ossification of posterior longitudinal ligament

Summary

Summary: A calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.

Top Publications

  1. Iwasaki K, Furukawa K, Tanno M, Kusumi T, Ueyama K, Tanaka M, et al. Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament. Calcif Tissue Int. 2004;74:448-57 pubmed
    ..Therefore, we propose that mechanical stress plays a key role in the progression of OPLL through an increase in Cbfa1 expression...
  2. Tanaka H, Nagai E, Murata H, Tsubone T, Shirakura Y, Sugiyama T, et al. Involvement of bone morphogenic protein-2 (BMP-2) in the pathological ossification process of the spinal ligament. Rheumatology (Oxford). 2001;40:1163-8 pubmed
    ..To investigate the function of bone morphogenic protein-2 (BMP-2) in the ossification of the spinal ligament (OSL)...
  3. Tahara M, Aiba A, Yamazaki M, Ikeda Y, Goto S, Moriya H, et al. The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms. Spine (Phila Pa 1976). 2005;30:877-80; discussion 881 pubmed
    A case-control study using radiograph findings and the PCR assay with regard to the susceptibility and the severity of ossification of posterior longitudinal ligament of the spine (OPLL).
  4. Chiba K, Ogawa Y, Ishii K, Takaishi H, Nakamura M, Maruiwa H, et al. Long-term results of expansive open-door laminoplasty for cervical myelopathy--average 14-year follow-up study. Spine (Phila Pa 1976). 2006;31:2998-3005 pubmed
    Retrospective case series on long-term follow-up results of original expansive open-door laminoplasty for cervical myelopathy due to cervical spondylosis (CSM) and ossification of posterior longitudinal ligament (OPLL).
  5. Matsunaga S, Kukita M, Hayashi K, Shinkura R, Koriyama C, Sakou T, et al. Pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament. J Neurosurg. 2002;96:168-72 pubmed
    ..The goal of this study was to clarify the pathogenesis of myelopathy in patients with ossification of the posterior longitudinal ligament (OPLL) based on the relationship between static compression factors and dynamic factors...
  6. Okamoto K, Kobashi G, Washio M, Sasaki S, Yokoyama T, Miyake Y, et al. Dietary habits and risk of ossification of the posterior longitudinal ligaments of the spine (OPLL); findings from a case-control study in Japan. J Bone Miner Metab. 2004;22:612-7 pubmed
    ..Our findings suggest that dietary habits may constitute independent risk factors for OPLL. Further studies will be needed to prospectively determine the relationship between dietary habits and OPLL risk...
  7. Saito T, Shimizu Y, Hori M, Taguchi M, Igarashi T, Fukumoto S, et al. A patient with hypophosphatemic rickets and ossification of posterior longitudinal ligament caused by a novel homozygous mutation in ENPP1 gene. Bone. 2011;49:913-6 pubmed publisher
    ..We here show a patient with hypophosphatemic rickets and widespread ossification of posterior longitudinal ligament (OPLL). The proband is a 62-year-old female...
  8. Koga H, Sakou T, Taketomi E, Hayashi K, Numasawa T, Harata S, et al. Genetic mapping of ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet. 1998;62:1460-7 pubmed
    ..0004). These observations of linkage and association, taken together, show that a genetic locus for OPLL lies close to the HLA region, on chromosome 6p...
  9. Matsunaga S. [Updates on ossification of posterior longitudinal ligament. Epidemiology and pathogenesis of OPLL]. Clin Calcium. 2009;19:1415-20 pubmed publisher
    ..Genetic analysis with participation of all Japan research institutes has started t and it is expected to elucidate pathogenic gene of OPLL in the near future...

More Information

Publications81

  1. Kobashi G, Washio M, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, et al. High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case-control study in multiple hospitals. Spine (Phila Pa 1976). 2004;29:1006-10 pubmed
    ..A sex- and age-matched case-control study was carried out...
  2. Tanno M, Furukawa K, Ueyama K, Harata S, Motomura S. Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments. Bone. 2003;33:475-84 pubmed
  3. Kawaguchi Y, Furushima K, Sugimori K, Inoue I, Kimura T. Association between polymorphism of the transforming growth factor-beta1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2003;28:1424-6 pubmed
    ..A study was conducted to examine the relation between the transforming growth factor-beta1 (TGF-beta1) polymorphism (T-->C transition in the signal sequence) and ossification of the posterior longitudinal ligament (OPLL)...
