quorum sensing

Summary

Summary: A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.

Top Publications

  1. Boedicker J, Vincent M, Ismagilov R. Microfluidic confinement of single cells of bacteria in small volumes initiates high-density behavior of quorum sensing and growth and reveals its variability. Angew Chem Int Ed Engl. 2009;48:5908-11 pubmed publisher
  2. Shao H, Demuth D. Quorum sensing regulation of biofilm growth and gene expression by oral bacteria and periodontal pathogens. Periodontol 2000. 2010;52:53-67 pubmed publisher
  3. Feliziani S, Luján A, Moyano A, Sola C, Bocco J, Montanaro P, et al. Mucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections. PLoS ONE. 2010;5: pubmed publisher
    ..Among these, mutations inactivating the regulators MucA (alginate biosynthesis), LasR (quorum sensing) and MexZ (multidrug-efflux pump MexXY) are the most frequently observed, with those inactivating the DNA ..
  4. Uroz S, Dessaux Y, Oger P. Quorum sensing and quorum quenching: the yin and yang of bacterial communication. Chembiochem. 2009;10:205-16 pubmed publisher
  5. Smith A, Rice A, Sutton B, Gabrilska R, Wessel A, Whiteley M, et al. Albumin Inhibits Pseudomonas aeruginosa Quorum Sensing and Alters Polymicrobial Interactions. Infect Immun. 2017;85: pubmed publisher
    ..aeruginosa and S. aureus We demonstrate that P. aeruginosa quorum sensing is inhibited by physiological levels of serum albumin, which appears to bind and sequester some homoserine ..
  6. Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, et al. High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology. 2017;163:754-764 pubmed publisher
    ..We also demonstrate that the intracellular c-di-GMP level determines the virulence of B. cenocepacia to Caenorhabditis elegans and Galleria mellonella. ..
  7. Lopez M, Mayer C, Fernández García L, Blasco L, Muras A, Ruiz F, et al. Quorum sensing network in clinical strains of A. baumannii: AidA is a new quorum quenching enzyme. PLoS ONE. 2017;12:e0174454 pubmed publisher
    ..Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen...
  8. Fuller A, Young P, Pierce B, Kitson Finuff J, Jain P, Schneider K, et al. Redox-mediated quorum sensing in plants. PLoS ONE. 2017;12:e0182655 pubmed publisher
    ..Mechanistically, this chemistry is similar to black and white photography with the emerging dynamic reaction-diffusion network laying the foundation for the precise temporal and spatial control underlying rhizosphere architecture...
  9. Crowe D, Nicholson A, Fleming A, Carey E, Sánchez Sanz G, Kelleher F. Conformational studies of Gram-negative bacterial quorum sensing 3-oxo N-acyl homoserine lactone molecules. Bioorg Med Chem. 2017;25:4285-4296 pubmed publisher

More Information

Publications77

  1. Szafranski S, Deng Z, Tomasch J, Jarek M, Bhuju S, Rohde M, et al. Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome. BMC Genomics. 2017;18:238 pubmed publisher
    ..act.), triggers expression of the quorum sensing (QS) regulon of Streptococcus mutans, a well-studied model organism for cariogenic streptococci, in dual-..
  2. Luo J, Dong B, Wang K, Cai S, Liu T, Cheng X, et al. Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal implant infection model. PLoS ONE. 2017;12:e0176883 pubmed publisher
    The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling virulence factors and biofilm formation in Pseudomonas aeruginosa...
  3. Kleinman C, Sycz G, Bonomi H, Rodríguez R, Zorreguieta A, Sieira R. ChIP-seq analysis of the LuxR-type regulator VjbR reveals novel insights into the Brucella virulence gene expression network. Nucleic Acids Res. 2017;45:5757-5769 pubmed publisher
    ..Taken together, our results bring new insights into the extent and functionality of LuxR-type-related transcriptional networks. ..
  4. Venturi V, Ahmer B. Editorial: LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria. Front Cell Infect Microbiol. 2015;5:89 pubmed publisher
  5. Richter K, Van den Driessche F, Coenye T. Innovative approaches to treat Staphylococcus aureus biofilm-related infections. Essays Biochem. 2017;61:61-70 pubmed publisher
    ..important human pathogen Staphylococcus aureus: (i) targeting the bacterial communication system with quorum sensing (QS) inhibitors, (ii) a 'Trojan Horse' strategy to disturb iron metabolism by using gallium-based therapeutics ..
