papillary muscles

Summary

Summary: Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.

Top Publications

  1. Niemann M, Liu D, Hu K, Herrmann S, Breunig F, Strotmann J, et al. Prominent papillary muscles in Fabry disease: a diagnostic marker?. Ultrasound Med Biol. 2011;37:37-43 pubmed publisher
    ..In addition, the areas of both papillary muscles, as well as the LV endocardial circumference, were manually traced in short axis views...
  2. Tobon Gomez C, Sukno F, Bijnens B, Huguet M, Frangi A. Realistic simulation of cardiac magnetic resonance studies modeling anatomical variability, trabeculae, and papillary muscles. Magn Reson Med. 2011;65:280-8 pubmed publisher
    ..Modifications include the modeling of trabeculae and papillary muscles based on clinical measurements and published data...
  3. Pires A, Pinho M, Sena C, Seica R, Leite Moreira A. Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide. Am J Physiol Heart Circ Physiol. 2012;302:H1131-7 pubmed publisher
    ..concentrations of IMD (10(-8) to 10(-6)M) on myocardial performance parameters in rat left ventricular (LV) papillary muscles with and without endocardial endothelium (EE) and in presence of receptor antagonists and intracellular ..
  4. Solis J, Levine R, Johnson B, Guerrero J, Handschumacher M, Sullivan S, et al. Polymer injection therapy to reverse remodel the papillary muscles: efficacy in reducing mitral regurgitation in a chronic ischemic model. Circ Cardiovasc Interv. 2010;3:499-505 pubmed publisher
    Ischemic mitral regurgitation (MR) results from displacement of the papillary muscles caused by ischemic ventricular distortion. Progressive left ventricular (LV) remodeling has challenged therapy...
  5. Janik M, Cham M, Ross M, Wang Y, Codella N, Min J, et al. Effects of papillary muscles and trabeculae on left ventricular quantification: increased impact of methodological variability in patients with left ventricular hypertrophy. J Hypertens. 2008;26:1677-85 pubmed publisher
    ..resonance imaging has been proposed as a standard for these indices, prior studies have variably included papillary muscles and trabeculae in myocardial volume...
  6. Crawford T, Mueller G, Good E, Jongnarangsin K, Chugh A, Pelosi F, et al. Ventricular arrhythmias originating from papillary muscles in the right ventricle. Heart Rhythm. 2010;7:725-30 pubmed publisher
    ..There are no prior studies describing the characteristics of the ventricular arrhythmias (VAs) arising from the right ventricular papillary muscles (RV PAPs).
  7. Wang L, Muthu P, Szczesna Cordary D, Kawai M. Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q. J Mol Cell Cardiol. 2013;62:153-63 pubmed publisher
  8. Hung J, Solis J, Guerrero J, Braithwaite G, Muratoglu O, Chaput M, et al. A novel approach for reducing ischemic mitral regurgitation by injection of a polymer to reverse remodel and reposition displaced papillary muscles. Circulation. 2008;118:S263-9 pubmed publisher
    Ischemic mitral regurgitation (MR) relates to displacement of the papillary muscles from ischemic ventricular distortion...
  9. Han Y, Peters D, Salton C, Bzymek D, Nezafat R, Goddu B, et al. Cardiovascular magnetic resonance characterization of mitral valve prolapse. JACC Cardiovasc Imaging. 2008;1:294-303 pubmed publisher

More Information

Publications62

  1. Chuang M, Gona P, Hautvast G, Salton C, Blease S, Yeon S, et al. Correlation of trabeculae and papillary muscles with clinical and cardiac characteristics and impact on CMR measures of LV anatomy and function. JACC Cardiovasc Imaging. 2012;5:1115-23 pubmed publisher
    The goal of this study was to assess the relationship of left ventricular (LV) trabeculae and papillary muscles (TPM) with clinical characteristics in a community-based, free-living adult cohort and to determine the effect of TPM on ..
