Summary: Inflammation of the SYNOVIAL MEMBRANE.

Top Publications

  1. Boesen M, Kubassova O, Bouert R, Axelsen M, Ostergaard M, Cimmino M, et al. Correlation between computer-aided dynamic gadolinium-enhanced MRI assessment of inflammation and semi-quantitative synovitis and bone marrow oedema scores of the wrist in patients with rheumatoid arthritis--a cohort study. Rheumatology (Oxford). 2012;51:134-43 pubmed publisher
    ..contrast-enhanced MRI (DCE-MRI) analysed by a novel computer-aided approach and semi-quantitative scores of synovitis and bone marrow oedema (BME) using the OMERACT-RA MRI Scoring (RAMRIS) system, in the wrist of patients with RA.
  2. Mandl P, Naredo E, Wakefield R, Conaghan P, D Agostino M. A systematic literature review analysis of ultrasound joint count and scoring systems to assess synovitis in rheumatoid arthritis according to the OMERACT filter. J Rheumatol. 2011;38:2055-62 pubmed publisher
    The OMERACT Ultrasound Task Force is currently developing a global synovitis score (GLOSS) with the objective of feasibly measuring global disease activity in patients with rheumatoid arthritis (RA)...
  3. Gandjbakhch F, Conaghan P, Ejbjerg B, Haavardsholm E, Foltz V, Brown A, et al. Synovitis and osteitis are very frequent in rheumatoid arthritis clinical remission: results from an MRI study of 294 patients in clinical remission or low disease activity state. J Rheumatol. 2011;38:2039-44 pubmed publisher
    ..Our objective was to determine the MRI characteristics of RA patients in clinical remission or low disease activity (LDA) state...
  4. Peterfy C, Countryman P, Gabriele A, Shaw T, Anisfeld A, Tsuji W, et al. Magnetic resonance imaging in rheumatoid arthritis clinical trials: emerging patterns based on recent experience. J Rheumatol. 2011;38:2023-30 pubmed publisher
    ..In this study, we pool MRI data from randomized controlled clinical trails (RCT) to determine which combination of MCP and wrist joints are most sensitive and discriminative for structural changes over time...
  5. Dougados M, Devauchelle Pensec V, Ferlet J, Jousse Joulin S, D Agostino M, Backhaus M, et al. The ability of synovitis to predict structural damage in rheumatoid arthritis: a comparative study between clinical examination and ultrasound. Ann Rheum Dis. 2013;72:665-71 pubmed publisher
    To evaluate synovitis (clinical vs ultrasound (US)) to predict structural progression in rheumatoid arthritis (RA).
  6. Wechalekar M, Lester S, Proudman S, Cleland L, Whittle S, Rischmueller M, et al. Active foot synovitis in patients with rheumatoid arthritis: applying clinical criteria for disease activity and remission may result in underestimation of foot joint involvement. Arthritis Rheum. 2012;64:1316-22 pubmed publisher
    ..To determine whether application of criteria for remission in rheumatoid arthritis (RA) may result in underestimation of foot joint involvement among patients in a clinic setting...
  7. Haugen I, Bøyesen P, Slatkowsky Christensen B, Sesseng S, van der Heijde D, Kvien T. Associations between MRI-defined synovitis, bone marrow lesions and structural features and measures of pain and physical function in hand osteoarthritis. Ann Rheum Dis. 2012;71:899-904 pubmed publisher
    ..To explore associations between MRI features and measures of pain and physical function in hand osteoarthritis (OA)...
  8. Chemel M, Le Goff B, Brion R, Cozic C, Berreur M, Amiaud J, et al. Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. Ann Rheum Dis. 2012;71:150-4 pubmed publisher
    ..Interleukin (IL) 34 is a new cytokine implicated in macrophage differentiation and osteoclastogenesis. This study assessed IL-34 expression in the tissue of patients with rheumatoid arthritis (RA)...
  9. Maeshima K, Yamaoka K, Kubo S, Nakano K, Iwata S, Saito K, et al. The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-? and interleukin-17 production by human CD4+ T cells. Arthritis Rheum. 2012;64:1790-8 pubmed publisher
    ..The aim of this study was to examine the effects of tofacitinib in vitro and in vivo in RA, in order to elucidate the role of JAK in the disease process...