  6. Abbas H, Shaldam M. Glyceryl trinitrate is a novel inhibitor of quorum sensing in Pseudomonas aeruginosa. Afr Health Sci. 2016;16:1109-1117 pubmed publisher
    Targeting quorum sensing is an alternative approach to antibiotics.Targeting quorum sensing-regulated virulence will disarm the pathogen without exerting pressure on its growth...
  7. Lasarre B, Aggarwal C, Federle M. Antagonistic Rgg regulators mediate quorum sensing via competitive DNA binding in Streptococcus pyogenes. MBio. 2013;3: pubmed publisher
    ..the fact that multiple members of the Rgg family of transcriptional regulators serve as key components of quorum sensing (QS) pathways that utilize peptides as intercellular signaling molecules...
  8. Silva K, Chellamuthu P, Boedicker J. Quantifying the strength of quorum sensing crosstalk within microbial communities. PLoS Comput Biol. 2017;13:e1005809 pubmed publisher
    ..This process, commonly known as quorum sensing, aids in the regulation of genes crucial for the survival of species within heterogeneous populations of ..
  9. Neethirajan S, Clond M, Vogt A. Medical biofilms--nanotechnology approaches. J Biomed Nanotechnol. 2014;10:2806-27 pubmed
  10. Park J, Ryu E, Li L, Choi B, Kim B. New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation. Eur J Med Chem. 2017;137:76-87 pubmed publisher
    ..factor secretion and biofilm formation are critical for survival, and are effectively regulated through quorum sensing, a mechanism of intra- and interspecies communication in response to changes in cell density and species ..
  11. Zimmermann H, Subota I, Batram C, Kramer S, Janzen C, Jones N, et al. A quorum sensing-independent path to stumpy development in Trypanosoma brucei. PLoS Pathog. 2017;13:e1006324 pubmed publisher
    For persistent infections of the mammalian host, African trypanosomes limit their population size by quorum sensing of the parasite-excreted stumpy induction factor (SIF), which induces development to the tsetse-infective stumpy stage...
  12. Prateeksha -, Singh B, Shoeb M, Sharma S, Naqvi A, Gupta V, et al. Scaffold of Selenium Nanovectors and Honey Phytochemicals for Inhibition of Pseudomonas aeruginosa Quorum Sensing and Biofilm Formation. Front Cell Infect Microbiol. 2017;7:93 pubmed publisher
    Honey is an excellent source of polyphenolic compounds that are effective in attenuating quorum sensing (QS), a chemical process of cell-to-cell communication system used by the opportunistic pathogen Pseudomonas aeruginosa to ..
  13. Sørensen M, Dahl P, Sams T. How fast is a collective bacterial state established?. PLoS ONE. 2017;12:e0180199 pubmed publisher
    ..The quorum sensing systems controlling this involve production and sensing of diffusive signal molecules...
  14. Deng Y, Wu J, Tao F, Zhang L. Listening to a new language: DSF-based quorum sensing in Gram-negative bacteria. Chem Rev. 2011;111:160-73 pubmed publisher
  15. Rutherford S, Bassler B. Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med. 2012;2: pubmed publisher
    b>Quorum sensing is a process of cell-cell communication that allows bacteria to share information about cell density and adjust gene expression accordingly...
  16. Boopathi S, Vashisth R, Manoharan P, Kandasamy R, Sivakumar N. Stigmatellin Y - An anti-biofilm compound from Bacillus subtilis BR4 possibly interferes in PQS-PqsR mediated quorum sensing system in Pseudomonas aeruginosa. Bioorg Med Chem Lett. 2017;27:2113-2118 pubmed publisher
    ..Stigmatellin Y thus might play a role of competitor for PQS to distract PQS-PqsR mediated communication in P. aeruginosa. The present investigation thus paves new avenues to develop anti-Pseudomonas virulent therapy. ..
  17. Albuquerque P, Nicola A, Nieves E, Paes H, Williamson P, Silva Pereira I, et al. Quorum sensing-mediated, cell density-dependent regulation of growth and virulence in Cryptococcus neoformans. MBio. 2013;5:e00986-13 pubmed publisher
    b>Quorum sensing (QS) is a cell density-dependent mechanism of communication between microorganisms, characterized by the release of signaling molecules that affect microbial metabolism and gene expression in a synchronized way...
