microbial interactions


Summary: The inter- and intra-relationships between various microorganisms. This can include both positive (like SYMBIOSIS) and negative (like ANTIBIOSIS) interactions. Examples include virus - bacteria and bacteria - bacteria.

Top Publications

  1. Saghaï A, Gutiérrez Preciado A, Deschamps P, Moreira D, Bertolino P, Ragon M, et al. Unveiling microbial interactions in stratified mat communities from a warm saline shallow pond. Environ Microbiol. 2017;19:2405-2421 pubmed publisher
    ..We identified potential biotic interactions between various high- and low-rank taxa. Notably, a strong positive correlation was observed between Lokiarchaeota and the poorly known candidate bacterial division TA06. ..
  2. Farag M, Song G, Park Y, Audrain B, Lee S, Ghigo J, et al. Biological and chemical strategies for exploring inter- and intra-kingdom communication mediated via bacterial volatile signals. Nat Protoc. 2017;12:1359-1377 pubmed publisher
    ..Using both these procedures, bacteria-bacteria communications and bacteria-plant interactions mediated by BVCs can be rapidly investigated (within 1-4 weeks). ..
  3. Limoli D, Whitfield G, Kitao T, Ivey M, Davis M, Grahl N, et al. Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection. MBio. 2017;8: pubmed publisher
    ..aeruginosa can coexist with S. aureus Finally, the approach used here can serve as a platform to investigate the interactions among other CF pathogens. ..
  4. Tsui C, Kong E, Jabra Rizk M. Pathogenesis of Candida albicans biofilm. Pathog Dis. 2016;74:ftw018 pubmed
    ..Further, the classes of antifungal agents used to combat these resilient infections are discussed along with mechanisms of drug resistance. ..
  5. Hidalgo Cantabrana C, Delgado S, Ruiz L, Ruas Madiedo P, Sanchez B, Margolles A. Bifidobacteria and Their Health-Promoting Effects. Microbiol Spectr. 2017;5: pubmed publisher
    ..In this review, we focus on the role of bifidobacteria as members of the human intestinal microbiota and their use as probiotics in the prevention and treatment of disease. ..
  6. Han Z, Willer T, Li L, Pielsticker C, Rychlik I, Velge P, et al. Influence of the Gut Microbiota Composition on Campylobacter jejuni Colonization in Chickens. Infect Immun. 2017;85: pubmed publisher
    ..jejuni colonization and prevent lesion development. Further studies are needed to identify key players of the gut microbiota and the mechanisms behind their protective role. ..
  7. Espinoza R, Silva Valenzuela C, Amaya F, Urrutia Í, Contreras I, Santiviago C. Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages. Biol Res. 2017;50:5 pubmed publisher
    ..Typhi with murine or human macrophages. We hypothesized that typhoid serovars have lost SPI-13 and maintained SPI-8 to improve their fitness during another phase of human infection. ..
  8. Thapa S, Pant N, Shrestha R, Gc G, Shrestha B, Pandey B, et al. Prevalence of dengue and diversity of cultivable bacteria in vector Aedes aegypti (L.) from two dengue endemic districts, Kanchanpur and Parsa of Nepal. J Health Popul Nutr. 2017;36:5 pubmed publisher
    ..aegypti. The paratransgenic approach to control vector might be possible by spreading the genetically modified bacteria in larval habitat or shelter of adult mosquitoes. ..
  9. Sharma A. Virulence mechanisms of Tannerella forsythia. Periodontol 2000. 2010;54:106-16 pubmed publisher

More Information


  1. Xu H, Jenkinson H, Dongari Bagtzoglou A. Innocent until proven guilty: mechanisms and roles of Streptococcus-Candida interactions in oral health and disease. Mol Oral Microbiol. 2014;29:99-116 pubmed
    ..In this review we summarize the literature on molecular interactions between members of this streptococcal group and C. albicans, with emphasis on their potential role in the pathogenesis of opportunistic oral mucosal infections. ..
