Summary: Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and PROTEINS.

Top Publications

  1. Seno K, Hayashi F. Palmitoylation is a prerequisite for dimerization-dependent raftophilicity of rhodopsin. J Biol Chem. 2017;292:15321-15328 pubmed publisher
    ..These results indicate that palmitoylated GPCRs such as Rh can acquire raftophilicity upon G protein-stabilized dimerization and thereby organize receptor-cluster rafts by recruiting raftophilic lipids. ..
  2. Zhang M, Hang H. Protein S-palmitoylation in cellular differentiation. Biochem Soc Trans. 2017;45:275-285 pubmed publisher
    ..We also highlight palmitoyl proteins and palmitoylation-related enzymes that are associated with cellular differentiation and/or tissue development in yeasts, protozoa, mammals, plants and other model eukaryotes. ..
  3. Kazim A, Storm P, Zhang E, Renstrom E. Palmitoylation of Ca2+ channel subunit CaV?2a induces pancreatic beta-cell toxicity via Ca2+ overload. Biochem Biophys Res Commun. 2017;491:740-746 pubmed publisher
    ..However, excessive number of palmitoylated CaV?2a leads to Ca2+ overload and beta cell death. ..
  4. Wang S, Mott K, Wawrowsky K, Kousoulas K, Luscher B, Ghiasi H. Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K. J Virol. 2017;91: pubmed publisher
  5. Habarou F, Hamel Y, Haack T, Feichtinger R, Lebigot E, Marquardt I, et al. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Am J Hum Genet. 2017;101:283-290 pubmed publisher
    ..reduced oxygen consumption rates, PDHc, ?-KGDHc activities, leucine catabolic flux, and decreased protein lipoylation. A normalization of lipoylation was observed after expression of wild-type LIPT2, arguing for LIPT2 requirement ..
  6. Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, et al. Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation. J Biol Chem. 2017;292:17703-17717 pubmed publisher
    ..Pharmacological manipulation of protein palmitoylation may be a strategy to alter cilia function. ..
  7. Chlanda P, Mekhedov E, Waters H, Sodt A, Schwartz C, Nair V, et al. Palmitoylation Contributes to Membrane Curvature in Influenza A Virus Assembly and Hemagglutinin-Mediated Membrane Fusion. J Virol. 2017;91: pubmed publisher
    ..Furthermore, our data on VLP and, by hypothesis, virus suggests that HA acylation, while not critical to fusion pore formation, contributes to pore expansion in a target-dependent fashion. ..
  8. Khananshvili D. How a helix imposes palmitoylation of a membrane protein: What one can learn from NCX. J Biol Chem. 2017;292:10753-10754 pubmed publisher
    ..A study of the sodium/calcium exchanger now suggests that secondary structure may hold the key to understanding the determinants of this modification. ..
  9. Nussinov R, Jang H, Tsai C, Liao T, Li S, Fushman D, et al. Intrinsic protein disorder in oncogenic KRAS signaling. Cell Mol Life Sci. 2017;74:3245-3261 pubmed publisher
    ..We believe that a broad picture helps to grasp and formulate key mechanisms in Ras cancer biology and assists in therapeutic intervention. ..

