muscle cramp

Summary

Summary: A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)

Top Publications

  1. Miller T, Layzer R. Muscle cramps. Muscle Nerve. 2005;32:431-42 pubmed
    ..Patients will benefit from further studies to better define the pathophysiology of muscle cramps and to find more effective medications with fewer side-effects...
  2. Kanai K, Kuwabara S, Arai K, Sung J, Ogawara K, Hattori T. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Brain. 2003;126:965-73 pubmed
  3. Stone M, Edwards J, Babington J, Ingersoll C, Palmieri R. Reliability of an electrical method to induce muscle cramp. Muscle Nerve. 2003;27:122-3 pubmed
  4. Laursen P, Watson G, Abbiss C, Wall B, Nosaka K. Hyperthermic fatigue precedes a rapid reduction in serum sodium in an ironman triathlete: a case report. Int J Sports Physiol Perform. 2009;4:533-7 pubmed
    ..To monitor the hydration, core temperature, and speed (pace) of a triathlete performing an Ironman triathlon...
  5. Morii H. [Safety profile of raloxifene]. Clin Calcium. 2004;14:100-4 pubmed
    ..Venous thromboembolism was the only adverse events of clinical significance but rare associated with raloxifene in Caucasian women, but was not observed so far in Asian countries...
  6. Kelemen J, Rice D, Bradley W, Munsat T, DiMauro S, Hogan E. Familial myoadenylate deaminase deficiency and exertional myalgia. Neurology. 1982;32:857-63 pubmed
    ..Three of 266 biopsied for other conditions were MADA-deficient. Despite some inconsistencies, MADA deficiency seems to be relevant to this clinical syndrome...
  7. Miller K, Mack G, Knight K. Gastric emptying after pickle-juice ingestion in rested, euhydrated humans. J Athl Train. 2010;45:601-8 pubmed publisher
    ..This effect may be neurologic rather than metabolic. Understanding PJ's gastric emptying would help to strengthen this theory...
  8. Vinciguerra G, Belcaro G, Cesarone M, Rohdewald P, Stuard S, Ricci A, et al. Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology. 2006;57:331-9 pubmed
  9. Getachew E, Prayson R. Pathologic quiz case: a man with exertion-induced cramps and myoglobinuria. McArdle disease (glycogenosis type V or myophosphorylase deficiency). Arch Pathol Lab Med. 2003;127:1227-8 pubmed

More Information

Publications62

  1. Hadjigeorgiou G, Papadimitriou A, Musumeci O, Paterakis K, Flabouriari K, Shanske S, et al. A new stop codon mutation (Y52X) in the myophosphorylase gene in a Greek patient with McArdle's disease. J Neurol Sci. 2002;194:83-6 pubmed
    ..Our data further expand the already remarkable genetic heterogeneity of McArdle's disease. The prevalence of the Y52X mutation in Greek patients with McArdle's disease remains to be determined...
  2. Flierl Hecht A, Pfäfflin M, May T, Kohlschütter S, Hensel B, Stefan H. [Is epilepsy in the elderly overlooked? An investigation in a home for the aged]. Nervenarzt. 2003;74:691-8 pubmed
    ..The results of our pilot study suggest that epilepsy in old people's homes is often unrecognised. Early diagnosis and treatment of epilepsy in the elderly is important to improve prognosis and social consequences for affected persons...
  3. Vural M, Arslantas A, Isiksoy S, Adapinar B, Atasoy M, Soylemezoglu F. Gangliocytic paraganglioma of the cauda equina with significant calcification: first description in pediatric age. Zentralbl Neurochir. 2008;69:47-50 pubmed publisher
    ..This report is the fifth paraganglioma case in the lumbar region and the first gangliocytic paraganglioma case in the pediatric age population...
  4. Waljee A, Joyce J, Wren P, Khan T, Higgins P. Patient reported symptoms during an ulcerative colitis flare: a Qualitative Focus Group Study. Eur J Gastroenterol Hepatol. 2009;21:558-64 pubmed publisher
    ..It has been assumed that the symptoms measured in disease activity indices for ulcerative colitis reflect those symptoms that patients find useful in evaluating the severity of a disease flare...