  2. Chimileski S, Franklin M, Papke R. Biofilms formed by the archaeon Haloferax volcanii exhibit cellular differentiation and social motility, and facilitate horizontal gene transfer. BMC Biol. 2014;12:65 pubmed publisher
    ..Because H. volcanii has one of the most advanced genetic systems for any archaeon, the phenotypes reported here may promote the study of genetic and developmental processes in archaeal biofilms. ..
  3. Gallegos Monterrosa R, Kankel S, Götze S, Barnett R, Stallforth P, Kovács Ã. Lysinibacillus fusiformis M5 Induces Increased Complexity in Bacillus subtilis 168 Colony Biofilms via Hypoxanthine. J Bacteriol. 2017;199: pubmed publisher
    ..fusiformis as a soil bacterium that is able to live alongside B. subtilis and modify the architecture of its biofilms. ..
  4. Petrovich M, Wu C, Rosenthal A, Chen K, Packman A, Wells G. Nitrosomonas europaea biofilm formation is enhanced by Pseudomonas aeruginosa. FEMS Microbiol Ecol. 2017;93: pubmed publisher
    ..europaea in biofilms. This favorable association of N. europaea with heterotrophic biofilms is expected to facilitate development of improved strategies for retention of N. europaea and other slow-growing AOB in engineered bioreactors...
  5. Kumar K, Lall C, Raj R, Vedhagiri K, Vijayachari P. Coexistence and survival of pathogenic leptospires by formation of biofilm with Azospirillum. FEMS Microbiol Ecol. 2015;91: pubmed publisher
    ..However, the mechanism of biofilm formation by leptospires needs to be explored to help devise an appropriate control strategy and reduce transmission of leptospires. ..
  6. O Donnell L, Millhouse E, Sherry L, Kean R, Malcolm J, Nile C, et al. Polymicrobial Candida biofilms: friends and foe in the oral cavity. FEMS Yeast Res. 2015;15: pubmed publisher
    ..studies and deep sequencing has enabled us to develop a greater understanding of how positive and negative microbial interactions influence disease outcomes...
  7. Raio A, Reveglia P, Puopolo G, Cimmino A, Danti R, Evidente A. Involvement of phenazine-1-carboxylic acid in the interaction between Pseudomonas chlororaphis subsp. aureofaciens strain M71 and Seiridium cardinale in vivo. Microbiol Res. 2017;199:49-56 pubmed publisher
    ..All these data support that the biological control of S. cardinale achieved by the application of P. chlororaphis subsp. aureofaciens M71 relies mainly on the ability of the bacterial strain to produce PCA in planta. ..
  8. Gómez Garzón C, Hernández Santana A, Dussan J. A genome-scale metabolic reconstruction of Lysinibacillus sphaericus unveils unexploited biotechnological potentials. PLoS ONE. 2017;12:e0179666 pubmed publisher
    ..Similarly, we highlighted the unanswered questions to be responded in order to gain a deeper understanding of the L. sphaericus TL biology. ..
  9. Song C, Li H, Zhang Y, Yu J. Effects of Pseudomonas aeruginosa and Streptococcus mitis mixed infection on TLR4-mediated immune response in acute pneumonia mouse model. BMC Microbiol. 2017;17:82 pubmed publisher
    ..05). Our results demonstrated that infection with S. mitis together with P. aeruginosa could alleviate lung inflammation in acute lung infection mouse models possibly via the TLR4 signaling pathway. ..
  10. Koo H, Bowen W. Candida albicans and Streptococcus mutans: a potential synergistic alliance to cause virulent tooth decay in children. Future Microbiol. 2014;9:1295-7 pubmed publisher
  11. Hotterbeekx A, Kumar Singh S, Goossens H, Malhotra Kumar S. In vivo and In vitro Interactions between Pseudomonas aeruginosa and Staphylococcus spp. Front Cell Infect Microbiol. 2017;7:106 pubmed publisher
    ..focusing on S. aureus, that not only is interesting from the bacterial evolution point of view, but also has important consequences for our understanding of the disease pathogenesis for better patient management. ..
