hyperostosis

Summary

Summary: Increase in the mass of bone per unit volume.

Top Publications

  1. Bikmaz K, Mrak R, Al Mefty O. Management of bone-invasive, hyperostotic sphenoid wing meningiomas. J Neurosurg. 2007;107:905-12 pubmed
    The hyperostosis frequently associated with sphenoid wing meningiomas is actual invasion of bone by the tumor...
  2. Waterval J, Van Dongen T, Stokroos R, Teule J, Kemerink G, Brans B, et al. Bone metabolic activity in hyperostosis cranialis interna measured with 18F-fluoride PET. Eur J Nucl Med Mol Imaging. 2011;38:884-93 pubmed publisher
    18)F-Fluoride PET/CT is a relatively undervalued diagnostic test to measure bone metabolism in bone diseases. Hyperostosis cranialis interna (HCI) is a (hereditary) bone disease characterised by endosteal hyperostosis and osteosclerosis ..
  3. Goyal N, Kakkar A, Sarkar C, Agrawal D. Does bony hyperostosis in intracranial meningioma signify tumor invasion? A radio-pathologic study. Neurol India. 2012;60:50-4 pubmed publisher
    ..While operating intracranial meningiomas, neurosurgeons commonly drill the hyperostotic bone and put the bone flap back...
  4. Gok F, Chefetz I, Indelman M, Kocaoglu M, Sprecher E. Newly discovered mutations in the GALNT3 gene causing autosomal recessive hyperostosis-hyperphosphatemia syndrome. Acta Orthop. 2009;80:131-4 pubmed
    Periosteal new bone formation and cortical hyperostosis often suggest an initial diagnosis of bone malignancy or osteomyelitis...
  5. Balemans W, Cleiren E, Siebers U, Horst J, Van Hul W. A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene. Bone. 2005;36:943-7 pubmed
    ..of van Buchem disease, a rare autosomal recessive sclerosing bone dysplasia characterized by a generalized hyperostosis of the skeleton mainly affecting the cranial bones...
  6. Frishberg Y, Ito N, Rinat C, Yamazaki Y, Feinstein S, Urakawa I, et al. Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23. J Bone Miner Res. 2007;22:235-42 pubmed
    ..Silencing GALNT3 resulted in enhanced processing of FGF23. Decreased function of FGF23 by enhanced processing is the cause of hyperphosphatemia in patients with GALNT3 mutation...
  7. Dumitrescu C, Kelly M, Khosravi A, Hart T, Brahim J, White K, et al. A case of familial tumoral calcinosis/hyperostosis-hyperphosphatemia syndrome due to a compound heterozygous mutation in GALNT3 demonstrating new phenotypic features. Osteoporos Int. 2009;20:1273-8 pubmed publisher
    A new case of familial tumoral calcinosis (FTC)/hyperostosis-hyperphosphatemia syndrome (HHS) due to a novel compound heterozygous mutation in N-acetylgalactosaminyltransferase 3 (GALNT3) and with new phenotypic findings is presented...
  8. Yu W, Baptiste D, Liu T, Odrobina E, Stanisz G, Fehlings M. Molecular mechanisms of spinal cord dysfunction and cell death in the spinal hyperostotic mouse: implications for the pathophysiology of human cervical spondylotic myelopathy. Neurobiol Dis. 2009;33:149-63 pubmed publisher
  9. Loots G, Kneissel M, Keller H, Baptist M, Chang J, Collette N, et al. Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease. Genome Res. 2005;15:928-35 pubmed
    ..5 (E14.5) mouse embryo, and discovered a novel function for sclerostin during limb development. Our approach represents a framework for characterizing distant regulatory elements associated with abnormal human phenotypes...

More Information

Publications90

  1. Waterval J, Stokroos R, Bauer N, de Bondt R, Manni J. Phenotypic manifestations and management of hyperostosis cranialis interna, a hereditary bone dysplasia affecting the calvaria and the skull base. Am J Med Genet A. 2010;152A:547-55 pubmed publisher
    b>Hyperostosis cranialis interna is a hereditary bone disorder that is characterized by endosteal hyperostosis and osteosclerosis of the calvaria and the skull base (OMIM 144755)...
