Summary: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.

Top Publications

  1. Antic M, Lautenschlager S, Itin P. Eosinophilic fasciitis 30 years after - what do we really know? Report of 11 patients and review of the literature. Dermatology. 2006;213:93-101 pubmed
    Eosinophilic fasciitis (EF) is a rare fibrosing disorder associated with peripheral eosinophilia and scleroderma-like induration of the distal extremities which affects substantially quality of life...
  2. Desvignes Engelbert A, Saulière N, Loeuille D, Blum A, Chary Valckenaere I. From diagnosis to remission: place of MRI in eosinophilic fasciitis. Clin Rheumatol. 2010;29:1461-4 pubmed publisher
    Eosinophilic fasciitis is a rare disease, but it must be considered in patients with adult myalgia...
  3. Oda K, Nakaseko C, Ozawa S, Nishimura M, Saito Y, Yoshiba F, et al. Fasciitis and myositis: an analysis of muscle-related complications caused by chronic GVHD after allo-SCT. Bone Marrow Transplant. 2009;43:159-67 pubmed publisher
    The muscle-related complications of fasciitis and myositis, caused by chronic GVHD after Allo-SCT are relatively rare, but at times will severely impair a patient's quality of life (QOL)...
  4. Bau J, Ly J, Lusk J. Quiz case. Nodular fasciitis. Eur J Radiol. 2003;47:54-6 pubmed
  5. Bouché R, Johnson C. Medial tibial stress syndrome (tibial fasciitis): a proposed pathomechanical model involving fascial traction. J Am Podiatr Med Assoc. 2007;97:31-6 pubmed
    ..Circumferential straps provided no dampening effect on tension directed to the medial tibial crest. ..
  6. Erickson Johnson M, Chou M, Evers B, Roth C, Seys A, Jin L, et al. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest. 2011;91:1427-33 pubmed publisher
    Nodular fasciitis (NF) is a relatively common mass-forming and self-limited subcutaneous pseudosarcomatous myofibroblastic proliferation of unknown pathogenesis...
  7. Naoui A, Bouslama K, Abdallah M, Hamzaoui S, Arbi T, Bahri F, et al. [Eosinophilic fasciitis (Shulman's disease): a case series of 11 patients]. Rev Med Interne. 2010;31:535-9 pubmed publisher
    Eosinophilic fasciitis or Shulman's disease is a rare condition of unknown etiology...
  8. Koizumi H, Mikami M, Doi M, Tadokoro M. Clonality analysis of nodular fasciitis by HUMARA-methylation-specific PCR. Histopathology. 2005;47:320-1 pubmed
  9. Smith L, Cox N. Dapsone treatment for eosinophilic fasciitis. Arch Dermatol. 2008;144:845-7 pubmed publisher

More Information


  1. French L, Shapiro M, Junkins Hopkins J, Wolfe J, Rook A. Eosinophilic fasciitis and eosinophilic cellulitis in a patient with abnormal circulating clonal T cells: increased production of interleukin 5 and inhibition by interferon alfa. J Am Acad Dermatol. 2003;49:1170-4 pubmed
    Eosinophilic fasciitis (Shulman's syndrome) and eosinophilic cellulitis are part of a spectrum of diseases characterized by tissue and peripheral blood eosinophilia...
  2. Saad R, Takei H, Lipscomb J, Ruiz B. Nodular fasciitis of parotid region: a pitfall in the diagnosis of pleomorphic adenomas on fine-needle aspiration cytology. Diagn Cytopathol. 2005;33:191-4 pubmed
    ..Both cases were later diagnosed on histologic examination as nodular fasciitis. Nodular fasciitis should be considered in the differential diagnosis of a mass arising in association with the ..