  12. Kononen E, Müller H. Microbiology of aggressive periodontitis. Periodontol 2000. 2014;65:46-78 pubmed publisher
  13. Papanicolaou G. Severe influenza and S. aureus pneumonia: for whom the bell tolls?. Virulence. 2013;4:666-8 pubmed publisher
  14. Traxler M, Watrous J, Alexandrov T, Dorrestein P, Kolter R. Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome. MBio. 2013;4: pubmed publisher
    ..These findings suggest that chemical interactions between actinomycetes are surprisingly complex and that coculture may be a promising strategy for finding new molecules from actinomycetes. ..
  15. Mirzaei M, Maurice C. Ménage à trois in the human gut: interactions between host, bacteria and phages. Nat Rev Microbiol. 2017;15:397-408 pubmed publisher
    ..As the most abundant biological entities in our gut, we must consider bacteriophages in our pursuit of personalized medicine. ..
  16. Marchal M, Goldschmidt F, Derksen Müller S, Panke S, Ackermann M, Johnson D. A passive mutualistic interaction promotes the evolution of spatial structure within microbial populations. BMC Evol Biol. 2017;17:106 pubmed publisher
  17. Fierer N, Ladau J. Predicting microbial distributions in space and time. Nat Methods. 2012;9:549-51 pubmed publisher
  18. Stevens M, Luo T, Vornhagen J, Jakubovics N, Gilsdorf J, Marrs C, et al. Coaggregation occurs between microorganisms isolated from different environments. FEMS Microbiol Ecol. 2015;91: pubmed publisher
    ..We propose that these organisms be labeled as 'cross-environment coaggregating organisms'. The ability to coaggregate may aid species to colonize non-indigenous biofilms. ..
  19. Lin C, Lin C, Wang Y, Liu F, Chien Y, Chuang Y, et al. Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC Syst Biol. 2014;8 Suppl 5:S6 pubmed publisher
    ..albicans and zebrafish during their competition for iron and glucose. Our proposed method can be easily extended to identify other such networks involved in the competition for essential resources during infection. ..
  20. Létoffé S, Audrain B, Bernier S, Delepierre M, Ghigo J. Aerial exposure to the bacterial volatile compound trimethylamine modifies antibiotic resistance of physically separated bacteria by raising culture medium pH. MBio. 2014;5:e00944-13 pubmed publisher
  21. Fleischmann J, Broeckling C, Lyons S. Candida krusei form mycelia along agar surfaces towards each other and other Candida species. BMC Microbiol. 2017;17:60 pubmed publisher
    ..We detected secretion of farnesol, tyrosol and tryptophol by C. krusei but none of these molecules induced this activity on agar surface making it unlikely that they are the ones utilized by this yeast for this activity. ..
  22. Shaw G, Liu A, Weng C, Chou C, Wang D. Inferring microbial interactions in thermophilic and mesophilic anaerobic digestion of hog waste. PLoS ONE. 2017;12:e0181395 pubmed publisher
    ..This research is still in its infancy, but it can help to depict the dynamics of microbial ecosystems and to lay the groundwork for understanding how microorganisms cohabit in the anaerobic digester. ..
  23. Blaser M. The microbiome revolution. J Clin Invest. 2014;124:4162-5 pubmed publisher
    ..difficile; how our microbiome mediates metabolism of xenobiotics; how the microbiota contribute to immunity as well as to metabolic and inflammatory diseases; and the role of commensal microbes in oncogenesis. ..
  24. Tan C, Wong P, Li M, Yang H, Ng L, O Neill S. wMel limits zika and chikungunya virus infection in a Singapore Wolbachia-introgressed Ae. aegypti strain, wMel-Sg. PLoS Negl Trop Dis. 2017;11:e0005496 pubmed publisher
    ..aegypti genetic background. These results also strongly suggest that female Aedes aegypti carrying Wolbachia will have a reduced capacity to transmit ZIKV and CHIKV. ..
