autism spectrum disorder

Summary

Summary: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)

Top Publications

  1. Siu M, Weksberg R. Epigenetics of Autism Spectrum Disorder. Adv Exp Med Biol. 2017;978:63-90 pubmed publisher
    b>Autism spectrum disorder (ASD), one of the most common childhood neurodevelopmental disorders (NDDs), is diagnosed in 1 of every 68 children. ASD is incredibly heterogeneous both clinically and aetiologically...
  2. Nashabat M, Maegawa G, Nissen P, Nexo E, Al Shamrani H, Al Owain M, et al. Long-term Outcome of 4 Patients With Transcobalamin Deficiency Caused by 2 Novel TCN2 Mutations. J Pediatr Hematol Oncol. 2017;39:e430-e436 pubmed publisher
    ..Two sibs, diagnosed at 2 months of age and immediately after birth, had autism spectrum disorder. Molecular investigations showed 2 novel mutations in TCN2 gene...
  3. Costa L, Chang Y, Cole T. Developmental Neurotoxicity of Traffic-Related Air Pollution: Focus on Autism. Curr Environ Health Rep. 2017;4:156-165 pubmed publisher
  4. Molnár C, Eldevik S. [Behavioral intervention for preschool children with autism – outcome of parent-based Intervention]. Z Kinder Jugendpsychiatr Psychother. 2017;45:181-191 pubmed publisher
    ..Early intensive behavioral intervention (EIBI) has proved to be an effective intervention for children with autism spectrum disorder (ASD)...
  5. Van Horn J, Pelphrey K. Neuroimaging of the developing brain. Brain Imaging Behav. 2015;9:1-4 pubmed publisher
  6. Glickman G, Harrison E, Dobkins K. Vaccination Rates among Younger Siblings of Children with Autism. N Engl J Med. 2017;377:1099-1101 pubmed publisher
  7. Higuchi T, Ishizaki Y, Noritake A, Yanagimoto Y, Kobayashi H, Nakamura K, et al. Spatiotemporal characteristics of gaze of children with autism spectrum disorders while looking at classroom scenes. PLoS ONE. 2017;12:e0175912 pubmed publisher
    ..Thus, they may have difficulties in understanding content in class, leading to maladaptation to school. ..
  8. Ly V, Bottelier M, Hoekstra P, Arias Vasquez A, Buitelaar J, Rommelse N. Elimination diets' efficacy and mechanisms in attention deficit hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry. 2017;26:1067-1079 pubmed publisher
    ..This review discusses an elimination diet as a treatment for attention deficit hyperactivity disorder and autism spectrum disorder, with a focus on the efficacy of the food additives exclusion diet, gluten-free/casein-free diet and ..
  9. Jansen A, Dieleman G, Smit A, Verhage M, Verhulst F, Polderman T, et al. Gene-set analysis shows association between FMRP targets and autism spectrum disorder. Eur J Hum Genet. 2017;25:863-868 pubmed publisher
    b>Autism spectrum disorder (ASD) is a heterogeneous group of disorders characterized by problems with social interaction, communication, and repetitive and restricted behavior...

More Information

Publications62

  1. Strati F, Cavalieri D, Albanese D, De Felice C, Donati C, Hayek J, et al. New evidences on the altered gut microbiota in autism spectrum disorders. Microbiome. 2017;5:24 pubmed publisher
  2. Bassett A, Lowther C, Merico D, Costain G, Chow E, Van Amelsvoort T, et al. Rare Genome-Wide Copy Number Variation and Expression of Schizophrenia in 22q11.2 Deletion Syndrome. Am J Psychiatry. 2017;174:1054-1063 pubmed publisher
    ..The findings have implications for understanding expression of psychotic illness and herald the importance of whole-genome sequencing to appreciate the overall genomic architecture of schizophrenia. ..
  3. Lammert D, Middleton F, PAN J, Olson E, Howell B. The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression. J Neurochem. 2017;142:89-102 pubmed publisher
    Despite the recent identification of over 40 missense heterozygous Reelin gene (RELN) mutations in autism spectrum disorder (ASD), none of these has been functionally characterized...
  4. Gillberg C, Fernell E, Kočovská E, Minnis H, Bourgeron T, Thompson L, et al. The role of cholesterol metabolism and various steroid abnormalities in autism spectrum disorders: A hypothesis paper. Autism Res. 2017;10:1022-1044 pubmed publisher
    ..of steroid abnormalities of various kinds (cortisol, testosterone, estrogens, progesterone, vitamin D) in autism spectrum disorder (ASD)...
