muscle rigidity

Summary

Summary: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)

Top Publications

  1. Hadad E, Weinbroum A, Ben Abraham R. Drug-induced hyperthermia and muscle rigidity: a practical approach. Eur J Emerg Med. 2003;10:149-54 pubmed
    ..We present six conditions, in decreasing order of gravity and potential lethality, in which hyperthermia plays an essential role, and suggest a clinical approach in such conditions...
  2. Wardas J, Konieczny J, Lorenc Koci E. SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats. Synapse. 2001;41:160-71 pubmed
    ..blockade of adenosine A(2A) receptors by a selective antagonist, SCH 58261, influenced parkinsonian-like muscle rigidity. Muscle tone was examined using a combined mechano- and electromyographic method which simultaneously ..
  3. Ray N, Jenkinson N, Wang S, Holland P, Brittain J, Joint C, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp Neurol. 2008;213:108-13 pubmed publisher
  4. Raoul S, Roualdes V, Deligny C, Leduc D, Lamy J, Lackmy Vallée A, et al. Subthalamic nucleus stimulation reverses spinal motoneuron activity in parkinsonian patients. Brain. 2012;135:139-47 pubmed publisher
  5. Pogosyan A, Yoshida F, Chen C, Martinez Torres I, Foltynie T, Limousin P, et al. Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization. Neuroscience. 2010;171:245-57 pubmed publisher
    ..In addition, they strengthen the link between pathological synchronization and the different motor features of Parkinsonism...
  6. Chen C, Hsu Y, Chan H, Chiou S, Tu P, Lee S, et al. Complexity of subthalamic 13-35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease. Exp Neurol. 2010;224:234-40 pubmed publisher
    ..The results strengthen the association between the dynamic structure of synchonised (LFP) activity in the beta frequency band in the STN and akinesia-rigidity...
  7. Endo T, Okuno R, Yokoe M, Akazawa K, Sakoda S. A novel method for systematic analysis of rigidity in Parkinson's disease. Mov Disord. 2009;24:2218-24 pubmed publisher
    ..The EMG index was useful for differentiating PD patients with slight rigidity from healthy elderly adults...
  8. Kuhn A, Tsui A, Aziz T, Ray N, Brücke C, Kupsch A, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity. Exp Neurol. 2009;215:380-7 pubmed publisher
  9. Konieczny J, Przegalinski E, Pokorski M. N-oleoyl-dopamine decreases muscle rigidity induced by reserpine in rats. Int J Immunopathol Pharmacol. 2009;22:21-8 pubmed
    ..to determine whether OLDA would affect muscle tone and akinesia in two rat models of PD: the reserpine-evoked muscle rigidity and the reserpine- and haloperidol-induced catalepsy...

More Information

Publications62

  1. Wardas J. Synergistic effect of SCH 58261, an adenosine A2A receptor antagonist, and L-DOPA on the reserpine-induced muscle rigidity in rats. Pol J Pharmacol. 2003;55:155-64 pubmed
    ..potentiates the attenuating effect of L-DOPA, the well-known antiparkinsonian drug, on parkinsonian-like muscle rigidity in rats...
  2. Levin J, Krafczyk S, Valkovic P, Eggert T, Claassen J, Bötzel K. Objective measurement of muscle rigidity in Parkinsonian patients treated with subthalamic stimulation. Mov Disord. 2009;24:57-63 pubmed publisher
    ..In view of its low technical requirements, this technique lends itself to use during DBS implantation surgery and in the clinical environment...
  3. Benabid A, Chabardes S, Mitrofanis J, Pollak P. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease. Lancet Neurol. 2009;8:67-81 pubmed publisher
    ..Further improvements, through basic research and methodological innovations, should make it applicable to earlier stages of the disease and increase its availability to patients in developing countries...
  4. Park B, Kwon Y, Kim J, Lee J, Eom G, Koh S, et al. Analysis of viscoelastic properties of wrist joint for quantification of parkinsonian rigidity. IEEE Trans Neural Syst Rehabil Eng. 2011;19:167-76 pubmed publisher
  5. Powell D, Threlkeld A, Fang X, Muthumani A, Xia R. Amplitude- and velocity-dependency of rigidity measured at the wrist in Parkinson's disease. Clin Neurophysiol. 2012;123:764-73 pubmed publisher
    ..Quantify the effects of increased amplitude and rate of muscle stretch on parkinsonian rigidity...