  25. Jarzembowski T, Daca A, Witkowski J, Rutkowski B, Gołebiewska J, Debska Slizien A. Does CMV infection impact the virulence of Enterococcus faecalis?. Virulence. 2013;4:641-5 pubmed publisher
  26. Ribera J, Gandía M, Marcos J, Bas M, Fink S, Schwarze F. Effect of Trichoderma-enriched organic charcoal in the integrated wood protection strategy. PLoS ONE. 2017;12:e0183004 pubmed publisher
    ..The addition of T-720-enriched biochar to the soil into which utility poles are placed may improve the efficiency of Cr-free wood preservatives. ..
  27. Van Raay T, Allen Vercoe E. Microbial Interactions and Interventions in Colorectal Cancer. Microbiol Spectr. 2017;5: pubmed publisher
    ..Finally, we discuss the potential for gut microbial modulation therapies, for example, probiotics, antibiotics, and others, to target and improve gut microbial dysbiosis as a strategy for the prevention or treatment of CRC. ..
  28. Foster K, Schlüter J, Coyte K, Rakoff Nahoum S. The evolution of the host microbiome as an ecosystem on a leash. Nature. 2017;548:43-51 pubmed publisher
    ..We suggest that the health benefits of the microbiome should be understood, and studied, as an interplay between microbial competition and host control...
  29. Rangan K, Hang H. Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria. Trends Biochem Sci. 2017;42:887-898 pubmed publisher
    ..Understanding the biochemical mechanisms of intestinal microbiota function should provide new opportunities for therapeutic development towards a variety of infectious diseases. ..
  30. Bauer E, Zimmermann J, Baldini F, Thiele I, Kaleta C. BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities. PLoS Comput Biol. 2017;13:e1005544 pubmed publisher
    ..Additionally, we could provide novel hypothesis concerning the metabolic interactions between the microbes. These results demonstrate the importance of spatial and temporal multi-scale modeling approaches such as BacArena. ..
  31. Koh H, Blaser M, Li H. A powerful microbiome-based association test and a microbial taxa discovery framework for comprehensive association mapping. Microbiome. 2017;5:45 pubmed publisher
    ..MiCAM also provides a hierarchical association map for numerous microbial taxa and can also be used as a guideline for further investigation on the roles of discovered taxa in human health and disease. ..
  32. Alshawaqfeh M, Serpedin E, Younes A. Inferring microbial interaction networks from metagenomic data using SgLV-EKF algorithm. BMC Genomics. 2017;18:228 pubmed publisher
    ..Performance analysis demonstrates that the proposed SgLV-EKF algorithm represents a powerful and reliable tool to infer MINs and track their dynamics. ..
  33. Szafranski S, Deng Z, Tomasch J, Jarek M, Bhuju S, Rohde M, et al. Quorum sensing of Streptococcus mutans is activated by Aggregatibacter actinomycetemcomitans and by the periodontal microbiome. BMC Genomics. 2017;18:238 pubmed publisher
    ..The data show that the complete QS regulon of S. mutans can be induced by an unrelated oral pathogen and S. mutans may be competent in oral biofilms in vivo. ..
  34. Succurro A, Moejes F, Ebenhöh O. A Diverse Community To Study Communities: Integration of Experiments and Mathematical Models To Study Microbial Consortia. J Bacteriol. 2017;199: pubmed publisher
    ..methods such as the use of mathematical models are not yet as well integrated into the research studying microbial interactions. The empirical complexity of microbial communities presents challenges that are difficult to address with <..
  35. Deng L, Gregory A, Yilmaz S, Poulos B, Hugenholtz P, Sullivan M. Contrasting life strategies of viruses that infect photo- and heterotrophic bacteria, as revealed by viral tagging. MBio. 2012;3: pubmed publisher
    ..quot; ..
  36. Moutinho T, Panagides J, Biggs M, Medlock G, Kolling G, Papin J. Novel co-culture plate enables growth dynamic-based assessment of contact-independent microbial interactions. PLoS ONE. 2017;12:e0182163 pubmed publisher
    ..There are limited available tools for characterizing diffusion-mediated, contact-independent microbial interactions. A practical and widely implemented technique in such characterization involves the simultaneous co-..
