metabolic bone diseases


Summary: Diseases that affect the METABOLIC PROCESSES of BONE TISSUE.

Top Publications

  1. Gnant M, Mlineritsch B, Luschin Ebengreuth G, Kainberger F, Kässmann H, Piswanger Sölkner J, et al. Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 5-year follow-up of the ABCSG-12 bone-mineral density substudy. Lancet Oncol. 2008;9:840-9 pubmed publisher
    ..The aim of this substudy is to gain insight into bone health in this setting...
  2. Huang J, Meixner L, Fernandez S, McCutchan J. A double-blinded, randomized controlled trial of zoledronate therapy for HIV-associated osteopenia and osteoporosis. AIDS. 2009;23:51-7 pubmed publisher
    ..To evaluate the efficacy of a single dose of intravenous zoledronate for the treatment of HIV-associated osteopenia and osteoporosis...
  3. Cook G, Gnanasegaran G, Chua S. Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 2010;40:52-61 pubmed publisher
  4. Cao H, Nazarian A, Ackerman J, Snyder B, Rosenberg A, Nazarian R, et al. Quantitative (31)P NMR spectroscopy and (1)H MRI measurements of bone mineral and matrix density differentiate metabolic bone diseases in rat models. Bone. 2010;46:1582-90 pubmed publisher
    ..These results demonstrate that the combined (31)P NMR/WASPI method is capable of discerning the difference in EBM between animals with osteoporosis and those with impaired bone mineralization...
  5. Klaphake E. A fresh look at metabolic bone diseases in reptiles and amphibians. Vet Clin North Am Exot Anim Pract. 2010;13:375-92 pubmed publisher
    b>Metabolic bone diseases (MBDs) are a common presenting complaint in reptiles and amphibians to veterinarians; however, understanding of the causes and diagnostic and treatment options is often extrapolated from human or other mammalian ..
  6. Marini H, Minutoli L, Polito F, Bitto A, Altavilla D, Atteritano M, et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med. 2007;146:839-47 pubmed
    ..Observational studies and small trials of short duration suggest that the isoflavone phytoestrogen genistein reduces bone loss, but the evidence is not definitive...
  7. Gibellini D, Borderi M, De Crignis E, Cicola R, Vescini F, Caudarella R, et al. RANKL/OPG/TRAIL plasma levels and bone mass loss evaluation in antiretroviral naive HIV-1-positive men. J Med Virol. 2007;79:1446-54 pubmed
  8. Hawse J, Iwaniec U, Bensamoun S, Monroe D, Peters K, Ilharreborde B, et al. TIEG-null mice display an osteopenic gender-specific phenotype. Bone. 2008;42:1025-31 pubmed publisher
    ..Taken together, these findings suggest that female TIEG(-/-) mice are osteopenic mainly due to a decrease in the total number of functional/mature OBs...
  9. Nazarian A, Cory E, Muller R, Snyder B. Shortcomings of DXA to assess changes in bone tissue density and microstructure induced by metabolic bone diseases in rat models. Osteoporos Int. 2009;20:123-32 pubmed publisher

More Information

Publications106 found, 100 shown here

  1. Kraenzlin M, Kraenzlin C, Meier C, Giunta C, Steinmann B. Automated HPLC assay for urinary collagen cross-links: effect of age, menopause, and metabolic bone diseases. Clin Chem. 2008;54:1546-53 pubmed publisher
    ..We evaluated the analytical and clinical performance of a commercially available PYD HPLC assay and established reference intervals in children and adults...
  2. Cabral W, Chang W, Barnes A, Weis M, Scott M, Leikin S, et al. Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta. Nat Genet. 2007;39:359-65 pubmed
    ..Proband collagen secretion was moderately delayed, but total collagen secretion was increased. Prolyl 3-hydroxylase 1 is therefore crucial for bone development and collagen helix formation...
  3. Harrison C, Johnson K, McKechnie E. Osteopenia of prematurity: a national survey and review of practice. Acta Paediatr. 2008;97:407-13 pubmed publisher
    ..The findings showed widely disparate practice regarding screening, prevention and treatment. We summarize the tests currently available for osteopenia and suggest guidelines for management of the at risk group...
  4. Delmas P. Clinical potential of RANKL inhibition for the management of postmenopausal osteoporosis and other metabolic bone diseases. J Clin Densitom. 2008;11:325-38 pubmed publisher
    ..The results of these human trials will also be discussed...
  5. Clay P, Voss L, Williams C, Daume E. Valid treatment options for osteoporosis and osteopenia in HIV-infected persons. Ann Pharmacother. 2008;42:670-9 pubmed publisher
    ..To review clinical data on bone ossification agents that may be considered for use in the treatment of osteoporosis and osteopenia in HIV-infected patients...