  18. Thompson J, Oliveira R, Djukovic A, Ubeda C, Xavier K. Manipulation of the quorum sensing signal AI-2 affects the antibiotic-treated gut microbiota. Cell Rep. 2015;10:1861-71 pubmed
    ..Given that bacteria use signals to communicate and regulate group behaviors (quorum sensing), we asked whether such communication between different commensal species can influence the interactions ..
  19. Decho A, Frey R, Ferry J. Chemical challenges to bacterial AHL signaling in the environment. Chem Rev. 2011;111:86-99 pubmed publisher
  20. Pistorius D, Ullrich A, Lucas S, Hartmann R, Kazmaier U, Muller R. Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity. Chembiochem. 2011;12:850-3 pubmed publisher
  21. Berger C, Rosenbaum M. Spontaneous quorum sensing mutation modulates electroactivity of Pseudomonas aeruginosa PA14. Bioelectrochemistry. 2017;117:1-8 pubmed publisher
    ..aeruginosa PA14 and the wildtype, we investigated the connection between the complex quorum sensing network and current production...
  22. Waheed H, Xiao Y, Hashmi I, Stuckey D, Zhou Y. Insights into quorum quenching mechanisms to control membrane biofouling under changing organic loading rates. Chemosphere. 2017;182:40-47 pubmed publisher
    ..In contrast, the pore blockage resistance became dominant in QQ MBRs (>40%). ..
  23. Kratochvil M, Yang T, Blackwell H, Lynn D. Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control. ACS Infect Dis. 2017;3:271-280 pubmed publisher
    We report the fabrication and biological evaluation of nonwoven polymer nanofiber coatings that inhibit quorum sensing (QS) and virulence in the human pathogen Staphylococcus aureus...
  24. Ball A, Chaparian R, van Kessel J. Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios. J Bacteriol. 2017;199: pubmed publisher
    The coordination of group behaviors in bacteria is accomplished via the cell-cell signaling process called quorum sensing. Vibrios have historically been models for studying bacterial communication due to the diverse and remarkable ..
  25. Lo Scrudato M, Borgeaud S, Blokesch M. Regulatory elements involved in the expression of competence genes in naturally transformable Vibrio cholerae. BMC Microbiol. 2014;14:327 pubmed publisher
    ..Natural competence is regulated by at least three pathways in this organism: chitin sensing/degradation, quorum sensing and carbon catabolite repression (CCR)...
  26. Martinez L, Casadevall A. Biofilm Formation by Cryptococcus neoformans. Microbiol Spectr. 2015;3: pubmed publisher
    ..of cryptococcal biofilms, including the role of its polysaccharide capsule in adherence, gene expression, and quorum sensing in biofilm formation...
  27. Tsuchikama K, Shimamoto Y, Anami Y. Truncated Autoinducing Peptide Conjugates Selectively Recognize and Kill Staphylococcus aureus. ACS Infect Dis. 2017;3:406-410 pubmed publisher
    ..aureus cell-killing assay than a nontargeting analogue. These findings highlight the potential of truncated AIP conjugates as useful chemical tools for in-depth biological studies and as effective anti-S. aureus agents...
  28. Antonova E, Hammer B. Genetics of Natural Competence in Vibrio cholerae and other Vibrios. Microbiol Spectr. 2015;3: pubmed publisher
    ..cholerae isolates and other Vibrio species. ..
  29. Mizan M, Bang H, Sadekuzzaman M, Lee N, Kim T, Ha S. Molecular characteristics, biofilm-forming abilities, and quorum sensing molecules in Vibrio parahaemolyticus strains isolated from marine and clinical environments in Korea. Biofouling. 2017;33:369-378 pubmed publisher
    ..The presence of tdh-positive V. parahaemolyticus in marine samples highlights the need for constant environmental monitoring to protect public health. ..
  30. Verbeurgt C, Veithen A, Carlot S, Tarabichi M, Dumont J, Hassid S, et al. The human bitter taste receptor T2R38 is broadly tuned for bacterial compounds. PLoS ONE. 2017;12:e0181302 pubmed publisher
    ..T2R38 was previously reported to bind to homoserine lactones (HSL), quorum sensing molecules specific of Pseudomonas Aeruginosa and other gram negative species...