  3. Park C, Park J, Lee K. Parosteal (nodular) fasciitis of the hand. Clin Radiol. 2004;59:376-8 pubmed
  4. Han W, Hu Q, Yang X, Wang Z, Huang X. Nodular fasciitis in the orofacial region. Int J Oral Maxillofac Surg. 2006;35:924-7 pubmed
    Nodular fasciitis (NF) is a benign, reactive proliferation of fibroblasts in subcutaneous tissues which commonly occurs in the deep fascia. It can only be diagnosed by histopathological examination of a biopsy...
  5. Kroft E, de Jong E, Evers A. Psychological distress in patients with morphea and eosinophilic fasciitis. Arch Dermatol. 2009;145:1017-22 pubmed publisher
    To examine the level of psychological distress and factors contributing to distress in patients with morphea or eosinophilic fasciitis.
  6. Serrano Grau P, Mascaró Galy J, Iranzo P. [Eosinophilic fasciitis after taking simvastatin]. Actas Dermosifiliogr. 2008;99:420-1 pubmed
  7. Dybowski F, Neuen Jacob E, Braun J. Eosinophilic fasciitis and myositis: use of imaging modalities for diagnosis and monitoring. Ann Rheum Dis. 2008;67:572-4 pubmed publisher
  8. Buchbinder R, Ptasznik R, Gordon J, Buchanan J, Prabaharan V, Forbes A. Ultrasound-guided extracorporeal shock wave therapy for plantar fasciitis: a randomized controlled trial. JAMA. 2002;288:1364-72 pubmed
    Extracorporeal shock wave therapy (ESWT) is increasingly used for plantar fasciitis, but limited evidence supports its use.
  9. Donner L, Silva T, Dobin S. Clonal rearrangement of 15p11.2, 16p11.2, and 16p13.3 in a case of nodular fasciitis: additional evidence favoring nodular fasciitis as a benign neoplasm and not a reactive tumefaction. Cancer Genet Cytogenet. 2002;139:138-40 pubmed
    This article describes a case of nodular fasciitis with the karyotype 47,XY,+4/46,XY,add(15)(p11.2), t(16;16)(p13.3;p11.2)...
  10. Reiser V, Alterman M, Shlomi B, Issakov J, Dagan Y, Kleinman S, et al. Oral intravascular fasciitis: a rare maxillofacial lesion. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e40-4 pubmed publisher
    Nodular fasciitis is a benign non-neoplastic myofibroblastic proliferation, involving the head in 7% to 20% of cases. Intravascular fasciitis (IVF) is a rare variant, with a unique intravascular growth pattern...
  11. Bukiej A, Dropinski J, Dyduch G, Szczeklik A. Eosinophilic fasciitis successfully treated with cyclosporine. Clin Rheumatol. 2005;24:634-6 pubmed
    We report on a 45-year-old female who developed eosinophilic fasciitis, characterized by scleroderma-like skin indurations, predominantly on the extremities and chest, with joint contractures and intermittent blood eosinophilia...
  12. Moulton S, Kransdorf M, Ginsburg W, Abril A, Persellin S. Eosinophilic fasciitis: spectrum of MRI findings. AJR Am J Roentgenol. 2005;184:975-8 pubmed
    Our objective was to describe the spectrum of MRI features of eosinophilic fasciitis.
  13. Plaza J, Mayerson J, Wakely P. Nodular fasciitis of the hand: a potential diagnostic pitfall in fine-needle aspiration cytopathology. Am J Clin Pathol. 2005;123:388-93 pubmed
    ..Nodular fasciitis, an uncommon pseudosarcomatous lesion of soft tissue, rarely occurs in the hand and, because of this, is not ..
  14. Denschlag D, Riener E, Vaith P, Tempfer C, Keck C. Palmar fasciitis and polyarthritis as a paraneoplastic syndrome associated with tubal carcinoma: a case report. Ann Rheum Dis. 2004;63:1177-8 pubmed
  15. Weinreb I, Shaw A, Perez Ordonez B, Goldblum J, Rubin B. Nodular fasciitis of the head and neck region: a clinicopathologic description in a series of 30 cases. J Cutan Pathol. 2009;36:1168-73 pubmed publisher
    Nodular fasciitis (NF) is a reactive lesion composed of fibroblasts/myofibroblasts and most commonly found in extremities and trunk. NF has been described in the head and neck region (HNR) in 13-20% of cases...
