morphine dependence

Summary

Summary: Strong dependence, both physiological and emotional, upon morphine.

Top Publications

  1. Hu Z, Deng Y, Hu C, Deng P, Bu Q, Yan G, et al. ¹H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention. Behav Brain Res. 2012;231:11-9 pubmed publisher
    Metabolic consequences of morphine dependence and withdrawal intervention have not been well explored...
  2. Diaz S, Barros V, Antonelli M, Rubio M, Balerio G. Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of mu-opioid receptors in prepubertal male and female mice. Synapse. 2006;60:132-40 pubmed
    ..The present results suggest that the effect of BAC in preventing the expression of MOR withdrawal signs could be related with the ability of BAC to reestablish the mu-opioid receptor labeling in certain brain areas...
  3. Bierczynska Krzysik A, Bonar E, Drabik A, Noga M, Suder P, Dylag T, et al. Rat brain proteome in morphine dependence. Neurochem Int. 2006;49:401-6 pubmed
    ..g. proteins that belong to GTPase and GST superfamilies, ATPase, asparaginase or proteasome subunit p27 families...
  4. Nunez C, Martín F, Földes A, Luisa Laorden M, Kovacs K, Victoria Milanés M. Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. J Neurochem. 2010;114:475-87 pubmed publisher
    ..in FosB/DeltaFosB expression in both hypothalamic and extrahypothalamic brain stress system during morphine dependence and withdrawal. Rats were made dependent on morphine and, on day 8, were injected with saline or naloxone...
  5. Wei Q, Wu N, Bian J, Chen Y, Su R, Li J. Involvement of hippocampal phosphatidylethanolamine-binding protein in morphine dependence and withdrawal. Addict Biol. 2013;18:230-40 pubmed publisher
    ..of hippocampal PEBP levels induced by antisense oligodeoxynucleotides resulted in aggravated morphine dependence. Together, these findings indicate that PEBP is involved in morphine dependence...
  6. Wu Y, Chen R, Zhao X, Li A, Li G, Zhou J. JWA regulates chronic morphine dependence via the delta opioid receptor. Biochem Biophys Res Commun. 2011;409:520-5 pubmed publisher
    ..Despite decades of intensive studies, the underlying mechanisms of morphine dependence are still unclear...
  7. Parvizpour A, Charkhpour M, Habibi Asl B, Shakhsi M, Ghaderi M, Hassanzadeh K. Repeated central administration of selegiline attenuated morphine physical dependence in rat. Pharmacol Rep. 2013;65:593-9 pubmed
    ..The purpose of this study was to evaluate the effects of systemic and intracerebroventricular (icv) administration of selegiline (a selective inhibitor of monoamine oxidase B) on the morphine withdrawal syndrome in rats...
  8. Nunez C, Castells M, Laorden M, Milanes M. Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:407-20 pubmed publisher
    ..drug addiction, but its role in activation of paraventricular nucleus and nucleus tractus solitarius during morphine dependence remain poorly understood...
  9. Riahi E, Mirzaii Dizgah I, Karimian S, Sadeghipour H, Roodsari H, Dehpour A. Attenuation of morphine withdrawal signs by a GABAB receptor agonist in the locus coeruleus of rats. Behav Brain Res. 2009;196:11-4 pubmed publisher
    ..On the other hand, baclofen effects were reversed by CGP35348. It may be concluded that activation of GABA(B) receptor mechanisms in the LC reduces precipitated withdrawal symptoms from chronic morphine treatment...

More Information

Publications62

  1. Emeterio E, Tramullas M, Hurlé M. Modulation of apoptosis in the mouse brain after morphine treatments and morphine withdrawal. J Neurosci Res. 2006;83:1352-61 pubmed
    ..The possible clinical implications of our findings are discussed...
  2. Li F, Wu N, Su R, Liu Y, Lu X, Li J. Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors. Eur J Pharmacol. 2009;612:1-8 pubmed publisher
    ..In the present study we compared the effects of moxonidine, rilmenidine and agmatine in the development of morphine dependence, and investigated the role of imidazoline I(1) receptor in the effects of these agents...