  31. Hubaud A, Regev I, Mahadevan L, Pourquie O. Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock. Cell. 2017;171:668-682.e11 pubmed publisher
    ..oscillations are a collective property of PSM cells that can be actively triggered in vitro by a dynamical quorum sensing signal involving Yap and Notch signaling...
  32. Patel B, Kumari S, Banerjee R, Samanta M, Das S. Disruption of the quorum sensing regulated pathogenic traits of the biofilm-forming fish pathogen Aeromonas hydrophila by tannic acid, a potent quorum quencher. Biofouling. 2017;33:580-590 pubmed publisher
    The quorum sensing (QS) phenomenon regulates a myriad of pathogenic traits in the biofilm forming fish pathogen, Aeromonas hydrophila. Blocking the QS mechanism of A. hydrophila is a novel strategy to prevent disease in fish...
  33. Thompson S, Coates J. Surface sensing and stress-signalling in Ulva and fouling diatoms - potential targets for antifouling: a review. Biofouling. 2017;33:410-432 pubmed publisher
    ..Targets for future antifouling coatings based on surface sensing are discussed, with an emphasis on pursuing NO-releasing coatings as a potentially universal antifouling strategy. ..
  34. Nandakumar N, Dandela R, Gopas J, Meijler M. Quorum sensing modulators exhibit cytotoxicity in Hodgkin's lymphoma cells and interfere with NF-?B signaling. Bioorg Med Chem Lett. 2017;27:2967-2973 pubmed publisher
    ..We have evaluated the cytotoxic effects and NF-?B inhibitory activities of a panel of quorum sensing molecules and their reactive analogs on Hodgkin's lymphoma cells (L428)...
  35. van Kessel J, Ulrich L, Zhulin I, Bassler B. Analysis of activator and repressor functions reveals the requirements for transcriptional control by LuxR, the master regulator of quorum sensing in Vibrio harveyi. MBio. 2013;4: pubmed publisher
    LuxR-type transcription factors are the master regulators of quorum sensing in vibrios. LuxR proteins are unique members of the TetR superfamily of transcription factors because they activate and repress large regulons of genes...
  36. Pennisi E. Origins. On the origin of cooperation. Science. 2009;325:1196-9 pubmed publisher
  37. Fusetani N. Antifouling marine natural products. Nat Prod Rep. 2011;28:400-10 pubmed publisher
  38. Potera C. Quorum-sensing signal disperses bacteria from biofilms. Environ Health Perspect. 2012;120:A420 pubmed publisher
  39. El Gohary N, Shaaban M. Synthesis, antimicrobial, antiquorum-sensing and antitumor activities of new benzimidazole analogs. Eur J Med Chem. 2017;137:439-449 pubmed publisher
    ..The in silico studies illustrated that all of the new benzimidazoles meet the optimal requirements for good oral absorption and bioavailability. Moreover, in silico toxicity assessment has been reported. ..
  40. Weiland Bräuer N, Pinnow N, Schmitz R. Novel reporter for identification of interference with acyl homoserine lactone and autoinducer-2 quorum sensing. Appl Environ Microbiol. 2015;81:1477-89 pubmed
    Two reporter strains were established to identify novel biomolecules interfering with bacterial communication (quorum sensing [QS])...
  41. Mellbye B, Schuster M. The sociomicrobiology of antivirulence drug resistance: a proof of concept. MBio. 2011;2: pubmed publisher
    ..b>Quorum sensing (QS) often controls cooperative virulence factor production and is therefore an attractive antivirulence ..
  42. Nguyen Y, Nguyen N, Rogers J, Liao J, Macmillan J, Jiang Y, et al. Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator. MBio. 2015;6: pubmed publisher
    Bacteria engage in chemical signaling, termed quorum sensing (QS), to mediate intercellular communication, mimicking multicellular organisms...