  2. Sievers B, Schrader S, Rehwald W, Hunold P, Barkhausen J, Erbel R. Left ventricular function assessment using a fast 3D gradient echo pulse sequence: comparison to standard multi-breath hold 2D steady state free precession imaging and accounting for papillary muscles and trabeculations. Acta Cardiol. 2011;66:349-57 pubmed
    b>Papillary muscles and trabeculae for ventricular function analysis are known to significantly contribute to accurate volume and mass measurements...
  3. Bogun F, Desjardins B, Crawford T, Good E, Jongnarangsin K, Oral H, et al. Post-infarction ventricular arrhythmias originating in papillary muscles. J Am Coll Cardiol. 2008;51:1794-802 pubmed publisher
    The aim of this study was to define the role of papillary muscles (PAPs) in post-infarction ventricular arrhythmias.
  4. Wang L, Muthu P, Szczesna Cordary D, Kawai M. Characterizations of myosin essential light chain's N-terminal truncation mutant ?43 in transgenic mouse papillary muscles by using tension transients in response to sinusoidal length alterations. J Muscle Res Cell Motil. 2013;34:93-105 pubmed publisher
    ..These results demonstrate the importance of the N-terminal extension of ELC in maintaining the myosin motor function during force generation and optimal cardiac performance...
  5. Zhang X, Tallini Y, Chen Z, Gan L, Wei B, Doran R, et al. Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res. 2009;84:253-62 pubmed publisher
    ..6 affects Ca(2+) sparks and mediates the inotropic action of isoproterenol (ISO), and to investigate the underlying mechanisms of cyclic ADP-ribose (cADPR) regulation of Ca(2+) sparks...
  6. Ker J, du Toit L. The accessory papillary muscle with inferior J-waves--peculiarity or hidden danger?. Cardiovasc Ultrasound. 2009;7:50 pubmed publisher
    ..In this case report a case of an accessory papillary muscle with a prominent J-wave is described. This may be the first of many possible cases where papillary muscle variants may be the cause of the J-wave...
  7. Ker J. The U wave and papillary muscle variants: revisiting an old association. Cardiovasc J Afr. 2009;20:256-7 pubmed
    ..of the earliest hypotheses on the origin of the U wave was that these waves represent repolarisation of the papillary muscles and their neighboring structures...
  8. Yamada T, Doppalapudi H, McElderry H, Okada T, Murakami Y, Inden Y, et al. Electrocardiographic and electrophysiological characteristics in idiopathic ventricular arrhythmias originating from the papillary muscles in the left ventricle: relevance for catheter ablation. Circ Arrhythm Electrophysiol. 2010;3:324-31 pubmed publisher
    Idiopathic ventricular arrhythmias (VAs) can originate from the left ventricular papillary muscles (PAMs)...
  9. Holmes J, Hünlich M, Hasenfuss G. Energetics of the Frank-Starling effect in rabbit myocardium: economy and efficiency depend on muscle length. Am J Physiol Heart Circ Physiol. 2002;283:H324-30 pubmed
    ..area, and myocardial oxygen consumption in eight isometrically contracting rabbit right ventricular papillary muscles. 2,3-Butanedione monoxime was used to partition nonbasal oxygen consumption into tension-independent and ..
  10. Axel L. Papillary muscles do not attach directly to the solid heart wall. Circulation. 2004;109:3145-8 pubmed
    The papillary muscles (PMs) play an important role in normal cardiac function, helping to prevent leakage through the AV valves during systole...
  11. Ripoll Vera T, Forteza Albertí J, Fernandez Palomeque C, Lazaro R, Bonnin O, Bethencourt A. [Spontaneous rupture of the papillary muscle with angiographically normal coronary vessels]. Rev Esp Cardiol. 2001;54:1010-2 pubmed
    ..The clinical and histopathologic literature, and mechanisms to explain this kind of rupture, are reviewed...
  12. Min J, Ding B, Wang J, Sullivan M, Morgan J. Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts. Eur J Pharmacol. 2001;422:115-25 pubmed
    ..and intracellular Ca(2+) ([Ca(2+)](i)) transients were simultaneously recorded in isolated left ventricular papillary muscles. Ischemia was simulated by immersing the muscles into fluorocarbon with hypoxia...