  6. Patrick S, Denington A, Gauthier M, Gillard D, Prochazka A. Quantification of the UPDRS Rigidity Scale. IEEE Trans Neural Syst Rehabil Eng. 2001;9:31-41 pubmed
    ..Mechanical impedance was nonlinearly related to UPDRS ratings of rigidity at the elbow and wrist; characterization of such relationships allows interpretation of impedance measurements in terms of the clinical rating scales...
  7. Mann J, Foote K, Garvan C, Fernandez H, Jacobson C, Rodriguez R, et al. Brain penetration effects of microelectrodes and DBS leads in STN or GPi. J Neurol Neurosurg Psychiatry. 2009;80:794-7 pubmed publisher
    ..Secondarily, to evaluate whether the longevity of the MER and lead placement effects were influenced by target location (subthalamic nucleus (STN) or globus pallidus interna (GPi))...
  8. Paoletti O, Fraire M, Sanchez Vallecillo M, Zernotti M, Olmos M, Zernotti M. [The use of fibrolaryngoscopy in muscle tension dysphonia in telemarketers]. Acta Otorrinolaringol Esp. 2012;63:200-5 pubmed publisher
    ..This report aims to compare the laryngeal features in telemarketer patients with MTD versus non-dysphonic control subjects...
  9. Hamada M, Ugawa Y, Tsuji S. High-frequency rTMS over the supplementary motor area improves bradykinesia in Parkinson's disease: subanalysis of double-blind sham-controlled study. J Neurol Sci. 2009;287:143-6 pubmed publisher
    ..Results support the hypothesis that neuronal activity of SMA was profoundly associated with hypokinetic symptoms in PD...
  10. El Otmani H, Jodoin N, Yaici S, Welter M, Bonnet A, Navarro S, et al. [Can subthalamic nucleus stimulation reveal parkinsonian rest tremor?]. Rev Neurol (Paris). 2009;165:81-5 pubmed publisher
    ..Results are often better than after l-dopa treatment. The occurrence of rest tremor after neurosurgery in patients without preoperative tremor is uncommon...
  11. Moran M, Allen N, Treacy E, King M. "Stiff neonate" with mitochondrial DNA depletion and secondary neurotransmitter defects. Pediatr Neurol. 2011;45:403-5 pubmed publisher
    ..This diagnosis should be considered in neonates or infants who present with hypertonia, hypokinesia rigidity, and progressive neurodegeneration...
  12. Sturman M, Vaillancourt D, Shapiro M, Metman L, Bakay R, Corcos D. Effect of short and long term STN stimulation periods on parkinsonian signs. Mov Disord. 2008;23:866-74 pubmed publisher
    ..As such, it is reasonable to evaluate the effect of DBS after 90 min of stimulation in clinical trials and research studies...
  13. Seibel L, Barlow S. Automatic measurement of nonparticipatory stiffness in the perioral complex. J Speech Lang Hear Res. 2007;50:1272-9 pubmed
  14. Tarsy D, Scollins L, Corapi K, O Herron S, Apetauerova D, Norregaard T. Progression of Parkinson's disease following thalamic deep brain stimulation for tremor. Stereotact Funct Neurosurg. 2005;83:222-7 pubmed
    ..UPDRS III motor scores were unchanged. However, global assessment of PD progression and increased mean L-dopa dose and L-dopa equivalent daily dose at the time of last follow-up visit indicated that a progression of PD had occurred...
  15. Skrebnitskaia L, Vishniakov G, Neĭman S, Rozhdestvenskaia Z, Andreev O, Levin G. [Two-dimensional reconstruction of birefringence map of the skeletal muscle sarcomere in relaxed and rigor states studied by interference microscopy]. Biofizika. 2001;46:518-23 pubmed
    ..The results obtained could be explained by a decrease of thick filaments anisotropy, due to the moving away of myosin heads from the rod during transition into the rigor state...
