Summary: The chemical reactions in living organisms by which energy is provided for vital processes and activities and new material is assimilated.

Top Publications

  1. Sigurdson A, Bhatti P, Chang S, Rajaraman P, Doody M, Bowen L, et al. Polymorphisms in estrogen biosynthesis and metabolism-related genes, ionizing radiation exposure, and risk of breast cancer among US radiologic technologists. Breast Cancer Res Treat. 2009;118:177-84 pubmed publisher
    ..However, potential breast cancer risk modification of low to moderate radiation dose by polymorphic estrogen metabolism-related gene variants has not been routinely investigated...
  2. Chen Q, Wu J, Zhang Y, Lin J. Qualitative and quantitative analysis of tumor cell metabolism via stable isotope labeling assisted microfluidic chip electrospray ionization mass spectrometry. Anal Chem. 2012;84:1695-701 pubmed publisher
    ..ionization mass spectrometry (SIL-chip-ESI-MS) platform for qualitative and quantitative analysis of cell metabolism was developed...
  3. Gluckman P. Epigenetics and metabolism in 2011: Epigenetics, the life-course and metabolic disease. Nat Rev Endocrinol. 2011;8:74-6 pubmed publisher
    ..Data published in 2011 suggest that epigenetic analysis could potentially have utility as a marker of early metabolic pathology and might enable early life prophylaxis. ..
  4. Bellet M, Orozco Solis R, Sahar S, Eckel Mahan K, Sassone Corsi P. The time of metabolism: NAD+, SIRT1, and the circadian clock. Cold Spring Harb Symp Quant Biol. 2011;76:31-8 pubmed publisher
  5. Rozas D, Gullón S, Mellado R. A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor. PLoS ONE. 2012;7:e31760 pubmed publisher
    ..coelicolor seems to influence various processes characterised by the transition from primary to secondary metabolism, as determined by proteomic and transcriptomic analyses...
  6. Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:81-90 pubmed publisher
    ..Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging...
  7. Leitsch D, Burgess A, Dunn L, Krauer K, Tan K, Duchene M, et al. Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia. J Antimicrob Chemother. 2011;66:1756-65 pubmed publisher
    ..This suppression is consistent with generalized impaired flavin metabolism in highly MTR(r) Trichomonas vaginalis...
  8. Bronikowski A, Vleck D. Metabolism, body size and life span: a case study in evolutionarily divergent populations of the garter snake (Thamnophis elegans). Integr Comp Biol. 2010;50:880-7 pubmed publisher
    We present a case study of metabolism, life history and aging in the western terrestrial garter snake (Thamnophis elegans)...
  9. Kokebie R, Aggarwal R, Lidder S, Hakimiyan A, Rueger D, Block J, et al. The role of synovial fluid markers of catabolism and anabolism in osteoarthritis, rheumatoid arthritis and asymptomatic organ donors. Arthritis Res Ther. 2011;13:R50 pubmed publisher
    ..Larger, better-defined patient cohorts are necessary to develop a biomarker algorithm for prognostic use. ..

More Information


  1. Krauss M, Schaller S, Borchers S, Findeisen R, Lippert J, Kuepfer L. Integrating cellular metabolism into a multiscale whole-body model. PLoS Comput Biol. 2012;8:e1002750 pubmed publisher
    Cellular metabolism continuously processes an enormous range of external compounds into endogenous metabolites and is as such a key element in human physiology...
  2. Nishi Y, Fujimoto S, Sasaki M, Mukai E, Sato H, Sato Y, et al. Role of mitochondrial phosphate carrier in metabolism-secretion coupling in rat insulinoma cell line INS-1. Biochem J. 2011;435:421-30 pubmed publisher
    ..We evaluated the role of PiC in metabolism-secretion coupling in pancreatic β-cells using INS-1 cells manipulated to reduce PiC expression by siRNA (small ..
  3. Hyduke D, Lewis N, Palsson B. Analysis of omics data with genome-scale models of metabolism. Mol Biosyst. 2013;9:167-74 pubmed publisher
    ..This improvement is largely due to knowledge bases providing a validated biological context for interpreting the data. ..