  13. Shah A, Kukar A, Chaudhry F, Sherrid M. Unusual anomalous single papillary muscle causing symptomatic mid-left ventricular cavity obstruction: octopus papillary muscle. J Am Soc Echocardiogr. 2006;19:939.e9-11 pubmed
    ..The papillary muscle and the arms divided the left ventricle into apical and subaortic chambers. Flow communicated between the two chambers through multiple openings between the arms with a systolic peak Doppler gradient of 50 mm Hg...
  14. Carosati E, Cruciani G, Chiarini A, Budriesi R, Ioan P, Spisani R, et al. Calcium channel antagonists discovered by a multidisciplinary approach. J Med Chem. 2006;49:5206-16 pubmed
    ..As a result, 20 compounds were tested in vitro, and functional and binding assays revealed several hits with promising behavior as CEBs...
  15. Weinsaft J, Cham M, Janik M, Min J, Henschke C, Yankelevitz D, et al. Left ventricular papillary muscles and trabeculae are significant determinants of cardiac MRI volumetric measurements: effects on clinical standards in patients with advanced systolic dysfunction. Int J Cardiol. 2008;126:359-65 pubmed
    ..Cardiac MRI (CMR) has been proposed as a standard for these indices. Prior studies have variably included papillary muscles and trabeculae in either intracavitary or myocardial volumes...
  16. Ker J. Solitary papillary muscle hypertrophy: a new echo-electrocardiographic syndrome? A case report. Angiology. 2007;58:502-3 pubmed
    ..Solitary hypertrophy of the anterior papillary muscle might be a new echo-electrocardiographic syndrome...
  17. Faucher F, Gannier F, Lignon J, Cosnay P, Malécot C. Roles of PKA, PI3K, and cPLA2 in the NO-mediated negative inotropic effect of beta2-adrenoceptor agonists in guinea pig right papillary muscles. Am J Physiol Cell Physiol. 2008;294:C106-17 pubmed
    ..We assessed the inotropic effects of beta(2)-adrenoceptor partial agonists in right papillary muscles. Salbutamol induced a small but significant concentration-dependent negative inotropic effect (NIE, -5% at ..
  18. Aomine M, Tatsukawa Y, Yamato T, Yamasaki S. Antiarrhythmic effects of magnesium on rat papillary muscle and guinea pig ventricular myocytes. Gen Pharmacol. 1999;32:107-14 pubmed
    ..In conclusion, the present study indicates that extracellular Mg2+, via whatever mechanism, exerts antiarrhythmic activities...
  19. Joudinaud T, Kegel C, Flecher E, Weber P, Lansac E, Hvass U, et al. The papillary muscles as shock absorbers of the mitral valve complex. An experimental study. Eur J Cardiothorac Surg. 2007;32:96-101 pubmed
    Although it is known that the papillary muscles ensure the continuity between the left ventricle (LV) and the mitral apparatus, their precise mechanism needs further study...
  20. Mao J, Tang J, Li Y, Sun P. Double-orifice mitral valve with multiple papillary muscles--a report of two patients. Angiology. 1999;50:771-5 pubmed
    Two patients with double-orifice mitral valve, in addition to ventricular septal defect in one patient and mitral insufficiency in the other, and multiplicity of left-ventricle papillary muscles are reported.
  21. Begum J, Khalil M, Rahman H, Adiluzzaman A. A morphological and morphometric study of the right ventricular papillary muscles of autopsied heart of Bangladeshi people. Mymensingh Med J. 2006;15:131-4 pubmed
    ..The different between males and females in the total number of papillary muscles was statistically non significant...
  22. Skwarek M, Hreczecha J, Grzybiak M, Kosiński A. Remarks on the morphology of the papillary muscles of the right ventricle. Folia Morphol (Warsz). 2005;64:176-82 pubmed
    In addition to the papillary muscles of right ventricle referred to in anatomical nomenclature, namely the anterior, posterior and septal, we have distinguished the "conal papillary muscle" and the "papillary muscle of the ..