  3. Nassirpour R, Bahima L, Lalive A, Lüscher C, Lujan R, Slesinger P. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. J Neurosci. 2010;30:13419-30 pubmed publisher
    ..These results demonstrate plasticity in neuronal GIRK signaling that may contribute to the abusive effects of morphine...
  4. Neugebauer N, Einstein E, Lopez M, McClure Begley T, Mineur Y, Picciotto M. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacol Biochem Behav. 2013;109:77-83 pubmed publisher
    Cholinergic signaling is thought to be involved in morphine dependence and withdrawal, but the specific mechanisms involved remain unclear...
  5. Joukar S, Atapour N, Kalantaripour T, Bashiri H, Shahidi A. Differential modulatory actions of GABAA agonists on susceptibility to GABAA antagonists-induced seizures in morphine dependent rats: possible mechanisms in seizure propensity. Pharmacol Biochem Behav. 2011;99:17-21 pubmed publisher
    ..Therefore, it seems that long-term morphine alters some properties of GABA system so that the responsive rate of GABA(A) receptors not only to its antagonists, but also to its agonists will change differently...
  6. Kang L, Wang D, Li B, Hu M, Zhang P, Li J. Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats. Am J Drug Alcohol Abuse. 2008;34:541-52 pubmed publisher
    ..Our results demonstrated that mirtazapine attenuates morphine withdrawal and morphine-induced CPP in rats and suggest that mirtazapine may have therapeutic potential in the treatment of opiate dependence...
  7. Nunez C, Földes A, Laorden M, Milanes M, Kovacs K. Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal. J Neurochem. 2007;101:1060-71 pubmed
    ..These activations however were not associated with induction of CRH or AVP hnRNAs...
  8. Mitchell J, Bergren L, Chen K, Fields H. Cholecystokinin is necessary for the expression of morphine conditioned place preference. Pharmacol Biochem Behav. 2006;85:787-95 pubmed
    ..These results indicate that endogenous CCK modulates the incentive-salience of morphine-associated cues and suggest that CCK antagonists may be useful in the treatment of drug craving...
  9. Ghazal P, Ciccocioppo R, Ubaldi M. Morphine dependence is associated with changes in neuropeptide S receptor expression and function in rat brain. Peptides. 2013;46:6-12 pubmed publisher
    ..These results demonstrated that morphine dependence induction led to (i) changes in NPSR mRNA expression; (ii) increased anxiety; and (iii) more potent ..
  10. Nunez C, Földes A, Pérez Flores D, García Borrón J, Laorden M, Kovacs K, et al. Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal. Endocrinology. 2009;150:3118-27 pubmed publisher
    ..Total TH protein levels were elevated in the NTS-A(2) from sham-operated rats during morphine dependence and withdrawal, whereas we did not find any alteration in ADX plus CORT animals...
  11. Kest B, Smith S, Schorscher Petcu A, Austin J, Ritchie J, Klein G, et al. Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. Neuroscience. 2009;162:1255-64 pubmed publisher
    ..These data strongly implicate the G alpha(o) protein in the locus coeruleus as contributing to interindividual variability in physical dependence on opioids in mice...
  12. Anghel A, Jamieson C, Ren X, Young J, Porche R, Ozigbo E, et al. Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake. Neuroscience. 2010;167:554-66 pubmed publisher
    ..Changes in genes related to food intake may uncover new pathways related to some of the physiological effects of opioids...
  13. Azizi H, Mirnajafi Zadeh J, Rohampour K, Semnanian S. Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats. Neurosci Lett. 2010;482:255-9 pubmed publisher
    ..These results suggest that activation of OXR1 in the LC might be involved in the expression of withdrawal signs in morphine dependent rats...
  14. Martin F, Mora L, Laorden M, Milanés M. Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal. Br J Pharmacol. 2011;163:857-75 pubmed publisher
  15. Navarro Zaragoza J, Nunez C, Ruiz Medina J, Laorden M, Valverde O, Milanes M. CRF? mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats. Br J Pharmacol. 2011;162:851-62 pubmed publisher
  16. Suder P, Bodzon Kulakowska A, Mak P, Bierczynska Krzysik A, Daszykowski M, Walczak B, et al. The proteomic analysis of primary cortical astrocyte cell culture after morphine administration. J Proteome Res. 2009;8:4633-40 pubmed publisher
    ..gel electrophoresis and nanoLC-ESI-MS/MS, we identified proteins and characterized their potential role in morphine dependence. Observed differences were also confirmed by Western blotting...