  2. Wapler U, Crubezy E, Schultz M. Is cribra orbitalia synonymous with anemia? Analysis and interpretation of cranial pathology in Sudan. Am J Phys Anthropol. 2004;123:333-9 pubmed
    ..5% of cribra orbitalia cases, there were no histologic features indicating changes due to anemia. Signs of other pathological conditions, such as inflammation or osteoporosis, as well as pseudopathological cases, were found...
  3. Frishberg Y, Topaz O, Bergman R, Behar D, Fisher D, Gordon D, et al. Identification of a recurrent mutation in GALNT3 demonstrates that hyperostosis-hyperphosphatemia syndrome and familial tumoral calcinosis are allelic disorders. J Mol Med (Berl). 2005;83:33-8 pubmed
    Hyperphosphatemia-hyperostosis syndrome (HHS) is a rare autosomal recessive metabolic disorder characterized by elevated serum phosphate levels and repeated attacks of acute, painful swellings of the long bones with radiological evidence ..
  4. Rohekar G, Inman R. Conundrums in nosology: synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and spondylarthritis. Arthritis Rheum. 2006;55:665-9 pubmed
  5. Dominguez Rodrigo M, Pickering T, Diez Martín F, Mabulla A, Musiba C, Trancho G, et al. Earliest porotic hyperostosis on a 1.5-million-year-old hominin, olduvai gorge, Tanzania. PLoS ONE. 2012;7:e46414 pubmed publisher
    ..The child's parietal fragments, excavated from 1.5-million-year-old sediments, show porotic hyperostosis, a pathology associated with anemia...
  6. van Bezooijen R, Ten Dijke P, Papapoulos S, Lowik C. SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. Cytokine Growth Factor Rev. 2005;16:319-27 pubmed
    ..The exclusive bone phenotype of good quality of patients with sclerosteosis and Van Buchem disease and the specific localization of sclerostin make it an attractive target for the development of bone forming therapeutics...
  7. Juergens P, Ratia J, Beinemann J, Krol Z, Schicho K, Kunz C, et al. Enabling an unimpeded surgical approach to the skull base in patients with cranial hyperostosis, exemplarily demonstrated for craniometaphyseal dysplasia. J Neurosurg. 2011;115:528-35 pubmed publisher
    ..dysplasia, and other infrequent conditions, craniometaphyseal dysplasia is characterized by progressive diffuse hyperostosis of the neuro- and viscerocranium...
  8. Umredkar A, Mohindra S, Chhabra R, Gupta R. Vertebral body hyperostosis as a presentation of Pott's disease: a report of two cases and literature review. Neurol India. 2010;58:125-7 pubmed publisher
    ..We present two patients of Pott's disease, in whom vertebral body hyperostosis was the radiological presentation...
  9. Magrey M, Khan M. New insights into synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Curr Rheumatol Rep. 2009;11:329-33 pubmed
    In 1987, synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome was proposed as an umbrella term for a group of diseases with similar musculoskeletal manifestations, in particular hyperostosis of anterior chest wall, ..
  10. Uchida K, Nakajima H, Watanabe S, Yayama T, Guerrero A, Inukai T, et al. Apoptosis of neurons and oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy): possible pathomechanism of human cervical compressive myelopathy. Eur Spine J. 2012;21:490-7 pubmed publisher
    ..Mutant twy/twy mouse developed ossification of the ligamentum flavum at C2-C3 and exhibited progressive paralysis...
  11. Xu K, Uchida K, Nakajima H, Kobayashi S, Baba H. Targeted retrograde transfection of adenovirus vector carrying brain-derived neurotrophic factor gene prevents loss of mouse (twy/twy) anterior horn neurons in vivo sustaining mechanical compression. Spine (Phila Pa 1976). 2006;31:1867-74 pubmed
    ..Immunohistochemical analysis after adenovirus (AdV)-mediated BDNF gene transfer in and around the area of mechanical compression in the cervical spinal cord of the hyperostotic mouse (twy/twy)...
  12. Shteyer E, Saada A, Shaag A, Al Hijawi F, Kidess R, Revel Vilk S, et al. Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene. Am J Hum Genet. 2009;84:412-7 pubmed publisher
    ..who suffered from congenital exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis, we excluded these disorders and identified, by using homozygosity mapping, a mutation in the COX4I2 gene...