  4. Schmidt M, Quinones Hinojosa A, Rosenberg W. Cervical myelopathy associated with degenerative spine disease and ossification of the posterior longitudinal ligament. Semin Neurol. 2002;22:143-8 pubmed
    ..Prospective, randomized trials with standardized outcome measures are needed to clarify the benefit of surgery conclusively...
  5. Chiba K, Yamamoto I, Hirabayashi H, Iwasaki M, Goto H, Yonenobu K, et al. Multicenter study investigating the postoperative progression of ossification of the posterior longitudinal ligament in the cervical spine: a new computer-assisted measurement. J Neurosurg Spine. 2005;3:17-23 pubmed
  6. Ogata N, Koshizuka Y, Miura T, Iwasaki M, Hosoi T, Shiraki M, et al. Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity. Spine (Phila Pa 1976). 2002;27:1765-71 pubmed
    ..A case-control association study and a stratified study investigating the genetic etiology for ossification of the posterior longitudinal ligament of the spine...
  7. Chen Y, Guo Y, Chen D, Lu X, Wang X, Tian H, et al. Diagnosis and surgery of ossification of posterior longitudinal ligament associated with dural ossification in the cervical spine. Eur Spine J. 2009;18:1541-7 pubmed publisher
    ..Therefore, ACCF is meritorious for the patient with OPLL associated with DO, although more difficult manipulation and higher risk of CSF leakage...
  8. Chen Y, Chen D, Wang X, Lu X, Guo Y, He Z, et al. Anterior corpectomy and fusion for severe ossification of posterior longitudinal ligament in the cervical spine. Int Orthop. 2009;33:477-82 pubmed publisher
    ..01). No severe neurological complication developed. We therefore concluded that anterior decompression and fusion was effective and safe in the treatment of the selected patients, although OPLL exceeded 50% diameter of the spinal canal...
  9. Furushima K, Shimo Onoda K, Maeda S, Nobukuni T, Ikari K, Koga H, et al. Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res. 2002;17:128-37 pubmed
    ..Only BMP4 reached criteria of suggestive evidence of linkage. Because this gene is a well-known factor in osteogenetic function, BMP4 should be screened in further study for the polymorphism responsible...
  10. Meng X, Wang H, Yang H, Hai Y, Tian B, Lin X. T allele at site 6007 of bone morphogenetic protein-4 gene increases genetic susceptibility to ossification of the posterior longitudinal ligament in male Chinese Han population. Chin Med J (Engl). 2010;123:2537-42 pubmed
    ..Thus, BMP4 may function in OPLL development. Appropriately, the relationship between BMP4 polymorphisms and OPLL was investigated...
  11. Horikoshi T, Maeda K, Kawaguchi Y, Chiba K, Mori K, Koshizuka Y, et al. A large-scale genetic association study of ossification of the posterior longitudinal ligament of the spine. Hum Genet. 2006;119:611-6 pubmed
    ..TGFB3 warrants further investigation because it is located within a genomic region that has been positively linked with OPLL...
  12. Iwasaki M, Okuda S, Miyauchi A, Sakaura H, Mukai Y, Yonenobu K, et al. Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 1: Clinical results and limitations of laminoplasty. Spine (Phila Pa 1976). 2007;32:647-53 pubmed
    ..Retrospective study of 66 patients who underwent laminoplasty for treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL)...
  13. Wang H, Liu D, Yang Z, Tian B, Li J, Meng X, et al. Association of bone morphogenetic protein-2 gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity in Chinese patients. Eur Spine J. 2008;17:956-64 pubmed publisher
  14. Chen Y, Chen D, Wang X, Guo Y, He Z. C5 palsy after laminectomy and posterior cervical fixation for ossification of posterior longitudinal ligament. J Spinal Disord Tech. 2007;20:533-5 pubmed
    To investigate the imaging findings correlated with C5 root palsies in the patients undergoing laminectomy and lateral mass screw fixation for ossification of posterior longitudinal ligament (OPLL), and clarify its pathogenic mechanism.