  6. Camacho P, Dayal A, Diaz J, Nabhan F, Agarwal M, Norton J, et al. Prevalence of secondary causes of bone loss among breast cancer patients with osteopenia and osteoporosis. J Clin Oncol. 2008;26:5380-5 pubmed publisher
    ..A high prevalence of secondary causes of bone loss among patients with breast cancer supports a comprehensive evaluation in these patients, particularly those considering therapy with an aromatase inhibitor. ..
  7. Nakai K, Komaba H, Fukagawa M. Management of mineral and bone disorder in chronic kidney disease: quo vadis?. Ther Apher Dial. 2009;13 Suppl 1:S2-6 pubmed publisher
    ..With a view to improving patient-level outcomes, further work should establish more precisely the role of calcimimetics and vitamin D analogs in combination with other therapeutic approaches for CKD-MBD management. ..
  8. Saito M, Marumo K. [CKD-MBD (Chronic Kidney Disease-Mineral and Bone Disorder). Bone quality in chronic kidney disease : enzymatic and non-enzymatic glycation or oxidation induced cross-links in bone]. Clin Calcium. 2010;20:1068-76 pubmed publisher
    ..Additionally, hyperhomocysteinemia induced animal model also showed the same collagen cross-links abnormalities as patients with hyperhomocysteinemia (Saito M, Osteoporos Int, 2010). In this review, we summarized the recent literature. ..
  9. Lopes F, Loureiro F, Alves C, Pereira A, Oliveira A. [Systemic bone mineral density versus clinical periodontal condition: cross-sectional study in postmenopausal women]. Rev Assoc Med Bras (1992). 2008;54:411-4 pubmed
    ..However, further longitudinal surveys are required to understand osteoporosis as a risk factor of periodontal disease. ..
  10. Salopek D, Grcevic D, Katavic V, Kovacic N, Lukic I, Marusic A. Increased bone resorption and osteopenia are a part of the lymphoproliferative phenotype of mice with systemic over-expression of interleukin-7 gene driven by MHC class II promoter. Immunol Lett. 2008;121:134-9 pubmed publisher
  11. Scholtissen S, Guillemin F, Bruyere O, Collette J, Dousset B, Kemmer C, et al. Assessment of determinants for osteoporosis in elderly men. Osteoporos Int. 2009;20:1157-66 pubmed publisher
    ..73 in the development and validation cohorts. Ageing, a lower BMI, higher CTX-1, family history, and prior fracture were associated with T-score. Our algorithm is a simple approach to identify men at risk for osteoporosis. ..
  12. Tural A, Yoldemir T, Erenus M. Assessment of bone mineral density should be considered earlier in perimenopausal women with vasomotor symptoms. Int J Gynaecol Obstet. 2009;107:114-6 pubmed publisher
    ..007). In the former, 6.1% of the women and in the latter, 32.6% of the women had a BMD value less than a 1.5 standard deviation from the mean (P=0.005). Women with vasomotor symptoms are more prone to have osteopenia or osteoporosis. ..
  13. Cubuk R, Tasali N, Kozakcioglu M, Guney S. Is bone mineral density measurements correlated with facet joint orientation? A dual energy X-ray absorptiometry study. Prague Med Rep. 2009;110:343-9 pubmed
    ..Since spondylolisthesis has been demonstrated to alter BMD measurements, we suggest that spinal degenerative disease secondary to spondylolisthesis is the main entity leading to measurement errors. ..
  14. Taguchi A. Triage screening for osteoporosis in dental clinics using panoramic radiographs. Oral Dis. 2010;16:316-27 pubmed publisher
    ..These findings support the possibility that dental clinics may offer a new triage platform to identify individuals with otherwise undetected osteoporosis. ..
  15. Kumamoto K, Nakamura T, Suzuki T, Gorai I, Fujinawa O, Ohta H, et al. Validation of the Japanese Osteoporosis Quality of Life Questionnaire. J Bone Miner Metab. 2010;28:1-7 pubmed publisher
    ..350-0.839). These results were consistent with that of the preceding study. It is concluded that the reliability and the validity of JOQOL were demonstrated in this study. ..
  16. Orlic L, Crncevic Z, Pavlovic D, Zaputovic L. Bone mineral densitometry in patients on hemodialysis: difference between genders and what to measure. Ren Fail. 2010;32:300-8 pubmed publisher
    ..The best correlation of BMD in different sites was between forearm and neck. BMD data in CKD patients should be interpreted with caution and appendicular skeletal sites should be included in the evaluation. ..