  13. Eser P, Bonel H, Seitz M, Villiger P, Aeberli D. Patients with diffuse idiopathic skeletal hyperostosis do not have increased peripheral bone mineral density and geometry. Rheumatology (Oxford). 2010;49:977-81 pubmed publisher
    ..Recent studies have suggested that areal BMD (aBMD) measured by DXA is elevated in patients with DISH. We used peripheral QCT (pQCT) to assess volumetric BMD (vBMD) and bone geometry of the radius, tibia and the third metacarpal bone...
  14. Hamersma H, Gardner J, Beighton P. The natural history of sclerosteosis. Clin Genet. 2003;63:192-7 pubmed
    Sclerosteosis (SCL) is a severe, progressive, autosomal-recessive craniotubular hyperostosis (MIM 269500)...
  15. Uchida K, Baba H, Maezawa Y, Kubota C. Progressive changes in neurofilament proteins and growth-associated protein-43 immunoreactivities at the site of cervical spinal cord compression in spinal hyperostotic mice. Spine (Phila Pa 1976). 2002;27:480-6 pubmed
    ..Immunohistochemical examination of the expression and localization of neurofilament (NF) proteins and growth-associated protein (GAP)-43 in spinal hyperostotic (twy/twy) mice with progressive compression of the cervical spinal cord...
  16. Walker P, Bathurst R, Richman R, Gjerdrum T, Andrushko V. The causes of porotic hyperostosis and cribra orbitalia: a reappraisal of the iron-deficiency-anemia hypothesis. Am J Phys Anthropol. 2009;139:109-25 pubmed publisher
    Porosities in the outer table of the cranial vault (porotic hyperostosis) and orbital roof (cribra orbitalia) are among the most frequent pathological lesions seen in ancient human skeletal collections...
  17. Kiss C, O Neill T, Mituszova M, Szilagyi M, Poór G. The prevalence of diffuse idiopathic skeletal hyperostosis in a population-based study in Hungary. Scand J Rheumatol. 2002;31:226-9 pubmed
    Diffuse idiopathic skeletal hyperostosis (DISH) is a skeletal disease characterized by ligamentous ossification of the antero-lateral side of the spine...
  18. Schwartz J, Rackson M. Diffuse idiopathic skeletal hyperostosis causes artificially elevated lumbar bone mineral density measured by dual X-ray absorptiometry. J Clin Densitom. 2001;4:385-8 pubmed
    ..Lumbar spine radiographs demonstrated abundant, flowing ossification of the anterior spinal ligament, predominantly at L3, consistent with diffuse idiopathic skeletal hyperostosis, which accounted for the increased BMD.
  19. Aiba A, Nakajima A, Okawa A, Koda M, Yamazaki M. Evidence of enhanced expression of osteopontin in spinal hyperostosis of the twy mouse. Spine (Phila Pa 1976). 2009;34:1644-9 pubmed publisher
    Gene expression and protein localization of osteopontin (OPN) in spinal hyperostosis of the twy mouse by means of in situ hybridization, immunohistochemistry, and Northern blot analysis.
  20. Noda D, Tsugu H, Nishikawa W, Shigekawa S, Fukushima T, Nabeshima K. [Case of idiopathic hypertrophic pachymeningitis presenting with hyperostosis]. No Shinkei Geka. 2008;36:717-23 pubmed
    We report a case of idiopathic hypertrophic pachymeningitis presenting with cranial hyperostosis. A 64-year-old man had suffered from pulsating headache during the last 3 months...
  21. Ichikawa S, Guigonis V, Imel E, Courouble M, Heissat S, Henley J, et al. Novel GALNT3 mutations causing hyperostosis-hyperphosphatemia syndrome result in low intact fibroblast growth factor 23 concentrations. J Clin Endocrinol Metab. 2007;92:1943-7 pubmed
    b>Hyperostosis-hyperphosphatemia syndrome (HHS) is a rare metabolic disorder characterized by hyperphosphatemia and localized hyperostosis...
  22. Lee D, Chung S, Dhong H, Kim H, Kim H, Bok K. Focal hyperostosis on CT of sinonasal inverted papilloma as a predictor of tumor origin. AJNR Am J Neuroradiol. 2007;28:618-21 pubmed
    To evaluate the CT characteristics of focal hyperostosis in patients with sinonasal inverted papilloma and to correlate these characteristics with the detection of the origins of tumors.