  5. Schmeisser K, Fardghassemi Y, Parker J. A rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders. Exp Neurol. 2017;293:101-114 pubmed publisher
    b>Autism spectrum disorder (ASD) is the most common neurodevelopmental disorder with a constantly increasing prevalence...
  6. Buxbaum J. DSM-5 and psychiatric genetics - round hole, meet square peg. Biol Psychiatry. 2015;77:766-8 pubmed publisher
  7. Franchini M, Glaser B, Wood de Wilde H, Gentaz E, Eliez S, Schaer M. Social orienting and joint attention in preschoolers with autism spectrum disorders. PLoS ONE. 2017;12:e0178859 pubmed publisher
    ..Further, reduced orienting to the social world in young children with ASD is related to socio communicative deficits and should, therefore, be a focus of intervention programs as early as possible. ..
  8. Kerley C, Power C, Gallagher L, Coghlan D. Lack of effect of vitamin D3 supplementation in autism: a 20-week, placebo-controlled RCT. Arch Dis Child. 2017;102:1030-1036 pubmed publisher
    Data suggest a potential role for vitamin D in autism spectrum disorder (ASD). We wanted to assess the effect of vitamin D3 supplementation compared with placebo in children with ASD...
  9. Kumazaki H, Warren Z, Muramatsu T, Yoshikawa Y, Matsumoto Y, Miyao M, et al. A pilot study for robot appearance preferences among high-functioning individuals with autism spectrum disorder: Implications for therapeutic use. PLoS ONE. 2017;12:e0186581 pubmed publisher
    ..of such technology for the development and subsequent validation of interventions for individuals with autism spectrum disorder (ASD)...
  10. Modabbernia A, Velthorst E, Reichenberg A. Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol Autism. 2017;8:13 pubmed publisher
    According to recent evidence, up to 40-50% of variance in autism spectrum disorder (ASD) liability might be determined by environmental factors...
  11. Caldwell H, Albers H. Oxytocin, Vasopressin, and the Motivational Forces that Drive Social Behaviors. Curr Top Behav Neurosci. 2016;27:51-103 pubmed
    ..Further, we discuss the implications for neuropsychiatric diseases and suggest future areas of investigation. ..
  12. Weiner D, Wigdor E, Ripke S, Walters R, Kosmicki J, Grove J, et al. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders. Nat Genet. 2017;49:978-985 pubmed publisher
    b>Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation...
  13. Aoki Y, Yoncheva Y, Chen B, Nath T, Sharp D, Lazar M, et al. Association of White Matter Structure With Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder. JAMA Psychiatry. 2017;74:1120-1128 pubmed publisher
    Clinical overlap between autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) is increasingly appreciated, but the underlying brain mechanisms remain unknown to date.
  14. Leppänen J, Ng K, Tchanturia K, Treasure J. Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions. Neurosci Biobehav Rev. 2017;78:125-144 pubmed publisher
    ..This review consists of 33 studies. Fifteen of the studies included people with autism spectrum disorder, schizophrenia, borderline personality disorder, frontotemporal dementia, anorexia nervosa, bulimia ..
  15. Wang S, Yang C, Liu Y, Shao Z, Jackson T. Early and late stage processing abnormalities in autism spectrum disorders: An ERP study. PLoS ONE. 2017;12:e0178542 pubmed publisher
    ..potentials (ERPs) elicited during the processing of different kinds of visual stimuli among children with Autism Spectrum Disorder (ASD) (n = 15) and typically developing (TD) children (n = 19)...
  16. Siew C, Mazzucchelli T, Rooney R, Girdler S. A specialist peer mentoring program for university students on the autism spectrum: A pilot study. PLoS ONE. 2017;12:e0180854 pubmed publisher
    The provision of peer mentoring may improve tertiary education outcomes of students with autism spectrum disorder (ASD)...
  17. Richards B. Caring for children with autism spectrum condition in paediatric emergency departments. Emerg Nurse. 2017;25:30-34 pubmed publisher
    ..This article promotes a multi-strategy approach to making reasonable adjustments to help meet the needs of these children and provide them with a positive hospital experience. ..
  18. Kaufmann W, Kidd S, Andrews H, Budimirovic D, Esler A, Haas Givler B, et al. Autism Spectrum Disorder in Fragile X Syndrome: Cooccurring Conditions and Current Treatment. Pediatrics. 2017;139:S194-S206 pubmed publisher
    Individuals with fragile X syndrome (FXS) are frequently codiagnosed with autism spectrum disorder (ASD). Most of our current knowledge about ASD in FXS comes from family surveys and small studies...
