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| rhabdomyolysisSummarySummary: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria. Top Publications
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b>Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins...
- Shanu A, Groebler L, Kim H, Wood S, Weekley C, Aitken J, et al. Selenium inhibits renal oxidation and inflammation but not acute kidney injury in an animal model of rhabdomyolysis. Antioxid Redox Signal. 2013;18:756-69 pubmed publisherAcute kidney injury (AKI) is a manifestation of rhabdomyolysis (RM). Extracellular myoglobin accumulating in the kidney after RM promotes oxidative damage, which is implicated in AKI.
- Micheletti M, Lavoratti G, Gasperini S, Donati M, Pela I. Hemolytic uremic syndrome and rhabdomyolysis in a patient with succinate coenzyme Q reductase (complex II) deficiency. Clin Nephrol. 2011;76:68-73 pubmed..b>Rhabdomyolysis is the dissolution of skeletal muscle due to various causes, including inborn errors of metabolism...
- Izumi R, Suzuki N, Nagata M, Hasegawa T, Abe Y, Saito Y, et al. A case of late onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting as recurrent rhabdomyolysis and acute renal failure. Intern Med. 2011;50:2663-8 pubmed..riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (MADD) characterized by episodic recurrent rhabdomyolysis and acute renal failure after the age of 46...
- Wu C, Huang J, Lin J, Hsia S. Factors associated with nontraumatic rhabdomyolysis and acute renal failure of children in Taiwan population. Pediatr Emerg Care. 2009;25:657-60 pubmedWe evaluated nontrauma causes of rhabdomyolysis and the factors associated with the development of acute renal failure (ARF) of children in Taiwan. We also explored the sex and age characteristics of patients with rhabdomyolysis.
- Shapiro M, Baldea A, Luchette F. Rhabdomyolysis in the intensive care unit. J Intensive Care Med. 2012;27:335-42 pubmed publisherb>Rhabdomyolysis is a clinical syndrome defined by muscle breakdown and subsequent release of intracellular contents...
- Unverdi S, Akay H, Ceri M, Inal S, Altay M, Demiroz A, et al. Acute kidney injury due to rhabdomyolysis in H1N1 influenza infection. Ren Fail. 2011;33:450-1 pubmed publisher..were documented for elevation of creatinine phosphokinase levels in the course of influenza infection, but rhabdomyolysis was rarely reported...
- Sevketoglu E, Kural B, Beskardes A, Hatipoglu S. Exertional rhabdomyolysis after influenza A (H3N2) infection in a basketball player boy. Ann Trop Paediatr. 2011;31:93-6 pubmed publisher..Two days after completing the course, he resumed basketball and developed rhabdomyolysis associated with acute renal failure and disseminated intravascular coagulation...
- Marotta R, Chin J, Kirby D, Chiotis M, Cook M, Collins S. Novel single base pair COX III subunit deletion of mitochondrial DNA associated with rhabdomyolysis. J Clin Neurosci. 2011;18:290-2 pubmed publisher..without ragged red fibres was found in a 27-year-old male patient with a single unprovoked episode of severe rhabdomyolysis. There was no family history of neuromuscular disorder and sequencing revealed a novel COX III single base ..
- de Carvalho J, da Mota L, Bonfa E. Fatal rhabdomyolysis in systemic lupus erythematosus. Rheumatol Int. 2011;31:1243-5 pubmed publisherThe authors describe herein the sixth lupus case that evolved with rhabdomyolysis. A 36-year-old woman with systemic lupus erythematosus was admitted to our hospital with malaise, myalgia, dysphagia, fever, preserved muscle strength, ..
- Hill O, Wahi M, Carter R, Kay A, McKinnon C, Wallace R. Rhabdomyolysis in the US Active Duty Army, 2004-2006. Med Sci Sports Exerc. 2012;44:442-9 pubmed publisherb>Rhabdomyolysis (RM) is a skeletal muscle disorder resulting in severe cellular injury caused by vigorous physical activity and other systemic etiologies...
- Matsusue A, Hara K, Kashiwagi M, Kageura M, Sugimura T, Kubo S. Genetic analysis of the rhabdomyolysis-associated genes in forensic autopsy cases of methamphetamine abusers. Leg Med (Tokyo). 2011;13:7-11 pubmed publisherMethamphetamine (MA) use sometimes causes rhabdomyolysis, which has been associated with mortality. We analyzed potential rhabdomyolysis-susceptibility genes from autopsy samples of 18 methamphetamine abusers...
