secretory pathway


Summary: A series of sequential intracellular steps involved in the transport of proteins (such as hormones and enzymes) from the site of synthesis to outside the cell. The pathway involves membrane-bound compartments through which the newly synthesized proteins undergo POST-TRANSLATIONAL MODIFICATIONS, packaging, storage, or transportation to the PLASMA MEMBRANE for secretion.

Top Publications

  1. Schneider M, Barnes C, Bryant S. Characterization of the chondrocyte secretome in photoclickable poly(ethylene glycol) hydrogels. Biotechnol Bioeng. 2017;114:2096-2108 pubmed publisher
    ..Biotechnol. Bioeng. 2017;114: 2096-2108. © 2017 Wiley Periodicals, Inc. ..
  2. Browning D, Richards K, Peswani A, Roobol J, Busby S, Robinson C. Escherichia coli "TatExpress" strains super-secrete human growth hormone into the bacterial periplasm by the Tat pathway. Biotechnol Bioeng. 2017;114:2828-2836 pubmed publisher
    ..TatExpress strains accumulate in excess of 30?mg?L-1 periplasmic recombinant hGH, even in shake flask cultures. A second target protein, an scFv, is also shown to be exported at much higher rates in TatExpress strains. ..
  3. Fitzgerald I, Glick B. Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting. Microb Cell Fact. 2014;13:125 pubmed publisher
    ..To identify roadblocks in the yeast secretory pathway, we used a monomeric superfolder GFP (msGFP) as a visual tracer in Saccharomyces cerevisiae and Pichia ..
  4. Litvinova L, Shupletsova V, Dunets N, Khaziakhmatova O, Yurova K, Khlusova M, et al. Imbalance of morphofunctional responses of Jurkat T lymphoblasts at short-term culturing with relief zinc- or copper-containing calcium phosphate coating on titanium. Dokl Biochem Biophys. 2017;472:35-39 pubmed publisher
    ..Changes in the concentration of essential trace elements contained in this coating can cause significant imbalance of molecular processes of differentiation, secretion, apoptosis, and necrosis and reduce tumor cell survival. ..
  5. Sun Z, Brodsky J. Guardians of the ERAD Galaxy. Cell. 2017;171:267-268 pubmed publisher
    ..degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al...
  6. Alcalá A, Hernández Bravo R, Medina F, Coll D, Zambrano J, Del Angel R, et al. The dengue virus non-structural protein 1 (NS1) is secreted from infected mosquito cells via a non-classical caveolin-1-dependent pathway. J Gen Virol. 2017;98:2088-2099 pubmed publisher
    ..that transports cholesterol inside the cell), but not SAR1 (a GTPase that participates in the classical secretory pathway), also results in a significant reduction of the secretion of NS1...
  7. Dang D, Prasad H, Rao R. Secretory pathway Ca2+ -ATPases promote in vitro microcalcifications in breast cancer cells. Mol Carcinog. 2017;56:2474-2485 pubmed publisher
    ..We show that the Secretory Pathway Ca2+ -ATPases SPCA1 and SPCA2 are strongly induced under osteogenic conditions that elicit ..
  8. Barbosa S, Carreira S, O Hare P. GSK-3-mediated phosphorylation couples ER-Golgi transport and nuclear stabilization of the CREB-H transcription factor to mediate apolipoprotein secretion. Mol Biol Cell. 2017;28:1565-1579 pubmed publisher
    ..It controls the production both of secretory pathway components and cargoes, including apolipoproteins ApoA-IV and ApoC-II, contributing to VLDL/HDL distribution ..
  9. Lund A, Kaas C, Brandl J, Pedersen L, Kildegaard H, Kristensen C, et al. Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data. BMC Syst Biol. 2017;11:37 pubmed publisher
    ..On the basis of manual curation of the literature on the yeast, human, and mouse secretory pathway, we have compiled a comprehensive catalogue of characterized proteins with functional annotation and their ..

