osteomalacia

Summary

Summary: Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.

Top Publications

  1. Dunnigan M, Henderson J, Hole D, Barbara Mawer E, Berry J. Meat consumption reduces the risk of nutritional rickets and osteomalacia. Br J Nutr. 2005;94:983-91 pubmed
    ..serum 25(OH)D3) is a necessary but insufficient requirement for the genesis of vitamin D-deficiency rickets and osteomalacia. The magnitude of the independent contributions of dietary factors to rachitic and osteomalacic risk remains ..
  2. Terrier B, Fakhouri F, Berezne A, Bouldouyre M, Guilpain P, Sogni P, et al. Osteomalacia revealing celiac disease and primary biliary cirrhosis-related Fanconi syndrome in a patient with systemic sclerosis. Clin Exp Rheumatol. 2008;26:467-70 pubmed
    ..Malabsorption syndrome may be responsible for weight loss, diarrhea, osteomalacia, and iron and vitamins deficiency...
  3. Pirola E, Vergani F, Casiraghi P, Leone E, Guerra P, Sganzerla E. Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. J Neurosurg Spine. 2009;10:329-33 pubmed publisher
    Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare...
  4. Sitara D, Razzaque M, Hesse M, Yoganathan S, Taguchi T, Erben R, et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004;23:421-32 pubmed
    ..of circulating FGF-23 were detected in patients with different phosphate-wasting disorders such as oncogenic osteomalacia (OOM) and X-linked hypophosphatemia (XLH), it is not yet clear whether FGF-23 is directly responsible for the ..
  5. Xu Y, Hashizume T, Shuhart M, Davis C, Nelson W, Sakaki T, et al. Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006;69:56-65 pubmed
    ..These and other data suggest that induction of CYP3A4-dependent 1,25(OH)(2)D(3) metabolism by antiepileptic drugs and other PXR ligands may diminish intestinal effects of the hormone and contribute to osteomalacia.
  6. Jan De Beur S. Tumor-induced osteomalacia. JAMA. 2005;294:1260-7 pubmed
    Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia...
  7. Zongping L. Studies on rickets and osteomalacia in Bactrian camels (Camelus bactrianus). Vet J. 2005;169:444-53 pubmed
    Epidemiological studies have indicated incidences of 32.9% and 27.8% for rickets and osteomalacia, respectively, in Bactrian camels (Camelus bactrianus), but there is an increased incidence under drought conditions, sometimes reaching 75%...
  8. Feng J, Clinkenbeard E, Yuan B, White K, Drezner M. Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia. Bone. 2013;54:213-21 pubmed publisher
  9. Zhou C, Assem M, Tay J, Watkins P, Blumberg B, Schuetz E, et al. Steroid and xenobiotic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest. 2006;116:1703-12 pubmed
    ..receptor (SXR) also enhances the expression of CYP24, providing a new molecular mechanism of drug-induced osteomalacia. However, here we showed that activation of SXR did not induce CYP24 expression in vitro and in vivo, nor did ..

More Information

Publications72

  1. Duck L, Devogelaer J, Persu A, Berliere M, Caussin E, Baurain J, et al. Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient. Gynecol Oncol. 2005;98:329-31 pubmed
    Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia.
  2. Yang Y, Peng C, Sia S, Huang C. Acquired hypophosphatemia osteomalacia associated with Fanconi's syndrome in Sjögren's syndrome. Rheumatol Int. 2007;27:593-7 pubmed
    ..b>Osteomalacia is a rare complication of renal tubular acidosis, and it was reported to be associated with distal renal ..
  3. de Menezes Filho H, de Castro L, Damiani D. Hypophosphatemic rickets and osteomalacia. Arq Bras Endocrinol Metabol. 2006;50:802-13 pubmed
    ..and hypophosphatemia, associated with inappropriately normal or low levels of calcitriol, causing osteomalacia or rickets in children and osteomalacia in adults...
  4. Inokuchi G, Tanimoto H, Ishida H, Sugimoto T, Yamauchi M, Miyauchi A, et al. A paranasal tumor associated with tumor-induced osteomalacia. Laryngoscope. 2006;116:1930-3 pubmed
    Tumor-induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region.
  5. Wanner D, Tyndall A, Walker U. Tenofovir-induced osteomalacia. Clin Exp Rheumatol. 2009;27:1001-3 pubmed
    ..pain, synovial effusions and multiple fractures secondary to a Fanconi syndrome with hypophosphatemia and osteomalacia. TDF interferes with the replication of mitochondrial DNA in the proximal tubules of the kidney, which can ..