  43. Chan X, How K, Yin W, Chan K. N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Aeromonas veronii biovar sobria Strain 159: Identification of LuxRI Homologs. Front Cell Infect Microbiol. 2016;6:7 pubmed publisher
  44. Cheng Y, Zhang Y, Shen Q, Gao J, Zhuang G, Zhuang X. Effects of exogenous short-chain N-acyl homoserine lactone on denitrifying process of Paracoccus denitrificans. J Environ Sci (China). 2017;54:33-39 pubmed publisher
    ..In contrast, exogenous C6-HSL stimulated the production of N2O under anaerobic condition, suggesting that the regulation of denitrification by quorum sensing may be important in N2O release.
  45. Kuboniwa M, Lamont R. Subgingival biofilm formation. Periodontol 2000. 2010;52:38-52 pubmed publisher
  46. Fernández Niño M, Giraldo D, Gomez Porras J, Dreyer I, González Barrios A, Arevalo Ferro C. A synthetic multi-cellular network of coupled self-sustained oscillators. PLoS ONE. 2017;12:e0180155 pubmed publisher
    ..The proposed artificial multicellular network provides a system framework for exploring how a given network generates a specific behaviour. ..
  47. Madhani H. Quorum sensing in fungi: Q&A. PLoS Pathog. 2011;7:e1002301 pubmed publisher
  48. Tiwary B, Ghosh R, Moktan S, Ranjan V, Dey P, Choudhury D, et al. Prospective bacterial quorum sensing inhibitors from Indian medicinal plant extracts. Lett Appl Microbiol. 2017;65:2-10 pubmed publisher
    As virulence of many pathogenic bacteria is regulated by the phenomenon of quorum sensing (QS), the present study aimed to find the QS-inhibiting (QS-I) property (if any) in 61 Indian medicinal plants...
  49. Mallick E, Bennett R. Sensing of the microbial neighborhood by Candida albicans. PLoS Pathog. 2013;9:e1003661 pubmed publisher
  50. Gui M, Wu R, Liu L, Wang S, Zhang L, Li P. Effects of quorum quenching by AHL lactonase on AHLs, protease, motility and proteome patterns in Aeromonas veronii LP-11. Int J Food Microbiol. 2017;252:61-68 pubmed publisher
    Food spoilage by some bacteria is reported to be regulated by quorum sensing (QS)...
  51. Din M, Danino T, Prindle A, Skalak M, Selimkhanov J, Allen K, et al. Synchronized cycles of bacterial lysis for in vivo delivery. Nature. 2016;536:81-85 pubmed publisher
    ..Our approach establishes a methodology for leveraging the tools of synthetic biology to exploit the natural propensity for certain bacteria to colonize disease sites. ..
  52. Bedi B, Maurice N, Ciavatta V, Lynn K, Yuan Z, Molina S, et al. Peroxisome proliferator-activated receptor-? agonists attenuate biofilm formation by Pseudomonas aeruginosa. FASEB J. 2017;31:3608-3621 pubmed publisher
    ..b>Quorum sensing (QS) is a mechanism wherein P...
  53. Ferrer Navarro M, Planell R, Yero D, Mongiardini E, Torrent G, Huedo P, et al. Abundance of the Quorum-Sensing Factor Ax21 in Four Strains of Stenotrophomonas maltophilia Correlates with Mortality Rate in a New Zebrafish Model of Infection. PLoS ONE. 2013;8:e67207 pubmed publisher
    ..Indeed, recent studies have demonstrated that this protein is a quorum-sensing-related virulence factor. ..
  54. D Almeida R, Molina R, Viola C, Luciardi M, Nieto Penalver C, Bardon A, et al. Comparison of seven structurally related coumarins on the inhibition of Quorum sensing of Pseudomonas aeruginosa and Chromobacterium violaceum. Bioorg Chem. 2017;73:37-42 pubmed publisher
    b>Quorum sensing (QS) is a cell-to-cell signaling communication system that controls the virulence behavior of a broad spectrum of bacterial pathogens, participating also in the development of biofilms, responsible of the antibiotic ..
  55. Riekhof W, Nickerson K. Quorum sensing in Candida albicans: farnesol versus farnesoic acid. FEBS Lett. 2017;591:1637-1640 pubmed publisher
    ..Read the Original article at doi: 10.1002/1873-3468.12636. ..
  56. Fan G, Bressloff P. Population Model of Quorum Sensing with Multiple Parallel Pathways. Bull Math Biol. 2017;79:2599-2626 pubmed publisher
    b>Quorum sensing (QS) is a bacterial communication mechanism that uses signal-receptor binding to regulate gene expression based on cell density, resulting in group behaviors such as biofilm formation, bioluminescence and stress response...