  16. Cardozo T. Eosinophilic fasciitis. Dermatol Online J. 2003;9:33 pubmed
    The case of a 76-year-old woman with eosinophilic fasciitis is presented. Reported etiologic associations and treatment options are discussed.
  17. Handa Y, Asai T, Tomita Y. Nodular fasciitis of the forehead in a pediatric patient. Dermatol Surg. 2003;29:867-8 pubmed
    Nodular fasciitis is a benign fibroblastic proliferation in soft tissue that is frequently misdiagnosed as a sarcoma. Most patients are middle aged, and the upper extremity is the most common localization...
  18. Toquet C, Hamidou M, Renaudin K, Jarry A, Foulc P, Barbarot S, et al. In situ immunophenotype of the inflammatory infiltrate in eosinophilic fasciitis. J Rheumatol. 2003;30:1811-5 pubmed
    Eosinophilic fasciitis (EF) is histologically characterized by a fibrous and inflammatory thickening of subcutaneous septal-fascial-perimysial collagenous scaffold...
  19. Dayan D, Nasrallah V, Vered M. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity: 1. Nodular fasciitis. J Oral Pathol Med. 2005;34:426-35 pubmed
    Nodular fasciitis (NF), a soft tissue lesion mainly composed of myofibroblastic cells, is well documented in various body locations however, in the oral cavity it is rare...
  20. Khan K, Farahani K, Roberts E, D Antoni A, Cavazos J, Dellacorte M. Pedal occurrence of nodular fasciitis: a case report. J Foot Ankle Surg. 2012;51:241-5 pubmed publisher
    Nodular fasciitis occurs primarily in the soft tissue structures of the upper extremities and, more rarely, in the lower extremities...
  21. Agnew K, Blunt D, Francis N, Bunker C. Magnetic resonance imaging in eosinophilic fasciitis. Clin Exp Dermatol. 2005;30:435-6 pubmed
  22. Le Corroller T, Kovacs T, Champsaur P. Nodular fasciitis with cortical involvement. Joint Bone Spine. 2009;76:101-3 pubmed publisher
    We report on the clinical and imaging features--including CT and MRI--of nodular fasciitis with cortical involvement in the shoulder...
  23. Znati K, Daoudi A, Elfatemi H, Chbani L, Bennis S, Boutayeb F, et al. [Ischemic fasciitis. A case report]. Ann Chir Plast Esthet. 2009;54:392-5 pubmed publisher
    Ischemic fasciitis, also called atypical decubital fibroplasia, was recently described as a distinctive fibroblastic proliferation occurring predominantly in elderly, bed-ridden individuals. It is very rare...
  24. Meng G, Zhang H, Zhang Z, Wei B, Bu H. Myofibroblastic sarcoma vs nodular fasciitis: a comparative study of chromosomal imbalances. Am J Clin Pathol. 2009;131:701-9 pubmed publisher
    ..copy number changes were analyzed by comparative genomic hybridization in 29 cases of MS and 5 cases of nodular fasciitis. The characteristic chromosomal imbalances in MS were gains at 1p11 --> p36.3 (19/29 [66%]), 12p12...
  25. Boin F, Hummers L. Scleroderma-like fibrosing disorders. Rheum Dis Clin North Am. 2008;34:199-220; ix pubmed publisher
    ..This article highlights nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy), eosinophilic fasciitis (Shulman's syndrome), scleromyxedema, and scleredema...
  26. Cavailhes A, Ingen Housz Oro S, Djennane S, Rafaa M, Fiszenson Albala F, Weber N, et al. [Occurrence of psoriasis in a patient presenting Shulman fasciitis treated with infliximab]. Ann Dermatol Venereol. 2007;134:363-7 pubmed
    ..Several case reports have recently been published concerning induction of paradoxical psoriasis during the course of anti-TNF therapy. We report a new case involving infliximab used to treat Shulman fasciitis.