  6. Beech T, Rokade A, Gittoes N, Johnson A. A haemangiopericytoma of the ethmoid sinus causing oncogenic osteomalacia: a case report and review of the literature. Int J Oral Maxillofac Surg. 2007;36:956-8 pubmed
    Oncogenic osteomalacia is a rare cause of osteomalacia. It is caused by a tumour which is generally benign. These tumours, when identified, are often found in the head and neck region...
  7. Thieler S, Scholmerich J. [Gastrointestinal diseases and osteomalacia]. Internist (Berl). 2008;49:1197-8, 1200, 1202-5 pubmed publisher
    b>Osteomalacia is a metabolic bone disease associated with impaired mineralization of the bone due to Vitamin D and Calcium deficiency that can develop in gastrointestinal disorders...
  8. Liu S, Tang W, Zhou J, Vierthaler L, Quarles L. Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab. 2007;293:E1636-44 pubmed
    ..WT bone explanted into Hyp mice developed rickets and osteomalacia, but Hyp bone explanted into WT mice displayed persistent osteomalacia and abnormalities in the primary ..
  9. Cheung F, Ma L, Wu W, Siu T, Choi P, Tai Y. Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies. Hong Kong Med J. 2006;12:319-21 pubmed
    A middle-aged man presented with bone pain at multiple sites due to tumour-induced osteomalacia. The underlying occult phosphaturic mesenchymal tumour was identified by octreotide scan 5 years after presentation and confirmed by computed ..
  10. Rowling M, Gliniak C, Welsh J, Fleet J. High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice. J Nutr. 2007;137:2608-15 pubmed
    ..However, neither high dietary Ca nor high dietary VD3 is sufficient to fully recover the phenotype of CYP27B1 KO mice...
  11. Lu Y, Liu S, Xie Y, Yu S, Quarles L, Bonewald L, et al. Use of the transgenic approach to determine the role of DMP1 in phosphate regulation. J Musculoskelet Neuronal Interact. 2007;7:309 pubmed
  12. Sahli H, Ben Mbarek R, Elleuch M, Azzouz D, Meddeb N, Cheour E, et al. Osteomalacia in a patient with primary intestinal lymphangiectasis (Waldmann's disease). Joint Bone Spine. 2008;75:73-5 pubmed
    ..The symptoms usually start in early infancy. We report a case of osteomalacia in a 63-year-old patient with delayed-onset of PIL, for which she was on dietary treatment...
  13. Harzy T, Benbouazza K, Amine B, Rahmouni R, Hajjaj Hassouni N. An unusual case of osteomalacia as the presenting feature of coeliac disease. Rheumatol Int. 2005;26:90-1 pubmed
  14. Hannan F, Athanasou N, Teh J, Gibbons C, Shine B, Thakker R. Oncogenic hypophosphataemic osteomalacia: biomarker roles of fibroblast growth factor 23, 1,25-dihydroxyvitamin D3 and lymphatic vessel endothelial hyaluronan receptor 1. Eur J Endocrinol. 2008;158:265-71 pubmed publisher
    Oncogenic osteomalacia (OOM) is characterised by tumour production of fibroblast growth factor 23 (FGF23) that results in hypophosphataemia and renal phosphate wasting, reduced 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) synthesis and ..
  15. Ogura E, Kageyama K, Fukumoto S, Yagihashi N, Fukuda Y, Kikuchi T, et al. Development of tumor-induced osteomalacia in a subcutaneous tumor, defined by venous blood sampling of fibroblast growth factor-23. Intern Med. 2008;47:637-41 pubmed
    ..He had no symptoms of osteomalacia at that time. Within the recent years, the tumor had grown in size and the patient developed lumbago...
  16. Ukinc K. Severe osteomalacia presenting with multiple vertebral fractures: a case report and review of the literature. Endocrine. 2009;36:30-6 pubmed publisher
    ..Here, we present a case of severe osteomalacia presenting with multiple vertebral fractures due to poor diet and a lack of exposure to sunlight.
  17. Bhadada S, Bhansali A, Upreti V, Dutta P, Santosh R, Das S, et al. Hypophosphataemic rickets/osteomalacia: a descriptive analysis. Indian J Med Res. 2010;131:399-404 pubmed
    Hypophosphataemic rickets/osteomalacia (HRO) is an uncommon metabolic bone disorder which affects all ages and either sex...
