Summary: A phenomenon manifested by an agent or substance adhering to or being adsorbed on the surface of a red blood cell, as tuberculin can be adsorbed on red blood cells under certain conditions. (Stedman, 25th ed)

Top Publications

  1. Li L, Qi Y. A novel amino acid position in hemagglutinin glycoprotein of measles virus is responsible for hemadsorption and CD46 binding. Arch Virol. 2002;147:775-86 pubmed
    Three recent isolates of measles virus Fu, IMA, and SMD obtained by using B95a cells did not exhibit hemadsorption with African green monkey red blood cells (AGM-RBC)...
  2. Winner F, Markova I, Much P, Lugmair A, Siebert Gulle K, Vogl G, et al. Phenotypic switching in Mycoplasma gallisepticum hemadsorption is governed by a high-frequency, reversible point mutation. Infect Immun. 2003;71:1265-73 pubmed
    ..Phenotypic switching in M. gallisepticum hemadsorption (HA) was found to correlate with phase variation of the GapA cytadhesin concurrently with that of the CrmA ..
  3. Jordan J, Chang H, Balish M, Holt L, Bose S, Hasselbring B, et al. Protein P200 is dispensable for Mycoplasma pneumoniae hemadsorption but not gliding motility or colonization of differentiated bronchial epithelium. Infect Immun. 2007;75:518-22 pubmed
    ..Thus, gliding may be necessary to overcome mucociliary clearance. ..
  4. Aamir U, Wernery U, Ilyushina N, Webster R. Characterization of avian H9N2 influenza viruses from United Arab Emirates 2000 to 2003. Virology. 2007;361:45-55 pubmed
    ..They continue to maintain H5N1-like genes and may augment the spread of H5N1 viruses through regional co-circulation and inapparent infection. These viruses may present as potential pandemic candidates themselves...
  5. Borca M, Kutish G, Afonso C, Irusta P, Carrillo C, Brun A, et al. An African swine fever virus gene with similarity to the T-lymphocyte surface antigen CD2 mediates hemadsorption. Virology. 1994;199:463-8 pubmed
    ..The structural and functional similarities of LMW8-DR to CD2, a protein that is involved in cell-cell adhesion and immune response modulation, suggest a possible role in the pathogenesis of ASFV infection. ..
  6. Lecouturier V, Fayolle J, Caballero M, Carabana J, Celma M, Fernández Muñoz R, et al. Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains. J Virol. 1996;70:4200-4 pubmed
    ..The former downregulate CD46, the putative cellular receptor of MV, are positive for hemadsorption, and are fusogenic in HeLa cells, whereas the latter are negative for these phenotypic markers...
  7. Seki M, Oie M, Ichihashi Y, Shida H. Hemadsorption and fusion inhibition activities of hemagglutinin analyzed by vaccinia virus mutants. Virology. 1990;175:372-84 pubmed
    ..We isolated 21 independent hemadsorption-negative (HAD-) mutant viruses from IHD-J and five HAD+ revertants from one of these mutants...
  8. Hausmann J, Kretzschmar E, Garten W, Klenk H. N1 neuraminidase of influenza virus A/FPV/Rostock/34 has haemadsorbing activity. J Gen Virol. 1995;76 ( Pt 7):1719-28 pubmed
    ..Substitutions on either of the two loops were sufficient for this effect. The mutated NAs retained full neuraminidase activity. In contrast, a mutated NA lacking neuraminidase activity still had haemadsorbing activity. ..
  9. Baseman J, Morrison Plummer J, Drouillard D, Puleo Scheppke B, Tryon V, Holt S. Identification of a 32-kilodalton protein of Mycoplasma pneumoniae associated with hemadsorption. Isr J Med Sci. 1987;23:474-9 pubmed
    ..directed against a 32-kilodalton (kDa) protein of Mycoplasma pneumoniae have been used to characterize a hemadsorption-negative (HA-) mutant class whose protein profile was previously indistinguishable from the wild-type, ..

