erectile dysfunction


Summary: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.

Top Publications

  1. Vardi Y. Microvascular complications in diabetic erectile dysfunction: do we need other alternatives?. Diabetes Care. 2009;32 Suppl 2:S420-2 pubmed publisher
  2. Plumb J, Guest J. Annual cost of erectile dysfunction to UK Society. Pharmacoeconomics. 1999;16:699-709 pubmed
    The objective of this study was to estimate the annual socioeconomic burden imposed by erectile dysfunction (ED) on UK society...
  3. Ayta I, McKinlay J, Krane R. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int. 1999;84:50-6 pubmed
    To project the likely worldwide increase in the prevalence of erectile dysfunction (ED) over the next 25 years, and to identify and discuss some possible health-policy consequences using the recent developments in the UK as a case study...
  4. Rosen R, Riley A, Wagner G, Osterloh I, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology. 1997;49:822-30 pubmed
    ..sound, with the sensitivity and specificity for detecting treatment-related changes in patients with erectile dysfunction. Relevant domains of sexual function across various cultures were identified via a literature search of ..
  5. Maresca L, D Agostino M, Castaldo L, Vitelli A, Mancini M, Torella G, et al. Exercise training improves erectile dysfunction (ED) in patients with metabolic syndrome on phosphodiesterase-5 (PDE-5) inhibitors. Monaldi Arch Chest Dis. 2013;80:177-83 pubmed
    b>Erectile dysfunction (ED) affects about 50% of males aged 40-70 years old. ED shares with atherosclerotic disease several common risk factors; therefore, it may be considered a surrogate marker of atherosclerosis...
  6. Tempany C, Rahmouni A, Epstein J, Walsh P, Zerhouni E. Invasion of the neurovascular bundle by prostate cancer: evaluation with MR imaging. Radiology. 1991;181:107-12 pubmed
  7. Liang B, Mackey T. Sexual medicine: Online risks to health--the problem of counterfeit drugs. Nat Rev Urol. 2012;9:480-2 pubmed publisher
  8. Tian G, Liu X, Zeng X, Su X, Wei W, Wang X. [Bibliometric analysis on relations between cardiovascular disease and erectile dysfunction]. Zhonghua Liu Xing Bing Xue Za Zhi. 2017;38:810-813 pubmed publisher
    b>Objective: To understand the current situation and trend on the relations between erectile dysfunction (ED) and cardiovascular disease (CVD) through analyzing the epidemiologic research data...
  9. Montorsi F, Guazzoni G, Strambi L, Da Pozzo L, Nava L, Barbieri L, et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol. 1997;158:1408-10 pubmed
    ..The potential complications related to the use of intracavernous injections must be clearly explained to patients. ..

More Information


  1. Seid A, Gerensea H, Tarko S, Zenebe Y, Mezemir R. Prevalence and determinants of erectile dysfunction among diabetic patients attending in hospitals of central and northwestern zone of Tigray, northern Ethiopia: a cross-sectional study. BMC Endocr Disord. 2017;17:16 pubmed publisher
    The prevalence of erectile dysfunction among diabetic men varies between 35-90%...
  2. Ben Josef A, Chen J, Wileyto P, Doucette A, BEKELMAN J, Christodouleas J, et al. Effect of Eischens Yoga During Radiation Therapy on Prostate Cancer Patient Symptoms and Quality of Life: A Randomized Phase II Trial. Int J Radiat Oncol Biol Phys. 2017;98:1036-1044 pubmed publisher
    A randomized phase II study was performed to measure the potential therapeutic effects of yoga on fatigue, erectile dysfunction, urinary incontinence, and overall quality of life (QOL) in prostate cancer (PCa) patients undergoing external ..
  3. Evans C. The use of penile prostheses in the treatment of impotence. Br J Urol. 1998;81:591-8 pubmed
  4. Dhaunsi G, Yousif M, Makki B, Akhtar S, Benter I. Angiotensin-(1-7) Downregulates Diabetes-Induced cGMP Phosphodiesterase Activation in Rat Corpus Cavernosum. Biomed Res Int. 2017;2017:5084961 pubmed publisher
    ..of the beneficial effects of angiotensin-(1-7), Ang-(1-7), in diabetes-related complications, including erectile dysfunction, remain unclear...