  23. Matsui Y, Suto Y, Shimura S, Fukada Y, Naito Y, Yasuda K, et al. Impact of papillary muscles approximation on the adequacy of mitral coaptation in functional mitral regurgitation due to dilated cardiomyopathy. Ann Thorac Cardiovasc Surg. 2005;11:164-71 pubmed
    We report early outcome of our modified papillary muscles approximation (PMA) as an adjunct to mitral annuloplasty (MAP) by analyzing the mitral coaptation zone echocardiographically and clinical outcome in three different procedures.
  24. Aktas E, Govsa F, Kocak A, Boydak B, Yavuz I. Variations in the papillary muscles of normal tricuspid valve and their clinical relevance in medicolegal autopsies. Saudi Med J. 2004;25:1176-85 pubmed
  25. Minakata K, Dearani J, Nishimura R, Maron B, Danielson G. Extended septal myectomy for hypertrophic obstructive cardiomyopathy with anomalous mitral papillary muscles or chordae. J Thorac Cardiovasc Surg. 2004;127:481-9 pubmed
    ..We reviewed our results of procedures designed to relieve obstruction with preservation of the mitral valve...
  26. Rossi T, Fano R, Castelli M, Malagoli M, Ruberto A, Baggio G, et al. Correlation between high intake of glycyrrhizin and myolysis of the papillary muscles: an experimental in vivo study. Pharmacol Toxicol. 1999;85:221-9 pubmed
    ..These effects begin to appear in the course of subchronic treatment, they manifest themselves in acute treatment and correlate closely with the electrocardiographic changes recorded in rats acutely treated with 18alpha-glycyrrhetic acid...
  27. Nigri G, Di Dio L, Baptista C. Papillary muscles and tendinous cords of the right ventricle of the human heart: morphological characteristics. Surg Radiol Anat. 2001;23:45-9 pubmed
    A series of 79 normal human hearts was studied focusing on the morphological characteristics of the papillary muscles of the right ventricle and their tendinous cords (chordae tendineae)...
  28. Hannon J, Cody M, Housmans P. Effects of isoflurane on intracellular calcium and myocardial crossbridge kinetics in tetanized papillary muscles. Anesthesiology. 2001;94:856-61 pubmed
    ..Measurements of the effects of isoflurane on crossbridge cycling kinetics during tetanic contractions, which provide a steady state level of activation in intact cardiac muscle, have not been previously reported...
  29. Meulemans A, Sipido K, Sys S, Brutsaert D. Atriopeptin III induces early relaxation of isolated mammalian papillary muscle. Circ Res. 1988;62:1171-4 pubmed
    ..M) induced early relaxation and decreased peak twitch of isometric and isotonic twitches of isolated papillary muscles of cat and rat, without affecting maximal unloaded velocity of shortening...
  30. Guterl K, Haggart C, Janssen P, Holmes J. Isometric contraction induces rapid myocyte remodeling in cultured rat right ventricular papillary muscles. Am J Physiol Heart Circ Physiol. 2007;293:H3707-12 pubmed
    ..We tested this hypothesis in working rat right ventricular papillary muscles using a recently developed technique for long-term muscle culture...
  31. Azuma M, Matsumura C, Kemmotsu O. Inotropic and electrophysiologic effects of propofol and thiamylal in isolated papillary muscles of the guinea pig and the rat. Anesth Analg. 1993;77:557-63 pubmed
    We compared the inotropic and electrophysiologic effects of propofol and thiamylal in isolated papillary muscles of the guinea pig and rat...
  32. Sakai T, Okita Y, Ueda Y, Tahata T, Ogino H, Matsuyama K, et al. Distance between mitral anulus and papillary muscles: anatomic study in normal human hearts. J Thorac Cardiovasc Surg. 1999;118:636-41 pubmed
    ..Even in patients who require excision of the mitral apparatus, the continuity can be restored. However, there is no guide to the proper length for the resuspension...
  33. Stuyvers B, McCulloch A, Guo J, Duff H, ter Keurs H. Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscle. J Physiol. 2002;544:817-30 pubmed
    ..These results may suggest a lower capacity of the SR for buffering Ca(2+), which makes the generation of force in mouse cardiac ventricle more dependent on Ca(2+) entering during action potentials, particularly at high heart rate...