  15. Shingyouchi Y, Nagahama A, Niida M. Ligamentous ossification of the cervical spine in the late middle-aged Japanese men. Its relation to body mass index and glucose metabolism. Spine (Phila Pa 1976). 1996;21:2474-8 pubmed
  16. Kong Q, Ma X, Li F, Guo Z, Qi Q, Li W, et al. COL6A1 polymorphisms associated with ossification of the ligamentum flavum and ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2007;32:2834-8 pubmed publisher
    ..A case-control association study was conducted to investigate the genetic etiology for ossification of the ligamentum flavum (OLF) and ossification of the posterior longitudinal ligament of the spine (OPLL)...
  17. Furukawa K. Current topics in pharmacological research on bone metabolism: molecular basis of ectopic bone formation induced by mechanical stress. J Pharmacol Sci. 2006;100:201-4 pubmed
    ..These observations provide information regarding the role of mechanical stress in the process of EBF...
  18. Iwasaki M, Okuda S, Miyauchi A, Sakaura H, Mukai Y, Yonenobu K, et al. Surgical strategy for cervical myelopathy due to ossification of the posterior longitudinal ligament: Part 2: Advantages of anterior decompression and fusion over laminoplasty. Spine (Phila Pa 1976). 2007;32:654-60 pubmed
    ..Retrospective study of 27 patients who underwent anterior decompression and fusion (ADF) for treatment of cervical myelopathy due to ossification of the posterior longitudinal ligament (OPLL)...
  19. Sato R, Uchida K, Kobayashi S, Yayama T, Kokubo Y, Nakajima H, et al. Ossification of the posterior longitudinal ligament of the cervical spine: histopathological findings around the calcification and ossification front. J Neurosurg Spine. 2007;7:174-83 pubmed
    ..The authors studied the histological and immunohistochemical features of ossified posterior longitudinal ligament (PLL) of the cervical spine, especially in the calcification and ossification front...
  20. Kim T, Kim T, Jun J, Joo K, Uhm W. Prevalence of ossification of posterior longitudinal ligament in patients with ankylosing spondylitis. J Rheumatol. 2007;34:2460-2 pubmed
    ..To determine the prevalence of ossification of the posterior longitudinal ligament (OPLL) in patients with ankylosing spondylitis (AS)...
  21. Kishiya M, Sawada T, Kanemaru K, Kudo H, Numasawa T, Yokoyama T, et al. A functional RNAi screen for Runx2-regulated genes associated with ectopic bone formation in human spinal ligaments. J Pharmacol Sci. 2008;106:404-14 pubmed
    ..These results suggest that angiopoietin-1 is downstream of Runx2 in both OPLL primary cells and osteoblasts. Angiopoietin-1 may play an important role in ectopic ossification...
  22. Hsieh J, Wu C, Lee S. Cervical intradural disc herniation after spinal manipulation therapy in a patient with ossification of posterior longitudinal ligament: a case report and review of the literature. Spine (Phila Pa 1976). 2010;35:E149-51 pubmed publisher
    ..Case report and review of the literature...
  23. Koga H, Hayashi K, Taketomi E, Matsunaga S, Yashiki S, Fujiyoshi T, et al. Restriction fragment length polymorphism of genes of the alpha 2(XI) collagen, bone morphogenetic protein-2, alkaline phosphatase, and tumor necrosis factor-alpha among patients with ossification of posterior longitudinal ligament and controls from t. Spine (Phila Pa 1976). 1996;21:469-73 pubmed
    ..This study investigates the genetic polymorphism of bone-induced factors in patients with ossification of the posterior longitudinal ligament and compares it with healthy control subjects...
  24. Chen Y, Guo Y, Lu X, Chen D, Song D, Shi J, et al. Surgical strategy for multilevel severe ossification of posterior longitudinal ligament in the cervical spine. J Spinal Disord Tech. 2011;24:24-30 pubmed publisher
    ..A retrospective clinical study was conducted...