  16. Tazawa Y, Okada K. Physical signs associated with excessive television-game playing and sleep deprivation. Pediatr Int. 2001;43:647-50 pubmed
    ..To elucidate significance of physical signs seen in excessive television-game (TVG) players complaining of unexplained persistent symptoms, a cross-sectional cohort study was designed...
  17. Aasly J, Toft M, Fernandez Mata I, Kachergus J, Hulihan M, White L, et al. Clinical features of LRRK2-associated Parkinson's disease in central Norway. Ann Neurol. 2005;57:762-5 pubmed
    ..The clinical features included asymmetric resting tremor, bradykinesia, and rigidity with a good response to levodopa and could not be distinguished from idiopathic Parkinson's disease...
  18. Bartolic A, Pirtosek Z, Rozman J, Ribaric S. Postural stability of Parkinson's disease patients is improved by decreasing rigidity. Eur J Neurol. 2005;12:156-9 pubmed
    ..The results of stabilometry and mUPDRS evaluations are in agreement with the effect of apomorphine on rigidity, indicating that postural stability of PD patients is improved by decreasing rigidity...
  19. Ceneviva G, Thomas N, Kees Folts D. Magnesium sulfate for control of muscle rigidity and spasms and avoidance of mechanical ventilation in pediatric tetanus. Pediatr Crit Care Med. 2003;4:480-4 pubmed
  20. Wardas J, Konieczny J, Pietraszek M. Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats. Psychopharmacology (Berl). 2003;168:299-306 pubmed
    ..g. catalepsy, muscle rigidity, ataxia)...
  21. Crocker A, Hemsley K. An animal model of extrapyramidal side effects induced by antipsychotic drugs: relationship with D2 dopamine receptor occupancy. Prog Neuropsychopharmacol Biol Psychiatry. 2001;25:573-90 pubmed
    1. Muscle rigidity was assessed quantitatively and objectively as increases in electromyographic (EMG) activity (muscle rigidity) in the hindlimb muscles of the rat following subcutaneous administration of haloperidol, fluphenazine and ..
  22. Ossowska K, Konieczny J, Wolfarth S, Wieronska J, Pilc A. Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. Neuropharmacology. 2001;41:413-20 pubmed
    ..Haloperidol, 0.25, 0.5 and 1mg/kg ip, was used to induce hypolocomotion, catalepsy and muscle rigidity, respectively...
  23. Setthawatcharawanich S, Sathirapanya P, Phabphal K, Limapichat K. Short questionnaire for Parkinson's disease as a screening instrument. Clin Neurol Neurosurg. 2011;113:885-8 pubmed publisher
    ..To validate and simplify a screening questionnaire for the determination of PD...
  24. Temperli P, Ghika J, Villemure J, Burkhard P, Bogousslavsky J, Vingerhoets F. How do parkinsonian signs return after discontinuation of subthalamic DBS?. Neurology. 2003;60:78-81 pubmed
    ..To study the reappearance of the clinical signs of PD when subthalamic nucleus (STN) deep brain stimulation (DBS) was turned off...
  25. Arima H, Sobue K, So M, Morishima T, Ando H, Katsuya H. Transient and reversible parkinsonism after acute organophosphate poisoning. J Toxicol Clin Toxicol. 2003;41:67-70 pubmed
    ..Patients should be carefully observed for the presence of neurological signs in this kind of poisoning. If present, an anti-parkinsonism drug should be considered...
  26. Vitek J, Bakay R, Freeman A, Evatt M, Green J, McDonald W, et al. Randomized trial of pallidotomy versus medical therapy for Parkinson's disease. Ann Neurol. 2003;53:558-69 pubmed
    ..0001), "off" motor (p < 0.0001) and complications of therapy subscores (p < 0.0001). Sustained improvement was also seen for tremor, rigidity, bradykinesia, percent on time and drug-induced dyskinesias...
  27. Bekkelund S, Lilleng H, Arntzen K. [Subacute worsening of rigidity in a patient with Parkinson disease]. Tidsskr Nor Laegeforen. 2008;128:2065-6 pubmed
    ..This case demonstrates the importance of considering other underlying neurological disease in parkinsonian patients presenting with rapid progression of parkinsonian symptoms...