  5. Walther A, Mahler F, Debelak R, Ehlert U. Psychobiological Protective Factors Modifying the Association Between Age and Sexual Health in Men: Findings From the Men's Health 40+ Study. Am J Mens Health. 2017;11:737-747 pubmed publisher
    Sexual health severely decreases with age. For males older than 40 years, erectile dysfunction (ED) is the most common sexual disorder...
  6. Jarow J, Lowe F. Penile trauma: an etiologic factor in Peyronie's disease and erectile dysfunction. J Urol. 1997;158:1388-90 pubmed
    ..The reduced incidence of engaging in sexual relations with a partial erection among the Peyronie's disease patients implies that partial impotence is not a predisposing factor for Peyronie's disease. ..
  7. Patchell R, Fellows H, Humphries L. Neurologic complications of anorexia nervosa. Acta Neurol Scand. 1994;89:111-6 pubmed
    ..In most patients, the neurologic complications were reversed completely after correction of nutritional deficiencies and fluid and electrolyte imbalances. ..
  8. Barocas D, Alvarez J, Resnick M, Koyama T, Hoffman K, Tyson M, et al. Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years. JAMA. 2017;317:1126-1140 pubmed publisher
    ..These findings may facilitate counseling regarding the comparative harms of contemporary treatments for prostate cancer. ..
  9. Rodda S, Tyldesley S, Morris W, Keyes M, Halperin R, Pai H, et al. ASCENDE-RT: An Analysis of Treatment-Related Morbidity for a Randomized Trial Comparing a Low-Dose-Rate Brachytherapy Boost with a Dose-Escalated External Beam Boost for High- and Intermediate-Risk Prostate Cancer. Int J Radiat Oncol Biol Phys. 2017;98:286-295 pubmed publisher
    To report the genitourinary (GU) and gastrointestinal (GI) morbidity and erectile dysfunction in a randomized trial comparing 2 methods of dose escalation for high- and intermediate-risk prostate cancer...
  10. Wilt T, Jones K, Barry M, Andriole G, Culkin D, Wheeler T, et al. Follow-up of Prostatectomy versus Observation for Early Prostate Cancer. N Engl J Med. 2017;377:132-142 pubmed publisher
    ..Uncertainty persists regarding nonfatal health outcomes and long-term mortality...
  11. Stone R. Mycology. Last stand for the body snatcher of the Himalayas?. Science. 2008;322:1182 pubmed publisher
  12. Glybochko P, Alyaev Y, Rapoport L, Grigorev N, Bezrukov E, Tsarichenko D, et al. [The role of waterjet dissection in improving erectile function and continence after nerve-sparing prostatectomy]. Urologiia. 2017;:43-49 pubmed
    b>Erectile dysfunction (ED) and urinary incontinence (UI) following radical prostatectomy (RP) adversely impact patients psycho-emotional status reducing the quality of life and treatment satisfaction...
  13. Burns Cox N, Burston A, Gingell J. Fifteen years experience of penile prosthesis insertion. Int J Impot Res. 1997;9:211-6 pubmed
    ..Also noted were risk factors for erectile dysfunction and the aetiology. Twenty patients were known to have died or moved away...
  14. Wang Z, Yang L, Chen H, Lin H, Tsai Y, Huang W. Effects of TNF-? on penile structure alteration in rats with hyperprolactinemia. PLoS ONE. 2017;12:e0181952 pubmed publisher
    ..Testicular TNF-? suppresses testosterone release, which in turn results in the erectile dysfunction (ED) seen in hyperPRL...
  15. Adimoelja A. Phytochemicals and the breakthrough of traditional herbs in the management of sexual dysfunctions. Int J Androl. 2000;23 Suppl 2:82-4 pubmed
    Traditional herbs have been a revolutionary breakthrough in the management of erectile dysfunction and have become known world-wide as an 'instant' treatment...
  16. Lin H, Lai H, Chen C, Huang C. Depression and Health-Related Quality of Life and Their Association With Resourcefulness in Survivors of Prostate Cancer. Arch Psychiatr Nurs. 2017;31:407-413 pubmed publisher
    ..Over half the patients had depressive symptoms, and 96.1% had erectile dysfunction. Lack of resourcefulness was found to decrease PC-specific quality of life (PCQOL) and physical quality of ..