  4. Metallo C, Vander Heiden M. Metabolism strikes back: metabolic flux regulates cell signaling. Genes Dev. 2010;24:2717-22 pubmed publisher
    ..This mechanism ensures that cells do not engage in anabolic metabolism when nutrients are limiting, and highlights how substrate availability for protein modifications can modulate ..
  5. Ellis B, Graham L, Molloy P. CRNDE, a long non-coding RNA responsive to insulin/IGF signaling, regulates genes involved in central metabolism. Biochim Biophys Acta. 2014;1843:372-86 pubmed publisher
    ..showed correlation with insulin/IGF signaling pathway components and responses, including glucose and lipid metabolism. Some of the genes are identical to those affected by insulin treatment in the same cell line...
  6. Rolls A, Schaich Borg J, de Lecea L. Sleep and metabolism: role of hypothalamic neuronal circuitry. Best Pract Res Clin Endocrinol Metab. 2010;24:817-28 pubmed publisher
    Sleep and metabolism are intertwined physiologically and behaviorally, but the neural systems underlying their coordination are still poorly understood...
  7. Chakraborty C, Doss C. Sirtuins family--recent development as a drug target for aging, metabolism, and age related diseases. Curr Drug Targets. 2013;14:666-75 pubmed
    ..we have described the roles of mammalian sirtuins-with particular emphasis on their associations to aging, metabolism, and age related diseases with recent references...
  8. Steinhauser M, Lechene C. Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry. Semin Cell Dev Biol. 2013;24:661-7 pubmed publisher
    ..Here we review the basic elements of MIMS and describe new applications of MIMS to the quantitative study of metabolic processes including protein and nucleic acid synthesis in model organisms ranging from microbes to humans. ..
  9. Harcombe W, Delaney N, Leiby N, Klitgord N, Marx C. The ability of flux balance analysis to predict evolution of central metabolism scales with the initial distance to the optimum. PLoS Comput Biol. 2013;9:e1003091 pubmed publisher
    The most powerful genome-scale framework to model metabolism, flux balance analysis (FBA), is an evolutionary optimality model...
  10. Rabinowitz J, White E. Autophagy and metabolism. Science. 2010;330:1344-8 pubmed publisher
    ..The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes...
  11. Stöwhas A, Latshang T, Lo Cascio C, Lautwein S, Stadelmann K, Tesler N, et al. Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS ONE. 2013;8:e70081 pubmed publisher
    ..However, the effects of acute exposure to moderate altitude on the cardiovascular system and metabolism are largely unknown...
  12. Sebastian C, Satterstrom F, Haigis M, Mostoslavsky R. From sirtuin biology to human diseases: an update. J Biol Chem. 2012;287:42444-52 pubmed publisher
    ..In this minireview, we provide an update on the known roles for each of the seven mammalian sirtuins in these areas. ..
  13. Chae L, Kim T, Nilo Poyanco R, Rhee S. Genomic signatures of specialized metabolism in plants. Science. 2014;344:510-3 pubmed publisher
    All plants synthesize basic metabolites needed for survival (primary metabolism), but different taxa produce distinct metabolites that are specialized for specific environmental interactions (specialized metabolism)...
  14. Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 2013;502:489-98 pubmed publisher
    ..Numerous connections between products of intermediary metabolism and chromatin proteins have recently been identified...
  15. Müller A, Aeschlimann S, Olekhnovitch R, Dacher M, Späth G, Bousso P. Photoconvertible pathogen labeling reveals nitric oxide control of Leishmania major infection in vivo via dampening of parasite metabolism. Cell Host Microbe. 2013;14:460-7 pubmed publisher
    ..The ability to probe pathogen biology in response to immune defense mechanisms in vivo should create opportunities for better dissecting host-pathogen interactions. ..
  16. Genard B, Moraga D, Pernet F, David E, Boudry P, Tremblay R. Expression of candidate genes related to metabolism, immunity and cellular stress during massive mortality in the American oyster Crassostrea virginica larvae in relation to biochemical and physiological parameters. Gene. 2012;499:70-5 pubmed publisher
    Quantification of mRNA of genes related to metabolism, immunity and cellular stress was examined in relation to a massive mortality event during the culture of American oyster larvae, Crassostrea virginica which was probably, in regard to ..