  25. Maeda S, Ishidou Y, Koga H, Taketomi E, Ikari K, Komiya S, et al. Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Res. 2001;16:948-57 pubmed
  26. Maeda S, Koga H, Matsunaga S, Numasawa T, Ikari K, Furushima K, et al. Gender-specific haplotype association of collagen alpha2 (XI) gene in ossification of the posterior longitudinal ligament of the spine. J Hum Genet. 2001;46:1-4 pubmed
    ..21). OPLL is predominantly observed in males. with a prevalence ratio of 2:1, and our gender-specific associations indicate that genetic factors involving COL11A2 play a specific role in the etiology of OPLL exclusively in males...
  27. Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet. 1998;19:271-3 pubmed
    ..Our results may lead to novel insights into the mechanism of ectopic ossification and the aetiology of human OPLL...
  28. Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K, et al. Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine. Am J Hum Genet. 2003;73:812-22 pubmed
    ..Identification of the locus of susceptibility to OPLL by genomewide linkage and linkage disequilibrium studies permits us to investigate the pathogenesis of the disease, which may lead to the development of novel therapeutic tools...
  29. Kim D, Jeong Y, Chon J, Yoo S, Kim H, Kang S, et al. Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament. Cytokine. 2011;55:343-6 pubmed publisher
    ..The purpose of this study was to investigate single nucleotide polymorphisms (SNPs) of the interleukin 15 receptor, alpha (IL15RA) gene as a risk factor in Korean patients with OPLL...
  30. Nakamura I, Ikegawa S, Okawa A, Okuda S, Koshizuka Y, Kawaguchi H, et al. Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL). Hum Genet. 1999;104:492-7 pubmed
    ..Thus, our study suggests that NPPS plays an important role in the etiology of human OPLL...
  31. Matsunaga S, Yamaguchi M, Hayashi K, Sakou T. Genetic analysis of ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 1999;24:937-8; discussion 939 pubmed
    ..The human leukocyte antigen (HLA) haplotypes in families of patients with known ossification of the posterior longitudinal ligament (OPLL) were reviewed...
  32. Washio M, Kobashi G, Okamoto K, Sasaki S, Yokoyama T, Miyake Y, et al. Sleeping habit and other life styles in the prime of life and risk for ossification of the posterior longitudinal ligament of the spine (OPLL): a case-control study in Japan. J Epidemiol. 2004;14:168-73 pubmed
    ..However, there is little information about the relationship between OPLL and life styles in the prime of life (between 30 and 50 years)...
  33. Liu Y, Zhao Y, Chen Y, Shi G, Yuan W. RUNX2 polymorphisms associated with OPLL and OLF in the Han population. Clin Orthop Relat Res. 2010;468:3333-41 pubmed publisher
  34. Matsunaga S, Sakou T, Arishima Y, Koga H, Hayashi K, Komiya S. Quality of life in elderly patients with ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2001;26:494-8 pubmed
    ..The study data suggest that surgical treatment should be chosen for patients exhibiting moderate myelopathy to obtain satisfactory quality of life for them over a long period. ..
  35. Mizuno J, Nakagawa H. Outcome analysis of anterior decompressive surgery and fusion for cervical ossification of the posterior longitudinal ligament: report of 107 cases and review of the literature. Neurosurg Focus. 2001;10:E6 pubmed
    ..Slight asymptomatic kyphotic deformity may be encountered. Of the graft materials used in our series, VB graft was considered most fragile, and thus least optimal. ..
  36. Kato Y, Kanchiku T, Imajo Y, Kimura K, Ichihara K, Kawano S, et al. Biomechanical study of the effect of degree of static compression of the spinal cord in ossification of the posterior longitudinal ligament. J Neurosurg Spine. 2010;12:301-5 pubmed publisher
  37. Liu K, Shi J, Jia L, Yuan W. Surgical technique: Hemilaminectomy and unilateral lateral mass fixation for cervical ossification of the posterior longitudinal ligament. Clin Orthop Relat Res. 2013;471:2219-24 pubmed publisher
    ..Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence. ..
  38. Koda M, Furuya T, Okawa A, Inada T, Kamiya K, Ota M, et al. Mid- to long-term outcomes of posterior decompression with instrumented fusion for thoracic ossification of the posterior longitudinal ligament. J Clin Neurosci. 2016;27:87-90 pubmed publisher
    ..PDF surgery for thoracic OPLL is thus considered a relatively safe and stable surgical procedure considering the mid- to long-term outcomes. ..
