cognitive dysfunction


Summary: Diminished or impaired mental and/or intellectual function.

Top Publications

  1. Davis R, Ohman J. Driving in Early-Stage Alzheimer's Disease: An Integrative Review of the Literature. Res Gerontol Nurs. 2017;10:86-100 pubmed publisher
    ..Research and practice must support interventions to help individuals maintain safety while driving, as well as cope with driving cessation. [Res Gerontol Nurs. 2017; 10(2):86-100.]. ..
  2. Qian J, Wolters F, Beiser A, Haan M, Ikram M, Karlawish J, et al. APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts. PLoS Med. 2017;14:e1002254 pubmed publisher
  3. Nalli C, Iodice A, Andreoli L, Galli J, Lojacono A, Motta M, et al. Long-term neurodevelopmental outcome of children born to prospectively followed pregnancies of women with systemic lupus erythematosus and/or antiphospholipid syndrome. Lupus. 2017;26:552-558 pubmed publisher
    ..Children born to women with SLE and/or APS may need a long-term follow-up focusing on milestones of neurodevelopment in order to detect and correct any alteration as early as possible. ..
  4. Lapa A, Postal M, Sinicato N, Bellini B, Fernandes P, Marini R, et al. S100? is associated with cognitive impairment in childhood-onset systemic lupus erythematosus patients. Lupus. 2017;26:478-483 pubmed publisher
    ..006). Conclusions S100? protein levels are increased in cSLE with cognitive impairment. S100? may be considered a potential biomarker that underlies central nervous system (CNS) dysfunction, especially cognitive impairment. ..
  5. Dwivedi R, Ramanujam B, Chandra P, Sapra S, Gulati S, Kalaivani M, et al. Surgery for Drug-Resistant Epilepsy in Children. N Engl J Med. 2017;377:1639-1647 pubmed publisher
    ..Neurosurgical treatment may improve seizures in children and adolescents with drug-resistant epilepsy, but additional data are needed from randomized trials...
  6. Lee J, Kim Y, Jeong Y, Na D, Kim J, Lee K, et al. Inference of brain pathway activities for Alzheimer's disease classification. BMC Med Inform Decis Mak. 2015;15 Suppl 1:S1 pubmed publisher
    ..Moreover, discriminatory pathways between patients and cognitively normal subjects may facilitate the interpretation of functional alterations during disease progression. ..
  7. Simonati A, Williams R, Nardocci N, Laine M, Battini R, Schulz A, et al. Phenotype and natural history of variant late infantile ceroid-lipofuscinosis 5. Dev Med Child Neurol. 2017;59:815-821 pubmed publisher
    ..Clinical features in a multicentre cohort of patients with CLN5 confirm that cognitive difficulties are early clinical markers of this condition. Severe mutations were associated with a more rapid decline of neurological function. ..
  8. Vacchiano C, Silva S. Characterization of bilateral frontal lobe cerebral oxygen saturation in patients with mild traumatic brain injury. Nurs Outlook. 2017;65:S36-S43 pubmed publisher
    ..The finding confirms and adds to previous research that indicates there is likely a vascular component to this mild form of brain injury. ..
  9. Squarzoni P, Tamashiro Duran J, Duran F, Leite C, Wajngarten M, Scazufca M, et al. High frequency of silent brain infarcts associated with cognitive deficits in an economically disadvantaged population. Clinics (Sao Paulo). 2017;72:474-480 pubmed publisher
    ..Emphatic attention should be paid to potentially deleterious effects of vascular brain lesions in poorly educated elderly individuals from economically disadvantaged environments. ..

More Information

Publications115 found, 100 shown here

  1. Bankstahl U, Görtelmeyer R. Measuring subjective complaints of attention and performance failures--development and psychometric validation in tinnitus of the self-assessment scale APSA. Health Qual Life Outcomes. 2013;11:86 pubmed publisher
    ..The subscales AP-F1 and AP-F2 may be helpful for detecting specific cognitive failures and may be sensitive to different interventional effects. ..