  5. Horak P, Jeck N, Frysak Z, Zadrazil J. Gitelman's syndrome in late adulthood. Clin Endocrinol (Oxf). 2005;63:697-9 pubmed
  6. Abou Setta A, Mansour R, Al Inany H, Aboulghar M, Kamal A, Aboulghar M, et al. Intrauterine insemination catheters for assisted reproduction: a systematic review and meta-analysis. Hum Reprod. 2006;21:1961-7 pubmed
    ..We systematically reviewed the literature so that we could evaluate the use of soft versus firm catheters in subfertile women undergoing IUI...
  7. van der Schaaf M, Vermeulen H, Storm Versloot M, Goossens A, Simons R, Eijsman L. Effectiveness of lactulose syrup after cardiac surgery. Appl Nurs Res. 2004;17:48-54 pubmed
    ..Based on these findings, it is safe to abolish the routine management of postoperative laxatives on a cardiac surgery ward...
  8. Breccia M, Stefanizzi C, Cannella L, Latagliata R, Frustaci A, Carmosino I, et al. Differences in hematological and non-hematological toxicity during treatment with imatinib in patients with early and late chronic phase chronic myeloid leukemia. Leuk Lymphoma. 2008;49:2328-32 pubmed publisher
  9. Sulzer N, Schwellnus M, Noakes T. Serum electrolytes in Ironman triathletes with exercise-associated muscle cramping. Med Sci Sports Exerc. 2005;37:1081-5 pubmed
    ..To compare serum electrolyte concentrations of cramping and control Ironman triathletes...
  10. Krzesinski J. [Arterial hypertension and tachycardia: monitoring the patient's personal drug therapy]. Rev Med Liege. 2002;57:497-501 pubmed
    ..The value of the 24 h blood pressure monitoring and the need for precise information on all drugs taken are stressed...
  11. Ragan R, Rock R, Buck H. Metoclopramide pretreatment attenuates emergency contraceptive-associated nausea. Am J Obstet Gynecol. 2003;188:330-3 pubmed
    ..The study was undertaken to determine whether metoclopramide pretreatment attenuates side effects associated with high-dose estrogen/progestin emergency contraception in at-risk patients...
  12. Scaioli V, Morandi L. Repetitive nerve stimulation and muscle membrane excitability: case report and review. Electromyogr Clin Neurophysiol. 2002;42:333-6 pubmed
  13. Deepak K, Behari M. Specific muscle EMG biofeedback for hand dystonia. Appl Psychophysiol Biofeedback. 1999;24:267-80 pubmed
    ..This specific type of EMG biofeedback appears to be a promising tool for hand dystonia and might also be applied to other types of dystonias...
  14. Morton D, Callister R. Characteristics and etiology of exercise-related transient abdominal pain. Med Sci Sports Exerc. 2000;32:432-8 pubmed
  15. Weeks S, Tsao J. Incorporation of another person's limb into body image relieves phantom limb pain: a case study. Neurocase. 2010;16:461-5 pubmed publisher
    ..We hypothesize that symptom relief results from incorporation of the foreign limb into the patient's body image, mediated by the sensory mirror neuron system, relieving pain by restoring concordance between sensory systems...
  16. Schwellnus M, Allie S, Derman W, Collins M. Increased running speed and pre-race muscle damage as risk factors for exercise-associated muscle cramps in a 56 km ultra-marathon: a prospective cohort study. Br J Sports Med. 2011;45:1132-6 pubmed publisher
    ..Despite the high prevalence of exercise-associated muscle cramping (EAMC) in endurance runners, the aetiology and risk factors for this condition are not fully understood...
  17. Zurlo J, Frank M. The long-term safety of danazol in women with hereditary angioedema. Fertil Steril. 1990;54:64-72 pubmed
    ..We conclude that, despite a relatively high incidence of adverse reactions, danazol has proven to be remarkably safe over the long-term in this group of patients...