  23. Inukai T, Uchida K, Nakajima H, Yayama T, Kobayashi S, Mwaka E, et al. Tumor necrosis factor-alpha and its receptors contribute to apoptosis of oligodendrocytes in the spinal cord of spinal hyperostotic mouse (twy/twy) sustaining chronic mechanical compression. Spine (Phila Pa 1976). 2009;34:2848-57 pubmed publisher
  24. Olauson H, Krajisnik T, Larsson C, Lindberg B, Larsson T. A novel missense mutation in GALNT3 causing hyperostosis-hyperphosphataemia syndrome. Eur J Endocrinol. 2008;158:929-34 pubmed publisher
    b>Hyperostosis-hyperphosphataemia syndrome (HHS) is a rare hereditary disorder characterized by hyperphosphataemia, inappropriately normal or elevated 1,25-dihydroxyvitamin D(3) and localized painful cortical hyperostosis...
  25. Gross Tsubery R, Chai O, Shilo Y, Miara L, Horowitz I, Shmueli A, et al. Computed tomographic analysis of calvarial hyperostosis in captive lions. Vet Radiol Ultrasound. 2010;51:34-8 pubmed
    ..CT is useful for detection of the calvarial abnormalities in lions and may be useful in further defining this syndrome...
  26. Dessinioti C, Katsambas A. Difficult and rare forms of acne. Clin Dermatol. 2017;35:138-146 pubmed publisher
    ..Rare forms of acne may be present in the context of complex syndromes, such as the synovitis, acne, pustulosis, hyperostosis, osteitis syndrome; pyogenic arthritis, pyoderma gangrenosum, acne syndrome; pyoderma gangrenosum, acne, and ..
  27. Dlouhy B, Menezes A. Osteopetrosis with Chiari I malformation: presentation and surgical management. J Neurosurg Pediatr. 2011;7:369-74 pubmed publisher
    ..Additionally, they review osteopetrosis and other diagnoses of calvarial hyperostosis presenting as CM-I.
  28. Mathes R, Holmes S, Coleman K, Radlinsky M, Moore P. Calvarial hyperostosis presenting as unilateral exophthalmos in a female English Springer Spaniel. Vet Ophthalmol. 2012;15:263-70 pubmed publisher
    ..Calvarial hyperostosis was diagnosed based upon appearance on imaging, lesion unilaterality, absence of mandibular involvement, and ..
  29. Naique S, Laheri V. Stenosis of the cervical canal in craniodiaphyseal dysplasia. J Bone Joint Surg Br. 2001;83:328-31 pubmed
    ..b>Hyperostosis can cause progressive foraminal stenosis leading to palsy of cranial nerves, epilepsy and mental retardation...
  30. Joly A, Pare A, Goga D, Laure B. Frontal cranioplasty in fronto-metaphyseal dysplasia. J Stomatol Oral Maxillofac Surg. 2017;118:310-312 pubmed publisher
    ..Craniofacial phenotype of FMD is characterized by supraorbital hyperostosis, hypertelorism, down-slanting palpebral fissures, broad nasal bridge and micrognathia...
  31. Latourte A, Charlon S, Etcheto A, Feydy A, Allanore Y, Dougados M, et al. Imaging Findings Suggestive of Axial Spondyloarthritis in Diffuse Idiopathic Skeletal Hyperostosis. Arthritis Care Res (Hoboken). 2017;: pubmed publisher
    To describe the magnetic resonance imaging (MRI) findings in diffuse idiopathic skeletal hyperostosis (DISH) patients and to assess the proportion of DISH patients whose MRI findings would fulfill the Assessment of Spondyloarthritis ..
  32. Hendrickx G, Boudin E, Steenackers E, Nielsen T, Andersen M, Brixen K, et al. Genetic Screening of WNT4 and WNT5B in Two Populations with Deviating Bone Mineral Densities. Calcif Tissue Int. 2017;100:244-249 pubmed publisher
    ..A WNT4 and WNT5B mutation screening was performed in patients with craniotubular hyperostosis using Sanger sequencing. Here, no putative causal mutations were detected...