- Grosso F, D INCALCI M, Cartoafa M, Nieto A, Fernández Teruel C, Alfaro V, et al. A comprehensive safety analysis confirms rhabdomyolysis as an uncommon adverse reaction in patients treated with trabectedin. Cancer Chemother Pharmacol. 2012;69:1557-65 pubmed publisherThis analysis determined the incidence of serious rhabdomyolysis events reported during trabectedin treatment since the first phase I clinical trial in April 1996 up to September 2010.
- Graziani G, Calvetta A, Cucchiari D, Valaperta S, Montanelli A. Life-threatening hypercalcemia in patients with rhabdomyolysis-induced oliguric acute renal failure. J Nephrol. 2011;24:128-31 pubmedIn a third of patients presenting with rhabdomyolysis-induced acute renal failure (ARF), a biphasic plasma calcium profile may occur...
- Marot A, Morelle J, Chouinard V, Jadoul M, Lambert M, Demoulin N. Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis: a case report and review of the literature. Acta Clin Belg. 2011;66:134-6 pubmedMyopathy, including rhabdomyolysis, is a well-known, albeit rare complication of statin therapy. Predisposing factors include comorbidities and the concomitant use of cytochrome P-450 (CYP) 3A4 inhibitors...
- Hinojosa Perez R, Porras Lopez M, Escoresca Ortega A, Herruzo Aviles A, Leon A, Noval J, et al. Severe rhabdomyolysis after allogeneic transplantation of facial structures: a case report. Transplant Proc. 2010;42:3081-2 pubmed publisher..type 1 who underwent allogeneic transplantation of facial structures, which was complicated by severe rhabdomyolysis and temporary oligoanuria...
- Siqueira A, Alexandre M, Mourão M, Santos V, Nagahashi Marie S, Alecrim M, et al. Severe rhabdomyolysis caused by Plasmodium vivax malaria in the Brazilian Amazon. Am J Trop Med Hyg. 2010;83:271-3 pubmed publisherSevere rhabdomyolysis (creatine phosphokinase = 29,400 U/L) developed in a 16-year-old boy from Manaus, Brazil, after he started treatment with chloroquine for infection with Plasmodium vivax...
- Better O, Abassi Z. Early fluid resuscitation in patients with rhabdomyolysis. Nat Rev Nephrol. 2011;7:416-22 pubmed publisherExtensive rhabdomyolysis is often lethal unless treated immediately. Early mortality arises from hypovolemic shock, hyperkalemia, acidosis and myoglobinuric acute kidney injury (AKI)...
- Bruso J, Hoffman M, Rogers I, Lee L, Towle G, Hew Butler T. Rhabdomyolysis and hyponatremia: a cluster of five cases at the 161-km 2009 Western States Endurance Run. Wilderness Environ Med. 2010;21:303-8 pubmed publisherFive of 400 starters of the 2009 Western States Endurance Run (WSER) were hospitalized with hyponatremia and rhabdomyolysis. This article explores the risk factors associated with development of hyponatremia and rhabdomyolysis.
- Zager R, Johnson A, Becker K. Plasma and urinary heme oxygenase-1 in AKI. J Am Soc Nephrol. 2012;23:1048-57 pubmed publisher..the induction and/or maintenance phases of four mouse models of AKI: ischemia/reperfusion, glycerol-induced rhabdomyolysis, cisplatin nephrotoxicity, and bilateral ureteral obstruction...
- Sav T, Unal A, Erden A, Gunal A. Single-dose-dexketoprofen-induced acute kidney injury due to massive rhabdomyolysis. Int Urol Nephrol. 2012;44:1581-3 pubmed publisher..Acute kidney injury caused by dexketoprofen-induced rhabdomyolysis was diagnosed by ruling out other possible causes, such as dermato/polymyositis, myxedema, brucellosis, and ..
- Catapano A. Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatin. Curr Vasc Pharmacol. 2012;10:257-67 pubmed..the potential to cause adverse events which can result in muscular inflammation (myositis), muscle breakdown (rhabdomyolysis) and, ultimately, kidney failure. While the incidence of rhabdomyolysis is approximately 3...
- Dakwar E, Rifkin S, Volcan I, Goodrich J, Uribe J. Rhabdomyolysis and acute renal failure following minimally invasive spine surgery: report of 5 cases. J Neurosurg Spine. 2011;14:785-8 pubmed publisher..b>Rhabdomyolysis (RM) is a rare but known complication of spine surgery, and acute renal failure (ARF) is in turn a potential ..
