virus uncoating


Summary: Intracellular step that follows VIRUS INTERNALIZATION during which the viral nucleic acid and CAPSID are separated.

Top Publications

  1. Rankovic S, Varadarajan J, Ramalho R, Aiken C, Rousso I. Reverse Transcription Mechanically Initiates HIV-1 Capsid Disassembly. J Virol. 2017;91: pubmed publisher
    ..The application of AFM technologies to study purified HIV-1 cores represents a new experimental platform for elucidating additional aspects of capsid disassembly and HIV-1 uncoating. ..
  2. Huffman J, Daniel G, Falck Pedersen E, Huet A, Smith G, Conway J, et al. The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores. J Virol. 2017;91: pubmed publisher
    ..pUL25 is found at each of the capsid vertices as part of the capsid vertex-specific component and implicates the importance of this complex for NPC binding and genome release. ..
  3. Burdick R, Delviks Frankenberry K, Chen J, Janaka S, Sastri J, HU W, et al. Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes. PLoS Pathog. 2017;13:e1006570 pubmed publisher
    ..These studies provide novel insights into the dynamics of viral complex-NE association, regulation of nuclear import, viral core uncoating, and intranuclear movements that precede integration site selection. ..
  4. Andrade A, Rodrigues R, Oliveira G, Andrade K, Bonjardim C, La Scola B, et al. Filling Knowledge Gaps for Mimivirus Entry, Uncoating, and Morphogenesis. J Virol. 2017;91: pubmed publisher
    ..Furthermore, we demonstrate that atypical virion morphologies can occur even in the absence of virophages. Our results, along with previous data, allow us to present an ultimate model for the mimivirus replication cycle. ..