  34. Sievers B, Kirchberg S, Bakan A, Franken U, Trappe H. Impact of papillary muscles in ventricular volume and ejection fraction assessment by cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2004;6:9-16 pubmed
    ..short-axis technique is time-consuming and thus, often not practicable for routine daily use, because papillary muscles and trabeculations have to be marked and their volumes subtracted from the total ventricular volume...
  35. Okazaki O, Suda N, Hongo K, Konishi M, Kurihara S. Modulation of Ca2+ transients and contractile properties by beta-adrenoceptor stimulation in ferret ventricular muscles. J Physiol. 1990;423:221-40 pubmed
    ..In addition, beta-adrenoceptor stimulation does not produce a marked change in the maximal tension level...
  36. Yang Z, Wang H, Zheng Y, Zhang Y, Liu Y, Li C. Possible arrhythmiogenic mechanism produced by ibuprofen. Acta Pharmacol Sin. 2008;29:421-9 pubmed publisher
    ..The aim of the present study was to investigate the electrophysiological effect of ibuprofen on the cardiac action potentials (AP) and electrocardiograms (ECG), and to identify its arrhythmiogenic mechanism...
  37. Kudo M, Yozu R, Aeba R, Kokaji K, Kimura N, Iwanaga S. A case report of surgical correction for congenital mitral regurgitation with subvalvular apparatus abnormality. Gen Thorac Cardiovasc Surg. 2008;56:36-8 pubmed publisher
    ..As an additional procedure for persistent regurgitation, an edge-to-edge technique to the posterior commissure side was performed, after which the mitral regurgitation disappeared...
  38. Turnbull L, Hoh J, Ludowyke R, Rossmanith G. Troponin I phosphorylation enhances crossbridge kinetics during beta-adrenergic stimulation in rat cardiac tissue. J Physiol. 2002;542:911-20 pubmed
    ..We conclude that TnI phosphorylation, mediated by cAMP-dependent protein kinase A, is the molecular basis for the enhanced crossbridge cycling seen during beta-adrenergic stimulation of the heart...
  39. Fattouch K, Murana G, Castrovinci S, Mossuto C, Sampognaro R, Borruso M, et al. Mitral valve annuloplasty and papillary muscle relocation oriented by 3-dimensional transesophageal echocardiography for severe functional mitral regurgitation. J Thorac Cardiovasc Surg. 2012;143:S38-42 pubmed publisher
    ..To plan mitral valve repair by annuloplasty and papillary muscle (PPM) relocation, we proposed a valve repair procedure oriented by the new main features obtained by real-time 3D TOE reconstruction of the mitral valve apparatus...
  40. Kim S, Lee S, Kim J, Kang H. High extracellular [Mg2+]-induced increase in intracellular [Mg2+] and decrease in intracellular [Na+] are associated with activation of p38 MAP kinase and ERK2 in guinea-pig heart. Exp Physiol. 2008;93:1223-32 pubmed publisher
    ..reversible increase in intracellular Mg(2+) concentrations ([Mg(2+)](i)) in beating and quiescent guinea-pig papillary muscles, accompanied by a definite decrease in intracellular Na(+) concentrations ([Na(+)](i))...
  41. Kozak M, Sivanandam S, De Marchi C, Kozak A, Croti U, Moscardini A, et al. A trileaflet "mitral valve" with three papillary muscles: brand new echocardiographic finding. Congenit Heart Dis. 2011;6:70-3 pubmed publisher
    ..We describe here a case report and present the images of a trileaflet mitral valve sustained by three papillary muscles in a young girl with subaortic stenosis.
  42. Haron H, Yusof M, Maskon O, Ooi J, Rahman M. Tricuspid valve papillary fibroelastoma: a rare tumor with a diagnostic dilemma. Heart Surg Forum. 2012;15:E59-60 pubmed publisher
    ..We present this case to emphasize the rarity of this tumor and the importance of a correct diagnosis to avoid delaying its prompt and definitive management...