  17. Cadoni G, Boccia S, Petrelli L, DI Giannantonio P, Arzani D, Giorgio A, et al. A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism. Acta Otorhinolaryngol Ital. 2012;32:1-11 pubmed
    The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer...
  18. Reed J. Shrinking the metabolic solution space using experimental datasets. PLoS Comput Biol. 2012;8:e1002662 pubmed publisher
    Constraint-based models of metabolism have been used in a variety of studies on drug discovery, metabolic engineering, evolution, and multi-species interactions...
  19. McDonald R, Zelinski E, Keeley R, Sutherland D, Fehr L, Hong N. Multiple effects of circadian dysfunction induced by photoperiod shifts: alterations in context memory and food metabolism in the same subjects. Physiol Behav. 2013;118:14-24 pubmed publisher
    ..on learning and memory function and various food related processes including diet consumption rates, food metabolism, and changes in body weight...
  20. Mardinoglu A, Gatto F, Nielsen J. Genome-scale modeling of human metabolism - a systems biology approach. Biotechnol J. 2013;8:985-96 pubmed publisher
    Altered metabolism is linked to the appearance of various human diseases and a better understanding of disease-associated metabolic changes may lead to the identification of novel prognostic biomarkers and the development of new therapies...
  21. Kaelin W, McKnight S. Influence of metabolism on epigenetics and disease. Cell. 2013;153:56-69 pubmed publisher
    ..remove such chemical modifications are known, or might be suspected, to be sensitive to changes in intracellular metabolism. This knowledge provides a conceptual foundation for understanding how mutations in the metabolic enzymes SDH, ..
  22. Husse J, Hintze S, Eichele G, Lehnert H, Oster H. Circadian clock genes Per1 and Per2 regulate the response of metabolism-associated transcripts to sleep disruption. PLoS ONE. 2012;7:e52983 pubmed publisher
  23. Abarzua S, Drechsler S, Fischer K, Pietschmann N, Stapel J, Duda S, et al. Online monitoring of cellular metabolism in the MCF-7 carcinoma cell line treated with phytoestrogen extracts. Anticancer Res. 2010;30:1587-92 pubmed
    ..was to isolate phytoestrogens from the flax root of Linum usitatissimum and to test their effect on cellular metabolism in the human mammalian carcinoma cell line MCF-7 using the Bionas 2500 analysis system...
  24. Rottiers V, Najafi Shoushtari S, Kristo F, Gurumurthy S, Zhong L, Li Y, et al. MicroRNAs in metabolism and metabolic diseases. Cold Spring Harb Symp Quant Biol. 2011;76:225-33 pubmed publisher
    ..NAD(+)-dependent sirtuin SIRT6, and the insulin signaling intermediate IRS2, key regulators of glucose and lipid metabolism. These results have revealed a highly integrated microRNA (miRNA)-host gene circuit governing cholesterol/lipid ..
  25. Soltow Q, Jones D, Promislow D. A network perspective on metabolism and aging. Integr Comp Biol. 2010;50:844-54 pubmed publisher
    ..Here, we advocate the use of metabolic networks to expand the work from genomics and proteomics. As metabolism is the final fingerprint of functionality and has been implicated in multiple theories of aging, metabolomic ..
  26. Hofmeyr J, Rohwer J. Supply-demand analysis a framework for exploring the regulatory design of metabolism. Methods Enzymol. 2011;500:533-54 pubmed publisher
    ..Supply-demand analysis has recently been generalized into a computational tool that can be used to study the regulatory behavior of kinetic models of metabolic systems up to genome-scale. ..
  27. Kuo J, Chen K, Cheng I, Tsai P, Lu Y, Lee N. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol. 2010;53:105-11 pubmed
    ..effects of Eleutherococcus senticosus (ES) supplementation on endurance capacity, cardiovascular functions and metabolism of recreationally trained males for 8 weeks...
  28. Conde J, Scotece M, Gomez R, Gomez Reino J, Lago F, Gualillo O. At the crossroad between immunity and metabolism: focus on leptin. Expert Rev Clin Immunol. 2010;6:801-8 pubmed publisher
    ..most important adipokines secreted by fat cells, with a variety of physiological roles related to the control of metabolism, energy homeostasis and inflammatory response...