  18. Bhan A, Rao A, Rao D. Osteomalacia as a result of vitamin D deficiency. Endocrinol Metab Clin North Am. 2010;39:321-31, table of contents pubmed publisher
    b>Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency...
  19. Carpenter T, Ellis B, Insogna K, Philbrick W, Sterpka J, Shimkets R. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J Clin Endocrinol Metab. 2005;90:1012-20 pubmed
    Oncogenic osteomalacia (OO), a tumor-associated phosphate-wasting syndrome, provides an opportunity to identify regulators of renal phosphate homeostasis. We established cultures from OO-associated tumors...
  20. Taylor H, Elbadawy E. Renal tubular acidosis type 2 with Fanconi's syndrome, osteomalacia, osteoporosis, and secondary hyperaldosteronism in an adult consequent to vitamin D and calcium deficiency: effect of vitamin D and calcium citrate therapy. Endocr Pract. 2006;12:559-67 pubmed
    To describe a unique example of renal tubular acidosis type 2 (RTA 2) in conjunction with Fanconi's syndrome and osteomalacia consequent to vitamin D and calcium deficiency in an adult without underlying gastrointestinal disease.
  21. Bhambri R, Naik V, Malhotra N, Taneja S, Rastogi S, Ravishanker U, et al. Changes in bone mineral density following treatment of osteomalacia. J Clin Densitom. 2006;9:120-7 pubmed
    b>Osteomalacia is characterized by defective mineralization and low bone mineral density (BMD)...
  22. Feng J, Ward L, Liu S, Lu Y, Xie Y, Yuan B, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006;38:1310-5 pubmed
    ..with a newly identified disorder, autosomal recessive hypophosphatemic rickets, manifest rickets and osteomalacia with isolated renal phosphate-wasting associated with elevated fibroblast growth factor 23 (FGF23) levels and ..
  23. Zimering M, Caldarella F, White K, Econs M. Persistent tumor-induced osteomalacia confirmed by elevated postoperative levels of serum fibroblast growth factor-23 and 5-year follow-up of bone density changes. Endocr Pract. 2005;11:108-14 pubmed
    To describe a case of persistent tumor-induced osteomalacia, determine whether serum fibroblast growth factor-23 (FGF-23) levels postoperatively indicate incomplete tumor resection, and report lumbar spine and forearm bone mineral density ..
  24. Leaf D, Pereira R, Bazari H, Juppner H. Oncogenic osteomalacia due to FGF23-expressing colon adenocarcinoma. J Clin Endocrinol Metab. 2013;98:887-91 pubmed publisher
    Oncogenic osteomalacia, a paraneoplastic syndrome associated with hypophosphatemia due to increased urinary phosphate excretion, is caused by excessive synthesis and secretion of fibroblast growth factor 23 (FGF23), a phosphaturic hormone ..
  25. Torres Isidro M, García Benayas T, del Val Gómez Martínez M, González Gallardo F, Gambí Pisonero N, Castilla Miguel S, et al. [Role of bone gammagraphy in the diagnosis of secondary osteomalacia in a patient treated with tenofovir]. Rev Esp Med Nucl. 2006;25:103-6 pubmed
    ..of 740 MBq of 99mTc-MDP, revealing an abnormal distribution with characteristic changes compatible with osteomalacia. In further analysis, a secondary hyperparathyroidism and osteomalacia were diagnosed in the context of Fanconi ..
  26. Kawashima M, Amano T, Morita Y, Yamamura M, Makino H. Hypokalemic paralysis and osteomalacia secondary to renal tubular acidosis in a case with primary Sjögren's syndrome. Mod Rheumatol. 2006;16:48-51 pubmed
    ..some local tender points over the costae of both sides, which was presumed to be due to pseudo-fractures based on osteomalacia. Hypokalemic paralysis and osteomalacia should be taken into consideration in the diagnosis of SS with RTA1.
  27. Bai X, Dinghong Q, Miao D, Goltzman D, Karaplis A. Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype. Am J Physiol Endocrinol Metab. 2009;296:E79-88 pubmed publisher
    ..phosphaturia, abnormal 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] metabolism} and skeletal (rickets and osteomalacia) abnormalities attributable to FGF23 action...
  28. Anderson P, Sawyer R, Moore A, May B, O Loughlin P, Morris H. Vitamin D depletion induces RANKL-mediated osteoclastogenesis and bone loss in a rodent model. J Bone Miner Res. 2008;23:1789-97 pubmed publisher
    ..These data indicate that serum 25D levels are a major determinant of osteoclastogenesis and bone mineral volume and are consistent with the levels of 25D recommended to reduce the risk of fracture in humans...