  33. Mørk N, Austad J, Kolbenstvedt A. Bamboo spine mimicking Bekhterev's disease caused by long-term acitretin treatment. Acta Derm Venereol. 2006;86:452-3 pubmed
  34. Karmon Y, Gadoth N. A head bulge. Arch Neurol. 2006;63:606-7 pubmed
  35. Porter M, Hales N, Nease C, Krempl G. Long-term results of inferior turbinate hypertrophy with radiofrequency treatment: a new standard of care?. Laryngoscope. 2006;116:554-7 pubmed
    ..RFVTR is a relatively new procedure, and therefore there are few long-term evaluations of its effectiveness; this is the first prospective study to document successful outcomes at 2 years follow-up. ..
  36. Takigawa T, Tanaka M, Nakahara S, Sugimoto Y, Ozaki T. SAPHO syndrome with rapidly progressing destructive spondylitis: two cases treated surgically. Eur Spine J. 2008;17 Suppl 2:S331-7 pubmed publisher
    The authors present two cases of synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome with rapidly progressing destructive spondylitis treated surgically...
  37. Yang X, Jiang Y, Han G, Shi Y, Zhou S, Ni F, et al. Altered Adipose-Derived Stem Cell Characteristics in Macrodactyly. Sci Rep. 2017;7:11090 pubmed publisher
    ..disease characterized by aggressive overgrowth of adipose tissue in digits or limbs frequently accompanied with hyperostosis and nerve enlargement; its pathological mechanism is poorly understood...
  38. Kashii M, Matuso Y, Sugiura T, Fujimori T, Nagamoto Y, Makino T, et al. Circulating sclerostin and dickkopf-1 levels in ossification of the posterior longitudinal ligament of the spine. J Bone Miner Metab. 2016;34:315-24 pubmed publisher
    ..characterized by pathological ectopic ossification of the posterior longitudinal ligament and ankylosing spinal hyperostosis. The aims of this study were to evaluate serum sclerostin and DKK1 levels in persons with OPLL and to identify ..
  39. Lim A, D Urso P. Single-level bilateral facet joint hypertrophy causing thoracic spinal canal stenosis. J Clin Neurosci. 2009;16:1363-5 pubmed publisher
    ..Postoperatively there was a marked improvement in symptoms and signs. We present a literature review on bilateral single-level facet joint hypertrophy producing canal stenosis and report our experience. ..
  40. Lee J, Lee J, Yoon H, Kim N, Sur J, Jeong S. Hypertrophic osteopathy associated with pulmonary adenosquamous carcinoma in a dog. J Vet Med Sci. 2012;74:667-72 pubmed
    ..This is the first case report of pulmonary adenosquamous carcinoma with HO in a dog in which we describe clinical, imaging, surgical, and histological findings. ..
  41. Gori F, Friedman L, Demay M. Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Dev Biol. 2006;295:498-506 pubmed
    ..Overall, our findings suggest that Wdr5 accelerates osteoblast differentiation in association with activation of the canonical Wnt pathway. ..
  42. Waterval J, van Dongen T, Stokroos R, De Bondt B, Chenault M, Manni J. Imaging features and progression of hyperostosis cranialis interna. AJNR Am J Neuroradiol. 2012;33:453-61 pubmed publisher
    ..The hyperostotic bone is less attenuated than normal cortical bone. The observed radiologic abnormalities explain the possible impairment of the olfactory, optic, trigeminal, facial, and vestibulocochlear nerves. ..
  43. Giddings C, Caulfield H, Dorward N. Diffuse idiopathic skeletal hyperostosis resulting in dysphagia and aspiration pneumonia. Br J Neurosurg. 2003;17:467-8 pubmed
  44. Yilmaz E, Kansu O, Ozgen B, Akcicek G, Kansu H. Radiographic manifestations of the temporomandibular joint in a case of Proteus syndrome. Dentomaxillofac Radiol. 2013;42:58444855 pubmed publisher
    ..of the classical craniofacial features of Proteus syndrome: pronounced hemifacial hypertrophy, macrodactyly and hyperostosis. Intraoral examination revealed a high arched palate and gingival hyperplasia...
  45. Rivero Garvía M, Márquez Rivas F, García Iglesias A, Gutiérrez González R. Intracranial hypertension in two cases of craniometaphyseal dysplasia: differing surgical options. Neurosurg Focus. 2011;31:E6 pubmed publisher
    ..The origin of intracranial hypertension in CMD is multifactorial. Previous intracranial pressure monitoring and a thorough understanding of neuroimaging studies are essential to achieve an accurate diagnosis and effective treatment. ..