  29. Ghishan F, Kiela P. Advances in the understanding of mineral and bone metabolism in inflammatory bowel diseases. Am J Physiol Gastrointest Liver Physiol. 2011;300:G191-201 pubmed publisher
    Chronic inflammatory disorders such as inflammatory bowel diseases (IBDs) affect bone metabolism and are frequently associated with the presence of osteopenia, osteoporosis, and increased risk of fractures...
  30. Massie C, Lynch A, Ramos Montoya A, Boren J, Stark R, Fazli L, et al. The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J. 2011;30:2719-33 pubmed publisher
    ..cancer and regulates cancer cell growth via its unexpected role as a hormone-dependent modulator of anabolic metabolism. In conclusion, it is possible to progress from transcriptional studies to a promising therapeutic target by ..
  31. Donato J, Cravo R, Frazao R, Elias C. Hypothalamic sites of leptin action linking metabolism and reproduction. Neuroendocrinology. 2011;93:9-18 pubmed publisher
    ..In this review, we discuss the recent advances in the field focused on the identification of potential site(s) or specific neuronal populations involved in leptin's effects in the neuroendocrine reproductive axis. ..
  32. Froy O. The circadian clock and metabolism. Clin Sci (Lond). 2011;120:65-72 pubmed publisher
    ..and physiological functions in addition to the expression and/or activity of enzymes and hormones involved in metabolism. In turn, key metabolic enzymes and transcription activators interact with and affect the core clock mechanism...
  33. Nakamura M, Ohki S, Suzuki A, Sakai K. Coral larvae under ocean acidification: survival, metabolism, and metamorphosis. PLoS ONE. 2011;6:e14521 pubmed publisher
    ..These results imply that acidified seawater impacts larval physiology, suggesting that suppressed metabolism and metamorphosis may alter the dispersal potential of larvae and subsequently reduce the resilience of coral ..
  34. Bass J, Takahashi J. Circadian integration of metabolism and energetics. Science. 2010;330:1349-54 pubmed publisher
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  35. Traves P, de Atauri P, Marin S, Pimentel Santillana M, Rodríguez Prados J, Marin de Mas I, et al. Relevance of the MEK/ERK signaling pathway in the metabolism of activated macrophages: a metabolomic approach. J Immunol. 2012;188:1402-10 pubmed publisher
    ..We concluded that inhibition of the MEK/ERK cascade interferes with central metabolism, and this cross-talk between signal transduction and metabolism also occurs in the presence of LPS.
  36. Jin L, Feng X, Rong H, Pan Z, Inaba Y, Qiu L, et al. The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism. Nat Commun. 2013;4:1937 pubmed publisher
    ..mice, with ivermectin decreases serum glucose and cholesterol levels, suggesting that ivermectin regulates metabolism through FXR...
  37. Fleming R, Thiele I. von Bertalanffy 1.0: a COBRA toolbox extension to thermodynamically constrain metabolic models. Bioinformatics. 2011;27:142-3 pubmed publisher
    In flux balance analysis of genome scale stoichiometric models of metabolism, the principal constraints are uptake or secretion rates, the steady state mass conservation assumption and reaction directionality...
  38. Lee Y, Kim E. AMP-activated protein kinase as a key molecular link between metabolism and clockwork. Exp Mol Med. 2013;45:e33 pubmed publisher
    ..Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks...
  39. Challet E. Circadian clocks, food intake, and metabolism. Prog Mol Biol Transl Sci. 2013;119:105-35 pubmed publisher
    ..has been shaped by evolution over millions of years generates an internal timing controlling the sleep-wake and metabolism cycles...
  40. Imai S, Yoshino J. The importance of NAMPT/NAD/SIRT1 in the systemic regulation of metabolism and ageing. Diabetes Obes Metab. 2013;15 Suppl 3:26-33 pubmed publisher
    ..We will also discuss the potential of key NAD intermediates as effective nutriceuticals for the prevention and the treatment of age-associated metabolic complications, such as type 2 diabetes. ..
  41. Smith R, Lindsey D, Dhulipala L, Harris A, Goodman S, Maloney W. Effects of intermittent hydrostatic pressure and BMP-2 on osteoarthritic human chondrocyte metabolism in vitro. J Orthop Res. 2011;29:361-8 pubmed publisher
    ..IHP and BMP-2 modulated OA chondrocyte metabolism in accordance with growth factor concentration independently, without evidence of synergism or antagonism...