  39. Jiang W, Ma W, Gu Y, Zhao L, Hu X, Yu L, et al. [French door segmented laminectomy decompression for severe cervical ossification of posterior longitudinal ligament complicated with spinal cord injury]. Zhongguo Gu Shang. 2017;30:844-848 pubmed publisher
    ..French door segmented laminectomy decompression is safe and feasible for severe cervical OPLL complicated with spinal cord injury, and it is worth to be popularized in future. ..
  40. Kumar H, Boban M, Tiwari M. Skeletal fluorosis causing high cervical myelopathy. J Clin Neurosci. 2009;16:828-30 pubmed publisher
    ..The clinical presentation of skeletal fluorosis and treatment options are discussed...
  41. Ogawa Y. [Updates on ossification of posterior longitudinal ligament. Clinical results and problems of posterior decompression for OPLL of the cervical spine]. Clin Calcium. 2009;19:1493-8 pubmed publisher
    ..To acquire satisfactory operative results, careful consideration for the indication of ELAP should be necessary for each patient. ..
  42. Yamazaki A, Homma T, Uchiyama S, Katsumi Y, Okumura H. Morphologic limitations of posterior decompression by midsagittal splitting method for myelopathy caused by ossification of the posterior longitudinal ligament in the cervical spine. Spine (Phila Pa 1976). 1999;24:32-4 pubmed
    ..Patients who exhibit significant risk factors for continued contact of the spinal cord should be morphologically considered for anterior decompression. ..
  43. Kalb S, Martirosyan N, Perez Orribo L, Kalani M, Theodore N. Analysis of demographics, risk factors, clinical presentation, and surgical treatment modalities for the ossified posterior longitudinal ligament. Neurosurg Focus. 2011;30:E11 pubmed publisher
    ..The outcomes of the various surgical treatments among the different populations with OPLL appear similar. Compared with other procedures, however, anterior decompression led to the best neurological outcomes. ..
  44. Andres R, Binggeli R. Ossification of the posterior longitudinal ligament. J Rheumatol. 2008;35:528-9 pubmed
  45. Shiraishi T, Yato Y. New double-door laminoplasty procedure for the axis to preserve all muscular attachments to the spinous process: technical note. Neurosurg Focus. 2002;12:E9 pubmed
    ..The technique for this procedure is described and its usefulness in preventing postoperative spinal malalignment is discussed. ..
  46. Tian W, Weng C, Liu B, Li Q, Sun Y, Yuan Q, et al. Intraoperative 3-dimensional navigation and ultrasonography during posterior decompression with instrumented fusion for ossification of the posterior longitudinal ligament in the thoracic spine. J Spinal Disord Tech. 2013;26:E227-34 pubmed publisher
    ..5 points at the final follow-up and a mean recovery rate of 54.5%. Intraoperative ultrasonography and ITN are safe and reliable imaging methods for posterior decompression and instrumented fusion for thoracic myelopathy caused by OPLL. ..
  47. Smith P, Knaub M, Kang J. Anterior cervical approaches for cervical radiculopathy and myelopathy. Instr Course Lect. 2003;52:455-63 pubmed
    ..The technical aspects of anterior diskectomy and corpectomy, methods of fusion, and the use of instrumentation are important treatment considerations. ..
  48. Bonneville F, Grossman R. [Quid? Ossification of the posterior common vertebral ligament]. J Radiol. 2003;84:1991-3 pubmed
  49. Li Q, Kong Q, Zhang L, Sun T, Li T, Gong Q, et al. [Discussion of surgical indications for posterior expansive open-door laminoplasty extended to C1 level]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2013;27:1214-20 pubmed
    ..2) There is a huge compression at the lower edge of C2-4 vertebrae, and the most prominent part of the diameter is exceed 7.0 mm, which can not be removed through the anterior cervical surgery, or the operation is high-risk. ..