  18. Alamowitch S, Plaisier E, Favrole P, Prost C, Chen Z, Van Agtmael T, et al. Cerebrovascular disease related to COL4A1 mutations in HANAC syndrome. Neurology. 2009;73:1873-82 pubmed publisher
    ..The aim of this study was to describe the cerebrovascular phenotype of HANAC...
  19. Uña E. Atypical presentation of acute neurotoxicity secondary to oxaliplatin. J Oncol Pharm Pract. 2010;16:280-2 pubmed publisher
    ..Subsequent doses were reduced by 25% and the infusions were prolonged to 3 h and the patient tolerated well except minimal paresthesia in her right hand lasting few minutes...
  20. Ochsner F. [The mucisian's cramp. About the illness of Robert Schumann]. Rev Med Suisse. 2012;8:66-9 pubmed
  21. Zyluk A, Puchalski P. Complex regional pain syndrome: observations on diagnosis, treatment and definition of a new subgroup. J Hand Surg Eur Vol. 2013;38:599-606 pubmed publisher
    ..A review of treatments for complex regional pain syndrome is presented, with opinion on their effectiveness: good in an early stage, less well in chronic and generally poor in the chronic, refractory subtype...
  22. Vanhaesebrouck A, Bhatti S, Franklin R, Van Ham L. Myokymia and neuromyotonia in veterinary medicine: a comparison with peripheral nerve hyperexcitability syndrome in humans. Vet J. 2013;197:153-62 pubmed publisher
    ..A more accurate classification of the different PNH syndromes will facilitate a more rapid diagnosis and guide further research into natural occurring PNH in animals. ..
  23. Jaworski C. Medical concerns of marathons. Curr Sports Med Rep. 2005;4:137-43 pubmed
    ..The focus of this article is on the evaluation and management of the varied medical concerns encountered on race day along with the essentials in prerace planning and preparedness...
  24. Jansen P, van Dijck J, Verbeek A, Durian F, Joosten E. Estimation of the frequency of the muscular pain-fasciculation syndrome and the muscular cramp-fasciculation syndrome in the adult population. Eur Arch Psychiatry Clin Neurosci. 1991;241:102-4 pubmed
    ..survey was carried out of the adult population of the Netherlands regarding fasciculation, muscle pain and muscle cramp. We conducted a population-based telephone interview with 780 Dutch adults, followed by a questionnaire ..
  25. Jankovic J, Schwartz K. Use of botulinum toxin in the treatment of hand dystonia. J Hand Surg Am. 1993;18:883-7 pubmed
    ..The results show that botulinum toxin injections effectively control hand dystonia in instances where other forms of therapy have failed...
  26. Shulman T, Heidenheim A, Kianfar C, Shulman S, Lindsay R. Preserving central blood volume: changes in body fluid compartments during hemodialysis. ASAIO J. 2001;47:615-8 pubmed
    ..These data suggest that plasma refilling during HD to preserve central blood volume is more dynamic from the leg ECF than from elsewhere and may, in turn, explain the frequent occurrence of leg cramps during and after hemodialysis...
  27. Gilchrist J. Time course of serum CK immediately before and after a single muscle cramp. Muscle Nerve. 2003;27:766 pubmed
  28. Coppin R, Wicke D, Little P. Managing nocturnal leg cramps--calf-stretching exercises and cessation of quinine treatment: a factorial randomised controlled trial. Br J Gen Pract. 2005;55:186-91 pubmed
    ..An uncontrolled study suggested that calf-stretching exercises could prevent nocturnal leg cramps (night cramps) but these findings have never been confirmed...
  29. Lopate G, Streif E, Harms M, Weihl C, Pestronk A. Cramps and small-fiber neuropathy. Muscle Nerve. 2013;48:252-5 pubmed publisher
    ..Muscle cramps are a common complaint and are thought to arise from spontaneous discharges of the motor nerve terminal. Polyneuropathy is often causative, but small-fiber neuropathy (SFN) has not been assessed...