  29. Liu S, Zhou J, Tang W, Menard R, Feng J, Quarles L. Pathogenic role of Fgf23 in Dmp1-null mice. Am J Physiol Endocrinol Metab. 2008;295:E254-61 pubmed publisher
    ..is characterized by renal phosphate wasting, aberrant regulation of 1alpha-hydroxylase activity, and rickets/osteomalacia, is caused by inactivating mutations of dentin matrix protein 1 (DMP1)...
  30. Nasu T, Kurisu S, Matsuno S, Tatsumi K, Kakimoto T, Kobayashi M, et al. Tumor-induced hypophosphatemic osteomalacia diagnosed by the combinatory procedures of magnetic resonance imaging and venous sampling for FGF23. Intern Med. 2008;47:957-61 pubmed
    This report describes a 37-year-old man with tumor-induced osteomalacia (TIO). The patient had hypophosphatemia and elevated fibroblast growth factor 23 (FGF23) in the peripheral blood...
  31. Frikha F, Snoussi M, Bahloul Z. Osteomalacia associated with cutaneous psoriasis as the presenting feature of coeliac disease: a case report. Pan Afr Med J. 2012;11:58 pubmed
    ..Malabsorption syndrome may be responsible for weight loss, diarrhea, osteomalacia, and vitamins deficiency...
  32. Pascussi J, Robert A, Nguyen M, Walrant Debray O, Garabedian M, Martin P, et al. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005;115:177-86 pubmed
    ..Prolonged therapy with rifampicin or phenobarbital has been shown to cause vitamin D deficiency or osteomalacia, particularly in patients with marginal vitamin D stores...
  33. Bahrami A, Weiss S, Montgomery E, Horvai A, Jin L, Inwards C, et al. RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia. Am J Surg Pathol. 2009;33:1348-54 pubmed publisher
    ..tissue type (PMTMCT) are extremely rare, histologically distinctive neoplasms, which cause tumor-induced osteomalacia (TIO) in most cases through the elaboration of a phosphaturic hormone, fibroblast growth factor-23 (FGF23)...
  34. Heaney R. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr. 2004;80:1706S-9S pubmed publisher
    ..There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D3 concentrations...
  35. Kenealy H, Holdaway I, Grey A. Occult nasal sinus tumours causing oncogenic osteomalacia. Eur J Intern Med. 2008;19:516-9 pubmed publisher
    Oncogenic osteomalacia (OOM) is a rare but curable cause of metabolic bone disease...
  36. Uramoto N, Furukawa M, Yoshizaki T. Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongue. Auris Nasus Larynx. 2009;36:104-5 pubmed publisher
    The majority of the oncogenic osteomalacia-associated mesenchymal tumors are considered to belong to the category of phosphaturic mesenchymal tumors, mixed connective tissue (PMTMCT) variant, of which malignant cases are very rare...
  37. Imel E, Peacock M, Pitukcheewanont P, Heller H, Ward L, Shulman D, et al. Sensitivity of fibroblast growth factor 23 measurements in tumor-induced osteomalacia. J Clin Endocrinol Metab. 2006;91:2055-61 pubmed
    Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of hypophosphatemia, decreased renal phosphate reabsorption, normal or low serum 1,25-dihydryxyvitamin-D concentration, myopathy, and osteomalacia...
  38. Chadha M, Singh A, Singh A. Hypophosphataemic osteomalacia in neurofibromatosis. Acta Orthop Belg. 2009;75:847-50 pubmed
    Oncogenic Osteomalacia syndrome is associated with mesenchymal tumours, caused by a protein secreted from tumours which inhibits tubular renal phosphate absorption and reduces 1,25 dihydroxy vitamin-D renal conversion...
  39. Sahnoune I, Tazi Mezalek Z, Essaadouni L, Harmouche H, Ismael F, Adnaoui M, et al. Oncogenic osteomalacia in a patient with hemangioma: a clinical diagnosis. Joint Bone Spine. 2006;73:115-8 pubmed
  40. McCance R. Osteomalacia with Looser's nodes (Milkman's syndrome) due to a raised resistance to vitamin D acquired about the age of 15 years. Q J Med. 1947;16:33-46 pubmed
  41. Parsonage M, Wilkins E, Snowden N, Issa B, Savage M. The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy. HIV Med. 2005;6:341-6 pubmed
    We report two cases in which osteomalacia developed in patients on tenofovir-containing highly active antiretroviral therapy (HAART) in the context of Fanconi syndrome with hypophosphataemia...