  50. Nishiyama S, Sugeno N, Tateyama M, Aoki M. Late-onset Charcot-Marie-Tooth disease type 1B due to a novel mutation in the extracellular disulfide bridge of MPZ gene. Clin Neurol Neurosurg. 2013;115:208-9 pubmed publisher
  51. Koyanagi I, Iwasaki Y, Hida K, Akino M, Imamura H, Abe H. Acute cervical cord injury without fracture or dislocation of the spinal column. J Neurosurg. 2000;93:15-20 pubmed
  52. Tsuji T, Fujita N, Watanabe K, Nakamura M, Matsumoto M, Ishii K. Correlation between preoperative physical signs and functional outcomes after laminoplasty for ossification of the posterior longitudinal ligament. J Orthop Sci. 2017;22:266-269 pubmed publisher
  53. Kikuchi S, Watanabe E, Hasue M. Spinal intermittent claudication due to cervical and thoracic degenerative spine disease. Spine (Phila Pa 1976). 1996;21:313-8 pubmed
    ..Neurogenic intermittent claudication can be caused by spinal cord compression. In this study, 20 patients with spinal intermittent claudication due to degenerative spine diseases were evaluated...
  54. Shiigi E, Sugiyama T, Tanaka H, Murata H, Shirakura Y, Kawai S. Possible involvement of vitamin D receptor gene polymorphism in male patients with ossification of spinal ligaments. J Bone Miner Metab. 2001;19:308-11 pubmed
    ..The present investigation is a small preliminary study, but the findings suggest, for the first time, that the B allele of the VDR acts as an inhibitor in the pathogenesis of human male OSL...
  55. Lee S, Chung C, Jahng T, Kim H. Long-term outcome of laminectomy for cervical ossification of the posterior longitudinal ligament. J Neurosurg Spine. 2013;18:465-71 pubmed publisher
    ..In this paper, the authors assessed the long-term outcome of laminectomy for cervical OPLL in terms of the changes in the cervical curvature and in the neurological status...
  56. Cruzeiro M, Vale T, Pires L, Franco G, Pennisi M. Tetraparesis secondary to cervical ossification of the posterior longitudinal ligament: case report. Arq Neuropsiquiatr. 2007;65:532-5 pubmed
    ..A case of an Afro-Brazilian 54-years-old woman presenting with tetraparesis due to cervical OPLL is presented. Emphasis is made for the inclusion of OPLL in the differential diagnosis of compressive cervical myelopathy...
  57. Hasegawa K, Homma T. Morphologic evaluation and surgical simulation of ossification of the posterior longitudinal ligament using helical computed tomography with three-dimensional and multiplanar reconstruction. Spine (Phila Pa 1976). 1997;22:537-43 pubmed
    ..Preoperative simulation also was performed, and the availability of these methods was evaluated...
  58. Wang G, Kang Y, Chen F, Wang B. Cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament in an-11-year old girl: case report and review of literature. Childs Nerv Syst. 2016;32:381-6 pubmed publisher
    ..of an 11 years old girl with cervical intervertebral disc calcification combined with ossification of posterior longitudinal ligament(OPLL)...
  59. Katsumi K, Yamazaki A, Watanabe K, Hirano T, Ohashi M, Endo N. The characteristic clinical symptoms of C-4 radiculopathy caused by ossification of the posterior longitudinal ligament. J Neurosurg Spine. 2014;20:480-4 pubmed publisher
    ..Based on this case study, the authors conclude that the characteristic symptoms of C-4 radiculopathy are the presence of pain behind the ear and in the clavicular region in the absence of upper-limb involvement. ..
  60. Okawa A, Ikegawa S, Nakamura I, Goto S, Moriya H, Nakamura Y. Mapping of a gene responsible for twy (tip-toe walking Yoshimura), a mouse model of ossification of the posterior longitudinal ligament of the spine (OPLL). Mamm Genome. 1998;9:155-6 pubmed
  61. Taniguchi T, Maejima H, Watarai A, Aki R, Katsuoka K. A case of psoriasis vulgaris with diffuse idiopathic skeletal hyperostosis involved with ossifications of posterior and anterior longitudinal ligament. Rheumatol Int. 2012;32:1343-5 pubmed publisher
    ..DISH is one of the entheseal disorders, and 10% of Japanese middle-aged and elderly men have DISH. Therefore, the differentiation of DISH from PsA is necessary in psoriasis patients with spinal involvement...
  62. Yamamoto Y, Furukawa K, Ueyama K, Nakanishi T, Takigawa M, Harata S. Possible roles of CTGF/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2002;27:1852-7 pubmed
    ..A biochemical and histochemical study investigating the role of CTGF/Hcs24 in the ossification of the posterior longitudinal ligament (OPLL) was conducted...