  19. Fründt O, Grashorn W, Schottle D, Peiker I, David N, Engel A, et al. Quantitative Sensory Testing in adults with Autism Spectrum Disorders. J Autism Dev Disord. 2017;47:1183-1192 pubmed publisher
    ..These findings suggest that central mechanisms during complex stimulus integration rather than peripheral dysfunctions probably determine somatosensory alterations in ASD. ..
  20. Ye B, Leung A, Wong M. The association of environmental toxicants and autism spectrum disorders in children. Environ Pollut. 2017;227:234-242 pubmed publisher
  21. Scott M, Jacob A, Hendrie D, Parsons R, Girdler S, Falkmer T, et al. Employers' perception of the costs and the benefits of hiring individuals with autism spectrum disorder in open employment in Australia. PLoS ONE. 2017;12:e0177607 pubmed publisher
    Research has examined the benefits and costs of employing adults with autism spectrum disorder (ASD) from the perspective of the employee, taxpayer and society, but few studies have considered the employer perspective...
  22. Jónsdóttir U, Lang J. How does autism spectrum disorder affect the risk and severity of childhood asthma?. Ann Allergy Asthma Immunol. 2017;118:570-576 pubmed publisher
    b>Autism spectrum disorder (ASD) and asthma are among the most common chronic disorders in childhood. Both are associated with altered immune regulation and share several risk factors...
  23. Sathe N, Andrews J, McPheeters M, Warren Z. Nutritional and Dietary Interventions for Autism Spectrum Disorder: A Systematic Review. Pediatrics. 2017;139: pubmed publisher
    Children with autism spectrum disorder (ASD) frequently use special diets or receive nutritional supplements to treat ASD symptoms...
  24. McClellan L, Dominick K, Pedapati E, Wink L, Erickson C. Lurasidone for the treatment of irritability and anger in autism spectrum disorders. Expert Opin Investig Drugs. 2017;26:985-989 pubmed publisher
    b>Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social interaction and communication as well as restricted patterns of behaviors and interests...
  25. Millenson M, Braun J, Calafat A, Barr D, Huang Y, Chen A, et al. Urinary organophosphate insecticide metabolite concentrations during pregnancy and children's interpersonal, communication, repetitive, and stereotypic behaviors at 8 years of age: The home study. Environ Res. 2017;157:9-16 pubmed publisher
    ..89). In this cohort, prenatal urinary DAP concentrations were not associated with children's social behaviors; these associations were not modified by child PON1 genotype. ..
  26. Cheng N, Alshammari F, Hughes E, Khanbabaei M, Rho J. Dendritic overgrowth and elevated ERK signaling during neonatal development in a mouse model of autism. PLoS ONE. 2017;12:e0179409 pubmed publisher
    b>Autism spectrum disorder (hereafter referred to as "ASD") is a heterogeneous neurodevelopmental condition characterized by impaired social communication and interactions, and restricted, repetitive activities or interests...
  27. Spain D, Sin J, Paliokosta E, Furuta M, Prunty J, Chalder T, et al. Family therapy for autism spectrum disorders. Cochrane Database Syst Rev. 2017;5:CD011894 pubmed publisher
  28. McHale S, Updegraff K, Feinberg M. Siblings of Youth with Autism Spectrum Disorders: Theoretical Perspectives on Sibling Relationships and Individual Adjustment. J Autism Dev Disord. 2016;46:589-602 pubmed
    A burgeoning research literature investigates the sibling relationships of youth with autism spectrum disorder (ASD) and their implications for individual adjustment...
  29. Delobel Ayoub M, Klapouszczak D, van Bakel M, Horridge K, Sigurdardottir S, Himmelmann K, et al. Prevalence and characteristics of autism spectrum disorders in children with cerebral palsy. Dev Med Child Neurol. 2017;59:738-742 pubmed publisher
    ..To evaluate the prevalence of co-occurring autism spectrum disorders (ASDs) among children with cerebral palsy (CP), and to describe their characteristics...
  30. Mei S, Zhang Z, Liu X, Gao T, Peng X. [Association between autism spectrum disorder and epilepsy in children]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:549-554 pubmed
    To examine the association between autism spectrum disorder (ASD) and epilepsy in children. A total of 190 children with ASD were enrolled...