  46. Sone T, Onaru K. [Bone and joint diseases in children. Abnormal bone mineral density in children]. Clin Calcium. 2010;20:859-65 pubmed publisher
    ..In this chapter, we reviewed the recent progress on the method to evaluate BMD in growing period and etiologies of abnormal BMD in children. ..
  47. Karagülle M, Kardeş S, Karagülle M. Real-life effectiveness of spa therapy in rheumatic and musculoskeletal diseases: a retrospective study of 819 patients. Int J Biometeorol. 2017;61:1945-1956 pubmed publisher
    ..tendinopathy, psoriatic arthritis, osteoporosis, fracture rehabilitation, and diffuse idiopathic skeletal hyperostosis. Statistically significant decrease in pain scores was found in all patients except hip osteoarthritis (p = 0...
  48. Belcastro M, Mariotti V, Bonfiglioli B, Todero A, Bocchini G, Bettuzzi M, et al. Dental status and 3D reconstruction of the malocclusion of the famous singer Farinelli (1705-1782). Int J Paleopathol. 2014;7:64-69 pubmed publisher
    ..The osteological study has revealed several skeletal features probably related to the effects of castration (Hyperostosis frontalis interna, long limb bones, persistence of epiphyseal lines, osteoporosis) (Belcastro et al., 2011)...
  49. Pei J, Jung S, Jin S, Moon K, Wen M, Li S, et al. Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas. Acta Neurochir (Wien). 2012;154:611-20; discussion 620 pubmed publisher
    Although bone invasion and hyperostosis are common phenomena in patients with intracranial meningiomas, the basic pathomechanism is not fully understood...
  50. Zhou Y, Wang T, Hamilton J, Chen D. Wnt/β-catenin Signaling in Osteoarthritis and in Other Forms of Arthritis. Curr Rheumatol Rep. 2017;19:53 pubmed publisher
    ..include erosive hand OA, temporomandibular joint (TMJ) OA, facet joint OA, diffuse idiopathic skeletal hyperostosis (DISH), and spondyloarthritis (SpA)...
  51. Hossain A, Abu Talha K. Anatomical location and bony reaction in intracranial meningiomas. Bangladesh Med Res Counc Bull. 2007;33:110-2 pubmed
  52. Yekeler E, Kumbasar B, Dursun M, Cantez S, Emiroglu H, Tunaci M. Pseudomass of the sternal manubrium in osteogenesis imperfecta. Skeletal Radiol. 2003;32:371-3 pubmed
    ..Computed tomography examination revealed a high-density mass-like lesion of the manubrium sterni. Ultrasonography and a lateral roentgenogram of the chest verified that this was a pseudomass caused by a bowed sternal manubrium. ..
  53. VAN ZEBEN W. Infantile cortical hyperostoses. Acta Paediatr. 1948;35:10-20 pubmed
  54. Waterval J, Bischoff M, Stokroos R, Anteunis L, Hilkman D, Kingma H, et al. Neurophysiologic, audiometric and vestibular function tests in patients with hyperostosis cranialis interna. Clin Neurol Neurosurg. 2013;115:1701-8 pubmed publisher
    b>Hyperostosis cranialis interna (HCI) is an autosomal dominant sclerosing bone dysplasia affecting the skull base and the calvaria, characterized by cranial nerve deficits due to stenosis of neuroforamina...
  55. Boudin E, Piters E, Fijalkowski I, Stevenheydens G, Steenackers E, Kuismin O, et al. Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis. Bone. 2013;52:292-5 pubmed publisher
    ..Frizzled related protein (sFRP) family, as candidate genes for mutation analysis in patients with craniotubular hyperostosis. Using Sanger sequencing we screened the exons and intron/exon boundaries of sFRP1 and sFRP4 in 53 patients...
  56. Steck E, Fischer J, Lorenz H, Gotterbarm T, Jung M, Richter W. Mesenchymal stem cell differentiation in an experimental cartilage defect: restriction of hypertrophy to bone-close neocartilage. Stem Cells Dev. 2009;18:969-78 pubmed publisher
    ..Thus, until better in vitro induction protocols become available for chondrogenesis of MSCs, their predifferentiation before transplantation may be unfavorable...