  43. Riede F, Dähnert I, Razek V, Kostelka M. Rupture of the papillary muscle of the tricuspid valve - echocardiographic diagnosis of a rare anomaly leading to critical tricuspid valve regurgitation in the newborn. Eur J Pediatr. 2010;169:165-6 pubmed publisher
    ..Therefore, timely diagnosis is mandatory for adequate preoperative management and subsequent surgical treatment...
  44. Veiga E, Portes L, Bocalini D, Antonio E, Santos A, Santos M, et al. Cardiac implications after myocardial infarction in rats previously undergoing physical exercise. Arq Bras Cardiol. 2013;100:37-43 pubmed
    ..Few studies have analyzed the cardiac effects of exercise prior to coronary occlusion...
  45. Hamaoka A, Shiraishi I, Yamagishi M, Hamaoka K. A neonate with the rupture of mitral chordae tendinae associated with maternal-derived anti-SSA antibody. Eur J Pediatr. 2009;168:741-3 pubmed publisher
    Acute mitral insufficiency due to the rupture of chordae tendinae from papillary muscles is a rare but sometimes fatal condition in neonates and infants...
  46. Vaquerizo B, Theriault Lauzier P, Piazza N. Percutaneous Transcatheter Mitral Valve Replacement: Patient-specific Three-dimensional Computer-based Heart Model and Prototyping. Rev Esp Cardiol (Engl Ed). 2015;68:1165-73 pubmed publisher
    ..It may provide new opportunities for a better understanding of the mitral anatomy-pathophysiology-device interaction, which is of critical importance for the advancement of transcatheter mitral valve replacement. ..
  47. Forcillo J, Lalonde A, Stevens L, Noiseux N. Troubleshooting a missing intra-cardiac tumor at the time of bypass. Perfusion. 2011;26:65-6 pubmed publisher
    ..This case report presents an unusual case of an intra-cardiac tumor which was missing at the time of surgical excision...
  48. Saito K, Okura H, Watanabe N, Obase K, Tamada T, Koyama T, et al. Influence of chronic tethering of the mitral valve on mitral leaflet size and coaptation in functional mitral regurgitation. JACC Cardiovasc Imaging. 2012;5:337-45 pubmed publisher
  49. Zimoń B, Tomaszewski A, Wysokinski A, Tomaszewski M, Czekajska Chehab E, Wolski A. [Papillary fibroelastoma of the left atrial appendage]. Kardiol Pol. 2011;69:284-6 pubmed
    ..We report 59 year-old male with left atrial appendage location of papillary fibroelastoma diagnosed during transesophageal echocardiography. Computed tomography confirmed morphological signs typical for this tumour...
  50. Vargiu R, Littarru G, Fraschini M, Perinu A, Tiano L, Capra A, et al. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle. Biofactors. 2010;36:229-39 pubmed publisher
    ..Compared to control, HS12607-treated papillary muscles showed a significant increase of maximum peak isometric tension (P(o)) (30.06 +/- 4.91 vs. 19.74 +/- 5...
  51. Fromentin S, Adris M, Jourda F, Fouche R, Philippon F. [Radiofrequency ablation of left premature ventricular complex from the papillary muscle]. Ann Cardiol Angeiol (Paris). 2012;61:389-93 pubmed publisher
    ..Radiofrequency ablation for incessant and symptomatic premature ventricular complex (PVC) localized in a left papillary muscle is uncommon. 3D mapping and cardiac MRI may be useful to achieve ablation success...
  52. Sternick E, Correa F, Negri R, Scarpelli R, Gerken L. Reversible cardiomyopathy provoked by focal ventricular arrhythmia originating from the base of the posterior papillary muscle. J Interv Card Electrophysiol. 2009;25:67-72 pubmed publisher
    ..The cardiac arrhythmia had a non-reentrant mechanism and none of the patients had left ventricular dysfunction...
  53. Isoda S, Osako M, Kimura T, Yamanaka N, Nakamura S, Maehara T. Papillary muscle approximation and relocation with a loop technique for mitral complex repair. Gen Thorac Cardiovasc Surg. 2011;59:454-8 pubmed publisher
    ..We introduce a surgical procedure that combines papillary muscle approximation to correct lateral shift and papillary muscle relocation using the loop technique to correct the apical shift with accuracy and technical ease...