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  1. Kobasa D, Rodgers M, Wells K, Kawaoka Y. Neuraminidase hemadsorption activity, conserved in avian influenza A viruses, does not influence viral replication in ducks. J Virol. 1997;71:6706-13 pubmed
    The N1 and N9 neuraminidase (NA) subtypes of influenza A viruses exhibit significant hemadsorption activity that localizes to a site distinct from that of the enzymatic active site...
  2. Uhlendorff J, Matrosovich T, Klenk H, Matrosovich M. Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses. Arch Virol. 2009;154:945-57 pubmed publisher
    ..NA) of the avian viruses has, in addition to the catalytic site, a separate sialic acid binding site (hemadsorption site) that is not present in human viruses...
  3. Johnston S, Wellens K, Siegel C. Comparison of hemagglutination and hemadsorption tests for influenza detection. Diagn Microbiol Infect Dis. 1992;15:363-5 pubmed
    ..of primary rhesus monkey kidney cell culture tubes inoculated with clinical specimens was compared with hemadsorption (HAd) of the same tube for identifying the presence of hemagglutinin activity due to influenza...
  4. Summers P, Dubois D, Cohen W, Macarthy P, Binn L, Sjogren M, et al. Solid-phase antibody capture hemadsorption assay for detection of hepatitis A virus immunoglobulin M antibodies. J Clin Microbiol. 1993;31:1299-302 pubmed
    A solid-phase antibody capture hemadsorption (SPACH) assay was developed to detect hepatitis A virus (HAV)-specific immunoglobulin M (IgM) antibodies in sera from humans recently infected with hepatitis...
  5. Mills R, Cain K, Woods G. Detection of influenza virus by centrifugal inoculation of MDCK cells and staining with monoclonal antibodies. J Clin Microbiol. 1989;27:2505-8 pubmed
    ..assay after incubation for 40 h, and (ii) conventional tissue cell culture with primary monkey cells and hemadsorption. For 100 of these specimens, direct examination of smears by the direct fluorescence assay with monoclonal ..
  6. Portincasa P, Conti G, Chezzi C. Defective insertion of haemagglutinin as a cause of abortivity of influenza A viruses in HeLa 229 cells. Microbiologica. 1991;14:351-5 pubmed
    ..We show that the incorrect insertion of virus-coded haemagglutinin into the plasma membrane might be the cause of the unpermissive condition of infection exhibited by this cellular host. ..
  7. Tanaka Y, Galinski M. Human parainfluenza virus type 3: analysis of the cytoplasmic tail and transmembrane anchor of the hemagglutinin-neuraminidase protein in promoting cell fusion. Virus Res. 1995;36:131-49 pubmed
  8. Tao W, Deyo D, Alpard S, Vertrees R, Hoang V, Zwischenberger J. Significant reduction in circuit pressure with modified plasma separation chamber for a heparin removal device. ASAIO J. 1999;45:50-2 pubmed
    ..01 between groups). There were no significant differences in ACT between groups. We conclude that enlarged chamber ports significantly lower circuit pressures for the HRD without changing heparin removal capability. ..
  9. Katz D, Ben Moshe H, Alon S. Titration of Newcastle disease virus and its neutralizing antibodies in microplates by a modified hemadsorption and hemadsorption inhibition method. J Clin Microbiol. 1976;3:227-32 pubmed
    ..Infectivity was detected by a combined hemadsorption-hemagglutination method. Inhibition of that reaction indicated the presence of neutralizing antibodies...
  10. Segawa H, Inakawa A, Yamashita T, Taira H. Functional analysis of individual oligosaccharide chains of Sendai virus hemagglutinin-neuraminidase protein. Biosci Biotechnol Biochem. 2003;67:592-8 pubmed
    ..in the structure and functions of the protein was identified by characterization of surface expression, hemadsorption, and neuraminidase activities of the corresponding mutant proteins...