  57. Michels F, De Smet L. Osseous overgrowth in congenital amputations of the upper limb: report of 3 cases treated with autologous stump plasty. Acta Orthop Belg. 2001;67:452-5 pubmed
    ..It is rather exceptional in congenital amputations. We report three cases of congenital amputation of the humerus with osseous overgrowth. They were treated with an autologous stump plasty according to Marquardt's technique...
  58. Noble J. Degenerative sternoclavicular arthritis and hyperostosis. Clin Sports Med. 2003;22:407-22, ix pubmed
    ..joint is relatively uncommon and can be a result of distant trauma, infection, and sternocostoclavicular hyperostosis, post-menopausal arthritis, condensing osteitis of the proximal clavicle, or secondary to an underlying ..
  59. Carlson M, Beatty C, Neff B, Link M, Driscoll C. Skull base manifestations of Camurati-Engelmann disease. Arch Otolaryngol Head Neck Surg. 2010;136:566-75 pubmed publisher
    To describe presenting symptoms, evaluation findings, and surgical management of cranial base hyperostosis in patients with Camurati-Engelmann disease (CED).
  60. Atalay A, Altaykan A, Ergin G, Kutsal Y. Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy. Rheumatol Int. 2004;24:297-300 pubmed
    ..The patient had flowing ossification along thoracic spine resembling diffuse idiopathic skeletal hyperostosis (DISH), but there was no ligament calcification in the lumbar spine or pelvis...
  61. Abraham P. What is the risk of cancer in a child with hemihypertrophy?. Arch Dis Child. 2005;90:1312-3 pubmed
  62. Cho S, Kim S, Lee K, Lee H. New bone formation in unilateral rhinosinusitis. Am J Rhinol. 2007;21:37-9 pubmed
    ..Computed tomography (CT) frequently shows abnormal bone thickening in patients with chronic rhinosinusitis. The sinus bone may be not in a static state, and remodeling occurs in response to chronic inflammation...
  63. Salles M, Olive A, Perez Andres R, Holgado S, Mateo L, Riera E, et al. The SAPHO syndrome: a clinical and imaging study. Clin Rheumatol. 2011;30:245-9 pubmed publisher
    ..is to describe the clinical and radiological manifestations of patients with the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Retrospective study (1984-2007) was performed in a single center...
  64. Altan E, Senaran H, Can N, Aydin B, Erkocak O. Diagnosis of hyperostosis of the medial calcaneal tubercle similar to a heel spur. J Am Podiatr Med Assoc. 2013;103:136-40 pubmed
    ..To our knowledge, we present the first report of a calcaneal osteochondroma in an adolescent patient that was surprisingly similar to a heel spur, and, in addition, symptoms due to compression of the medial plantar nerve were present...
  65. Buzon M. Health of the non-elites at Tombos: Nutritional and disease stress in New Kingdom Nubia. Am J Phys Anthropol. 2006;130:26-37 pubmed
    ..While status may have played a role in the differences seen in the comparative populations, it is likely that parasites and/or other infections led to childhood illness and death...
  66. Morishita K, Kasai Y, Uchida A. Hypertrophic change of facet joint in the cervical spine. Med Sci Monit. 2008;14:CR62-64 pubmed
    ..This study was conducted to examine the image and clinical characteristics of patients with cervical facet hypertrophy and the significance of such characteristics...
  67. Li F, Lu Y, Ding M, Wu G, Sinha S, Wang S, et al. Putative function of TAP63? during endochondral bone formation. Gene. 2012;495:95-103 pubmed publisher
    ..Together, our results suggest a role of TAP63? upon skeletal development. TAP63a may promote endochondral ossification through interaction with genes relevant to matrix mineralization and chondrocyte maturation or apoptosis...
  68. Galadari H, Bishop A, Venna S, Sultan E, Do D, Zeltser R. Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate. J Am Acad Dermatol. 2009;61:123-5 pubmed publisher
    Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin...
  69. Caldarini C, Caprara M, Carboni L, De Angelis F, Di Giannantonio S, Minozzi S, et al. [Life in imperial Rome: new data from recent excavations in Suburbium]. Med Secoli. 2006;18:799-813 pubmed
    ..In particular Harris's lines, porotic hyperostosis and enamel hypoplasia are been considered...
  70. Fleming J, Linder J, Karcioglu Z. Orbital hyperostosis following exenteration. Ophthalmic Plast Reconstr Surg. 2008;24:378-82 pubmed publisher
    To report the development of unilateral, diffuse hyperostosis of orbital bones in 3 postexenteration patients.