  17. Winder K, Seifert F, Kohrmann M, Crodel C, Kloska S, Dorfler A, et al. Lesion mapping of stroke-related erectile dysfunction. Brain. 2017;140:1706-1717 pubmed publisher
    ..This study intended to determine associations between stroke-related erectile dysfunction and cerebral ischaemic lesion sites using voxel-based lesion mapping. In 52 males (mean age 60.5 ± 10...
  18. Graham J, Oppenheimer D. Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy. J Neurol Neurosurg Psychiatry. 1969;32:28-34 pubmed
  19. Crofts M, Mead K, Persad R, Horner P. How to manage the chronic pelvic pain syndrome in men presenting to sexual health services. Sex Transm Infect. 2014;90:370-3 pubmed publisher
  20. Epifanova M, Chalyi M, Krasnov A. [Investigation of mechanisms of action of growth factors of autologous platelet-rich plasma used to treat erectile dysfunction]. Urologiia. 2017;:46-48 pubmed
    ..Also, the study showed that the content of growth factors in APRP after of freezing/thawing is higher than in APRP that has not been frozen. This is due to the cell membrane destruction at extremely low temperatures during freezing. ..
  21. King J. Impotence after fractures of the pelvis. J Bone Joint Surg Am. 1975;57:1107-9 pubmed
    ..Litigation did not seem to be associated with the problem. ..
  22. Samlali H, Udrescu C, Lapierre A, Enachescu C, Ruffion A, Jalade P, et al. Prospective evaluation of a specific technique of sexual function preservation in external beam radiotherapy for prostate cancer. Br J Radiol. 2017;90:20160877 pubmed publisher
    ..Eleven patients, with no erectile dysfunction (ED), were treated with daily IMRT-IGRT (total dose: 76-78 Gy)...
  23. Povelitsa E, Dosta N, Parhomenko O, Nitkin D, Shesternja A, Anichkin V. [Transperineal ultrasound imaging of the internal pudendal artery in arteriogenic erectile dysfunction]. Urologiia. 2017;:55-61 pubmed
    ..of transperineal ultrasound imaging of the internal pudendal artery (IPA) in patients with arteriogenic erectile dysfunction (ED)...
  24. Montague D, Angermeier K, Lakin M, Ingleright B. AMS 3-piece inflatable penile prosthesis implantation in men with Peyronie's disease: comparison of CX and Ultrex cylinders. J Urol. 1996;156:1633-5 pubmed straighten the penis in men who received a 3-piece AMS 700 series inflatable penile prosthesis for erectile dysfunction and erectile deformity due to Peyronie's disease...
  25. Gelber A. Gout and Association with Erectile Dysfunction. J Rheumatol. 2015;42:1731-3 pubmed publisher
  26. Xu Y, Xin H, Wu Y, Guan R, Lei H, Fu X, et al. Effect of icariin in combination with daily sildenafil on penile atrophy and erectile dysfunction in a rat model of bilateral cavernous nerves injury. Andrology. 2017;5:598-605 pubmed publisher
    ..was to assess the efficacy and mechanisms of icariin in combination with daily sildenafil on neurogenic erectile dysfunction and penile atrophy in a rat model of bilateral cavernous nerves injury...
  27. Kockott G. Human sexual inadequacy--behavior therapy and the Masters and Johnson technique. Adv Biosci. 1973;10:219-24 pubmed
  28. Efremov E, Kasatonova E, Melnik Y, Nikushina A. [PDE-5 inhibitors: patients preferences]. Urologiia. 2017;:120-126 pubmed
    To date, multidisciplinary approach is commonly used to treat erectile dysfunction (ED), and the first line of ED pharmacotherapy, despite its multiple causes, is phosphodiesterase inhibitors of type 5 (PDE-5)...