  28. Chouinard G, Margolese H. Manual for the Extrapyramidal Symptom Rating Scale (ESRS). Schizophr Res. 2005;76:247-65 pubmed
    ..ESRS specificity was investigated through two different approaches, path analyses and ANCOVA PANSS factors changes, which found that ESRS measurement of drug-induced EPS is valid and discriminative from psychiatric symptoms...
  29. Baker I, Jackson M, Bass C. Catatonia causing permanent cognitive impairment: a case study. Cogn Behav Neurol. 2005;18:141-3 pubmed
    ..We describe a case of psychogenic malignant catatonia resulting in permanent cognitive impairment...
  30. Bhat V, Weiner W. Parkinson's disease. Diagnosis and the initiation of therapy. Minerva Med. 2005;96:145-54 pubmed
    ..Initiation of therapy should be tailored to individual patients with the emphasis on symptom control, with the hope that new approaches to treatment of PD (including neuroprotection) will be forthcoming...
  31. Bourgeois J, Hilty D. Prolonged delirium managed with risperidone. Psychosomatics. 2005;46:90-1 pubmed
  32. Sedaghat F, Gotzamani Psarrakou A, Dedousi E, Arnaoutoglou M, Psarrakos K, Baloyannis I, et al. Evaluation of dopaminergic function in frontotemporal dementia using I-FP-CIT single photon emission computed tomography. Neurodegener Dis. 2007;4:382-5 pubmed
    ..Since an effective treatment for FTD is still to be established, there is a need for evaluating the efficacy of dopaminergic drugs...
  33. Brvar M, Bunc M. Video of dantrolene effectiveness on neuroleptic malignant syndrome associated muscular rigidity and tremor. Crit Care. 2007;11:415 pubmed
  34. Cohen I, Kaplan R. Repeat episodes of severe muscle rigidity in a child receiving sevoflurane. Paediatr Anaesth. 2006;16:1077-9 pubmed
    We report on a patient who developed two episodes of severe muscle rigidity, increased endtidal CO2 and increased creatine phosphate kinase associated with sevoflurane anesthesia...
  35. Knowles A, Ferguson R, Brandmeier B, Sun Y, Trentham D, Irving M. Orientation of the essential light chain region of myosin in relaxed, active, and rigor muscle. Biophys J. 2008;95:3882-91 pubmed publisher
    ..During isometric contraction the ELC orientation distribution peaked at beta approximately 105 degrees , similar to that determined previously for the RLC region...
  36. Hayashi R, Hashimoto T, Tada T, Ikeda S. Relation between changes in long-latency stretch reflexes and muscle stiffness in Parkinson's disease--comparison before and after unilateral pallidotomy. Clin Neurophysiol. 2001;112:1814-21 pubmed
    ..To study the effects of posteroventral pallidotomy on both the size of long-latency stretch reflex (LLR) and the muscle stiffness in the wrist flexor muscles...
  37. Hubbuch M, Farmakis G, Schaefer A, Behnke S, Schneider S, Hellwig D, et al. FP-CIT SPECT does not predict the progression of motor symptoms in Parkinson's disease. Eur Neurol. 2011;65:187-92 pubmed publisher
    ..In this study, we examined the prognostic value of FP-CIT SPECT concerning the PD motor symptoms...
  38. Schmidt C, Redyk K, Meissner B, Krack L, von Ahsen N, Roeber S, et al. Clinical features of rapidly progressive Alzheimer's disease. Dement Geriatr Cogn Disord. 2010;29:371-8 pubmed publisher
    ..To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD)...
  39. Krack P, Dostrovsky J, Ilinsky I, Kultas Ilinsky K, Lenz F, Lozano A, et al. Surgery of the motor thalamus: problems with the present nomenclatures. Mov Disord. 2002;17 Suppl 3:S2-8 pubmed
    ..There is a need to better define the limits of the sensory and cerebellar afferent receiving thalamic nuclei as well as those of the cerebellar and pallidal afferent receiving territories in humans...