  11. Bian H, Fournier P, Moormann R, Peeters B, Schirrmacher V. Selective gene transfer to tumor cells by recombinant Newcastle Disease Virus via a bispecific fusion protein. Int J Oncol. 2005;26:431-9 pubmed
    ..b>Hemadsorption (HA) and neuraminidase activities (NA) of the HN protein of NDV were shown to be blocked by alphaHN-IL-2 ..
  12. Okazaki K, Honda E, Kono Y. Expression of bovine herpesvirus 1 glycoprotein gIII by a recombinant baculovirus in insect cells. J Gen Virol. 1994;75 ( Pt 4):901-4 pubmed
    ..Antisera raised to recombinant gIII neutralized the infectivity of BHV-1. These data suggest that recombinant gIII produced in insect cells may be a useful immunogen in a BHV-1 vaccine. ..
  13. Mittal S, Tikoo S, van den Hurk J, Breker Klassen M, Yoo D, Babiuk L. Functional characterization of bovine parainfluenza virus type 3 hemagglutinin-neuraminidase and fusion proteins expressed by adenovirus recombinants. Intervirology. 1998;41:253-60 pubmed
    ..Our results suggest that HN and F expressed by HAd5 recombinants were functionally similar to the native HN and F expressed in BPIV3-infected cells. ..
  14. Kloss T, Haupt W, Philipp T, Diener H. [Therapy of acute Guillain-Barré syndrome. A national multicenter study]. Nervenarzt. 1994;65:881-3 pubmed
    ..This study compares intravenous immune globulin, plasma exchange, and selective adsorption. The study is currently underway. ..
  15. Medeiros R, Escriou N, Naffakh N, Manuguerra J, Van Der Werf S. Hemagglutinin residues of recent human A(H3N2) influenza viruses that contribute to the inability to agglutinate chicken erythrocytes. Virology. 2001;289:74-85 pubmed
    ..b>Hemadsorption assays following transient expression of mutated HA proteins showed that the successive Gln226 --> Leu --&..
  16. Vedeler C, Gilhus N, Matre R. Expression of complement C3b/C4b receptors (CR1) on erythrocytes from patients with myasthenia gravis. Acta Neurol Scand. 1990;82:259-62 pubmed
    ..This was also true for the subgroup of MG patients with additional autoimmune diseases. No correlation between ECR1 expression and severity of myasthenic symptoms was demonstrated. ..
  17. Vikerfors T, Lindegren G, Grandien M, van der Logt J. Diagnosis of influenza A virus infections by detection of specific immunoglobulins M, A, and G in serum. J Clin Microbiol. 1989;27:453-8 pubmed
    ..The IgM response, analyzed by the hemadsorption immunosorbent technique, was compared with the IgG and IgA responses analyzed by an indirect enzyme-linked ..
  18. Tachibana T, Worst P, Klein E. Detection of cell surface antigens on monolayer cells. II. The application of mixed haemadsorption on a micro scale. Immunology. 1970;19:809-16 pubmed
  19. Melhus A, Hermansson A, Forsgren A, Prellner K. Intra- and interstrain differences of virulence among nontypeable Haemophilus influenzae strains. APMIS. 1998;106:858-68 pubmed
    ..As all three strains lacked genes necessary for encapsulation, in no case could any part of the increased virulence be attributed to the expression of small amounts of capsule. ..
  20. Lockaby S, Hoerr F, Lauerman L, Smith B, Samoylov A, Toivio Kinnucan M, et al. Factors associated with virulence of Mycoplasma synoviae. Avian Dis. 1999;43:251-61 pubmed
    ..of a possible cytadhesin and for functional attachment to host cells as indicated by hemagglutination and hemadsorption. Three representative isolates, K1968, 92D8034, and FMT, were evaluated for attachment and colonization in ..
  21. Gunasegaran K, Lim T, Ahmed A, Aaskov J, Lam S, Pang T. Hemadsorption immunosorbent technique for the detection of dengue immunoglobulin M antibody. J Clin Microbiol. 1986;23:170-4 pubmed
    We developed a highly specific, sensitive, and economical hemadsorption immunosorbent technique for the detection of dengue-specific immunoglobulin M (IgM) antibody...