  29. Sugihara K, Moriya Y, Akasu T, Fujita S. Pelvic autonomic nerve preservation for patients with rectal carcinoma. Oncologic and functional outcome. Cancer. 1996;78:1871-80 pubmed
  30. Freeman K. Arsenic and erectile dysfunction: drinking contaminated well water increases risk. Environ Health Perspect. 2008;116:A172 pubmed
  31. Pushkar D, Dyakov V, Vasilyev A, Kotenko D. [Comparison of functional outcomes after retropubic and robot-assisted radical nerve-sparing prostatectomy conducted by surgeons with total caseloads of over 1000 prostatectomies]. Urologiia. 2017;:50-53 pubmed
    ..05). The study findings showed the superiority of RARP over RRP performed by nerve-sparing technique in restoring continence and erectile function. ..
  32. Garber B. Inflatable penile prosthesis: results of 150 cases. Br J Urol. 1996;78:933-5 pubmed
    ..These results suggest that for men with organic impotence, a Mentor Alpha 1 implant is an effective treatment option with acceptable morbidity and good mechanical reliability. ..
  33. Gay H, Sanda M, Liu J, Wu N, Hamstra D, Wei J, et al. External Beam Radiation Therapy or Brachytherapy With or Without Short-course Neoadjuvant Androgen Deprivation Therapy: Results of a Multicenter, Prospective Study of Quality of Life. Int J Radiat Oncol Biol Phys. 2017;98:304-317 pubmed publisher
    ..The improved survival in intermediate- and high-risk patients receiving NADT and EBRT necessitates pretreatment counseling of the HRQOL effect of NADT and EBRT. ..
  34. Smith Harrison L, Starke N, Smith R, Kovac J. Drugs in preclinical to phase II clinical development for the treatment of erectile dysfunction. Expert Opin Investig Drugs. 2017;26:669-675 pubmed publisher
    Erectile function is an important aspect in the quality of life of many men. For men with erectile dysfunction (ED), a spectrum of treatment options exists...
  35. Chiang H, Wu C, Wen T. 10 years of experience with penile prosthesis implantation in Taiwanese patients. J Urol. 2000;163:476-80 pubmed
    ..prosthesis implantation still has its place as definitive therapy in some patients with uncorrectable erectile dysfunction. In Taiwanese society more consideration of prosthesis selection, surgical preparation and patient-partner ..
  36. Ertekin C, Reel F. Bulbocavernosus reflex in normal men and in patients with neurogenic bladder and/or impotence. J Neurol Sci. 1976;28:1-15 pubmed
    ..The value and the practical application of the BC reflex in the BC reflex in the differential diagnosis of bladder dysfunction and of impotence was stressed. ..
  37. Frimodt Møller C. Diabetic cystopathy: epidemiology and related disorders. Ann Intern Med. 1980;92:318-21 pubmed
    ..The higher frequency of urinary tract infections in diabetics is not related to diabetic cystopathy but to the frequent occurrence of non-neurogenic bladder outlet disorders, especially in older women. ..
  38. O Callaghan M, Raymond E, Campbell J, Vincent A, Beckmann K, Roder D, et al. Patient-Reported Outcomes After Radiation Therapy in Men With Prostate Cancer: A Systematic Review of Prognostic Tool Accuracy and Validity. Int J Radiat Oncol Biol Phys. 2017;98:318-337 pubmed publisher
    ..predicted gastrointestinal/rectal symptoms, 29 tools predicted genitourinary symptoms, 4 tools predicted erectile dysfunction, and no tools predicted quality of life...
  39. Chew K, Stuckey B. Use of transurethral alprostadil (MUSE) (prostaglandin E1) for glans tumescence in a patient with penile prosthesis. Int J Impot Res. 2000;12:195-6 pubmed
    ..MUSE was used successfully in a patient with a Dynaflex penile prosthesis to enhance the tumescence of the glans penis. It will be a useful adjunct for patients in similar circumstances. ..
  40. Gamidov S, Ovchinnikov R, Popova A, Izhbaev S. [Phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction: past, present and future]. Urologiia. 2017;:103-107 pubmed
    This review article describes the differences in efficacy and side effects between available phosphodiesterase type 5 (PDE-5) inhibitors used for treating erectile dysfunction. The most studied PDE-5 inhibitor is sildenafil.
