical precursors. Cereb Cortex. 2011;21:1840-56 pubmed publisher
    ..These observations suggest p57(Kip2) coordinates multiple stages of corticogenesis and exhibits distinct and common activities compared with related family member p27(Kip1). ..
  52. Wittko I, Schänzer A, Kuzmichev A, Schneider F, Shibuya M, Raab S, et al. VEGFR-1 regulates adult olfactory bulb neurogenesis and migration of neural progenitors in the rostral migratory stream in vivo. J Neurosci. 2009;29:8704-14 pubmed publisher
    ..This study reveals that proper RMS migration is dependent on endogenous VEGF-A protein. ..
  53. Coburn L, Cerone L, Torney C, Couzin I, Neufeld Z. Tactile interactions lead to coherent motion and enhanced chemotaxis of migrating cells. Phys Biol. 2013;10:046002 pubmed publisher