  2. Makizako H, Shimada H, Doi T, Park H, Yoshida D, Uemura K, et al. Poor balance and lower gray matter volume predict falls in older adults with mild cognitive impairment. BMC Neurol. 2013;13:102 pubmed publisher
    The risk of falling is associated with cognitive dysfunction. Older adults with mild cognitive impairment (MCI) exhibit an accelerated reduction of brain volume, and face an increased risk of falling...
  3. Zhou Q, Goryawala M, Cabrerizo M, Wang J, Barker W, Loewenstein D, et al. An optimal decisional space for the classification of Alzheimer's disease and mild cognitive impairment. IEEE Trans Biomed Eng. 2014;61:2245-53 pubmed publisher
    ..Furthermore, hippocampal atrophy is seen to be the most significant for aMCI, while Accumbens area and ventricle are most significant for naMCI. ..
  4. Li F, Tran L, Thung K, Ji S, Shen D, Li J. A Robust Deep Model for Improved Classification of AD/MCI Patients. IEEE J Biomed Health Inform. 2015;19:1610-6 pubmed publisher
    ..Experimental results showed that the dropout technique is very effective in AD diagnosis, improving the classification accuracies by 5.9% on average as compared to the classical deep learning methods. ..
  5. Ben Assayag E, Eldor R, Korczyn A, Kliper E, Shenhar Tsarfaty S, Tene O, et al. Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline. Stroke. 2017;48:2368-2374 pubmed publisher
    ..T2DM and lower eCCl have an independent and additive effect on brain atrophy and the risk of cognitive decline. URL: Unique identifier: NCT01926691. ..
  6. Hoffman P, Sajjadi S, Patterson K, Nestor P. Data-driven classification of patients with primary progressive aphasia. Brain Lang. 2017;174:86-93 pubmed publisher
    ..The observed patterns were scarcely affected by inclusion/exclusion of non-linguistic cognitive scores. ..
  7. McCarthy E, Kiely M, Hannon G, Ahearne C, Kenny L, Hourihane J, et al. Microcytosis is associated with low cognitive outcomes in healthy 2-year-olds in a high-resource setting. Br J Nutr. 2017;118:360-367 pubmed publisher
    ..This exploratory study emphasises the need for re-evaluation of the diagnostic criteria for Fe deficiency in young children, with further research in adequately powered studies warranted. ..
  8. Farina N, Llewellyn D, Isaac M, Tabet N. Vitamin E for Alzheimer's dementia and mild cognitive impairment. Cochrane Database Syst Rev. 2017;4:CD002854 pubmed publisher
    ..These conclusions have changed since the previous update, however they are still based on small numbers of trials and participants and further research is quite likely to affect the results. ..
  9. Yavuz B, Varan H, O Caoimh R, Kızılarslanoğlu M, Kilic M, Molloy D, et al. Validation of the Turkish Version of the Quick Mild Cognitive Impairment Screen. Am J Alzheimers Dis Other Demen. 2017;32:145-156 pubmed publisher
    ..A similar pattern was shown for distinguishing MCI from dementia. Test reliability for the Q mci-TR was strong. The Q mci-TR is a reliable and useful screening tool for discriminating MCI from SMC and dementia in a Turkish population. ..
  10. Yeung L, Olsen R, Bild Enkin H, D Angelo M, Kacollja A, McQuiggan D, et al. Anterolateral Entorhinal Cortex Volume Predicted by Altered Intra-Item Configural Processing. J Neurosci. 2017;37:5527-5538 pubmed publisher
    ..This is the first study to demonstrate a cognitive role related to alERC volume in humans. This task can be adapted to serve as an early detection method for Alzheimer's disease pathology. ..
  11. Marshall G, Donovan N, Lorius N, Gidicsin C, Maye J, Pepin L, et al. Apathy is associated with increased amyloid burden in mild cognitive impairment. J Neuropsychiatry Clin Neurosci. 2013;25:302-7 pubmed publisher
    ..These results suggest that increased apathy is associated with greater amyloid burden but not regional hypometabolism in MCI. ..