  17. Trebacz H, Wójtowicz K. Thermostability of bone tissue after immobilization induced osteopenia in a rat model. Folia Histochem Cytobiol. 2008;46:379-82 pubmed publisher
    ..Immobilization of load-bearing bones influences stability of collagen in bone tissue. Free remobilization was not sufficient for recovery of thermal parameters of bone. ..
  18. Choi J, Sutor S, Lindquist L, Evans G, Madden B, Bergen H, et al. Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009;5:e1000750 pubmed publisher
    ..These data provide significant new mechanistic insight into the pathophysiology of OI and reveal how the members of the P3H1/CRTAP/CypB complex interact to direct proper formation of collagen and bone. ..
  19. Kido T, Tabara Y, Igase M, Uetani E, Ochi N, Miki T, et al. Associations between short one-leg standing time and speed of sound of calcaneal bone in a general population: the Shimanami Health Promoting Program (J-SHIPP) study. Geriatr Gerontol Int. 2010;10:138-44 pubmed publisher
    ..1). OLS time less than 60 s was significantly associated with reduced SOS independent of age, sex and muscle mass in the lower extremity. ..
  20. Stubbs B, Zapata Bravo E, Haw C. Screening for osteoporosis: a survey of older psychiatric inpatients at a tertiary referral centre. Int Psychogeriatr. 2009;21:180-6 pubmed publisher
    ..Peripheral DEXA scanning is acceptable to these patients and identifies those at high risk of fractures. Some behaviorally disturbed patients are not suitable for central scans or for some osteoporosis drug treatments. ..
  21. Roca B. Adverse drug reactions to antiretroviral medication. Front Biosci (Landmark Ed). 2009;14:1785-92 pubmed
    ..Adverse reactions are common with antiretrovirals, and they are an important cause of medication non-adherence and suboptimal control of HIV infection. In this article we review the most relevant of those toxicities. ..
  22. Shen C, Chyu M, Yeh J, Felton C, Xu K, Pence B, et al. Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial. BMC Musculoskelet Disord. 2009;10:110 pubmed publisher
  23. Naylor K, Clowes J, Finigan J, Paggiosi M, Peel N, Eastell R. The effect of cessation of raloxifene treatment on bone turnover in postmenopausal women. Bone. 2010;46:592-7 pubmed publisher
    ..The beneficial effect on bone turnover of 96 weeks of raloxifene was lost 6 months after cessation of treatment. ..
  24. Benameur Y, Guerrouj H, Ghfir I, Ben Rais Aouad N. Unusual pathological fracture of the clavicle revealing primary hyperparathyroidism: a case report. J Med Case Rep. 2017;11:342 pubmed publisher
    ..Whenever multiple osteolytic lesions are found in a patient without any known tumor, metabolic bone diseases including hyperparathyroidism should be highly considered.
  25. Mears S, McCarthy E, Jones L, Hungerford D, Mont M. Characterization and pathological characteristics of spontaneous osteonecrosis of the knee. Iowa Orthop J. 2009;29:38-42 pubmed
    ..This study demonstrated that spontaneous osteonecrosis of the knee is not an osteonecrotic condition and has been misnamed. Osteopenia and osteoarthritis may play a role in the pathogenesis of this disease. ..
  26. Pollock E, Klotsas A, Compston J, Gkrania Klotsas E. Bone health in HIV infection. Br Med Bull. 2009;92:123-33 pubmed publisher
    ..More studies of the mechanisms of bone loss, the skeletal effects of antiretroviral therapy and the therapeutic outcome of bone-protective therapy in HIV-positive individuals are needed. ..
  27. Paradis J, Wilke M, Haston C. Osteopenia in Cftr-deltaF508 mice. J Cyst Fibros. 2010;9:239-45 pubmed publisher
    ..To determine whether this phenotype is present in cystic fibrosis mouse models with the DeltaF508 Cftr mutation we assessed the femora of adult FVB/N Cftr(tm1Eur) and C57BL/6 Cftr(tm1Kth) mice...
  28. Sellmeyer D. Atypical fractures as a potential complication of long-term bisphosphonate therapy. JAMA. 2010;304:1480-4 pubmed publisher
  29. Van Scoy G, George E, Opoku Asantewaa F, Kerns L, Saunders M, Prieto Langarica A. A cellular automata model of bone formation. Math Biosci. 2017;286:58-64 pubmed publisher
    ..But efforts to understand the multicellular complexity can ultimately lead to eradication of metabolic bone diseases such as osteoporosis and improved implant longevity...