  31. DeVilbiss E, Magnusson C, Gardner R, Rai D, Newschaffer C, Lyall K, et al. Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. BMJ. 2017;359:j4273 pubmed publisher
    ..determine whether nutritional supplementation during pregnancy is associated with a reduced risk of autism spectrum disorder (ASD) with and without intellectual disability in offspring...
  32. Mackus M, Kruijff D, Otten L, Kraneveld A, Garssen J, Verster J. Differential Gender Effects in the Relationship between Perceived Immune Functioning and Autistic Traits. Int J Environ Res Public Health. 2017;14: pubmed publisher
    Altered immune functioning has been demonstrated in individuals with autism spectrum disorder (ASD). The current study explores the relationship between perceived immune functioning and experiencing ASD traits in healthy young adults...
  33. Chenausky K, Nelson C, Tager Flusberg H. Vocalization Rate and Consonant Production in Toddlers at High and Low Risk for Autism. J Speech Lang Hear Res. 2017;60:865-876 pubmed publisher
    Previous work has documented lower vocalization rate and consonant acquisition delays in toddlers with autism spectrum disorder (ASD)...
  34. Kichukova T, Popov N, Ivanov I, Vachev T. Profiling of Circulating Serum MicroRNAs in Children with Autism Spectrum Disorder using Stem-loop qRT-PCR Assay. Folia Med (Plovdiv). 2017;59:43-52 pubmed publisher
    Development of biomarkers for autism spectrum disorder (ASD) has still remained a challenge to date...
  35. Estes M, McAllister A. IMMUNOLOGY. Maternal TH17 cells take a toll on baby's brain. Science. 2016;351:919-20 pubmed publisher
  36. Morales D, Slattery J, Evans S, Kurz X. Antidepressant use during pregnancy and risk of autism spectrum disorder and attention deficit hyperactivity disorder: systematic review of observational studies and methodological considerations. BMC Med. 2018;16:6 pubmed publisher
    Antidepressant exposure during pregnancy has been associated with an increased risk of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) in several observational studies...
  37. Bieleninik Ł, Posserud M, Geretsegger M, Thompson G, Elefant C, Gold C. Tracing the temporal stability of autism spectrum diagnosis and severity as measured by the Autism Diagnostic Observation Schedule: A systematic review and meta-analysis. PLoS ONE. 2017;12:e0183160 pubmed publisher
    Exploring ways to improve the trajectory and symptoms of autism spectrum disorder is prevalent in research, but less is known about the natural prognosis of autism spectrum disorder and course of symptoms...
  38. Kosmicki J, Samocha K, Howrigan D, Sanders S, Slowikowski K, Lek M, et al. Refining the role of de novo protein-truncating variants in neurodevelopmental disorders by using population reference samples. Nat Genet. 2017;49:504-510 pubmed publisher
    ..Using aggregated data from 9,246 families with autism spectrum disorder, intellectual disability, or developmental delay, we found that ?1/3 of de novo variants are ..
  39. Denisova K, Zhao G, Wang Z, Goh S, Huo Y, Peterson B. Cortical interactions during the resolution of information processing demands in autism spectrum disorders. Brain Behav. 2017;7:e00596 pubmed publisher
    ..Increasing evidence suggests that the balance between levels of signal and noise during information processing may be disrupted in individuals with Autism Spectrum Disorders (ASD)...
  40. Roording Ragetlie S, Klip H, Buitelaar J, Slaats Willemse D. Working memory training in children with neuropsychiatric disorders and mild to borderline intellectual functioning, the role of coaching; a double-blind randomized controlled trial. BMC Psychiatry. 2017;17:114 pubmed publisher
    ..A double-blind RCT with children (age 10.0-13.11) with neuropsychiatric disorders (ADHD and/or autism spectrum disorder (ASD)) and MBID (IQ: 60 < IQ < 85)...
  41. Singer A, Burstyn I, Thygesen M, Mortensen P, Fallin M, Schendel D. Parental exposures to occupational asthmagens and risk of autism spectrum disorder in a Danish population-based case-control study. Environ Health. 2017;16:31 pubmed publisher
    Environmental exposures and immune conditions during pregnancy could influence development of autism spectrum disorder (ASD) in offspring. However, few studies have examined immune-triggering exposures in relation to ASD...
  42. Mazarati A, Lewis M, Pittman Q. Neurobehavioral comorbidities of epilepsy: Role of inflammation. Epilepsia. 2017;58 Suppl 3:48-56 pubmed publisher
    ..This review focuses on the association of epilepsy with autism spectrum disorder (ASD) and depression. There is high concordance of these behavioral pathologies with epilepsy...