  41. Wang C, Jackson G, Jones T, Matsumoto A, Nehra A, Perelman M, et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care. 2011;34:1669-75 pubmed publisher
  42. Bolat D, Kozacioglu Z, Polat S, Koras O, Arslan M, Minareci S. Synchronous penoscrotal implantation of penile prosthesis and artificial urinary sphincter after radical prostatectomy. Arch Esp Urol. 2017;70:367-372 pubmed
    ..dual implantation of penile (PP) and artificial urinary sphincter prosthesis (AUSP) in patients with severe erectile dysfunction (ED) and urinary incontinence (UI) after radical prostatectomy (RP)...
  43. Hippisley Cox J, Coupland C, Brindle P. Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study. BMJ. 2017;357:j2099 pubmed publisher
    ..We also considered erectile dysfunction diagnosis or treatment in men...
  44. Akkus E, Carrier S, Baba K, Hsu G, Padma Nathan H, Nunes L, et al. Structural alterations in the tunica albuginea of the penis: impact of Peyronie's disease, ageing and impotence. Br J Urol. 1997;79:47-53 pubmed
    To investigate whether changes in the structure of the tunica albuginea influence the development of erectile dysfunction. Biopsy specimens taken from the tunica of 64 patients (both potent and impotent) with and without Peyronie's ..
  45. Hald G. Comment on: Is Pornography Use Associated with Sexual Difficulties and Dysfunctions among Younger Heterosexual Men?. J Sex Med. 2015;12:1140-1 pubmed publisher
  46. Qiao Z, Li X, Liu H, Zhang L, Cao J, Xie G, et al. Using Statistics and Data Mining Approaches to Analyze Male Sexual Behaviors and Use of Erectile Dysfunction Drugs Based on Large Questionnaire Data. Stud Health Technol Inform. 2017;235:206-210 pubmed
    The prevalence of erectile dysfunction (ED) has been extensively studied worldwide. Erectile dysfunction drugs has shown great efficacy in preventing male erectile dysfunction...
  47. Kutlu O, Karaguzel E, Okatan A, Mentese A, Yulug E, Kazaz I, et al. Dipyridamole reduces penile apoptosis in a rat model of post-prostatectomy erectile dysfunction. Int Braz J Urol. 2017;43:966-973 pubmed publisher
    Despite the nerve-sparing technique, many patients suffer from erectile dysfunction after radical prostatectomy (RP) due to cavernous nerve injury...
  48. Nickel J. Understanding chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). World J Urol. 2013;31:709-10 pubmed publisher
  49. Weiss R. Effects of antihypertensive agents on sexual function. Am Fam Physician. 1991;44:2075-82 pubmed
    ..It is important to obtain an adequate history before and after initiating therapy. If sexual dysfunction develops in a patient, a different class of medication can be tried. ..
  50. Tallon L, Manjourides J, Pun V, Mittleman M, Kioumourtzoglou M, Coull B, et al. Erectile dysfunction and exposure to ambient Air pollution in a nationally representative cohort of older Men. Environ Health. 2017;16:12 pubmed publisher
    Little is known about the association between air pollution and erectile dysfunction (ED), a disorder occurring in 64% of men over the age of 70, and to date, no studies have been published...
  51. Levine L, Dimitriou R. A surgical algorithm for penile prosthesis placement in men with erectile failure and Peyronie's disease. Int J Impot Res. 2000;12:147-51 pubmed
    ..The developed algorithm helps define prosthesis placement and straightening techniques to obtain optimal results with minimal complications. ..
  52. Azmi S, Ferdousi M, Alam U, Petropoulos I, Ponirakis G, Marshall A, et al. Small-fibre neuropathy in men with type 1 diabetes and erectile dysfunction: a cross-sectional study. Diabetologia. 2017;60:1094-1101 pubmed publisher
    The aim of this study was to identify the contribution of small- and large-fibre neuropathy to erectile dysfunction in men with type 1 diabetes mellitus...
  53. Mohamad Al Ali B, Ponholzer A, Augustin H, Madersbacher S, Pummer K. The Long-Term Effect of Radical Prostatectomy on Erectile Function, Urinary Continence, and Lower Urinary Tract Symptoms: A Comparison to Age-Matched Healthy Controls. Biomed Res Int. 2017;2017:9615080 pubmed publisher
    ..Healthy men have a higher IPSS presumably due to the presence of bladder outlet obstruction. ..