- Star K, Iessa N, Almandil N, Wilton L, Curran S, Edwards I, et al. Rhabdomyolysis reported for children and adolescents treated with antipsychotic medicines: a case series analysis. J Child Adolesc Psychopharmacol. 2012;22:440-51 pubmed publisherb>Rhabdomyolysis is a rare and potentially serious adverse drug reaction (ADR) to antipsychotic medicines...
- Michot C, Hubert L, Romero N, Gouda A, Mamoune A, Mathew S, et al. Study of LPIN1, LPIN2 and LPIN3 in rhabdomyolysis and exercise-induced myalgia. J Inherit Metab Dis. 2012;35:1119-28 pubmed publisherRecessive LPIN1 mutations were identified as a cause of severe rhabdomyolysis in pediatric patients. The human lipin family includes two other closely related members, lipin-2 and 3, which share strong homology and similar activity...
- Stoyianni A, Kapodistrias N, Kampletsas E, Pentheroudakis G, Pavlidis N. Trabectedin-related rhabdomyolysis: an uncommon but fatal toxicity. Tumori. 2011;97:252-5 pubmed publisherb>Rhabdomyolysis is defined as the dissolution of striped muscle characterized by the leakage of intracellular muscle components into the circulation, which can ultimately lead to renal failure with a possible fatal outcome...
- Fearnley R, Lines S, Lewington A, Bodenham A. Influenza A-induced rhabdomyolysis and acute kidney injury complicated by posterior reversible encephalopathy syndrome. Anaesthesia. 2011;66:738-42 pubmed publisherWe report a case of Influenza A-induced rhabdomyolysis causing acute kidney injury in a young adult female who required invasive ventilation and renal replacement therapy...
- Dlamini N, Voermans N, Lillis S, Stewart K, Kamsteeg E, Drost G, et al. Mutations in RYR1 are a common cause of exertional myalgia and rhabdomyolysis. Neuromuscul Disord. 2013;23:540-8 pubmed publisher..We sequenced RYR1 in 39 unrelated families with rhabdomyolysis and/or exertional myalgia, frequent presentations in the neuromuscular clinic that often remain unexplained ..
- Gupta A, Khaira A, Lata S, Agarwal S, Tiwari S. Rhabdomyolysis, acute kidney injury and transverse myelitis due to naive heroin exposure. Saudi J Kidney Dis Transpl. 2011;22:1223-5 pubmed..like seizures, stroke, spongiform encephalopathy, transverse myelopathy, plexopathy, compartment syndrome, rhabdomyolysis and renal failure due to various mechanisms...
- Oshima Y. Characteristics of drug-associated rhabdomyolysis: analysis of 8,610 cases reported to the U.S. Food and Drug Administration. Intern Med. 2011;50:845-53 pubmedTo describe the characteristics of cases with drug-associated rhabdomyolysis reported to the U.S. Food and Drug Administration (FDA).
- Barrey E, Jayr L, Mucher E, Gospodnetic S, Joly F, Benech P, et al. Transcriptome analysis of muscle in horses suffering from recurrent exertional rhabdomyolysis revealed energetic pathway alterations and disruption in the cytosolic calcium regulation. Anim Genet. 2012;43:271-81 pubmed publisherRecurrent exertional rhabdomyolysis (RER) is frequently observed in race horses like trotters. Some predisposing genetic factors have been described in epidemiological studies. However, the exact aetiology is still unknown...
- Marciante K, Durda J, Heckbert S, Lumley T, Rice K, McKnight B, et al. Cerivastatin, genetic variants, and the risk of rhabdomyolysis. Pharmacogenet Genomics. 2011;21:280-8 pubmed publisherThe withdrawal of cerivastatin involved an uncommon but serious adverse reaction, rhabdomyolysis. The bimodal response, rhabdomyolysis in a small proportion of users, points to genetic factors as a potential cause...
- Wen Z, Chuanwei L, Chunyu Z, Hui H, Weimin L. Rhabdomyolysis presenting with severe hypokalemia in hypertensive patients: a case series. BMC Res Notes. 2013;6:155 pubmed publisherb>Rhabdomyolysis presenting with severe hypokalemia as the first manifestation of primary hyperaldosteronism is extremely rare.
- MATHEW A, Chrispal A, David T. Acute myocardial injury and rhabdomyolysis caused by multiple bee stings. J Assoc Physicians India. 2011;59:518-20 pubmed..Acute myocardial ischemia due to bee envenomation is a rare event. We report the case of a 65 year old lady who presented with acute myocardial ischemia, severe rhabdomyolysis and angioedema following massive bee envenomation.