More Information


  1. Rabouille C, Malhotra V, Nickel W. Diversity in unconventional protein secretion. J Cell Sci. 2012;125:5251-5 pubmed publisher
  2. Nottingham R, Pfeffer S. Defining the boundaries: Rab GEFs and GAPs. Proc Natl Acad Sci U S A. 2009;106:14185-6 pubmed publisher
  3. Wang Y, Zhang H, Shi M, Liou Y, Lu L, Yu F. Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons. Development. 2017;144:1851-1862 pubmed publisher
    ..However, it is unknown whether the secretory pathway plays a role in dendrite pruning...
  4. Bitter W, Houben E, Bottai D, Brodin P, Brown E, Cox J, et al. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 2009;5:e1000507 pubmed publisher
  5. Pfeffer S. Rab GTPases: master regulators that establish the secretory and endocytic pathways. Mol Biol Cell. 2017;28:712-715 pubmed publisher
  6. Filloux A. Secretion signal and protein targeting in bacteria: a biological puzzle. J Bacteriol. 2010;192:3847-9 pubmed publisher
  7. Tanaka A, Tanaka M. A novel gene, cilia flagella associated protein 44, encoding an enzyme cleaving FtsZ and tubulin contributes to the regulation of secretory pathway. Biochem Biophys Res Commun. 2017;493:399-408 pubmed publisher
  8. Denison M. Seeking membranes: positive-strand RNA virus replication complexes. PLoS Biol. 2008;6:e270 pubmed publisher
  9. Farhan H, Kundu M, Ferro Novick S. The link between autophagy and secretion: a story of multitasking proteins. Mol Biol Cell. 2017;28:1161-1164 pubmed publisher
    ..The intersection of these pathways may play an important role in remodeling membranes during cellular stress. ..
  10. Bao J, Huang M, Petranovic D, Nielsen J. Moderate Expression of SEC16 Increases Protein Secretion by Saccharomyces cerevisiae. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..However, the limited capacity of the secretory pathway may reduce its productivity...
  11. Samad M, Mohsin M, Razu B, Hossain M, Mahzabeen S, Unnoor N, et al. [6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic ?-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hypergl. BMC Complement Altern Med. 2017;17:395 pubmed publisher
  12. Brahms A, Mudhasani R, Pinkham C, Kota K, Nasar F, Zamani R, et al. Sorafenib Impedes Rift Valley Fever Virus Egress by Inhibiting Valosin-Containing Protein Function in the Cellular Secretory Pathway. J Virol. 2017;91: pubmed publisher
    ..p97/valosin-containing protein (VCP), which is involved in membrane remodeling in the secretory pathway and a known target of sorafenib, was found to be important for RVFV egress...
  13. Trajkovic K, Jeong H, Krainc D. Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway. J Neurosci. 2017;37:9000-9012 pubmed publisher
    ..We found that the protein is secreted via a late endosomal/lysosomal unconventional secretory pathway. Moreover, mHtt secretion can be reduced significantly by phosphatidylinositol 3-kinase and neutral ..
  14. Jain A, Holthuis J. Membrane contact sites, ancient and central hubs of cellular lipid logistics. Biochim Biophys Acta Mol Cell Res. 2017;1864:1450-1458 pubmed publisher
    ..This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. ..
  15. LaRock C, Cookson B. Burning down the house: cellular actions during pyroptosis. PLoS Pathog. 2013;9:e1003793 pubmed publisher
  16. Kirkland J, Tchkonia T. Cellular Senescence: A Translational Perspective. EBioMedicine. 2017;21:21-28 pubmed publisher
    ..Several senolytic agents, which appear to alleviate multiple senescence-related phenotypes in pre-clinical models, are beginning the process of being translated into clinical interventions that could be transformative. ..
  17. Ruth C, Buchetics M, Vidimce V, Kotz D, Naschberger S, Mattanovich D, et al. Pichia pastoris Aft1--a novel transcription factor, enhancing recombinant protein secretion. Microb Cell Fact. 2014;13:120 pubmed publisher
    ..pastoris. Furthermore, we discovered possible novel functions of Aft1 in carbohydrate metabolism and provide evidence arguing against a direct role of Aft1 in P. pastoris iron regulation. ..