More Information


  1. van Loon J, Menke E, L ami J, Jonckheer Sheehy V, Back W, René van Weeren P. Analgesic and anti-hyperalgesic effects of epidural morphine in an equine LPS-induced acute synovitis model. Vet J. 2012;193:464-70 pubmed publisher
    ..17 ± 0.02 mg/kg) were therefore investigated in horses with acute synovitis. In a cross-over study, synovitis was induced in the talocrural joint by intra-articular lipopolysaccharide (LPS)..
  2. Baker K, Matthan N, Lichtenstein A, Niu J, Guermazi A, Roemer F, et al. Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study. Osteoarthritis Cartilage. 2012;20:382-7 pubmed publisher
    ..The goal of our study was to assess the association of fasting plasma phospholipid n-6 and n-3 PUFAs with synovitis as measured by synovial thickening on contrast enhanced (CE) knee MRI and cartilage damage among subjects in the ..
  3. Nakamura T, Fujihara S, Yamamoto Nagata K, Katsura T, Inubushi T, Tanaka E. Low-intensity pulsed ultrasound reduces the inflammatory activity of synovitis. Ann Biomed Eng. 2011;39:2964-71 pubmed publisher
    ..membrane cells stimulated with inflammatory cytokines, and to evaluate the effectiveness of LIPUS treatment of synovitis in the knee joints of animal models for rheumatoid arthritis...
  4. Zhao Y, Ma X, Jin Z, Li K, Liu G, Zeng Y. Cerebral activation during unilateral clenching in patients with temporomandibular joint synovitis and biting pain: an functional magnetic resonance imaging study. Chin Med J (Engl). 2011;124:2136-43 pubmed
    ..The objective of this study was to investigate the brain activities using functional magnetic resonance imaging (fMRI) during unilateral maximal voluntary clenching tasks in the TMD synovitis patients with biting pain.
  5. Scanzello C, Goldring S. The role of synovitis in osteoarthritis pathogenesis. Bone. 2012;51:249-57 pubmed publisher
    ..The histological changes observed in the SM in OA generally include features indicative of an inflammatory "synovitis"; specifically they encompass a range of abnormalities, such as synovial lining hyperplasia, infiltration ..
  6. Yeremenko N, Noordenbos T, Cantaert T, van Tok M, van de Sande M, Canete J, et al. Disease-specific and inflammation-independent stromal alterations in spondylarthritis synovitis. Arthritis Rheum. 2013;65:174-85 pubmed publisher
    ..Therefore, we aimed to identify novel and unsuspected disease-specific pathways in SpA by a systematic and unbiased synovial gene expression analysis...
  7. Arend W, Firestein G. Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis. Nat Rev Rheumatol. 2012;8:573-86 pubmed publisher
    ..Subsequent engagement of Fc receptors and complement activation would lead to secondary inflammation in the synovium with induction of a perpetuating cycle of chronic synovitis.
  8. Mizutani Y, Matsuoka K, Takeda H, Shiogama K, Inada K, Hayakawa K, et al. Novel approach to identifying autoantibodies in rheumatoid synovitis with a biotinylated human autoantigen library and the enzyme-labeled antigen method. J Immunol Methods. 2013;387:57-70 pubmed publisher
    ..The purpose of the present study is to identify and localize autoantibodies produced in these immunocytes in RA synovitis. We developed a novel screening system for detecting specific autoantigens...
  9. Sakellariou G, Scirè C, Verstappen S, Montecucco C, Caporali R. In patients with early rheumatoid arthritis, the new ACR/EULAR definition of remission identifies patients with persistent absence of functional disability and suppression of ultrasonographic synovitis. Ann Rheum Dis. 2013;72:245-9 pubmed publisher
    ..Rheumatology/European League Against Rheumatism (ACR/EULAR) and disease activity score in 44 and 28 joints (DAS, DAS28) definitions of remission in early rheumatoid arthritis (RA), against disability and ultrasound-detectable synovitis.
  10. Abramowicz S, Simon L, Susarla H, Lee E, Cheon J, Kim S, et al. Are panoramic radiographs predictive of temporomandibular joint synovitis in children with juvenile idiopathic arthritis?. J Oral Maxillofac Surg. 2014;72:1063-9 pubmed publisher
    To identify specific panoramic radiographic findings associated with temporomandibular joint (TMJ) synovitis in children with juvenile idiopathic arthritis (JIA).