  30. Moya Angeler J, Lane J, Rodriguez J. Metabolic Bone Diseases and Total Hip Arthroplasty: Preventing Complications. J Am Acad Orthop Surg. 2017;25:725-735 pubmed publisher
    b>Metabolic bone diseases are a diverse group of conditions characterized by abnormalities in calcium metabolism and/or bone cell physiology...
  31. Khatri I, Chaudhry U, Seikaly M, Browne R, Iannaccone S. Low bone mineral density in spinal muscular atrophy. J Clin Neuromuscul Dis. 2008;10:11-7 pubmed publisher
    ..05). We conclude that osteopenia is common in children with neuromuscular disorders. Patients with SMA have the lowest BMD. ..
  32. Wang Q, Teo J, Ghasem Zadeh A, Seeman E. Women and men with hip fractures have a longer femoral neck moment arm and greater impact load in a sideways fall. Osteoporos Int. 2009;20:1151-6 pubmed publisher
    ..We hypothesized that the hip geometry in elderly with hip fractures produces a greater impact on the hip during a sideways fall...
  33. van der Steenhoven T, Schaasberg W, de Vries A, Valstar E, Nelissen R. Augmentation with silicone stabilizes proximal femur fractures: an in vitro biomechanical study. Clin Biomech (Bristol, Avon). 2009;24:286-90 pubmed publisher
    ..Future improvements in minimal invasive excavation and injection could make silicone femoroplasty an attractive alternative strategy in the prevention of hip fracture surgery in the growing population of low-demand, elderly patients. ..
  34. Caradonna P, Rigante D. Bone health as a primary target in the pediatric age. Eur Rev Med Pharmacol Sci. 2009;13:117-28 pubmed
  35. Ozaki K, Okamoto M, Fukasawa K, Iezaki T, Onishi Y, Yoneda Y, et al. Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice. J Pharmacol Sci. 2015;129:72-7 pubmed publisher
    ..Our results suggest that supplementation with β-cryptoxanthin would be beneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation.
  36. Breijawi N, Eckardt A, Pitton M, Hoelzl A, Giesa M, von Stechow D, et al. Bone mineral density and vitamin D status in female and male patients with osteoarthritis of the knee or hip. Eur Surg Res. 2009;42:1-10 pubmed publisher
    ..The incidence of low BMD in the male cohort was notably higher than expected. We detected a high prevalence of vitamin D deficiency, independent of the BMD. ..
  37. Huang M, Sprague S. Bone disease in kidney transplant patients. Semin Nephrol. 2009;29:166-73 pubmed publisher
    ..Evaluating and managing post-kidney transplantation bone disease remains an integral part of posttransplant medical care. ..
  38. Sebastian A, Loots G. Transcriptional control of Sost in bone. Bone. 2017;96:76-84 pubmed publisher
    ..bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such as osteoporosis and in facilitating fracture repair...
  39. Bacchetta J, Boutroy S, Juillard L, Vilayphiou N, Guebre Egziabher F, Pelletier S, et al. Bone imaging and chronic kidney disease: will high-resolution peripheral tomography improve bone evaluation and therapeutic management?. J Ren Nutr. 2009;19:44-9 pubmed publisher
    ..High-resolution peripheral quantitative computed tomography may be useful in predicting fractures and assessing bone preventive or therapeutic strategies in CKD patients. It should be evaluated in long-term, longitudinal follow-ups. ..
  40. Ting Ma H, Griffith J, Yang Z, Kwok A, Leung P, Lee R. Effect of vertebral morphology on lumbar kinematics in elderly subjects with decreased bone mineral density. Conf Proc IEEE Eng Med Biol Soc. 2008;2008:883-6 pubmed publisher
  41. Hamada Y, Fukagawa M. [Chronic kidney disease (CKD) and bone. The mechanisms of chronic kidney disease--mineral and bone disorder (CKD-MBD)]. Clin Calcium. 2009;19:486-92 pubmed publisher
    ..In order to prevent the disorders, control of serum phosphate and calcium levels are needed. ..
  42. Balsa J, Botella Carretero J, Peromingo R, Caballero C, Muñoz Malo T, Villafruela J, et al. Chronic increase of bone turnover markers after biliopancreatic diversion is related to secondary hyperparathyroidism and weight loss. Relation with bone mineral density. Obes Surg. 2010;20:468-73 pubmed publisher
    ..38, P=0.002 and r=-0.30, P=0.02, respectively). Chronic SH and the loss of weight determine a high rate of bone turnover that is associated with decreasing BMD in BPD patients. ..