More Information


  1. Kathayat R, Cao Y, Elvira P, Sandoz P, Zaballa M, Springer M, et al. Active and dynamic mitochondrial S-depalmitoylation revealed by targeted fluorescent probes. Nat Commun. 2018;9:334 pubmed publisher
    ..Altogether, this work reveals that mitochondrial S-palmitoylation is actively regulated by "eraser" enzymes that respond to alterations in mitochondrial lipid homeostasis. ..
  2. Babina I, McSherry E, Donatello S, Hill A, Hopkins A. A novel mechanism of regulating breast cancer cell migration via palmitoylation-dependent alterations in the lipid raft affiliation of CD44. Breast Cancer Res. 2014;16:R19 pubmed publisher
    ..Our results support a novel mechanism whereby CD44 palmitoylation and consequent lipid raft affiliation inversely regulate breast cancer cell migration, and may act as a new therapeutic target in breast cancer metastasis. ..
  3. Tortosa E, Adolfs Y, Fukata M, Pasterkamp R, Kapitein L, Hoogenraad C. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017;94:809-825.e7 pubmed publisher
    ..We propose a model in which MAP6's palmitoylation mediates microtubule stabilization, allows efficient organelle trafficking, and controls axon maturation in vitro and in situ. ..
  4. Shibata T, Hadano J, Kawasaki D, Dong X, Kawabata S. Drosophila TG-A transglutaminase is secreted via an unconventional Golgi-independent mechanism involving exosomes and two types of fatty acylations. J Biol Chem. 2017;292:10723-10734 pubmed publisher
    ..In conclusion, TG-A is secreted through an unconventional ER/Golgi-independent pathway involving two types of fatty acylations and exosomes. ..
  5. Tremp A, Al Khattaf F, Dessens J. Palmitoylation of Plasmodium alveolins promotes cytoskeletal function. Mol Biochem Parasitol. 2017;213:16-21 pubmed publisher
    ..These findings support the hypothesis that alveolin palmitoylation enhances cytoskeletal function by strengthening the connection between the SPN and the adjoining inner membrane complex via lipid anchoring. ..
  6. Chen X, Ma H, Wang Z, Zhang S, Yang H, Fang Z. EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression. Cancer Res. 2017;77:4998-5010 pubmed publisher
    ..Taken together, our work highlighted ZDHHC5 as a candidate therapeutic target for management of p53-mutated gliomas. Cancer Res; 77(18); 4998-5010. ©2017 AACR. ..
  7. Kharbanda A, Runkle K, Wang W, Witze E. Induced sensitivity to EGFR inhibitors is mediated by palmitoylated cysteine 1025 of EGFR and requires oncogenic Kras. Biochem Biophys Res Commun. 2017;493:213-219 pubmed publisher
    ..Finally, the small molecule, 2-bromopalmitate, which has been shown to inhibit palmitoyl transferases, acts synergistically with gefitinib to induce cell death in the gefitinib resistant cell line NCI-H1975. ..
  8. Li R, Li K, Yang Y, Sun P, Chen A, Ni Y. [Palmitoylation of heat shock protein 90 in mouse sperm]. Sheng Li Xue Bao. 2017;69:298-304 pubmed
    ..In conclusion, this study reveals that protein palmitoylation is present in mouse sperm and the palmitoylated Hsp90 is associated with different physiological conditions in sperm. ..
  9. Tabaczar S, Czogalla A, Podkalicka J, Biernatowska A, Sikorski A. Protein palmitoylation: Palmitoyltransferases and their specificity. Exp Biol Med (Maywood). 2017;242:1150-1157 pubmed publisher
    ..Another important question is the role of depalmitoylation enzymes. This review should help to formulate questions concerning the regulation of activity of particular PATs as well as of depalmitoylating enzymes (APT). ..
  10. Wittouck S, van Noort V. Correlated duplications and losses in the evolution of palmitoylation writer and eraser families. BMC Evol Biol. 2017;17:83 pubmed publisher
    ..A general pattern of correlated evolution appears between writer and eraser domains. These co-evolution patterns could be used in new methods for interaction prediction based on phylogenies. ..
  11. Zhang Y, Li E, Feng Q, Zhao X, Ge F, Zhang Y, et al. Protein palmitoylation is critical for the polar growth of root hairs in Arabidopsis. BMC Plant Biol. 2015;15:50 pubmed publisher
    ..Although some of these effects are likely indirect, the cytological data reported here will contribute to a deep understanding of protein palmitoylation during tip growth in plants. ..
  12. Plain F, Congreve S, Yee R, Kennedy J, Howie J, Kuo C, et al. An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. J Biol Chem. 2017;292:10745-10752 pubmed publisher
    ..NCX1 palmitoylation is governed by a distal secondary structure element rather than by local primary sequence. ..
  13. Gamage D, Leikina E, Quinn M, Ratinov A, Chernomordik L, Millay D. Insights into the localization and function of myomaker during myoblast fusion. J Biol Chem. 2017;292:17272-17289 pubmed publisher
    ..These data reveal that myoblast fusion requires myomaker activity at the plasma membrane and is potentially regulated by proper myomaker trafficking. ..
  14. Chalabaev S, Chauhan A, Novikov A, Iyer P, Szczesny M, Beloin C, et al. Biofilms formed by gram-negative bacteria undergo increased lipid a palmitoylation, enhancing in vivo survival. MBio. 2014;5: pubmed publisher
    ..While these results provide new insights into the biofilm lifestyle, they also suggest that the level of lipid A palmitoylation could be used as an indicator to monitor the development of biofilm infections on medical surfaces. ..