  63. Sohn S, Chung C. Increased bone mineral density and decreased prevalence of osteoporosis in cervical ossification of the posterior longitudinal ligament: a case-control study. Calcif Tissue Int. 2013;92:28-34 pubmed publisher
    ..01, 0.03, respectively). A positive correlation was observed between lumbar spine BMD and the number of cervical spine levels involved with OPLL (p = 0.004)...
  64. Gokhale Y, Godkar D, Hedge U, Hase N. Quadriplegia complicating ossification of the posterior longitudinal ligament. J Assoc Physicians India. 2002;50:432-4 pubmed
    We report a case of quadriplegia complicating ossification of posterior longitudinal ligament (OPLL) in a patient who was also found to have diffuse idiopathic skeletal hyperostosis (DISH). She also had osteomalacia (Vit...
  65. Kato S, Murakami H, Demura S, Yoshioka K, Hayashi H, Tsuchiya H. Novel surgical technique for ossification of posterior longitudinal ligament in the thoracic spine. J Neurosurg Spine. 2012;17:525-9 pubmed publisher
    ..After removal of the ossified PLL, posterior instrumented fusion was performed. This surgical procedure allows the surgeon to perform, safely and effectively, anterior decompression via a posterior approach for thoracic OPLL...
  66. Kamizono J, Matsunaga S, Hayashi K, Shinkura R, Koriyama C, Sakou T, et al. Occupational recovery after open-door type laminoplasty for patients with ossification of the posterior longitudinal ligament. Spine (Phila Pa 1976). 2003;28:1889-92 pubmed
    ..A cross-sectional survey of occupational recovery after surgery with patients who had ossification of the posterior longitudinal ligament...
  67. Tani T, Ushida T, Ishida K, Iai H, Noguchi T, Yamamoto H. Relative safety of anterior microsurgical decompression versus laminoplasty for cervical myelopathy with a massive ossified posterior longitudinal ligament. Spine (Phila Pa 1976). 2002;27:2491-8 pubmed
    ..A retrospective clinical study was conducted...
  68. Nakae R, Onda H, Yokobori S, Araki T, Fuse A, Toda S, et al. Clinical analysis of spinal cord injury with or without cervical ossification of the posterior longitudinal ligament, spondylosis, and canal stenosis in elderly head injury patients. Neurol Med Chir (Tokyo). 2010;50:461-5 pubmed
    ..To decrease the occurrence of cervical myelopathy, prevention by increasing social awareness and avoiding traffic accidents and falls is important...
  69. Ito K, Matsuyama Y, Yukawa Y, Kato F, Ishiguro N. Analysis of interleukin-8, interleukin-10, and tumor necrosis factor-alpha in the cerebrospinal fluid of patients with cervical spondylotic myelopathy. J Spinal Disord Tech. 2008;21:145-7 pubmed publisher
    ..Retrospective cohort study...
  70. Chitoku S, Nishiura I, Fukuda M, Amano S. Ossification of the Yellow Ligament Combined with Ossification of the Posterior Longitudinal Ligament at the Cervicothoracic Junction. World Neurosurg. 2017;103:952.e19-952.e22 pubmed publisher
    ..Early diagnosis and surgical therapy is recommended for the good prognosis of this pathologic condition, as well as careful long-term follow-up for the early detection of its recurrence. ..
  71. Karasugi T, Nakajima M, Ikari K, Tsuji T, Matsumoto M, Chiba K, et al. A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine. J Bone Miner Metab. 2013;31:136-43 pubmed publisher
    ..43, P = 0.00027) at D20S894 on chromosome 20p12 in a subgroup that had no complication of diabetes mellitus. Our result would shed a new light on genetic aspects of OPLL...
  72. Murakami M, Seichi A, Chikuda H, Takeshita K, Nakamura K, Kimura A. Long-term follow-up of the progression of ossification of the posterior longitudinal ligament. J Neurosurg Spine. 2010;12:577-9 pubmed publisher
    ..Segmental-type OPLL developed into mixed-type extensive OPLL. This case shows an accelerating maturation process of OPLL over the course of a few years. Segmental-type OPLL appears to represent an initial stage of extensive OPLL...