  43. Aithal H, Kinjavdekar P, Amarpal -, Pawde A, Singh G, Pattanaik A, et al. Effects of Nandrolone and TGF-beta1 in growing rabbits with osteopenia induced by over-supplementation of calcium and vitamin D3. Vet Res Commun. 2009;33:331-43 pubmed publisher
    ..D3 results in osteopenia in growing rabbits. Administration of Nandrolone helps to increase the mineral density in osteopenic bones, whereas TGF-beta1 does not seem to have positive effect on the skeletal mineralization. ..
  44. Johnson M, Das P, Dewar D, Forbes A, Ciclitira P, Nicholls R. Medical management of patients with ileal pouch anal anastomosis after restorative procto-colectomy. Eur J Gastroenterol Hepatol. 2009;21:9-17 pubmed publisher
    ..As research develops in this area, other complications are being found. The aim of this review is to provide an up-to-date, evidence-based approach to the clinical management of these patients. ..
  45. Cao H, Yu S, Yao Z, Galson D, Jiang Y, Zhang X, et al. Activating transcription factor 4 regulates osteoclast differentiation in mice. J Clin Invest. 2010;120:2755-66 pubmed publisher
    ..These results demonstrate that ATF4 plays a direct role in regulating OCL differentiation and suggest that it may be a therapeutic target for treating bone diseases associated with increased OCL activity. ..
  46. Brufsky A. The evolving role of bone-conserving therapy in patients with breast cancer. Semin Oncol. 2010;37 Suppl 1:S12-9 pubmed publisher
    ..Overall, these data warrant further consideration of the role of bisphosphonates in BC. Ongoing studies will further investigate the bone-protective and potential anticancer benefits of BPs across all stages of breast disease. ..
  47. Aliprantis A, Ueki Y, Sulyanto R, Park A, Sigrist K, Sharma S, et al. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008;118:3775-89 pubmed publisher
    ..Taken together, our study demonstrates that NFATc1 is required for remodeling of the growing and adult skeleton and suggests that NFATc1 may be an effective therapeutic target for osteoporosis associated with inflammatory states...
  48. Alvisa Negrín J, Gonzalez Reimers E, Santolaria Fernández F, García Valdecasas Campelo E, Valls M, Pelazas González R, et al. Osteopenia in alcoholics: effect of alcohol abstinence. Alcohol Alcohol. 2009;44:468-75 pubmed publisher
    ..Serum telopeptide increased in both groups. Ethanol consumption leads to osteopenia, and decreased serum osteocalcin, which improve with abstinence, whereas those who continue drinking show a worsening of both parameters. ..
  49. Christoforidis A, Economou M, Papadopoulou E, Kazantzidou E, Gompakis N, Athanassiou Metaxa M. Bone status of children with hemophilia A assessed with quantitative ultrasound sonography (QUS) and dual energy X-ray absorptiometry (DXA). J Pediatr Hematol Oncol. 2010;32:e259-63 pubmed publisher
    ..262). In conclusion, our study showed that only a small number of children and young adults with hemophilia have impaired bone properties as assessed both by DXA and QUS; no correlation was observed between these 2 methods. ..
  50. Vestergaard P. Skeletal effects of drugs to treat cancer. Curr Drug Saf. 2008;3:173-7 pubmed
    ..With the increasing long-term survival of patients with cancer, preventive measures against osteoporosis must be considered...
  51. Klein G. The interaction between burn injury and vitamin D metabolism and consequences for the patient. Curr Clin Pharmacol. 2008;3:204-10 pubmed
    ..Thus vitamin D supplementation is the only means by which to ensure vitamin D sufficiency for burn victims. The proper requirement for vitamin D in acutely burned patients remains unknown...
  52. Gal Moscovici A, Sprague S. Role of bone biopsy in stages 3 to 4 chronic kidney disease. Clin J Am Soc Nephrol. 2008;3 Suppl 3:S170-4 pubmed publisher
    ..Thus, because biochemical data cannot predict bone pathology in stages 3 and 4 chronic kidney disease, bone biopsy should be used to define these bone changes and to allow appropriate therapeutic approaches...
  53. Cheour E, Hamdi W, Sahli H, Landolsi F, Fekih M, Meddeb N, et al. [Osteopenia in patients with Crohn disease]. Tunis Med. 2007;85:920-4 pubmed
    ..Osteoporosis and osteopenia are frequently reported during chronic inflammatory bowel diseases, particularly in Crohn disease (CD)...
  54. Shomali T, Rezaian M, Rassouli A, Asadi F. Effect of eicosapentaenoic acid on bone changes due to methylprednisolone in rats. Basic Clin Pharmacol Toxicol. 2009;105:46-50 pubmed publisher
    ..Eicosapentaenoic acid, especially, at the dose of 160 mg/kg exerts beneficial effects on methylprednisolone-induced bone changes in rats; these effects are similar or sometimes even better than alendronate...