  17. Bu Q, Yang Y, Yan G, Hu Z, Hu C, Duan J, et al. Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention. J Proteomics. 2012;75:1330-42 pubmed publisher
    ..However, the proteins involved in neuroadaptive processes and withdrawal symptom in primates of morphine dependence have not been well explored...
  18. Narita M, Suzuki M, Kuzumaki N, Miyatake M, Suzuki T. Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. Ann N Y Acad Sci. 2008;1141:96-104 pubmed publisher
    ..These findings provide direct evidence that astrocytes may, at least in part, contribute to the development of the rewarding effects induced by drugs of abuse in the nucleus accumbens and cingulate cortex...
  19. Zhang Y, Zhang F, Yang C, Jin H, Yang Y, Xu M. Dopamine affects the change of pain-related electrical activity induced by morphine dependence. Neurochem Res. 2012;37:977-82 pubmed publisher
    ..neurons (PENs) and pain-inhibition neurons (PINs) in the caudate nucleus (Cd) following the development of morphine dependence. We also observed the role of DA on these changes...
  20. Abul Husn N, Annangudi S, Ma ayan A, Ramos Ortolaza D, Stockton S, Gomes I, et al. Chronic morphine alters the presynaptic protein profile: identification of novel molecular targets using proteomics and network analysis. PLoS ONE. 2011;6:e25535 pubmed publisher
    ..morphine withdrawal, suggesting that Hsp90 upregulation at the presynapse plays a role in the expression of morphine dependence. Thus, integration of proteomics, network analysis, and behavioral studies has provided a greater ..
  21. Bodzon Kułakowska A, Kułakowski K, Drabik A, Moszczynski A, Silberring J, Suder P. Morphinome--a meta-analysis applied to proteomics studies in morphine dependence. Proteomics. 2011;11:5-21 pubmed publisher
    ..It gives a chance for fast comparison of results without hours spent on life science literature mining...
  22. Almela P, Martínez Laorden E, Atucha N, Milanes M, Laorden M. Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase. J Mol Cell Cardiol. 2011;51:129-39 pubmed publisher
    ..In this study, we investigated Hsp27 and phospho-Hsp27 expression during morphine dependence and withdrawal and evaluated the involvement of ERK in the phosphorylation of Hsp27 in the rat right ..
  23. Habibey R, Pazoki Toroudi H. Morphine dependence protects rat kidney against ischaemia-reperfusion injury. Clin Exp Pharmacol Physiol. 2008;35:1209-14 pubmed publisher
    ..c., for 5 days) to develop morphine dependence (MD). Three weeks before the I/R procedure, the right kidney was removed...
  24. Contet C, Filliol D, Matifas A, Kieffer B. Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity. Neuropharmacology. 2008;54:475-86 pubmed
  25. Harris G, Aston Jones G. Activation in extended amygdala corresponds to altered hedonic processing during protracted morphine withdrawal. Behav Brain Res. 2007;176:251-8 pubmed
  26. Klein G, Juni A, Waxman A, Arout C, Inturrisi C, Kest B. A survey of acute and chronic heroin dependence in ten inbred mouse strains: evidence of genetic correlation with morphine dependence. Pharmacol Biochem Behav. 2008;90:447-52 pubmed publisher
    ..These data suggest that the genetic liability to heroin dependence remains constant across a period of heroin intake, and that heroin and morphine dependence may benefit from common treatment strategies.
  27. Zhang Y, Yang C, Xu X, Jiao R, Jin H, Lv Y, et al. Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus. Biochem Biophys Res Commun. 2008;372:179-85 pubmed publisher
  28. Zhang Z, Schulteis G. Withdrawal from acute morphine dependence is accompanied by increased anxiety-like behavior in the elevated plus maze. Pharmacol Biochem Behav. 2008;89:392-403 pubmed publisher
    ..6 mg/kg dose. Thus, anxiety-like behavior is a prominent feature of the negative emotional consequences of naloxone-precipitated withdrawal from acute opioid dependence...