  12. Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch Contreras J, Thubron E, et al. Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging. 2017;53:36-47 pubmed publisher
  13. Cullen B, Smith D, Deary I, Evans J, Pell J. The 'cognitive footprint' of psychiatric and neurological conditions: cross-sectional study in the UK Biobank cohort. Acta Psychiatr Scand. 2017;135:593-605 pubmed publisher
    ..Although the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group. ..
  14. Sharma A, Piplani P. Design and synthesis of some acridine-piperazine hybrids for the improvement of cognitive dysfunction. Chem Biol Drug Des. 2017;90:926-935 pubmed publisher
    ..5a-5m) was designed, synthesized and evaluated as multifunctional cholinesterase (ChE) inhibitors against cognitive dysfunction. Heterocyclic moieties acridine and piperazine were conjugated with suitable linkers in a single scaffold, ..
  15. Gschwind Y, Bridenbaugh S, Reinhard S, Granacher U, Monsch A, Kressig R. Ginkgo biloba special extract LI 1370 improves dual-task walking in patients with MCI: a randomised, double-blind, placebo-controlled exploratory study. Aging Clin Exp Res. 2017;29:609-619 pubmed publisher
    ..The observed gait improvements add to the understanding of the self-reported unspecified improvements among MCI patients when treated with standardised GBE. ..
  16. van der Plas E, Schachar R, Hitzler J, Crosbie J, Guger S, Spiegler B, et al. Brain structure, working memory and response inhibition in childhood leukemia survivors. Brain Behav. 2017;7:e00621 pubmed publisher
    ..We performed MRI measurements of white and gray matter volume to explore how variation in brain structure may be related to cognitive abilities in ALL survivors and healthy controls...
  17. Gott C, Gates T, Dermody N, Brew B, Cysique L. Cognitive change trajectories in virally suppressed HIV-infected individuals indicate high prevalence of disease activity. PLoS ONE. 2017;12:e0171887 pubmed publisher
    ..Moreover, 57% of our cohort is undergoing slow evolution of their disease, challenging the notion of prevalent neurocognitive stability in virally suppressed HIV infection. ..
  18. Huang M, Kwon S, He W, Meltzer H. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia. Pharmacol Biochem Behav. 2017;157:16-23 pubmed publisher
    ..A D4 agonist may be useful for treating CIAS, especially as augmentation of those atypical APDs which are not potent D4 antagonists. ..
  19. Chen M, Chiu Y, Wei P, Hsu W. [Reducing the Care-Related Burdens of a Family Caregiver of a Person With Mild Cognitive Impairment: A Home-Based Case Management Program]. Hu Li Za Zhi. 2017;64:105-111 pubmed publisher
  20. Han J, Son K, Byun H, Ko J, Kim K, Hong J, et al. Efficacy of the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program among patients with mild cognitive impairment: a randomized controlled crossover trial. Alzheimers Res Ther. 2017;9:39 pubmed publisher
    ..The 4-week USMART modestly improved information retrieval in older people with MCI, and was well accepted with minimal technical support. NCT01688128 . Registered 12 September 2012. ..
  21. Andreasson U, Lautner R, Schott J, Mattsson N, Hansson O, Herukka S, et al. CSF biomarkers for Alzheimer's pathology and the effect size of APOE ?4. Mol Psychiatry. 2014;19:148-9 pubmed publisher
  22. Oscanoa T, Cieza E, Parodi J, Paredes N. [Evaluation of peruvian money test in screening of cognitive impairment among older adults]. Rev Peru Med Exp Salud Publica. 2016;33:67-73 pubmed
    ..5% and specificity of 83.3% with cut-off value of 24. Conclusions The Peruvian adapted version of the Eurotest, called prueba de la moneda peruana could be useful in screening for cognitive impairment among older adults. ..