  55. Lee N, Radford Smith G, Forwood M, Wong J, Taaffe D. Body composition and muscle strength as predictors of bone mineral density in Crohn's disease. J Bone Miner Metab. 2009;27:456-63 pubmed publisher
    ..Preserving or augmenting muscle mass in this population may be a useful strategy to preserve BMD and thereby reduce fracture risk...
  56. Wesół Kucharska D, Laskowska J, Sibilska M, Friedman Gruszczyńska J, Błońska M, Gawecka A, et al. [Prevention of osteopenia in premature infants]. Med Wieku Rozwoj. 2008;12:924-32 pubmed
    ..Physical activities, together with appropriate mineral, protein and energy intake may decrease the risk of osteopenia. Laboratory assessment of calcium and phosphorus homeostasis is recommended every 2 weeks, from 6(th) week of life...
  57. Kao H, Chang W, Lee C, Lee H, Huang G. Missed brown tumors in a young adult with decreased bone density. South Med J. 2010;103:371-3 pubmed publisher
    ..Based on the radiographic findings and biochemistry results in a young adult patient, brown tumor was suspected and subsequently definitively diagnosed...
  58. Pi M, Chen L, Huang M, Zhu W, Ringhofer B, Luo J, et al. GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS ONE. 2008;3:e3858 pubmed publisher
    ..GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown...
  59. Hines S, Mincey B, Sloan J, Thomas S, Chottiner E, Loprinzi C, et al. Phase III randomized, placebo-controlled, double-blind trial of risedronate for the prevention of bone loss in premenopausal women undergoing chemotherapy for primary breast cancer. J Clin Oncol. 2009;27:1047-53 pubmed publisher
    ..Risedronate prevents bone loss in postmenopausal women. The purpose of this study was to determine whether risedronate prevents bone loss in premenopausal women undergoing chemotherapy for breast cancer...
  60. Silva M, Brodt M, Lynch M, McKenzie J, Tanouye K, Nyman J, et al. Type 1 diabetes in young rats leads to progressive trabecular bone loss, cessation of cortical bone growth, and diminished whole bone strength and fatigue life. J Bone Miner Res. 2009;24:1618-27 pubmed publisher
    ..Diabetic bone has greatly increased nonenzymatic collagen cross-links but only modestly reduced material properties. The loss of whole bone strength under both monotonic and fatigue loading is attributed mainly to reduced bone size...
  61. Ferguson G, Calverley P, Anderson J, Jenkins C, Jones P, Willits L, et al. Prevalence and progression of osteoporosis in patients with COPD: results from the TOwards a Revolution in COPD Health study. Chest. 2009;136:1456-1465 pubmed publisher
  62. Ahmadpoor P, Reisi S, Makhdoomi K, Ghafari A, Sepehrvand N, Rahimi E. Osteoporosis and related risk factors in renal transplant recipients. Transplant Proc. 2009;41:2820-2 pubmed publisher
    ..05). A hip z score of less than 1 was related to the posttransplantation period (P = .02). In conclusion, osteoporosis is a frequent complication that requires detection and treatment to reduce morbidity...
  63. Cuneo F, Costa Paiva L, Pinto Neto A, Morais S, Amaya Farfan J. Effect of dietary supplementation with collagen hydrolysates on bone metabolism of postmenopausal women with low mineral density. Maturitas. 2010;65:253-7 pubmed publisher
    ..Collagen hydrolysates (CH), obtained by an enzymatic hydrolysis process of gelatins, have potential application as oral supplements...
  64. Hunt K, Walsh B, Voegeli D, Roberts H. Inflammation in aging part 2: implications for the health of older people and recommendations for nursing practice. Biol Res Nurs. 2010;11:253-60 pubmed publisher
    ..Part 2 of this two-part article provides an overview of the health effects of inflammaging, addressing the extent to which it contributes to the syndromes of frailty and disability with aging...
  65. Svacina S. [Diabetic osteopathy: previously disputed but most likely important ailment]. Vnitr Lek. 2010;56:736-8 pubmed
    ..This risk can be positively and negatively modified by antidiabetic drugs. It is important to find some markers for fracture risk in diabetes. Nowadays only bone densitometry can be used with some limitations to quantify this risk...
  66. Mehler P, MacKenzie T. Treatment of osteopenia and osteoporosis in anorexia nervosa: a systematic review of the literature. Int J Eat Disord. 2009;42:195-201 pubmed publisher
    ..To systematically review the evidence supporting treatment of osteopenia and osteoporosis in patients with anorexia nervosa (AN)...