  30. Eaton J. Is this really a muscle cramp?. Postgrad Med. 1989;86:227-32 pubmed
    ..If that is ineffective, carisoprodol (Rela, Soma, Soprodol), vitamin E, or verapamil hydrochloride (Calan, Isoptin) may be used. Quinine sulfate (Quine, Quinamm) is potentially toxic and may not be effective...
  31. Chatrath H, Liangpunsakul S, Ghabril M, Otte J, Chalasani N, Vuppalanchi R. Prevalence and morbidity associated with muscle cramps in patients with cirrhosis. Am J Med. 2012;125:1019-25 pubmed publisher
    ..Patients with cirrhosis often experience muscle cramps with varying severity. We investigated the factors associated with the prevalence and morbidity associated with muscle cramps...
  32. Collins D, Lambert M, Tannenbaum J, Oliverio M, Schwab S. Tolerance of hemodialysis: a randomized prospective trial of high-flux versus conventional high-efficiency hemodialysis. J Am Soc Nephrol. 1993;4:148-54 pubmed
    ..It was concluded that noncellulosic membranes do not offer any significant advantage over cellulosic membranes in reducing the acute complications of hemodialysis...
  33. Schilling B, Stone M, Utter A, Kearney J, Johnson M, Coglianese R, et al. Creatine supplementation and health variables: a retrospective study. Med Sci Sports Exerc. 2001;33:183-8 pubmed
    ..This retrospective study was performed to examine markers related to health, the incidence of reported side effects and the perceived training benefits in athletes supplementing with creatine monohydrate...
  34. Gomes J, Lloyd O, Norman N. The health of the workers in a rapidly developing country: effects of occupational exposure to noise and heat. Occup Med (Lond). 2002;52:121-8 pubmed
    ..Non-use of personal protective equipment and poor occupational hygiene and safety measures were also seen to affect eye and ear health adversely among the workers at the foundry...
  35. Nakao K, Yazawa S, Hayashi Y, Nishino I, Shiomi K, Nakazato M. [Late-onset sarcoglycanopathy: a cause of repeated muscle cramps after exertion]. Rinsho Shinkeigaku. 2009;49:167-71 pubmed
    ..Late-onset sarcoglycanopathy has rarely been described. In the present patient, his mild clinical condition, subclinical cardiomyopathy and possible involvement of polyneuropathy are unique features...
  36. Knower M, Bowton D, Owen J, Dunagan D. Quinine-induced disseminated intravascular coagulation: case report and review of the literature. Intensive Care Med. 2003;29:1007-1011 pubmed publisher
    ..To describe the clinical course of quinine-induced disseminated intravascular coagulation (DIC) and review all previous cases reported in the medical literature...
  37. Patel P, Mercy J, Shenoy J, Ashwini B. Factors associated with acute diarrhoea in children in Dhahira, Oman: a hospital-based study. East Mediterr Health J. 2008;14:571-8 pubmed
    ..Antibiotics were prescribed in 36.2% of cases and the resistance to the common antibiotics tested was low...
  38. Dalbo V, Roberts M, Stout J, Kerksick C. Putting to rest the myth of creatine supplementation leading to muscle cramps and dehydration. Br J Sports Med. 2008;42:567-73 pubmed publisher
  39. Anderson T. Cochrane made simple. Interventions for leg cramps in pregnancy. Pract Midwife. 2007;10:40 pubmed
  40. Ziltener J, Leal S. [Exercise-associated muscle cramps]. Rev Med Suisse. 2006;2:1787-91 pubmed
    ..physical examination and a limited laboratory screen could help to determine the various possible causes of muscle cramp. The "historical" and more recent physiopathological assumptions are systematically reviewed, just as ..
  41. Tangaro S, Fanizzi A, Amoroso N, Corciulo R, Garuccio E, Gesualdo L, et al. Computer Aided Detection System for Prediction of the Malaise during Hemodialysis. Comput Math Methods Med. 2016;2016:8748156 pubmed publisher
    ..60% and 71.40%, respectively, thus suggesting the CAD as an effective tool to support expert nephrologists in telemonitoring the patients. ..