  23. Richter N, Michel A, Onur O, Kracht L, Dietlein M, Tittgemeyer M, et al. White matter lesions and the cholinergic deficit in aging and mild cognitive impairment. Neurobiol Aging. 2017;53:27-35 pubmed publisher
    ..Pharmacologic studies are warranted to explore whether this influences the response to cholinergic treatment. ..
  24. Cardoso B, Hare D, Bush A, Li Q, Fowler C, Masters C, et al. Selenium Levels in Serum, Red Blood Cells, and Cerebrospinal Fluid of Alzheimer's Disease Patients: A Report from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL). J Alzheimers Dis. 2017;57:183-193 pubmed publisher
    ..The lack of change in the Se level is at odds with our previous observations in a Brazilian population deficient in Se, and we attribute this to the Australian cohort being Se-replete. ..
  25. Meijer K, Eijlers A, Douw L, Uitdehaag B, Barkhof F, Geurts J, et al. Increased connectivity of hub networks and cognitive impairment in multiple sclerosis. Neurology. 2017;88:2107-2114 pubmed publisher
    ..These findings indicate that cognitive impairment in MS features disturbed communication of hub-rich networks, but only with the more peripheral (i.e., nonhub) regions of the brain. ..
  26. Maclagan L, Maxwell C, Gandhi S, Guan J, Bell C, Hogan D, et al. Frailty and Potentially Inappropriate Medication Use at Nursing Home Transition. J Am Geriatr Soc. 2017;65:2205-2212 pubmed publisher
    ..PIMs are more likely to be started in frail individuals following admission. Interventions to support deprescribing of PIMs should be implemented targeting frail individuals during the transition to nursing home. ..
  27. Akl A, Taati B, Mihailidis A. Autonomous unobtrusive detection of mild cognitive impairment in older adults. IEEE Trans Biomed Eng. 2015;62:1383-1394 pubmed publisher
    ..97 and an area under the precision-recall curve of 0.93 using a time window of 24 weeks. This study is of great significance since it can potentially assist in the early detection of cognitive impairment in older adults. ..
  28. Huang M, Jiang X, Liang Y, Liu Q, Chen S, Guo Y. Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of ?-amyloid in APP/tau/PS1 mouse model of Alzheimer's disease. Exp Gerontol. 2017;91:25-33 pubmed publisher
    ..In summary, berberine shows neuroprotective effects on 3×Tg-AD mice and may be a promising multitarget drug in the preventionand protection against AD. ..
  29. Jacus J. Awareness, apathy, and depression in Alzheimer's disease and mild cognitive impairment. Brain Behav. 2017;7:e00661 pubmed publisher
    ..012). These results evidence comparable awareness between AD and MCI patients. The correlates were more affective and behavioral than cognitive, independently from assessment method. ..
  30. Baxter M, Newman R, Longpré S, Polo K. Occupational Therapy's Role in Cancer Survivorship as a Chronic Condition. Am J Occup Ther. 2017;71:7103090010P1-7103090010P7 pubmed publisher
    ..Research, advocacy, and education efforts are needed to focus on the specific rehabilitation and habilitation needs of cancer survivors to increase access to occupational therapy's distinct value. ..
  31. Burn D, Barker R. Mild cognitive impairment in Parkinson's disease: millstone or milestone?. Pract Neurol. 2013;13:68-9 pubmed publisher
  32. Wang S, Yuan J, Guo X, Teng L, Jiang H, Gu H, et al. Correlation between prefrontal-striatal pathway impairment and cognitive impairment in patients with leukoaraiosis. Medicine (Baltimore). 2017;96:e6703 pubmed publisher
    ..DTI may be of great help for an early pathology of white matter microstructure underlying in patients with LA. ..
  33. Ge S, Wu B, Bailey D, Dong X. Social Support, Social Strain, and Cognitive Function Among Community-Dwelling U.S. Chinese Older Adults. J Gerontol A Biol Sci Med Sci. 2017;72:S16-S21 pubmed publisher
    ..59, SE = 1.17, p < .01). Social support and strain were associated with cognitive outcomes. Future longitudinal studies should be conducted. ..