- Kim H, Shanu A, Wood S, Parry S, Collet M, McMahon A, et al. Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Free Radic Res. 2011;45:1000-12 pubmed publisherb>Rhabdomyolysis (RM) caused by severe burn releases extracellular myoglobin (Mb) that accumulates in the kidney. Extracellular Mb is a pro-oxidant...
- Chen S, Liu K, Chang H, Lee Y, Chen C, Lee M. Rhabdomyolysis following pandemic influenza A (H1N1) infection. Neth J Med. 2010;68:317-9 pubmed..Although pneumonia and acute respiratory distress syndrome are the most common severe complications of H1N1/09 infection, clinicians should be aware that H1N1/09 infection may be complicated by rhabdomyolysis.
- Frohlich G, Grawe A, Schmidt N, Roth R, Märker Hermann E. [Difficult course of rhabdomyolysis in influenza A/H1N1]. Dtsch Med Wochenschr. 2013;138:2351-4 pubmed publisher..A 37-year-old man complained about a lack of strength, an unproductive cough and myalgia predominantly thigh-focused with subfebrile temperatures for days...
- Comak E, Koyun M, Kiliçarslan Akkaya B, Bircan I, Akman S. Severe rhabdomyolysis and acute renal failure in an adolescent with hypothyroidism. Turk J Pediatr. 2011;53:586-9 pubmedHypothyroidism has been reported rarely as the cause of rhabdomyolysis in adults and children...
- Cziraky M, Willey V, McKenney J, Kamat S, Fisher M, Guyton J, et al. Risk of hospitalized rhabdomyolysis associated with lipid-lowering drugs in a real-world clinical setting. J Clin Lipidol. 2013;7:102-8 pubmed publisherThe occurrence of low rates of rhabdomyolysis among patients receiving lipid-lowering drugs (LLDs) in randomized clinical trials may be elucidated with population-based studies.
- Kenney K, Landau M, Gonzalez R, Hundertmark J, O BRIEN K, Campbell W. Serum creatine kinase after exercise: drawing the line between physiological response and exertional rhabdomyolysis. Muscle Nerve. 2012;45:356-62 pubmed publisher..In this investigation we assessed the spectrum of creatine kinase (CK) responses in military recruits undergoing basic training...
- de Wolff J. Rhabdomyolysis. Br J Hosp Med (Lond). 2012;73:C30-2 pubmedb>Rhabdomyolysis is the destruction of a significant amount of striated muscle, leading to disruptions in fluid balance, electrolytes and renal function. It may have either traumatic (such as crush injury) or non-traumatic causes...
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..statin induced myotoxicity includes asymptomatic rise in creatine kinase concentration, myalgia, myositis and rhabdomyolysis. In certain cases, the cessation of statin therapy does not result in the resolution of muscular symptoms or ..
- Amend K, Landon J, Thyagarajan V, NIEMCRYK S, McAfee A. Incidence of hospitalized rhabdomyolysis with statin and fibrate use in an insured US population. Ann Pharmacother. 2011;45:1230-9 pubmed publisherThe incidence of hospitalized rhabdomyolysis is not well characterized among patients taking statin-fibrate combination therapies.
- Delaney K, Givens M, Vohra R. Use of RIFLE criteria to predict the severity and prognosis of acute kidney injury in emergency department patients with rhabdomyolysis. J Emerg Med. 2012;42:521-8 pubmed publisherRIFLE criteria (Risk, Injury, Failure, Loss, End-stage) have not been evaluated in Emergency Department (ED) patients at risk of acute kidney injury (AKI). AKI occurs in rhabdomyolysis.
- Ardalan M, Ghabili K, Mirnour R, Shoja M. Hypothyroidism-induced rhabdomyolysis and renal failure. Ren Fail. 2011;33:553-4 pubmed publisherRenal failure, due to rhabdomyolysis, is a rare complication of hypothyroidism. We report an elderly patient with primary hypothyroidism symptoms initially presented with inability to walk, leading to renal failure...
- Sorrentino S, Kielstein J, Lukasz A, Sorrentino J, Gohrbandt B, Haller H, et al. High permeability dialysis membrane allows effective removal of myoglobin in acute kidney injury resulting from rhabdomyolysis. Crit Care Med. 2011;39:184-6 pubmed publisherThe objective of this study was to test the ability of myoglobin removal of a novel, high-permeability polysulphone dialyzer in acute kidney injury as a result of rhabdomyolysis.