  67. Hartman A, te Winkel M, van Beek R, de Muinck Keizer Schrama S, Kemper H, Hop W, et al. A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009;53:64-71 pubmed publisher
    ..We performed a randomized study investigating whether an exercise program could prevent these side effects...
  68. Li Z, Lu W, Deng L, Chiu P, Fang D, Lam R, et al. The morphology and lattice structure of bone crystal after strontium treatment in goats. J Bone Miner Metab. 2010;28:25-34 pubmed publisher
    ..Our findings showed that Sr administration at current dosages for prevention and treatment of osteoporosis might not change the bone crystal morphology and structure...
  69. Ganesan P, Thulkar S, Gupta R, Bakhshi S. Childhood aleukemic leukemia with hypercalcemia and bone lesions mimicking metabolic bone disease. J Pediatr Endocrinol Metab. 2009;22:463-7 pubmed
    ..We discuss the diagnostic challenges of this rare entity of aleukemic leukemia with hypercalcemia and lytic bone lesions, and review all the previously reported pediatric literature...
  70. Mussa A, Repici M, Fiore L, Tuli G, Porta F, Matarazzo P. Bone quantitative ultrasound in congenital and acquired childhood multiple pituitary failure. Ultrasound Med Biol. 2010;36:726-32 pubmed publisher
    ..Phalangeal QUS measurements of BTT and AD-SoS promise as a reliable method for obtaining quantitative measurements of bone disease in individuals with hypopituitarism but more studies are needed for verification...
  71. Lurati A, Cimaz R, Gattinara M, Gerloni V, Teruzzi B, Salmaso A, et al. [Skeletal mineralization in a prepubertal female population affected by juvenile idiopathic arthritis]. Reumatismo. 2008;60:224-9 pubmed
    ..Growth failure and impairment of sexual maturation are frequent manifestations of chronic illnesses in the paediatric population, and chronic rheumatologic disorders such as juvenile idiopathic arthritis (JIA) are no exception to this...
  72. Hamada Y, Fujii H, Kitazawa R, Yodoi J, Kitazawa S, Fukagawa M. Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia: a novel role of oxidative stress and therapeutic implications. Bone. 2009;44:936-41 pubmed publisher
    ..Increased oxidative stress in diabetic condition contributes to the development of diabetic osteopenia. Suppression of increased oxidative stress by TRX induction could be a potential therapeutic approach for diabetic osteopenia...
  73. Tsukamoto Y. [Chronic kidney disease (CKD) and bone. From renal osteodystrophy to CKD-MBD: new disease entity]. Clin Calcium. 2009;19:479-84 pubmed publisher
    ..This entity accurately reflects a diversity in mineral and bone disorder associated with CKD. According to this new definition, renal osteodystrophy should be used to express only bone lesion associated with CKD...
  74. Baig L, Mansuri F, Karim S. Association of menopause with osteopenia and osteoporosis: results from population based study done in Karachi. J Coll Physicians Surg Pak. 2009;19:240-4 pubmed publisher
    ..To assess the association of osteopenia and osteoporosis with menopause and compare the health seeking behaviour of women related to menopause in different strata of society...
  75. Zofkova I. [Celiac disease and its relation to bone metabolism]. Cas Lek Cesk. 2009;148:246-8 pubmed
    ..The promising therapy appears to be new molecules with reparative effect on intestinal mucose such as AT-1001...
  76. Zhang H, Ding J, Jin J, Guo J, Liu J, Karaplis A, et al. Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res. 2010;25:640-52 pubmed publisher
    ..Bmi-1 therefore plays a critical role in promoting osteogenesis...
  77. Iwaniec U, Turner R, Koo S, Kaur R, Ho E, Wong C, et al. Consumption of green tea extract results in osteopenia in growing male mice. J Nutr. 2009;139:1914-9 pubmed publisher
  78. Mataliotakis G, Lykissas M, Mavrodontidis A, Kontogeorgakos V, Beris A. Femoral neck fractures secondary to renal osteodystrophy. Literature review and treatment algorithm. J Musculoskelet Neuronal Interact. 2009;9:130-7 pubmed
    ..A conclusive treatment algorithm is proposed where all the relevant parameters are incorporated...
  79. Jager P, Slart R, Webber C, Adachi J, Papaioannou A, Gulenchyn K. Combined vertebral fracture assessment and bone mineral density measurement: a patient-friendly new tool with an important impact on the Canadian Risk Fracture Classification. Can Assoc Radiol J. 2010;61:194-200 pubmed publisher
    ..Our purpose was to determine the added value of VFA and its impact on the Canadian fracture risk classification using data from a Dutch academic cohort...