  11. Schueller Weidekamm C, Lodemann K, Grisar J, Schueller G, Weber M, Kainberger F, et al. Contrast-enhanced MR imaging of hand and finger joints in patients with early rheumatoid arthritis: do we really need a full dose of gadobenate dimeglumine for assessing synovial enhancement at 3 T?. Radiology. 2013;268:161-9 pubmed publisher
    ..the diagnostic value of a half dose compared with a full dose of gadobenate dimeglumine in the assessment of synovitis or tenosynovitis in the wrist and finger joints in patients with early rheumatoid arthritis (RA) and a disease ..
  12. Zou C, Zhu L, Li Y, Mo Y, Zheng D, Ma J, et al. The association between hepatitis B virus infection and disease activity, synovitis, or joint destruction in rheumatoid arthritis. Clin Rheumatol. 2013;32:787-95 pubmed publisher
    ..Except for higher subintimal CD3+ cell density in the past HBV infection group, Krenn's synovitis score, mean densities of subintima positive-staining cells (CD20, CD38, CD79a, and CD68), and CD34+ microvessel ..
  13. Roemer F, Felson D, Yang T, Niu J, Crema M, Englund M, et al. The association between meniscal damage of the posterior horns and localized posterior synovitis detected on T1-weighted contrast-enhanced MRI--the MOST study. Semin Arthritis Rheum. 2013;42:573-81 pubmed publisher
    b>Synovitis is thought to be a secondary phenomenon in the osteoarthritis (OA) process and the menisci might be triggers of localized synovitis...
  14. Fukae J, Isobe M, Kitano A, Henmi M, Sakamoto F, Narita A, et al. Positive synovial vascularity in patients with low disease activity indicates smouldering inflammation leading to joint damage in rheumatoid arthritis: time-integrated joint inflammation estimated by synovial vascularity in each finger joint. Rheumatology (Oxford). 2013;52:523-8 pubmed publisher
    ..To investigate the relationship between synovial vascularity and joint damage progression in each finger joint of patients with RA under low disease activity during treatment with biologic agents...
  15. Ambarus C, Noordenbos T, de Hair M, Tak P, Baeten D. Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis. Arthritis Res Ther. 2012;14:R74 pubmed publisher
    ..Here, we aimed to evaluate the polarization status of synovial macrophages in spondyloarthritis (SpA) and rheumatoid arthritis (RA)...
  16. Li J, Ju Y, Bouta E, Xing L, Wood R, Kuzin I, et al. Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow. Arthritis Rheum. 2013;65:130-8 pubmed publisher
    ..The aim of this study was to examine whether the efficacy of B cell depletion therapy is associated with restoration of lymphatic drainage due to removal of obstructing nodal B cells...
  17. Gandjbakhch F, Foltz V, Mallet A, Bourgeois P, Fautrel B. Bone marrow oedema predicts structural progression in a 1-year follow-up of 85 patients with RA in remission or with low disease activity with low-field MRI. Ann Rheum Dis. 2011;70:2159-62 pubmed publisher
    ..To identify the predictive factors of MRI-determined structural progression in patients with rheumatoid arthritis (RA) in remission or with low disease activity (LDA)...
  18. Hammer H, Terslev L. Role of ultrasound in managing rheumatoid arthritis. Curr Rheumatol Rep. 2012;14:438-44 pubmed publisher
    ..b>Synovitis is usually scored semiquantitatively for both gray scale synovitis and power Doppler activity, and use of an ..
  19. Simonini G, Xu Z, Caputo R, de Libero C, Pagnini I, Pascual V, et al. Clinical and transcriptional response to the long-acting interleukin-1 blocker canakinumab in Blau syndrome-related uveitis. Arthritis Rheum. 2013;65:513-8 pubmed publisher
  20. Conaghan P, Durez P, Alten R, Burmester G, Tak P, Klareskog L, et al. Impact of intravenous abatacept on synovitis, osteitis and structural damage in patients with rheumatoid arthritis and an inadequate response to methotrexate: the ASSET randomised controlled trial. Ann Rheum Dis. 2013;72:1287-94 pubmed publisher
    ..This randomised, double-blind, placebo-controlled phase IIIb study evaluated the impact of abatacept on MRI pathology as a primary outcome in methotrexate (MTX)-refractory patients with rheumatoid arthritis...
  21. Peterfy C, Østergaard M, Conaghan P. MRI comes of age in RA clinical trials. Ann Rheum Dis. 2013;72:794-6 pubmed publisher
    ..than radiographs, but importantly it can measure the upstream drivers of erosions and cartilage loss, synovitis and osteitis...