  22. Oka T. The possibility of improving biocompatibility by removing anaphylatoxins from the circuit of blood-perfused artificial organs. ASAIO Trans. 1989;35:778-83 pubmed
    ..The adsorption ability influenced the reduction in neutropenia. The heparinized uncoated AC and the column with large volumes of HEMA-coated AC had the best effect.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  23. Nagy E, Derbyshire J, Dobos P, Krell P. Cloning and expression of NDV hemagglutinin-neuraminidase cDNA in a baculovirus expression vector system. Virology. 1990;176:426-38 pubmed
    ..HN was copurified with extracellular virus (ECV) from the extracellular medium and was used to immunize chickens. The anti recHN serum was specific to NDV in both ELISA and Western blot analysis. ..
  24. Hahon N, Stewart J, Eckert H. Quantitative assessment of hemadsorption by myxoviruses: anti-immunoglobulin G hemadsorption-inhibition test. Appl Microbiol. 1973;25:601-5 pubmed
    A quantitative hemadsorption-inhibition test was developed to estimate myxovirus serum antibodies within 24 h by determining the serum dilution inhibiting hemadsorption in 50% of the infected cells...
  25. Murakami T, Haruki K, Seto Y, Kimura T, Minoshiro S, Shibe K. Agglutination of human O erythrocytes by influenza A(H1N1) viruses freshly isolated from patients. J Virol Methods. 1991;32:49-56 pubmed
    ..The results of a hemadsorption test indicated that chicken erythrocytes possess less affinity to MDCK cells infected with the A/Osaka City/2/..
  26. Fadul J, Alarabi A, Wikstrom B, Danielson B, Nilsson B. Identification of complement activators and elucidation of the fate of complement activation products during extracorporeal plasma purification therapy. J Clin Apher. 1998;13:167-73 pubmed
    ..It is the plasma separator that plays a key role in the process of complement activation. Different ECPP treatments may have different effects regarding the levels of individual CAPs. ..
  27. Xiu W, Nakajima K, Nobusawa E. [Analysis of the amino acid changes of the hemagglutinin of H5 avian influenza virus]. Bing Du Xue Bao. 2008;24:34-40 pubmed
    ..The percentage of amino acid changes on the HA domain that did not abrogate hemadsorption activity was calculated to be 89%...
  28. Henrickson K, Kuhn S, Savatski L, Sedmak J. Recovery of human parainfluenza virus types one and two. J Virol Methods. 1994;46:189-205 pubmed
    ..Immunofluorescent antibody (IFA) and hemadsorption (HAd) assays were compared for their speed and efficiency in viral detection...
  29. Arisoy E, Demmler G, Thakar S, Doerr C. Meningitis due to parainfluenza virus type 3: report of two cases and review. Clin Infect Dis. 1993;17:995-7 pubmed
    ..one of the most common causes of viral respiratory infection in infancy, can also produce infection of the CNS and that hemadsorption testing of CSF specimens submitted for viral culture is necessary for detecting these paramyxoviruses.
  30. Furukawa K, Ayata M, Kimura M, Seto T, Matsunaga I, Murata R, et al. Hemadsorption expressed by cloned H genes from subacute sclerosing panencephalitis (SSPE) viruses and their possible progenitor measles viruses isolated in Osaka, Japan. Microbiol Immunol. 2001;45:59-68 pubmed
    ..SSPE) viruses, including our Osaka-1, -2, and -3 strains isolated in Osaka, have shown negative hemadsorption (HAD) by African green monkey red blood cells...
  31. Seth S, Shaila M. The hemagglutinin-neuraminidase protein of peste des petits ruminants virus is biologically active when transiently expressed in mammalian cells. Virus Res. 2001;75:169-77 pubmed
    ..The transiently expressed PPRV HN protein was found to be biologically active in possessing hemadsorption and neuraminidase activities...