  43. Mezzacappa A, Lasica P, Gianfagna F, Cazas O, Hardy P, Falissard B, et al. Risk for Autism Spectrum Disorders According to Period of Prenatal Antidepressant Exposure: A Systematic Review and Meta-analysis. JAMA Pediatr. 2017;171:555-563 pubmed publisher
    ..Maternal psychiatric disorders in treatment before pregnancy rather than antenatal exposure to antidepressants could have a major role in the risk for ASDs. Future studies should address the problem of this potential confounder. ..
  44. Zuckerman K, Lindly O, Reyes N, Chavez A, Macias K, Smith K, et al. Disparities in Diagnosis and Treatment of Autism in Latino and Non-Latino White Families. Pediatrics. 2017;139: pubmed publisher
    To compare barriers to autism spectrum disorder (ASD) diagnosis and current ASD-related service use among non-Latino white (NLW) families and Latino families with English proficiency (L-EP) or limited English proficiency (L-LEP)...
  45. Zhang R, Zhang H, Han J, Han S. Genes Related to Oxytocin and Arginine-Vasopressin Pathways: Associations with Autism Spectrum Disorders. Neurosci Bull. 2017;33:238-246 pubmed publisher
    b>Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorders characterized by impaired social interactions, communication deficits, and repetitive behavior...
  46. Gump B, Dykas M, MacKenzie J, Dumas A, Hruska B, Ewart C, et al. Background lead and mercury exposures: Psychological and behavioral problems in children. Environ Res. 2017;158:576-582 pubmed publisher
    ..psychological functioning assessments included hostility, disruptive behaviors, emotion regulation, and autism spectrum disorder behaviors...
  47. Sipowicz K, Pietras T. [The case of an adult man with savant syndrome in the course of autism spectrum disorder]. Pol Merkur Lekarski. 2017;43:32-34 pubmed
    The paper reports on a case of 57-year man with autism spectrum disorder and epilepsy with an unusual feature of calendar calculation...
  48. Margolis K, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson G, et al. Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. J Clin Invest. 2016;126:2221-35 pubmed publisher
    b>Autism spectrum disorder (ASD) is an increasingly common behavioral condition that frequently presents with gastrointestinal (GI) disturbances. It is not clear, however, how gut dysfunction relates to core ASD features...
  49. Dudas R, Lovejoy C, Cassidy S, Allison C, Smith P, Baron Cohen S. The overlap between autistic spectrum conditions and borderline personality disorder. PLoS ONE. 2017;12:e0184447 pubmed publisher
    ..Finally, on the SQ-R, we found the ASC and BPD group both scored higher than controls. Similar to ASC, BPD patients have elevated autistic traits and a strong drive to systemize, suggesting an overlap between BPD and ASC. ..
  50. Durkin M, Maenner M, Baio J, Christensen D, Daniels J, Fitzgerald R, et al. Autism Spectrum Disorder Among US Children (2002-2010): Socioeconomic, Racial, and Ethnic Disparities. Am J Public Health. 2017;107:1818-1826 pubmed publisher
    To describe the association between indicators of socioeconomic status (SES) and the prevalence of autism spectrum disorder (ASD) in the United States during the period 2002 to 2010, when overall ASD prevalence among children more than ..
  51. Marcello E, Borroni B, Pelucchi S, Gardoni F, Di Luca M. ADAM10 as a therapeutic target for brain diseases: from developmental disorders to Alzheimer's disease. Expert Opin Ther Targets. 2017;21:1017-1026 pubmed publisher
    ..Expert opinion: A progress in the understanding of the molecular mechanisms driving ADAM10 activity at synapses and its alterations in brain disorders is the first step before designing a specific drug able to modulate ADAM10 activity. ..
  52. Noroozi R, Ghafouri Fard S, Omrani M, Habibi M, Sayad A, Taheri M. Association study of the vesicular monoamine transporter 1 (VMAT1) gene with autism in an Iranian population. Gene. 2017;625:10-14 pubmed publisher
    ..Considering the role of VMAT1 in regulation of monoamines, the dysregulated expression of this protein during early stages of brain development might be implicated in ASD. ..
  53. Yamasue H. [Voxel-Based Morphometry in Autism Spectrum Disorder]. Brain Nerve. 2017;69:529-538 pubmed publisher
    b>Autism spectrum disorder shows deficits in social communication and interaction including nonverbal communicative behaviors (e.g...