  37. Lin Q, De Vrieze J, Li C, Li J, Li J, Yao M, et al. Temperature regulates deterministic processes and the succession of microbial interactions in anaerobic digestion process. Water Res. 2017;123:134-143 pubmed publisher
    Temperature plays crucial roles in microbial interactions that affect the stability and performance of anaerobic digestion...
  38. Venturi V, Ahmer B. Editorial: LuxR Solos are Becoming Major Players in Cell-Cell Communication in Bacteria. Front Cell Infect Microbiol. 2015;5:89 pubmed publisher
  39. Lorenz B, Wichmann C, Stöckel S, Rösch P, Popp J. Cultivation-Free Raman Spectroscopic Investigations of Bacteria. Trends Microbiol. 2017;25:413-424 pubmed publisher
    ..further improved by combining Raman spectroscopy with methods such as stable isotope probing to elucidate microbial interactions. In conjunction with extensive statistical analysis, Raman spectroscopy will allow identification of (non)..
  40. Ngba Essebe C, Visvikis O, Fines Guyon M, Vergne A, Cattoir V, Lecoustumier A, et al. Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model. Front Cell Infect Microbiol. 2017;7:77 pubmed publisher
    ..This study showed that H. kunzii decreased the virulence of S. aureus without modifying directly the host defense response. Factor(s) produced by this bacterium modulating the staphylococci virulence must be investigated. ..
  41. Robinson L, Lewis W, Lewis A. The sialate O-acetylesterase EstA from gut Bacteroidetes species enables sialidase-mediated cross-species foraging of 9-O-acetylated sialoglycans. J Biol Chem. 2017;292:11861-11872 pubmed publisher
    ..We conclude that EstA specifically unlocks the nutritive potential of 9-O-acetylated mucus sialic acids for foraging by bacteria that otherwise are prevented from accessing this carbon source. ..
  42. Richards T, Leonard G, Wideman J. What Defines the "Kingdom" Fungi?. Microbiol Spectr. 2017;5: pubmed publisher
    ..Our hope is that, by summarizing these data in the form of a discussion, we can illustrate the ongoing efforts to understand what drove the evolutionary diversification of fungi. ..
  43. Claussen J, Skieceviciene J, Wang J, Rausch P, Karlsen T, Lieb W, et al. Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome. PLoS Comput Biol. 2017;13:e1005361 pubmed publisher
  44. Neville B, d Enfert C, Bougnoux M. Candida albicans commensalism in the gastrointestinal tract. FEMS Yeast Res. 2015;15: pubmed publisher
    ..albicans, the C. albicans genes and phenotypes that are necessary for commensalism and the host factors that influence C. albicans carriage. ..
  45. Lazazzara V, Perazzolli M, Pertot I, Biasioli F, Puopolo G, Cappellin L. Growth media affect the volatilome and antimicrobial activity against Phytophthora infestans in four Lysobacter type strains. Microbiol Res. 2017;201:52-62 pubmed publisher
    Bacterial volatile organic compounds (VOCs) play important ecological roles in soil microbial interactions. Lysobacter spp...
  46. Zaura E, Mira A. Editorial: the oral microbiome in an ecological perspective. Front Cell Infect Microbiol. 2015;5:39 pubmed publisher
  47. Ebersole J, Dawson D, Morford L, Peyyala R, Miller C, González O. Periodontal disease immunology: 'double indemnity' in protecting the host. Periodontol 2000. 2013;62:163-202 pubmed publisher
  48. Teles R, Teles F, Frias Lopez J, PASTER B, Haffajee A. Lessons learned and unlearned in periodontal microbiology. Periodontol 2000. 2013;62:95-162 pubmed publisher
    ..We will conclude by reviewing how novel systems-biology approaches promise to unravel new details of the pathogenesis of periodontal diseases and hopefully lead to a better understanding of their mechanisms. ..