  40. Loopuijt L. Local application of L- threo-hydroxyaspartate and malonate in rats in vivo induces rigidity and damages neurons of the substantia nigra, pars compacta. J Neural Transm (Vienna). 2002;109:1275-94 pubmed
    ..05). This indicates, that a minimum amount of damage to neurons in the ventral part of the substantia nigra, pars compacta might be required for the expression of rigidity...
  41. Cizkova D, Kakinohana O, Kucharova K, Marsala S, Johe K, Hazel T, et al. Functional recovery in rats with ischemic paraplegia after spinal grafting of human spinal stem cells. Neuroscience. 2007;147:546-60 pubmed
    ..These data indicate that spinal grafting of hSSCs can represent an effective therapy for patients with spinal ischemic paraplegia...
  42. Popovic M, Dzoljic E, Kostic V. A method to assess hand motor blocks in Parkinson's disease with digitizing tablet. Tohoku J Exp Med. 2008;216:317-24 pubmed
    ..This low-cost instrument may be included in a clinical test battery because of short testing time and trouble-free preparation of patient...
  43. Ramakrishna H, Trentman T, Hall B, Sprung J. Ondansetron and carpopedal spasm. Can J Anaesth. 2008;55:55-6 pubmed publisher
  44. Visaria R, Westenskow D. Model-based detection of partially obstructed endotracheal tube. Crit Care Med. 2005;33:149-54; discussion 249-50 pubmed
    ..Cases with positive end-expiratory pressure were also included in the analysis to see the effects of positive end-expiratory pressure on the model...
  45. Wilson R, Arnold S, Buchman A, Tang Y, Bennett D. Odor identification and progression of parkinsonian signs in older persons. Exp Aging Res. 2008;34:173-87 pubmed publisher
    ..The results suggest that impaired odor identification is associated with more rapid progression of parkinsonism in old age, particularly parkinsonian gait disturbance...
  46. Houltram B, Scanlan M. Extrapyramidal side effects. Nurs Stand. 2004;18:39-41 pubmed
  47. Louis E, Tang M, Schupf N. Mild parkinsonian signs are associated with increased risk of dementia in a prospective, population-based study of elders. Mov Disord. 2010;25:172-8 pubmed publisher
    ..Baseline MPS seems to be a predictor of incident dementia. These motor signs might, therefore, serve as a useful biomarker for emerging dementia...
  48. Zhao Shea R, Cohen B, Just H, McClure Begley T, Whiteaker P, Grady S, et al. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB J. 2010;24:49-57 pubmed publisher
  49. Hemsley K, Crocker A. Atropine reduces raclopride-induced muscle rigidity by acting in the ventral region of the striatum. Eur J Pharmacol. 2002;434:117-23 pubmed
    ..extrapyramidal motor side effects associated with the use of antipsychotic drugs, such as increased muscle rigidity, are thought to result from blockade of striatal dopamine D2 receptors...
  50. Nardocci N, Zorzi G, Blau N, Fernandez Alvarez E, Sesta M, Angelini L, et al. Neonatal dopa-responsive extrapyramidal syndrome in twins with recessive GTPCH deficiency. Neurology. 2003;60:335-7 pubmed
    ..Treatment with L-dopa/carbidopa, started at age 1 year, was associated with sustained recovery from all neurologic signs. The patients were homozygous for a new recessive mutation in the GHI gene...
  51. Lewis M, Du G, Sen S, Kawaguchi A, Truong Y, Lee S, et al. Differential involvement of striato- and cerebello-thalamo-cortical pathways in tremor- and akinetic/rigid-predominant Parkinson's disease. Neuroscience. 2011;177:230-9 pubmed publisher
    ..These findings underscore the importance of integrating CTC circuits in understanding PD and other disorders of the basal ganglia...
  52. Oppenheim C, Touze E, Meder J. [Case no 5. Wilson's disease]. J Radiol. 2003;84:87-8 pubmed
  53. Gujjar A, Al Mamari A, Jacob P, Jain R, Balkhair A, Al Asmi A. Extrapontine myelinolysis as presenting manifestation of adrenal failure: a case report. J Neurol Sci. 2010;290:169-71 pubmed publisher
    ..This case report highlights the range of clinical and imaging phenomena associated with hyponatremic myelinolysis...