  22. Østergaard M, Emery P, Conaghan P, Fleischmann R, Hsia E, Xu W, et al. Significant improvement in synovitis, osteitis, and bone erosion following golimumab and methotrexate combination therapy as compared with methotrexate alone: a magnetic resonance imaging study of 318 methotrexate-naive rheumatoid arthritis patients. Arthritis Rheum. 2011;63:3712-22 pubmed publisher
    ..To evaluate the effects of golimumab on inflammation/structural damage detected by magnetic resonance imaging (MRI) in patients with rheumatoid arthritis (RA)...
  23. Conaghan P, Peterfy C, Olech E, Kaine J, Ridley D, Dicarlo J, et al. The effects of tocilizumab on osteitis, synovitis and erosion progression in rheumatoid arthritis: results from the ACT-RAY MRI substudy. Ann Rheum Dis. 2014;73:810-6 pubmed publisher
    ..To examine the imaging-detected mechanism of reduction of structural joint damage progression by tocilizumab (TCZ) in patients with rheumatoid arthritis (RA) using MRI...
  24. Mandl P, Balint P, Brault Y, Backhaus M, D Agostino M, Grassi W, et al. Metrologic properties of ultrasound versus clinical evaluation of synovitis in rheumatoid arthritis: results of a multicenter, randomized study. Arthritis Rheum. 2012;64:1272-82 pubmed publisher
    To evaluate the intraobserver reliability, face validity, and discriminant capacity of different global ultrasound (US) scoring systems for measuring synovitis in rheumatoid arthritis (RA).
  25. Hammer H, Fagerhol M, Wien T, Kvien T. The soluble biomarker calprotectin (an S100 protein) is associated to ultrasonographic synovitis scores and is sensitive to change in patients with rheumatoid arthritis treated with adalimumab. Arthritis Res Ther. 2011;13:R178 pubmed publisher
    ..Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power Doppler (PD))...
  26. Doody K, Bussières Marmen S, Li A, Paquet M, Henderson J, Tremblay M. T cell protein tyrosine phosphatase deficiency results in spontaneous synovitis and subchondral bone resorption in mice. Arthritis Rheum. 2012;64:752-61 pubmed publisher
    ..The aim of this study was to evaluate the effect of TC-PTP deficiency on the bone and joint environment using a knockout mouse model...
  27. Noordenbos T, Yeremenko N, Gofita I, van de Sande M, Tak P, Canete J, et al. Interleukin-17-positive mast cells contribute to synovial inflammation in spondylarthritis. Arthritis Rheum. 2012;64:99-109 pubmed publisher
    Studies comparing spondylarthritis (SpA) to rheumatoid arthritis (RA) synovitis suggest that innate immune cells may play a predominant role in the pathogenesis of SpA...
  28. Foltz V, Gandjbakhch F, Etchepare F, Rosenberg C, Tanguy M, Rozenberg S, et al. Power Doppler ultrasound, but not low-field magnetic resonance imaging, predicts relapse and radiographic disease progression in rheumatoid arthritis patients with low levels of disease activity. Arthritis Rheum. 2012;64:67-76 pubmed publisher
    ..The aim of this study was to compare the ability of ultrasonography and magnetic resonance imaging (MRI) to predict relapse and radiographic progression in these patients...
  29. Zayat A, Conaghan P, Sharif M, Freeston J, Wenham C, Hensor E, et al. Do non-steroidal anti-inflammatory drugs have a significant effect on detection and grading of ultrasound-detected synovitis in patients with rheumatoid arthritis? Results from a randomised study. Ann Rheum Dis. 2011;70:1746-51 pubmed publisher
    To determine whether non-steroidal anti-inflammatory drugs (NSAIDs) have a significant effect on ultrasonographic (US) grey scale (GS) and power Doppler (PD) assessment of synovitis in rheumatoid arthritis (RA).
  30. Naredo E, Wakefield R, Iagnocco A, Terslev L, Filippucci E, Gandjbakhch F, et al. The OMERACT ultrasound task force--status and perspectives. J Rheumatol. 2011;38:2063-7 pubmed publisher
    ..following studies were presented: (1) intra- and interobserver reliability of ultrasound detecting and scoring synovitis in different joints of patients with rheumatoid arthritis (RA); (2) systematic review of previous ultrasound ..