  80. Nieves J. Nutritional therapies (including fosteum). Curr Osteoporos Rep. 2009;7:5-11 pubmed
    ..The ability of soy products, particularly genistein aglycone, to provide skeletal benefit has been recently studied, including some data that support a new medical food marketed as Fosteum (Primus Pharmaceuticals, Scottsdale, AZ)...
  81. Akdeniz N, Akpolat V, Kale A, Erdemoglu M, Kuyumcuoglu U, Celik Y. Risk factors for postmenopausal osteoporosis: anthropometric measurements, age, age at menopause and the time elapsed after menopause onset. Gynecol Endocrinol. 2009;25:125-9 pubmed publisher
    ..The aim of this study was to determine, how much the anthropometric measurements and age affect the femur and vertebra T-scores by using correlation and regression analysis in postmenopausal women...
  82. Colak M, Canbaz H, Ayan I, Karabacak T, Kuyurtar F. Intrapelvic mass causing femoral compression neuropathy in a patient with Gaucher disease: a case report. Eklem Hastalik Cerrahisi. 2009;20:169-73 pubmed
    ..The neurological impairment caused by compression by a tumor should be distinguished from the ones reported in neurogenic forms of the disease...
  83. Humphries B, Fenning A, Dugan E, Guinane J, MacRae K. Whole-body vibration effects on bone mineral density in women with or without resistance training. Aviat Space Environ Med. 2009;80:1025-31 pubmed
  84. Howe W, Davis E, Valentine J. Pamidronate improves pain, wellbeing, fracture rate and bone density in 14 children and adolescents with chronic neurological conditions. Dev Neurorehabil. 2010;13:31-6 pubmed publisher
    ..To investigate if intravenous pamidronate improves bone density in a cohort of patients with chronic neurological conditions and low bone density, in whom fractures and bone pain are impacting on care...
  85. Ruck J, Chabot G, Rauch F. Vibration treatment in cerebral palsy: A randomized controlled pilot study. J Musculoskelet Neuronal Interact. 2010;10:77-83 pubmed
    ..In conclusion, the WBV protocol used in this study appears to be safe in children with cerebral palsy and may improve mobility function but we did not detect a positive treatment effect on bone...
  86. Guevarra M, Yeh J, Castro Magana M, Aloia J. Synergistic effect of parathyroid hormone and growth hormone on trabecular and cortical bone formation in hypophysectomized rats. Horm Res Paediatr. 2010;73:248-57 pubmed publisher
    ..Growth hormone (GH) deficiency in pediatric patients results in short stature and osteopenia. We postulated that the GH and parathyroid hormone (PTH) combination would result in improvement in bone growth and bone formation...
  87. Via M, Gallagher E, Mechanick J. Bone physiology and therapeutics in chronic critical illness. Ann N Y Acad Sci. 2010;1211:85-94 pubmed publisher
    ..We review the mechanisms by which these factors contribute to the metabolic bone disease of chronic critical illness and suggest potential therapeutics...
  88. Tolomio S, Ermolao A, Travain G, Zaccaria M. Short-term adapted physical activity program improves bone quality in osteopenic/osteoporotic postmenopausal women. J Phys Act Health. 2008;5:844-53 pubmed
    ..The aim of our study was to evaluate the effects on bone tissue and muscular strength of a short-term exercise program in osteopenic/osteoporotic postmenopausal women...
  89. Waits C, Burton D, McIff T. Cement augmentation of pedicle screw fixation using novel cannulated cement insertion device. Spine (Phila Pa 1976). 2009;34:E478-83 pubmed publisher
    ..A biomechanical study with human cadaveric osteopenic lumbar vertebrae evaluating a novel method for cement augmentation of pedicle screw fixation...
  90. Eun I, Park W, Suh K, Kim J, Lee J. Association between osteoprotegerin gene polymorphism and bone mineral density in patients with adolescent idiopathic scoliosis. Eur Spine J. 2009;18:1936-40 pubmed publisher
    ..These results suggest that the OPG gene 1181 G --> C polymorphism is associated with LSBMD in girls with AIS...
  91. Lecka Czernik B. Bone as a target of type 2 diabetes treatment. Curr Opin Investig Drugs. 2009;10:1085-90 pubmed
    ..In summary, bone is a target of certain antidiabetic therapies and, therefore, caution is necessary in the choice of treatment for patients who are at risk of skeletal complications...
  92. Kull M, Kallikorm R, Lember M. Bone mineral density reference range in Estonia: a comparison with the standard database (NHANES III). J Clin Densitom. 2009;12:468-74 pubmed publisher
    ..and the additional benefit of adding the FRAX (World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK) tool to fracture prediction and osteoporosis diagnosis are needed in Estonia...