  42. Kreider R. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003;244:89-94 pubmed
  43. Krivosic Horber R, Depret T, Wagner J, Maurage C. Malignant hyperthermia susceptibility revealed by increased serum creatine kinase concentrations during statin treatment. Eur J Anaesthesiol. 2004;21:572-4 pubmed
  44. Heuss D. [Muscle cramp--what is at the bottom of it? Only a little strained or seriously sick?]. MMW Fortschr Med. 2006;148:71-2 pubmed
  45. Newsom Davis J. Neuromyotonia. Rev Neurol (Paris). 2004;160:S85-9 pubmed
    ..These discoveries should aid diagnosis and offer new approaches to treatment...
  46. Joshi P, Deschauer M, Zierz S. Clinically symptomatic heterozygous carnitine palmitoyltransferase II (CPT II) deficiency. Wien Klin Wochenschr. 2012;124:851-4 pubmed publisher
    ..Although CPT II deficiency is an autosomal recessive disorder, the reported patients indicate that heterozygotes might also have typical attacks of myalgia, pareses or rhabdomyolysis...
  47. Lonnqvist T, Pihko H. Hereditary neuropathy with liability to pressure palsies (HNPP) in a toddler presenting with toe-walking, pain and stiffness. Neuromuscul Disord. 2003;13:827-9 pubmed
    ..His father, paternal aunt and grandmother had similar symptoms, but they had never been investigated. The typical 1.5 Mb deletion on chromosome 17p11.2-12 was found in our patient and his affected relatives...
  48. Gospe S, Lazaro R, Lava N, Grootscholten P, Scott M, Fischbeck K. Familial X-linked myalgia and cramps: a nonprogressive myopathy associated with a deletion in the dystrophin gene. Neurology. 1989;39:1277-80 pubmed
    ..Other patients with deletions in this region may have truncated dystrophin without clinical signs of progressive muscle disease...
  49. Schmidt A, Jabusch H, Altenmuller E, Hagenah J, Bruggemann N, Hedrich K, et al. Dominantly transmitted focal dystonia in families of patients with musician's cramp. Neurology. 2006;67:691-3 pubmed
    ..Our results suggest a genetic contribution to FTSD with phenotypic variability, including musician's dystonia...
  50. Herrero Morín J, Rodriguez J, Coto E, Gil Peña H, Alvarez V, Espinosa L, et al. Gitelman syndrome in Gypsy paediatric patients carrying the same intron 9 + 1 G>T mutation. Clinical features and impact on quality of life. Nephrol Dial Transplant. 2011;26:151-5 pubmed publisher
    ..Gitelman syndrome is a primary tubular disorder causing hypokalaemic metabolic alkalosis with hypocalciuria. Its prevalence is high in Gypsies, who harbour an identical mutation, intron 9 + 1 G>T, in the SLC12A3 gene...
  51. Brasic J. Should people with nocturnal leg cramps drink tonic water and bitter lemon?. Psychol Rep. 1999;84:355-67 pubmed
    A literature search from 1993 to 1997 using MEDLINE and key-words beverages, muscle cramp, and quinine was performed. Three beverages containing quinine were examined in grocery stores...
  52. Serrao M, Arendt Nielsen L, Ge H, Pierelli F, Sandrini G, Farina D. Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps. Exp Brain Res. 2007;182:301-8 pubmed
    ..9 +/- 3.2 muV and 101.6 +/- 6.0 Hz; P < 0.05). The results suggest that nociceptive muscle afferent activity induced by injection of hypertonic saline facilitates the generation of electrically elicited muscle cramps...
  53. Goddard J, Upshaw S, Held D, Johnnson K. Severe reaction from envenomation by the brown widow spider, Latrodectus geometricus (Araneae: Theridiidae). South Med J. 2008;101:1269-70 pubmed publisher
    ..Symptoms included severe pain, cramps, nausea/vomiting, and fasciculations in the pectoral and quadriceps muscles. This report signals a need to re-evaluate previously held ideas that brown widow bites are of minor consequence...