  31. Keen H, Redmond A, Wakefield R, Freeston J, Grainger A, Hensor E, et al. An ultrasonographic study of metatarsophalangeal joint pain: synovitis, structural pathology and their relationship to symptoms and function. Ann Rheum Dis. 2011;70:2140-3 pubmed publisher
    ..Pain in the first metatarsophalangeal joint (MTPJ) is common, though the link between pathology and symptoms is poorly understood...
  32. Boissier M, Semerano L, Challal S, Saidenberg Kermanac h N, Falgarone G. Rheumatoid arthritis: from autoimmunity to synovitis and joint destruction. J Autoimmun. 2012;39:222-8 pubmed publisher
  33. Sfriso P, Caso F, Tognon S, Galozzi P, Gava A, Punzi L. Blau syndrome, clinical and genetic aspects. Autoimmun Rev. 2012;12:44-51 pubmed publisher
    ..Clinical and genetic aspects of the familial and the sporadic form of BS will be discussed and focused on. A description of a case study of an Italian family is also included...
  34. Iagnocco A, Ceccarelli F, Rizzo C, Truglia S, Massaro L, Spinelli F, et al. Ultrasound evaluation of hand, wrist and foot joint synovitis in systemic lupus erythematosus. Rheumatology (Oxford). 2014;53:465-72 pubmed publisher
    ..To assess the prevalence and severity of inflammatory abnormalities of the hand, wrist and foot joints in SLE patients by US and to correlate them with clinical, laboratory and disease activity score parameters...
  35. Terao C, Hashimoto M, Yamamoto K, Murakami K, Ohmura K, Nakashima R, et al. Three groups in the 28 joints for rheumatoid arthritis synovitis--analysis using more than 17,000 assessments in the KURAMA database. PLoS ONE. 2013;8:e59341 pubmed publisher
    ..We also found that RA synovitis could be classified into three categories of joints in the correlation analyses: large joints with wrist joints, ..
  36. Ross T, Kisiday J, Hess T, McIlwraith C. Evaluation of the inflammatory response in experimentally induced synovitis in the horse: a comparison of recombinant equine interleukin 1 beta and lipopolysaccharide. Osteoarthritis Cartilage. 2012;20:1583-90 pubmed publisher
    To compare two transient models of synovitis-osteoarthritis (OA) in horses by characterizing biological changes in synovial fluid and joint tissue.
  37. Murakami A, Hash T, Hepinstall M, Lyman S, Nestor B, Potter H. MRI evaluation of rotational alignment and synovitis in patients with pain after total knee replacement. J Bone Joint Surg Br. 2012;94:1209-15 pubmed publisher
    ..Using the additional soft-tissue detail provided by this modality, we also evaluated the extent of synovitis within these two groups...
  38. Tan Y, Østergaard M, Conaghan P. Imaging tools in rheumatoid arthritis: ultrasound vs magnetic resonance imaging. Rheumatology (Oxford). 2012;51 Suppl 7:vii36-42 pubmed publisher
  39. Walsh D, Bonnet C, Turner E, Wilson D, Situ M, McWilliams D. Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis Cartilage. 2007;15:743-51 pubmed
    ..We investigated whether indices of osteochondral and synovial angiogenesis display different relationships with synovitis, disease severity and chondrocalcinosis in patients with OA.
  40. Mobasheri A, Moskaluk C, Marples D, Shakibaei M. Expression of aquaporin 1 (AQP1) in human synovitis. Ann Anat. 2010;192:116-21 pubmed publisher
    Rheumatoid arthritis (RA) is an autoimmune disorder characterized by synovial proliferation (synovitis), articular cartilage and subchondral bone degradation as well as joint swelling...
  41. Yu W, Burns C. All-trans retinoic acid-induced focal myositis, synovitis, and mononeuritis. J Clin Rheumatol. 2009;15:358-60 pubmed publisher
    ..Here we report a patient with newly diagnosed acute promyelocytic leukemia who developed acute focal myositis, synovitis, and possible vasculitis, after receiving all-trans retinoic acid therapy...
  42. Funck Brentano T, Etchepare F, Joulin S, Gandjbakch F, Pensec V, Cyteval C, et al. Benefits of ultrasonography in the management of early arthritis: a cross-sectional study of baseline data from the ESPOIR cohort. Rheumatology (Oxford). 2009;48:1515-9 pubmed publisher
    ..To assess ultrasonography's (US) performance to detect the structural damage in the initial evaluation of early arthritis (EA) using the Etude et Suivides Polyarthrites Indifférenciées Récentes (ESPOIR) cohort...