- Isgren C, Upjohn M, Fernandez Fuente M, Massey C, Pollott G, Verheyen K, et al. Epidemiology of exertional rhabdomyolysis susceptibility in standardbred horses reveals associated risk factors and underlying enhanced performance. PLoS ONE. 2010;5:e11594 pubmed publisherExertional rhabdomyolysis syndrome is recognised in many athletic horse breeds and in recent years specific forms of the syndrome have been identified...
- Vilar S, Harpaz R, Chase H, Costanzi S, Rabadan R, Friedman C. Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis. J Am Med Inform Assoc. 2011;18 Suppl 1:i73-80 pubmed publisher..Various data mining approaches have been developed that use AERS to detect signals identifying associations between drugs and ADE. The signals must then be monitored further by domain experts, which is a time-consuming task...
- Weibrecht K, Dayno M, Darling C, Bird S. Liver aminotransferases are elevated with rhabdomyolysis in the absence of significant liver injury. J Med Toxicol. 2010;6:294-300 pubmed publisherb>Rhabdomyolysis is an uncommon finding in the emergency department. However, the clinical implications of rhabdomyolysis are important, with a significant minority of patients developing acute renal failure and multiorgan failure...
- Jones P, Davidson M. Reporting rate of rhabdomyolysis with fenofibrate + statin versus gemfibrozil + any statin. Am J Cardiol. 2005;95:120-2 pubmed..The findings suggest that the use of fenofibrate in combination with statins results in fewer reports of rhabdomyolysis per million prescriptions dispensed than does the use of gemfibrozil.
- Dorman R, Wunder C, Brock R. Cobalt protoporphyrin protects against hepatic parenchymal injury and microvascular dysfunction during experimental rhabdomyolysis. Shock. 2005;23:275-80 pubmedAlthough heme is necessary in many life-sustaining functions, its overwhelming systemic release with rhabdomyolysis (RM) is believed to be the cause of subsequent organ injury and dysfunction...
- Reynaud F, Mallet L, Lyon A, Rodolfo J. Rhabdomyolysis and acute renal failure in Plasmodium falciparum malaria. Nephrol Dial Transplant. 2005;20:847 pubmed
- Akoglu H, Yilmaz R, Kirkpantur A, Arici M, Altun B, Turgan C. Combined organ failure with combination antihyperlipidemic treatment: a case of hepatic injury and acute renal failure. Ann Pharmacother. 2007;41:143-7 pubmedTo report a case of acute hepatic injury and acute renal failure secondary to rhabdomyolysis associated with fluvastatin-gemfibrozil combination therapy for hyperlipidemia...
- Punukollu G, Gowda R, Khan I, Mehta N, Navarro V, Vasavada B, et al. Elevated serum cardiac troponin I in rhabdomyolysis. Int J Cardiol. 2004;96:35-40 pubmedTo examine the etiology and clinical significance of elevated serum cardiac troponin I (cTnI) in patients with rhabdomyolysis.
- Ertekin V, Selimoglu M, Altinkaynak S. A combination of unusual presentations of Datura stramonium intoxication in a child: rhabdomyolysis and fulminant hepatitius. J Emerg Med. 2005;28:227-8 pubmed
- Glassman D, Merriam W, Trabulsi E, Byrne D, Gomella L. Rhabdomyolysis after laparoscopic nephrectomy. JSLS. 2007;11:432-7 pubmed..The development of postoperative rhabdomyolysis is a known but rare complication of laparoscopic renal surgery...
- Walder A, Baumann P. Increased creatinine kinase and rhabdomyolysis in anorexia nervosa. Int J Eat Disord. 2008;41:766-7 pubmed publisher..Seven weeks after admission to hospital, laboratory findings showed an extremely high level of serum creatinine kinase (CK) (>20,000 U/L) without clinical signs for rhabdomyolysis or renal depression.
- Espiritu R, Stan M. Rhabdomyolysis after withdrawal of thyroid hormone in a patient with papillary thyroid cancer. Endocr Pract. 2008;14:1023-6 pubmedTo report a case of rhabdomyolysis presenting with severe hyperkalemia after withdrawal of thyroid hormone in a patient with differentiated thyroid cancer.
- Leaf D, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2010;25:1335-7 pubmed publisherb>Rhabdomyolysis-induced acute kidney injury (AKI) is characterized by hyperphosphataemia and hypocalcaemia...