  57. Niu W, Guo J, Lian J, Song Y, Lu C, Li H, et al. Rapid start-up of denitrifying granular sludge by dosing with semi-starvation fluctuation C/N ratio strategy. Bioresour Technol. 2017;241:945-950 pubmed publisher
    ..The result demonstrates that ppGpp, AHLs, EPS and the denitrifying sludge granulation process are associated. A mechanism for denitrifying sludge granulation with SSF strategy was proposed from the aspect of quorum sensing (QS).
  58. Galetti R, Andrade L, Clímaco E, Pitondo Silva A, Ferreira J, Darini A. Genomic diversification and virulence features in SPM-1-producing Pseudomonas aeruginosa 13 years later. Diagn Microbiol Infect Dis. 2015;82:179-80 pubmed publisher
  59. Marsh P, Moter A, Devine D. Dental plaque biofilms: communities, conflict and control. Periodontol 2000. 2011;55:16-35 pubmed publisher
  60. Blackwell H, Fuqua C. Introduction to bacterial signals and chemical communication. Chem Rev. 2011;111:1-3 pubmed publisher
  61. Witzgall F, Ewert W, Blankenfeldt W. Structures of the N-Terminal Domain of PqsA in Complex with Anthraniloyl- and 6-Fluoroanthraniloyl-AMP: Substrate Activation in Pseudomonas Quinolone Signal (PQS) Biosynthesis. Chembiochem. 2017;18:2045-2055 pubmed publisher
    ..The complex with 6FABA-AMP explains why 6FABA, an inhibitor of PQS biosynthesis, is a good substrate of PqsA. Together, our data might pave a way to new pathoblockers in P.?aeruginosa infections. ..
  62. Gerdt J, Wittenwyler D, Combs J, Boursier M, Brummond J, Xu H, et al. Chemical Interrogation of LuxR-type Quorum Sensing Receptors Reveals New Insights into Receptor Selectivity and the Potential for Interspecies Bacterial Signaling. ACS Chem Biol. 2017;12:2457-2464 pubmed publisher
    ..In addition, we discovered a set of AHLs that could be used to selectively activate LasR and selectively inhibit AbaR in polymicrobial experiments. ..
  63. Arciola C. New concepts and new weapons in implant infections. Int J Artif Organs. 2009;32:533-6 pubmed
    ..the cascade of regulatory genes in bacteria so as to interfere with biofilm production using gene therapy or quorum sensing inhibitors are also discussed in this issue...
  64. Shi Y, Huang J, Zeng G, Gu Y, Chen Y, Hu Y, et al. Exploiting extracellular polymeric substances (EPS) controlling strategies for performance enhancement of biological wastewater treatments: An overview. Chemosphere. 2017;180:396-411 pubmed publisher
    ..aggregates performance and in alleviating membrane fouling, including limitation strategies (inhibition of quorum sensing (QS) systems, regulation of environmental conditions, enzymatic degradation of key components, energy ..
  65. Szermer Olearnik B, Drab M, Mąkosa M, Zembala M, Barbasz J, Dabrowska K, et al. Aggregation/dispersion transitions of T4 phage triggered by environmental ion availability. J Nanobiotechnology. 2017;15:32 pubmed publisher
    ..Our results implicate operation of group behavior in phage and suggest a new kind of quorum sensing among its virions that is mediated by ions...
  66. Armbruster C, Hong W, Pang B, Weimer K, Juneau R, Turner J, et al. Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. MBio. 2010;1: pubmed publisher
    ..influenzae strains that cause airway infections may also significantly impact chronic M. catarrhalis disease by removing a reservoir of the AI-2 signal that promotes M. catarrhalis persistence within biofilm. ..
  67. Pollitt E, Diggle S. Defining motility in the Staphylococci. Cell Mol Life Sci. 2017;74:2943-2958 pubmed publisher
    ..We discuss the characteristics of the various forms of Staphylococci motility, the molecular mechanisms involved and the potential future research directions. ..
  68. Galloway W, Hodgkinson J, Bowden S, Welch M, Spring D. Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways. Chem Rev. 2011;111:28-67 pubmed publisher