  42. Oste L, Bervoets A, Behets G, Dams G, Marijnissen R, Geryl H, et al. Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats. Kidney Int. 2005;67:920-30 pubmed
    ..impaired renal function can accumulate strontium in the bone, which has been associated with the development of osteomalacia. A causal role for strontium in the development of the disease was presented in chronic renal failure (CRF) ..
  43. Harish S, Jurriaans E, Jan E, Sur M, Colterjohn N. Giant cell tumour of soft tissue causing oncogenic osteomalacia: report demonstrating the use of octreotide scintigraphy in tumour localization. Clin Radiol. 2008;63:101-7 pubmed
  44. Chong W, Molinolo A, Chen C, Collins M. Tumor-induced osteomalacia. Endocr Relat Cancer. 2011;18:R53-77 pubmed publisher
    Tumor-induced osteomalacia (TIO) is a rare and fascinating paraneoplastic syndrome in which patients present with bone pain, fractures, and muscle weakness...
  45. Xiao L, Naganawa T, Lorenzo J, Carpenter T, Coffin J, Hurley M. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. J Biol Chem. 2010;285:2834-46 pubmed publisher
    ..The phenotype of TgHMW mice included dwarfism, decreased bone mineral density (BMD), osteomalacia, and decreased serum phosphate (P(i))...
  46. Sciubba D, Petteys R, Shakur S, Gokaslan Z, McCarthy E, Collins M, et al. En bloc spondylectomy for treatment of tumor-induced osteomalacia. J Neurosurg Spine. 2009;11:600-4 pubmed publisher
    ..A 56-year-old woman, who suffered from severe tumor-induced osteomalacia, was found to have a fibroblast growth factor-23-secreting phosphaturic mesenchymal tumor in the T-8 vertebral ..
  47. Jacob J, Finny P, Thomas M, Thomas N, John M. Oncogenic osteomalacia. J Assoc Physicians India. 2007;55:231-3 pubmed
    ..Biochemical tests confirmed the initial clinical diagnosis of osteomalacia. Blood pool scanning revealed a focal hot spot on the site of the clinically visible swelling close to the ..
  48. Clifton Bligh R, Hofman M, Duncan E, Sim I, Darnell D, Clarkson A, et al. Improving diagnosis of tumor-induced osteomalacia with Gallium-68 DOTATATE PET/CT. J Clin Endocrinol Metab. 2013;98:687-94 pubmed publisher
    Tumor-induced osteomalacia (TIO) is a rarely diagnosed disorder presenting with bone pain, fractures, muscle weakness, and moderate-to-severe hypophosphatemia resulting from fibroblast growth factor 23-mediated renal phosphate wasting...
  49. Hesse E, Moessinger E, Rosenthal H, Laenger F, Brabant G, Petrich T, et al. Oncogenic osteomalacia: exact tumor localization by co-registration of positron emission and computed tomography. J Bone Miner Res. 2007;22:158-62 pubmed
    In oncogenic osteomalacia, the causative tumor is almost always difficult to find...
  50. Togawa D, Lieberman I, Bauer T, Reinhardt M, Kayanja M. Histological evaluation of biopsies obtained from vertebral compression fractures: unsuspected myeloma and osteomalacia. Spine (Phila Pa 1976). 2005;30:781-6 pubmed
    A histological evaluation of biopsies obtained from presumed osteoporotic vertebral compression fractures (VCF) to confirm possible osteomalacia after tetracycline labeling.
  51. Koriyama N, Nishimoto K, Kodama T, Nakazaki M, Kurono Y, Yoshida H, et al. Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. Am J Med Sci. 2006;332:142-7 pubmed
    We herein describe the rare case of a 41-year-old woman with oncogenic osteomalacia due to a tumor in the maxillary sinus who presented with chronic general pain that had been gradually deteriorating...
  52. Khadgawat R, Singh Y, Kansara S, Tandon N, Bal C, Seith A, et al. PET/CT localisation of a scapular haemangiopericytoma with tumour-induced osteomalacia. Singapore Med J. 2009;50:e55-7 pubmed
    Oncogenic osteomalacia, or tumour-induced osteomalacia (TIO), is a rare paraneoplastic syndrome characterised by hypophosphataemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphataemia...