  43. Kotschwar J, Coetzee J, Anderson D, Gehring R, Kukanich B, Apley M. Analgesic efficacy of sodium salicylate in an amphotericin B-induced bovine synovitis-arthritis model. J Dairy Sci. 2009;92:3731-43 pubmed publisher
    This study examined the efficacy of sodium salicylate for providing analgesia in an amphotericin B-induced bovine synovitis-arthritis model using 10 male Holstein calves, 4 to 6 mo old and weighing approximately 250 kg...
  44. Lindegaard C, Thomsen M, Larsen S, Andersen P. Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses. Vet Anaesth Analg. 2010;37:171-85 pubmed publisher
    To compare the analgesic effect of intra-articular (IA) and intravenous (IV) morphine in horses with experimentally induced synovitis.
  45. van Kuijk A, Tak P. Synovitis in psoriatic arthritis: immunohistochemistry, comparisons with rheumatoid arthritis, and effects of therapy. Curr Rheumatol Rep. 2011;13:353-9 pubmed publisher
    ..Most patients with PsA present with peripheral synovitis of the oligoarticular or polyarticular subtype...
  46. McGonagle D, Lories R, Tan A, Benjamin M. The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum. 2007;56:2482-91 pubmed
  47. Bird P, Ejbjerg B, Lassere M, Østergaard M, McQueen F, Peterfy C, et al. A multireader reliability study comparing conventional high-field magnetic resonance imaging with extremity low-field MRI in rheumatoid arthritis. J Rheumatol. 2007;34:854-6 pubmed
    ..However, for synovitis and bone edema, considerable intermachine and interreader variability was found...
  48. Roemer F, Guermazi A, Zhang Y, Yang M, Hunter D, Crema M, et al. Hoffa's Fat Pad: Evaluation on Unenhanced MR Images as a Measure of Patellofemoral Synovitis in Osteoarthritis. AJR Am J Roentgenol. 2009;192:1696-700 pubmed publisher
    The purpose of this study was to compare synovitis-like signal changes in Hoffa's fat pad on unenhanced proton density-weighted fat-suppressed sequences with signal alterations in Hoffa's fat pad and peripatellar synovial thickening on ..
  49. Satoh K, Ogura N, Akutsu M, Kuboyama N, Kuyama K, Yamamoto H, et al. Expression of cyclooxygenase-1 and -2 in IL-1beta-induced synovitis of the temporomandibular joint. J Oral Pathol Med. 2009;38:584-90 pubmed publisher
    ..This study investigated the expression of COX-1 and COX-2 in cultured human FLS and rat TMJ synovium following stimulation with IL-1beta...
  50. Dong W, Li X, Feng Y, Fan C, Chen Z, Zhu P. The differential expressions of 78-kDa glucose-regulated protein of infiltrating plasma cells in peripheral joints with the histopathological variants of rheumatoid synovitis. Arthritis Res Ther. 2009;11:R4 pubmed publisher
    ..the potential links between the activation of the UPR of infiltrating plasma cells in inflamed peripheral joints and the histopathological variants of rheumatoid synovitis as well as the local production of pathogenic autoantibodies.
  51. Tarasevicius S, Robertsson O, Kesteris U, Kalesinskas R, Wingstrand H. Effect of femoral head size on polyethylene wear and synovitis after total hip arthroplasty: a sonographic and radiographic study of 39 patients. Acta Orthop. 2008;79:489-93 pubmed publisher
    The role of synovitis and high fluid pressure in the loosening process after total hip arthroplasty has gained increasing attention. We investigated the correlation between head size, polyethylene wear, and capsular distention.
  52. Atzeni F, Sarzi Puttini P, Lama N, Bonacci E, Bobbio Pallavicini F, Montecucco C, et al. Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis. Arthritis Res Ther. 2008;10:R51 pubmed publisher
    ..The purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data...
  53. Weiner S, Jurenz S, Uhl M, Lange Nolde A, Warnatz K, Peter H, et al. Ultrasonography in the assessment of peripheral joint involvement in psoriatic arthritis : a comparison with radiography, MRI and scintigraphy. Clin Rheumatol. 2008;27:983-9 pubmed publisher
    ..detection of erosions and osteoproliferations and MRI as gold standard for the detection of joint effusion and synovitis. US, MRI and scintigraphy had a higher sensitivity in the detection of overall joint pathology than radiography ..