  32. O Boyle K, Senter P, Bhargava K, Chun S, Anthony G, Markowitz A, et al. Effects of a hybrid recombinant human alpha interferon (A/D) on in vitro cytotoxicity and in vivo localization of monoclonal antibody L6-cytosine deaminase conjugate in a colon cancer model. Cancer Biother Radiopharm. 1998;13:33-42 pubmed
    ..demonstrated binds well to HT29 human colon carcinoma cells by flow cytometry, whole cell ELISA, and mixed hemadsorption. In vitro cytotoxicity studies revealed that the monoclonal antibody L6-cytosine deaminase (L6-CD) ..
  33. Sbih F, Kourouma K, Bougermouh A, Chikhi A. Persistent measles virus infection in vero and McCoy cell lines. Acta Virol. 1990;34:272-81 pubmed
    ..Our results suggest that the presence of defective interfering particles in Vero cells and an antiviral factor in the supernatant of McCoy cells contributed to the maintenance of persistent infection. ..
  34. Peng Z, Carter M, Kellum J. Effects of hemoadsorption on cytokine removal and short-term survival in septic rats. Crit Care Med. 2008;36:1573-7 pubmed publisher
    ..11, p = .005). Hemoadsorption reduced circulating cytokines, improved MAP, and resulted in better short-term survival in CLP-induced septic rats. ..
  35. Prokudina E, Semenova N. Localization of the influenza virus nucleoprotein: cell-associated and extracellular non-virion forms. J Gen Virol. 1991;72 ( Pt 7):1699-702 pubmed
    ..Comparative analysis of the kinetics of the accumulation of NP in the supernatant of infected cells, on the cell surface and inside the cells in relation to virus production, showed that there is a significant correlation between them. ..
  36. Sommer A, Mennen S. Multiplication and haemadsorbing activity of infectious salmon anaemia virus in the established Atlantic salmon cell line. J Gen Virol. 1997;78 ( Pt 8):1891-5 pubmed
    ..Growth of ISAV was inhibited by actinomycin D but not by 5-bromo-2-deoxyuridine treatment, which indicates that ISAV may be an aquatic orthomyxovirus. ..
  37. Xuan X, Maeda K, Mikami T, Otsuka H. Characterization of canine herpesvirus glycoprotein C expressed by a recombinant baculovirus in insect cells. Virus Res. 1996;46:57-64 pubmed
    ..The hemadsorption activity was inhibited by heparin, indicating that the CHV gC binds to heparan sulfate on the surface of ..
  38. Plapp F, Sinor L, Rachel J. The evolution of pretransfusion testing: from agglutination to solid-phase red cell adherence tests. Crit Rev Clin Lab Sci. 1989;27:179-209 pubmed
    ..However, adherence tests are not restricted to this format. Therefore, blood grouping dipsticks have been produced, which permit testing of individual blood samples even outside of the laboratory. ..
  39. Valdivieso Garcia A, Rosendal S, Serebrin S. Adherence of Mycoplasma mycoides subspecies mycoides to cultured endothelial cells. Zentralbl Bakteriol. 1989;272:210-5 pubmed
    ..Difference in cytoadherence was observed between strains of the LC-type. The interaction between the most adherent LC-type strain and caprine endothelial cells was examined by transmission and scanning electron microscopy...
  40. Fischer M, Kirchhoff H. Interaction of Mycoplasma mobile 163K with erythrocytes. Zentralbl Bakteriol Mikrobiol Hyg A. 1987;266:497-505 pubmed
    ..b>Hemadsorption to the colonies of M...
  41. Leung H, Li O, Chan R, Chan M, Nicholls J, Poon L. Entry of influenza A Virus with a ?2,6-linked sialic acid binding preference requires host fibronectin. J Virol. 2012;86:10704-13 pubmed publisher
  42. Ebata S, Prevec L, Graham F, Dimock K. Function and immunogenicity of human parainfluenza virus 3 glycoproteins expressed by recombinant adenoviruses. Virus Res. 1992;24:21-33 pubmed
    ..These results support future work using recombinant adenoviruses to study the immune response to individual HPIV3 glycoproteins as well as in protection studies using animal models. ..