  71. Bruno E, Alessandrini M, De Angelis E. [Giant cervical hyperostosis of the prevertebral space: presentation of two cases and review of the literature]. Acta Otorhinolaryngol Ital. 1996;16:532-6 pubmed
    ..The present work describes two clinical cases of hyperostosis of the cervical column both of which presented discrete dysphagia, intermittent dyspnea and swelling in the ..
  72. Ozturk S, Zor F, Coskun U, Gul D, Duzgun S, Sengezer M. Situs inversus totalis with accompanying craniodiaphysial dysplasia: a new syndrome?. J Craniofac Surg. 2004;15:865-9 pubmed
    ..Similar features except situs inversus totalis are also present in two of his sisters. The authors believe this to be the first reported case of CDD with accompanying situs inversus totalis...
  73. Rudmann D, Page T, Vahle J, Chouinard L, Haile S, Poitout F, et al. Rat-specific decreases in platelet count caused by a humanized monoclonal antibody against sclerostin. Toxicol Sci. 2012;125:586-94 pubmed publisher
    ..The species-specific nature of these reversible toxicological findings combined with the ease of clinical monitoring using standard hematology enabled the safe initiation of clinical studies in human volunteers...
  74. Breburda E, Wirth T, Leiser R, Griss P. The influence of intermittent external dynamic pressure and tension forces on the healing of an epiphyseal fracture. Arch Orthop Trauma Surg. 2001;121:443-9 pubmed
    ..We conclude that a temporary ischemia with a reactive hyperemia takes place, which we could document by histological analysis and MRI. These results could modify the current clinical therapy of growth plate fractures...
  75. Nadroo A, Shringari S, Garg M, al Sowailem A. Prostaglandin induced cortical hyperostosis in neonates with cyanotic heart disease. J Perinat Med. 2000;28:447-52 pubmed
    To study the side effects of prolonged prostaglandin therapy especially hyperostosis and other musculoskeletal changes.
  76. Yilmaz A, Musluman A, Cavusoglu H, Colak I, Tanik C, Aydin Y. Meningioma causing hyperostosis of the cranial convexity in a child. J Clin Neurosci. 2010;17:926-9 pubmed publisher
    We present an 8-year-old girl with meningioma-associated hyperostosis. The patient was referred to our clinic due to headache and a frontoparietal midline swelling that was more prominent on the right side of the cranium...
  77. Piters E, Culha C, Moester M, van Bezooijen R, Adriaensen D, Mueller T, et al. First missense mutation in the SOST gene causing sclerosteosis by loss of sclerostin function. Hum Mutat. 2010;31:E1526-43 pubmed publisher
    ..Together with a significant reduced ability to bind to LRP5 and inhibit Wnt signaling, the p.Cys167Arg mutation leads to a complete loss of function of sclerostin and thus to the characteristic sclerosteosis phenotype...
  78. Kacker A, Huang C, Anand V. Incidence of chronic hyperostotic rhinosinusitis in patients undergoing primary sinus surgery compared to revision surgery. Rhinology. 2002;40:80-2 pubmed
    ..The surgical management of chronic hyperostotic rhinosinusitis with prolonged pre and post-operative antibiotic therapy can alter clinical course of the disease process...
  79. Cornero S, Puche R. [Cribra orbitalia (Porotic hyperostosis) in a prehistoric population of Parana Medio]. Medicina (B Aires). 2002;62:169-72 pubmed
    The observation of porotic hyperostosis in the orbits (criba orbitalia) in bone remains of a funeral site at the north of the Santa Fe province strongly suggests the occurrence of severe anemia among dwellers...
  80. Garchar D, Lewis J, DiDomenico L. Hypertrophic sustentaculum tali causing a tarsal tunnel syndrome: a case report. J Foot Ankle Surg. 2001;40:110-2 pubmed
    ..Complete resolution of the patient's symptoms has been obtained through resection of the hypertrophic anatomy. The authors also discuss possible etiologies of tarsal tunnel syndrome...
  81. Stimmer H. Enlargement of the cochlear aqueduct: does it exist?. Eur Arch Otorhinolaryngol. 2011;268:1655-61 pubmed publisher
    ..According to our findings, it seems to be very unlikely that CA-enlargement is a reason for pathologic inner ear condition as it is in case of large vestibular aqueduct...