  29. Murray F, Harrison N, Grimwood S, Bristow L, Hutson P. Nucleus accumbens NMDA receptor subunit expression and function is enhanced in morphine-dependent rats. Eur J Pharmacol. 2007;562:191-7 pubmed
    ..Taken together, these data support several studies in the literature indicating that NMDA receptors in the nucleus accumbens are involved in the process of opiate dependence...
  30. Maldonado R, Blendy J, Tzavara E, Gass P, Roques B, Hanoune J, et al. Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science. 1996;273:657-9 pubmed
    ..Thus, CREB-dependent gene transcription is a factor in the onset of behavioral manifestations of opiate dependence...
  31. Laorden M, Castells M, Milanés M. Effects of morphine and morphine withdrawal on brainstem neurons innervating hypothalamic nuclei that control the pituitary-adrenocortical axis in rats. Br J Pharmacol. 2002;136:67-75 pubmed
  32. Frenois F, Cador M, Caillé S, Stinus L, Le Moine C. Neural correlates of the motivational and somatic components of naloxone-precipitated morphine withdrawal. Eur J Neurosci. 2002;16:1377-89 pubmed
    ..b>Morphine dependence was induced by subcutaneous implantation of slow-release morphine pellets for 6 days and withdrawal was ..
  33. Wang Y, Wan C, Zhou W, Peng T, Liu Y, Wang Z, et al. The role of mPer1 in morphine dependence in mice. Neuroscience. 2005;130:383-8 pubmed
    ..targeting mPer1 to interfere the expression of mPer1 in CNS in mice and studied the role of mPer1 on morphine dependence. We found that the DNAzyme could attenuate the expression of mPer1 in CNS in mice...
  34. Trang T, Sutak M, Quirion R, Jhamandas K. Spinal administration of lipoxygenase inhibitors suppresses behavioural and neurochemical manifestations of naloxone-precipitated opioid withdrawal. Br J Pharmacol. 2003;140:295-304 pubmed
    ..4. The results of this study suggest that activity of LOX products, at the spinal level, contributes to the expression of opioid physical dependence, and that this activity may be expressed through increased sensory neuropeptide release...
  35. Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, Bleckmann S, et al. Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology. 2004;29:1122-33 pubmed
    ..Our results emphasize the selective role played by neuronal CREB in emotional-like behavior and the somatic expression morphine withdrawal, without participating in the rewarding properties induced by morphine and cocaine...
  36. Zafar S, Ahmad M, Siddiqui T. Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice. J Ethnopharmacol. 2001;78:95-8 pubmed
  37. Bexis S, Ong J, White J. Attenuation of morphine withdrawal signs by the GABA(B) receptor agonist baclofen. Life Sci. 2001;70:395-401 pubmed
    ..It can be concluded that baclofen has some potential in the treatment of opioid withdrawal and that GABA(B) receptors may be implicated in such a withdrawal...
  38. Robbe D, Bockaert J, Manzoni O. Metabotropic glutamate receptor 2/3-dependent long-term depression in the nucleus accumbens is blocked in morphine withdrawn mice. Eur J Neurosci. 2002;16:2231-5 pubmed
  39. Azar M, Jones B, Schulteis G. Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal. Psychopharmacology (Berl). 2003;170:42-50 pubmed
    ..Conditioned place aversion (CPA) is known to be a sensitive measure of the aversive motivational state produced by opioid withdrawal in rats made chronically dependent on opioids...
  40. Nakagawa T, Satoh M. Involvement of glial glutamate transporters in morphine dependence. Ann N Y Acad Sci. 2004;1025:383-8 pubmed
    There are several lines of evidence implying the involvement of the central glutamatergic system in morphine dependence. Extracellular glutamate released from nerve terminals is counterbalanced by glutamate transporters in neurons (EAAC1 ..
  41. Taraschenko O, Panchal V, Maisonneuve I, Glick S. Is antagonism of alpha3beta4 nicotinic receptors a strategy to reduce morphine dependence?. Eur J Pharmacol. 2005;513:207-18 pubmed
    ..The results of the present study provide evidence that alpha3beta4 nicotinic receptors are involved in the expression of at least two signs of opioid withdrawal...