  43. Oeffner F, Klenk H, Herrler G. The cytoplasmic tail of the influenza C virus glycoprotein HEF negatively affects transport to the cell surface. J Gen Virol. 1999;80 ( Pt 2):363-9 pubmed
    ..The results show that the short cytoplasmic tail of HEF has a negative effect on the folding and surface transport of this protein. How this effect may be prevented during a virus infection is discussed. ..
  44. Lyte M. In vitro production of interleukin-2 by lymphocytes in whole blood and isolated culture. J Clin Lab Immunol. 1988;26:189-93 pubmed
    ..The use of whole blood culture, while not permitting a precise in vitro dissection of the cellular mechanisms governing IL-2 production, may more accurately reflect the mechanisms governing in vivo lymphocyte activation. ..
  45. Itamura S, Morikawa Y, Shida H, Nerome K, Oya A. Biological and immunological characterization of influenza virus haemagglutinin expressed from the haemagglutinin locus of vaccinia virus. J Gen Virol. 1990;71 ( Pt 6):1293-301 pubmed
    ..These findings demonstrate the usefulness of this eukaryotic vector system. ..
  46. Payne H, Storz J. Scanning electron microscopic characterization of bovine coronavirus plaques in HRT cells. Zentralbl Veterinarmed B. 1990;37:501-8 pubmed
    ..The survival of cells in the plaque interior reflects a non-productively infected population with evidence of viral persistence. ..
  47. Portincasa P, Conti G, Chezzi C. Abortive replication of influenza A viruses in HeLa 229 cells. Virus Res. 1990;18:29-40 pubmed
    ..Therefore it seems that during the maturation of viral particles there is a failure of the haemagglutinin to perform a correct insertion into the plasma membrane of infected HeLa 229 cells. ..
  48. Spinola S, Castellazzo A, Shero M, Apicella M. Characterization of pili expressed by Haemophilus ducreyi. Microb Pathog. 1990;9:417-26 pubmed
    ..We conclude that H. ducreyi expressed pili, that the relative molecular mass of the pilin monomer was 24 k, that pilus expression was not readily lost in passage and that H. ducreyi pili may not bind to an erythrocyte receptor...
  49. Sato T. [Development of anti-Treponema pallidum-IgM antibodies detection methods using purified antigen--comparison with conventional methods]. Kansenshogaku Zasshi. 1993;67:758-66 pubmed
    ..In addition, the SPHA (solid phase hemadsorption) test with the Hypaque-purified antigen to anti-Tp-IgM antibodies was carried out using the sera of patients ..
  50. Aspehaug V, Mikalsen A, Snow M, Biering E, Villoing S. Characterization of the infectious salmon anemia virus fusion protein. J Virol. 2005;79:12544-53 pubmed
    ..Size estimates of F1 and F2 and the localization of the putative fusion peptide and theoretical trypsin cleavage sites suggest that the proteolytic cleavage site is after residue K276 in the protein sequence. ..
  51. Thomson T, Rettig W, Chesa P, Green S, Mena A, Old L. Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp Cell Res. 1988;174:533-9 pubmed
    ..Thus, our findings demonstrate that NGFR is much more widely expressed in human cells and tissues than was previously thought. ..
  52. Taggart E, Crist G, Billetdeaux E, Langer J, Petti C. Utility of terminal hemadsorption for detection of hemadsorbing respiratory viruses from conventional shell vial cultures for laboratories using R-Mix cultures. J Clin Virol. 2009;44:86-7 pubmed publisher
    ..inoculate other shell vial cultures to improve the recovery of viruses, and in particular, perform terminal hemadsorption (THad) following 10-14 days of incubation to improve detection of respiratory viruses...
  53. Baumann A, Buchwald D, Annecke T, Hellmich M, Zahn P, Hohn A. RECCAS - REmoval of Cytokines during CArdiac Surgery: study protocol for a randomised controlled trial. Trials. 2016;17:137 pubmed publisher
    ..German Clinical Trials Register number DRKS00007928 (Date of registration 3 Aug 2015). ..