  27. Kim K, Kim Y, Won Lee J, Kim Y, Park S, Lim M, et al. Can necrotizing infectious fasciitis be differentiated from nonnecrotizing infectious fasciitis with MR imaging?. Radiology. 2011;259:816-24 pubmed publisher
    To retrospectively evaluate whether magnetic resonance (MR) imaging findings can be used to differentiate necrotizing infectious fasciitis (NIF) from nonnecrotizing infectious fasciitis (non-NIF).
  28. Hull K, Wong K, Wood G, Chu W, Kastner D. Monocytic fasciitis: a newly recognized clinical feature of tumor necrosis factor receptor dysfunction. Arthritis Rheum. 2002;46:2189-94 pubmed
    ..analysis of the specimen demonstrated normal myofibrils but a severely destructive monocytic fasciitis. These results suggest that the myalgia experienced by individuals with TRAPS is due to a monocytic fasciitis ..
  29. Harish S, Kuruvilla M, Alowami S, Denardi F, Ghert M. Intra-articular nodular fasciitis of the shoulder: a case report and review of the literature. Skeletal Radiol. 2011;40:1383-6 pubmed publisher
    Nodular fasciitis is a benign proliferation of myofibroblasts usually arising adjacent to the fascia...
  30. Nishi S, Brey N, Sanchez R. Dermal nodular fasciitis: three case reports of the head and neck and literature review. J Cutan Pathol. 2006;33:378-82 pubmed
    Nodular fasciitis is a benign reactive myofibroblastic proliferative process of unknown etiology. It presents as a solitary painless, rapidly growing nodule over several weeks' duration...
  31. Shah A, Jack A, Liu H, Hopkins R. Neoplastic/paraneoplastic dermatitis, fasciitis, and panniculitis. Rheum Dis Clin North Am. 2011;37:573-92 pubmed publisher
    ..Effective treatment of the associated neoplasm often leads to improvement of the cutaneous manifestations and should be the primary focus of each patient's management...
  32. Singh R, Sharma A. Nodular fasciitis of the thumb: a case report. Hand Surg. 2004;9:117-20 pubmed
    Nodular fasciitis is an uncommon, benign, reactive fibroblastic soft tissue tumour. It is infrequently seen in the hand...
  33. Sugaya M, Tamaki K. Does thrombosis cause intravascular fasciitis?. Acta Derm Venereol. 2007;87:369-70 pubmed
  34. Nikolaidis P, Gabriel H, Lamba A, Chan N. Sonographic appearance of nodular fasciitis. J Ultrasound Med. 2006;25:281-5 pubmed
  35. Hornick J, Fletcher C. Intraarticular nodular fasciitis--a rare lesion: clinicopathologic analysis of a series. Am J Surg Pathol. 2006;30:237-41 pubmed
    Nodular fasciitis is a benign myofibroblastic proliferation with a predilection for the subcutaneous tissues of the upper extremities, trunk, and head and neck of young adults...
  36. Scanlon R, Kelehan P, Flannelly G, McDonald D, McCluggage W. Ischemic fasciitis: an unusual vulvovaginal spindle cell lesion. Int J Gynecol Pathol. 2004;23:65-7 pubmed
    Ischemic fasciitis is a benign reactive lesion that most commonly occurs in elderly, immobile patients in weight-bearing areas that are subject to intermittent ischemia with subsequent tissue breakdown and regenerative changes...
  37. Nandeesh B, Ananthamurthy A, Inchara Y, Correa M, Garg I. Papillary thyroid carcinoma with nodular fasciitis-like stroma: a case report. Ear Nose Throat J. 2011;90:E8-E10 pubmed
    ..PTC with nodular fasciitis-like stroma (PTC-NFS) is one of the unusual variants of PTC, with only a few cases being reported in the ..