  42. Yan C, Hou Y. Effects of morphine dependence and withdrawal on levels of neurosteroids in rat brain. Acta Pharmacol Sin. 2004;25:1285-91 pubmed
    To investigate the effects of morphine dependence and withdrawal on the concentrations of neurosteroids in rat brain.
  43. Laorden M, Nunez C, Almela P, Milanes M. Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones. J Neurochem. 2002;83:132-40 pubmed
  44. Ozawa T, Nakagawa T, Shige K, Minami M, Satoh M. Changes in the expression of glial glutamate transporters in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal. Brain Res. 2001;905:254-8 pubmed
    ..of mRNAs for the glial glutamate transporters, GLT-1 and GLAST, in the rat brain accompanied with morphine dependence and naloxone-precipitated withdrawal was investigated by Northern blot analysis...
  45. Wells J, Bartlett J, Ananthan S, Bilsky E. In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence. J Pharmacol Exp Ther. 2001;297:597-605 pubmed
    ..p.) elicited much less vertical jumping than naloxone (10 mg/kg i.p.) in acute and chronic morphine dependence models. SoRI 9409 also suppressed withdrawal jumping when coadministered with naloxone...
  46. Mamiya T, Noda Y, Ren X, Hamdy M, Furukawa S, Kameyama T, et al. Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor. Br J Pharmacol. 2001;132:1111-7 pubmed
    In this study, we examined whether morphine dependence was inhibited by rolipram, a cyclic AMP selective phosphodiesterase inhibitor in mice, since a role for the cyclic AMP systems in the development of morphine dependence has been ..
  47. Matthes H, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature. 1996;383:819-23 pubmed
    ..We conclude that the mu-opioid-receptor gene product is the molecular target of morphine in vivo and that it is a mandatory component of the opioid system for morphine action...
  48. Ren X, Noda Y, Mamiya T, Nagai T, Nabeshima T. A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinase. Behav Brain Res. 2004;152:243-50 pubmed
    ..we investigated how the neurosteroid, dehydroepiandrosterone sulfate (DHEAS) affects the development of morphine dependence and tolerance in mice...
  49. Wang C, Mo Z, Tu H. Effect of sinomenine on morphine dependence in isolated guinea pig ileum. Di Yi Jun Yi Da Xue Xue Bao. 2003;23:329-31 pubmed
    ..To investigate the effects of sinomenine on morphine withdrawal response and acetylchline (Ach)-induced contracture in isolated guinea pig ileum...
  50. Ammon Treiber S, Hollt V. Morphine-induced changes of gene expression in the brain. Addict Biol. 2005;10:81-9 pubmed
    ..These long-term changes in receptor expression suggest a persistent alteration of synaptic signalling after morphine treatment...
  51. Liu N, Liu Y, Fan Y, Yu H, Wilson F, Ma Y, et al. EEG activities in the orbitofrontal cortex and dorsolateral prefrontal cortex during the development of morphine dependence, tolerance and withdrawal in rhesus monkeys. Brain Res. 2005;1053:137-45 pubmed
    ..Moreover, we found that although the changes in EEG activities in the OFC and DLPFC at 30-35 min after injection were similar, the DLPFC was more sensitive to the effect of morphine than the OFC...
  52. Dizgah I, Karimian S, Zarrindast M, Sohanaki H. Attenuation of morphine withdrawal signs by a D1 receptor agonist in the locus coeruleus of rats. Neuroreport. 2005;16:1683-6 pubmed
    ..On the other hand, SCH23390 (25 ng/site) reversed the SKF38393 effect. It may be concluded that activation of dopamine D(1) receptors in the locus coeruleus attenuates naloxone-induced withdrawal...
  53. Kest B, Palmese C, Hopkins E, Adler M, Juni A, Mogil J. Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence. Neuroscience. 2002;115:463-9 pubmed
    ..The genetic relationship between acute and chronic morphine dependence was thus presently studied by comparing mice of 11 inbred strains (129P3, A, AKR, BALB/c, C3H/He, C57BL/6, ..