  53. Seijas R, Ares O, Sierra J, Perez Dominguez M. Oncogenic osteomalacia: two case reports with surprisingly different outcomes. Arch Orthop Trauma Surg. 2009;129:533-9 pubmed publisher
    Oncogenic osteomalacia is a rare paraneoplastic syndrome of acquired hypophosphatemic osteomalacia, resulting from a deficit in renal tubular phosphate reabsorption, in which fibroblast growth factor 23 (FGF23) seems to be implicated...
  54. Landolsi H, Bouajina E, Mankai A, Zeglaoui H, Skandrani K, Ghedira I. Severe osteomalacia due to undiagnosed coeliac disease: three case reports of Tunisian women. Rheumatol Int. 2006;26:261-3 pubmed
    We describe three cases of osteomalacia presenting in Tunisian women, all of whom had previously-undiagnosed coeliac disease (CD)...
  55. Anderson H, Harmey D, Camacho N, Garimella R, Sipe J, Tague S, et al. Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. Am J Pathol. 2005;166:1711-20 pubmed
    ..Thus, the osteomalacia of Akp2-/- mice and the hypomineralized phenotype of the long bones of Enpp1-/- mice are not rescued by ..
  56. Winters R, Bihlmeyer S, McCahill L, Cooper K. Phosphaturic mesenchymal tumour-mixed connective tissue variant without oncogenic osteomalacia. J Clin Pathol. 2009;62:760-1 pubmed publisher
    ..mesenchymal tumour-mixed connective tissue variant is a rare tumour classically associated with oncogenic osteomalacia. This report describes two patients with this distinct tumour type but with no evidence of the paraneoplastic ..
  57. Woodward C, Hall A, Williams I, Madge S, Copas A, Nair D, et al. Tenofovir-associated renal and bone toxicity. HIV Med. 2009;10:482-7 pubmed publisher
  58. DiPaola C, Bible J, Biswas D, DiPaola M, Grauer J, Rechtine G. Survey of spine surgeons on attitudes regarding osteoporosis and osteomalacia screening and treatment for fractures, fusion surgery, and pseudoarthrosis. Spine J. 2009;9:537-44 pubmed publisher
    Osteoporosis and osteomalacia are significant risk factors for fracture and spine instrumentation failure. Low-energy fractures are becoming increasingly more common because of an increase in life expectancy and age of the population...
  59. Schouten B, Doogue M, Soule S, Hunt P. Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Ann Clin Biochem. 2009;46:167-9 pubmed publisher
    Iron-induced renal phosphate wasting, hypophosphataemia and osteomalacia have previously been reported in a small number of Japanese patients receiving parenteral iron sucrose...
  60. Westerberg P, Olauson H, Toss G, Wikstrom B, Morales O, Linde T, et al. Preoperative tumor localization by means of venous sampling for fibroblast growth factor-23 in a patient with tumor-induced osteomalacia. Endocr Pract. 2008;14:362-7 pubmed
    To report on a novel strategy for tumor localization in a 62-year-old man with hypophosphatemic tumor-induced osteomalacia (TIO).
  61. Chua S, O Connor S, Wong W, Ganatra R. Case report: Solitary plasmacytoma of bone with oncogenic osteomalacia: recurrence of tumour confirmed by PET/CT. A case report with a review of the radiological literature. Br J Radiol. 2008;81:e110-4 pubmed publisher
    We describe a case of oncogenic osteomalacia secondary to solitary plasmacytoma of the vertebral body of T3. The patient presented with symptoms of hypophosphataemia...
  62. Hosseinpour F, Ellfolk M, Norlin M, Wikvall K. Phenobarbital suppresses vitamin D3 25-hydroxylase expression: a potential new mechanism for drug-induced osteomalacia. Biochem Biophys Res Commun. 2007;357:603-7 pubmed
    Prolonged therapy with phenobarbital may cause vitamin D deficiency or osteomalacia. In the current study, we propose a novel mechanism for drug-induced osteomalacia involving impaired bioactivation of vitamin D(3) due to decreased 25-..
  63. Yoshioka K, Nagata R, Ueda M, Yamaguchi T, Konishi Y, Hosoi M, et al. Phosphaturic mesenchymal tumor with symptoms related to osteomalacia that appeared one year after tumorectomy. Intern Med. 2006;45:1157-60 pubmed
    ..quot;benign unclassified mesenchymal tumor" in the skull, but there were no clinical symptoms related to osteomalacia. His laboratory examination revealed low serum phosphate, high alkaline phosphatase, and normal calcium levels...