  38. Sillo P, Pintér D, Ostorhazi E, Mazán M, Wikonkál N, Pónyai K, et al. Eosinophilic Fasciitis associated with Mycoplasma arginini infection. J Clin Microbiol. 2012;50:1113-7 pubmed publisher
    Eosinophilic fasciitis (EF) with generalized sclerodermiform skin lesions developed over a 19-month period in a previously healthy 23-year-old man...
  39. Kroft E, de Jong E, Evers A. Physical burden of symptoms in patients with localized scleroderma and eosinophilic fasciitis. Arch Dermatol. 2008;144:1394-5 pubmed publisher
  40. Kong C, Cha I. Nodular fasciitis: diagnosis by fine needle aspiration biopsy. Acta Cytol. 2004;48:473-7 pubmed
    To describe the cytomorphologic features of nodular fasciitis that differentiate it from schwannoma.
  41. Kijima H, Okada K, Ito H, Shimada Y, Nanjo H, Itoi E. Nodular fasciitis of the finger. Skeletal Radiol. 2005;34:121-3 pubmed
    Nodular fasciitis is a benign reactive lesion, often mistaken for a soft tissue sarcoma in clinical practice...
  42. Lebeaux D, Sene D. Eosinophilic fasciitis (Shulman disease). Best Pract Res Clin Rheumatol. 2012;26:449-58 pubmed publisher
    The eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues...
  43. Heidary N, Cheung W, Wang N, Kamino H, Franks A. Eosinophilic fasciitis/generalized morphea overlap. Dermatol Online J. 2009;15:2 pubmed
    ..course of one year, the patient began to develop signs and symptoms suggestive of a diagnosis of eosinophilic fasciitis, which included the characteristic groove sign on the upper extremities...
  44. Chi A, Dunlap W, Richardson M, Neville B. Intravascular fasciitis: report of an intraoral case and review of the literature. Head Neck Pathol. 2012;6:140-5 pubmed publisher
    Intravascular fasciitis (IF) is an unusual variant of nodular fasciitis. It is characterized by intraluminal, intramural, and extramural involvement of small to large arteries or veins...
  45. Wang L, Wang G, Wang L, Gao T. Myxoid intravascular fasciitis. J Cutan Pathol. 2011;38:63-6 pubmed publisher
    Nodular fasciitis is a common reactive proliferation of soft tissue. It is composed of high density of fibroblasts and myofibroblasts, and sometimes shows a sarcomatoid appearance histologically...
  46. Weber H, Schaller M, Metzler G, Rocken M, Berneburg M. Eosinophilic fasciitis and combined UVA1--retinoid--corticosteroid treatment: two case reports. Acta Derm Venereol. 2008;88:304-6 pubmed publisher
  47. Endo Y, Tamura A, Matsushima Y, Iwasaki T, Hasegawa M, Nagai Y, et al. Eosinophilic fasciitis: report of two cases and a systematic review of the literature dealing with clinical variables that predict outcome. Clin Rheumatol. 2007;26:1445-51 pubmed
    We reported two patients with refractory eosinophilic fasciitis (EF) and provided a systematic review of the literature to determine the clinical variables associated with prognosis of EF...
  48. Bacac M, Migliavacca E, Stehle J, McKee T, Delorenzi M, Coindre J, et al. A gene expression signature that distinguishes desmoid tumours from nodular fasciitis. J Pathol. 2006;208:543-53 pubmed
    Nodular fasciitis (NF) is a rapidly growing cellular mass composed of fibroblasts/myofibroblasts, usually localized in subcutaneous tissues, that typically undergoes fibrosis and almost never recurs...
  49. Degiovanni C, Chard M, Woollons A. Eosinophilic fasciitis secondary to treatment with atorvastatin. Clin Exp Dermatol. 2006;31:131-2 pubmed
  50. Stone D, Chodosh J. Epibulbar nodular fasciitis associated with floppy eyelids. Cornea. 2005;24:361-2 pubmed
    To report a case of epibulbar nodular fasciitis in a patient with floppy eyelids.