  42. Halbirk M, Nørrelund H, Møller N, Schmitz O, Gøtzsche L, Nielsen R, et al. Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function. Am J Physiol Heart Circ Physiol. 2010;299:H1220-5 pubmed publisher
    ..In conclusion, acipimox caused minor changes in whole body metabolism and decreased the FFA supply, but a long-term reduction in circulating FFAs with acipimox did not change ..
  43. Wijsman C, Westendorp R, Verhagen E, Catt M, Slagboom P, de Craen A, et al. Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial. J Med Internet Res. 2013;15:e233 pubmed publisher
    Lack of physical activity leads to detrimental changes in body composition and metabolism, functional decline, and increased risk of disease in old age...
  44. Houston A. Evolutionary models of metabolism, behaviour and personality. Philos Trans R Soc Lond B Biol Sci. 2010;365:3969-75 pubmed publisher
    I explore the relationship between metabolism and personality by establishing how selection acts on metabolic rate and risk-taking in the context of a trade-off between energy and predation...
  45. Sullivan E, Smith M, Grove K. Perinatal exposure to high-fat diet programs energy balance, metabolism and behavior in adulthood. Neuroendocrinology. 2011;93:1-8 pubmed publisher
    ..The perinatal environment plays an important role in programming many aspects of physiology and behavior including metabolism, body weight set point, energy balance regulation and predisposition to mental health-related disorders such as ..
  46. Zhang G, Yang P, Guo P, Miele L, Sarkar F, Wang Z, et al. Unraveling the mystery of cancer metabolism in the genesis of tumor-initiating cells and development of cancer. Biochim Biophys Acta. 2013;1836:49-59 pubmed publisher
    Robust anaerobic metabolism plays a causative role in the origin of cancer cells; however, the oncogenic metabolic genes, factors, pathways, and networks in genesis of tumor-initiating cells (TICs) have not yet been systematically ..
  47. Chen X, McClusky R, Itoh Y, Reue K, Arnold A. X and Y chromosome complement influence adiposity and metabolism in mice. Endocrinology. 2013;154:1092-104 pubmed publisher
    ..The results reveal a role for the Y chromosome in metabolism independent of testes and gonadal hormones and point to a small number of X-Y gene pairs with similar coding ..
  48. Collins S, Reznik E, Segrè D. Temporal expression-based analysis of metabolism. PLoS Comput Biol. 2012;8:e1002781 pubmed publisher
    Metabolic flux is frequently rerouted through cellular metabolism in response to dynamic changes in the intra- and extra-cellular environment...
  49. Alokail M, Al Daghri N, Alarifi S, Draz H, Hussain T, Yakout S. Long-term exposure to incense smoke alters metabolism in Wistar albino rats. Cell Biochem Funct. 2011;29:96-101 pubmed publisher
    ..Taken together, these data suggest that incense smoke influences metabolism adversely in rats...
  50. Priyadarshini S, Aich P. Effects of psychological stress on innate immunity and metabolism in humans: a systematic analysis. PLoS ONE. 2012;7:e43232 pubmed publisher
    ..of the physiological response to psychological stress by analyzing interactions between innate immunity and metabolism at systems level by analyzing the data available in the literature...
  51. Burcelin R. Regulation of metabolism: a cross talk between gut microbiota and its human host. Physiology (Bethesda). 2012;27:300-7 pubmed publisher
  52. Hamtiaux L, Hansoulle L, Dauguet N, Muccioli G, Gallez B, Lambert D. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS ONE. 2011;6:e26823 pubmed publisher
    ..More particularly, this emphasizes the great potential benefit of designing novel anti-cancerous therapies based on the association of endocannabinoids and inhibitors of their hydrolysis. ..
  53. Canto C, Auwerx J. NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol. 2011;76:291-8 pubmed publisher
  54. Xu X, Gopalacharyulu P, Seppanen Laakso T, Ruskeepää A, Aye C, Carson B, et al. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. PLoS Genet. 2012;8:e1002478 pubmed publisher
    The insulin/IGF signaling pathway is a highly conserved regulator of metabolism in flies and mammals, regulating multiple physiological functions including lipid metabolism...