  51. Wong N, Di F. Pseudosarcomatous fasciitis and myositis: diagnosis by fine-needle aspiration cytology. Am J Clin Pathol. 2009;132:857-65 pubmed publisher
    Nodular fasciitis (NF), proliferative fasciitis (PF), and proliferative myositis (PM) are pseudosarcomatous lesions that typically resolve spontaneously...
  52. Kato T, Nakajima A, Soejima M, Nagai R, Yago T, Tanohara K, et al. Therapeutic efficacy of intravenous cyclophosphamide concomitant with moderate- to high-dose prednisolone in two patients with fasciitis panniculitis syndrome. Mod Rheumatol. 2008;18:193-9 pubmed publisher
    b>Fasciitis panniculitis syndrome (FPS) has been proposed as a new category of 'fasciitis' and includes the well-established eosinophilic fasciitis (EF)...
  53. Bischoff L, Derk C. Eosinophilic fasciitis: demographics, disease pattern and response to treatment: report of 12 cases and review of the literature. Int J Dermatol. 2008;47:29-35 pubmed publisher
    Eosinophilic fasciitis is a rare scleroderma-like illness. The clinical spectrum of the disease has evolved since its initial description.
  54. Squillaci S, Tallarigo F, Patarino R, Bisceglia M. Nodular fasciitis of the male breast: a case report. Int J Surg Pathol. 2007;15:69-72 pubmed
    A case of nodular fasciitis is reported that involved the breast parenchyma of a 40-year-old man. The differential diagnosis of nodular fasciitis in the male breast mainly includes fibromatosis and myofibroblastoma...
  55. Ilaslan H, Joyce M, Bauer T, Sundaram M. Decubital ischemic fasciitis: clinical, pathologic, and MRI features of pseudosarcoma. AJR Am J Roentgenol. 2006;187:1338-41 pubmed
    The purpose of this report is to describe clinical, pathologic, and MRI findings on decubital ischemic fasciitis, which is a rare soft-tissue tumor sarcoma simulator.
  56. Ikeda K, Hagiwara N, Funaki K, Tomita K, Sudo Y. Nodular fasciitis of the ulnar nerve at the palm. Scand J Plast Reconstr Surg Hand Surg. 2005;39:249-51 pubmed
    ..As the mass was impossible to separate from the ulnar nerve, we excised the mass together with the digital nerve and grafted 4cm of the sural nerve. The final diagnosis was nodular fasciitis.
  57. Giannakopoulos C, Kyriakidou G, Toufexi G. Palmar fasciitis and polyarthritis associated with secondary ovarian carcinoma. Case report. Eur J Gynaecol Oncol. 2005;26:339-41 pubmed
    Palmar fasciitis and a polyarthritis syndrome (PFPAS) is an uncommon paraneoplastic syndrome often associated with occult neoplasms, including ovarian and pancreatic carcinomas...
  58. Baumann F, Brühlmann P, Andreisek G, Michel B, Marincek B, Weishaupt D. MRI for diagnosis and monitoring of patients with eosinophilic fasciitis. AJR Am J Roentgenol. 2005;184:169-74 pubmed
    The objective of this study was to describe MRI findings in patients with eosinophilic fasciitis (EF) and to correlate clinical and laboratory findings with the MRI findings.
  59. Roukis T, Weil L, Borrelli A. Extracorporeal shock wave therapy for the treatment of chronic plantar fasciitis: indications, protocol, intermediate results, and a comparison of results to fasciotomy. J Foot Ankle Surg. 2002;41:166-72 pubmed
    ..of the history, mechanism of action, and application of extracorporeal shock wave therapy for chronic plantar fasciitis is presented. The results of 40 feet treated with this modality are reviewed after a mean follow-up time of 8...