  34. Mijalkov M, Kakaei E, Pereira J, Westman E, Volpe G. BRAPH: A graph theory software for the analysis of brain connectivity. PLoS ONE. 2017;12:e0178798 pubmed publisher
    ..In the second study, using resting-state fMRI data, we compared healthy controls and Parkinson's patients with mild cognitive impairment. ..
  35. Thompson L, Bobonis Babilonia M. Distinguishing Depressive Symptoms From Similar Cancer-Related Somatic Symptoms: Implications for Assessment and Management of Major Depression after Breast Cancer. South Med J. 2017;110:667-672 pubmed publisher
    ..Evidence-based nonpharmacological interventions such as cognitive behavioral therapy and antidepressant medications are recommended treatment options...
  36. van de Pol L, Scheltens P. Medial temporal lobe atrophy scores translated to clinical practice: editorial comment on 'influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs'. J Intern Med. 2014;275:331-3 pubmed publisher
  37. Jie B, Shen D, Zhang D. Brain connectivity hyper-network for MCI classification. Med Image Comput Comput Assist Interv. 2014;17:724-32 pubmed
    ..The experimental results demonstrate the efficacy of our proposed method for MCI classification with comparison to the conventional connectivity network based methods. ..
  38. Abdullah L, Evans J, Emmerich T, Crynen G, Shackleton B, Keegan A, et al. APOE ?4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease. Aging (Albany NY). 2017;9:964-985 pubmed publisher
    ..Despite the small sample size and a short follow-up, these results suggest that blood PL could potentially serve as biomarkers of preclinical MCI/AD...
  39. Neergaard J, Dragsbæk K, Christiansen C, Nielsen H, Brix S, Karsdal M, et al. Metabolic Syndrome, Insulin Resistance, and Cognitive Dysfunction: Does Your Metabolic Profile Affect Your Brain?. Diabetes. 2017;66:1957-1963 pubmed publisher
    ..aim of this study was to assess the potential association among these precursors of type 2 diabetes and cognitive dysfunction. Using data from the Prospective Epidemiological Risk Factor (PERF) Study (n = 2,103), a ..
  40. Contreras F, Albacete A, Tebe C, Benejam B, Caño A, Menchon J. Patients with schizophrenia activate behavioural intentions facilitated by counterfactual reasoning. PLoS ONE. 2017;12:e0178860 pubmed publisher
    ..Nevertheless, the patients showed more difficulty than the controls with the task, adding support to the concept of CFT as a potential new target for consideration in future therapeutic approaches for this illness. ..
  41. Ball G, Aljabar P, Nongena P, Kennea N, Gonzalez Cinca N, Falconer S, et al. Multimodal image analysis of clinical influences on preterm brain development. Ann Neurol. 2017;82:233-246 pubmed publisher
    ..This data-driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233-246. ..
  42. Zhu D, Yang N, Liu Y, Zheng J, Ji C, Zuo P. M2 Macrophage Transplantation Ameliorates Cognitive Dysfunction in Amyloid-?-Treated Rats Through Regulation of Microglial Polarization. J Alzheimers Dis. 2016;52:483-95 pubmed publisher
    ..This drove microglial polarization to the M2 phenotype, promoted termination of neuroinflammation, and resulted in improved cognitive abilities. ..
  43. Sanchis J, Ruiz V, Bonanad C, Valero E, Ruescas Nicolau M, Ezzatvar Y, et al. Prognostic Value of Geriatric Conditions Beyond Age After Acute Coronary Syndrome. Mayo Clin Proc. 2017;92:934-939 pubmed publisher
    ..40; 95% CI, 0.16-0.65; and integrated discrimination improvement, 0.04; 95% CI, 0.01-0.10). In conclusion, frailty and comorbidity are mortality predictors that significantly reclassify risk beyond age after acute coronary syndrome. ..
  44. Johansson P, Almqvist E, Wallin A, Johansson J, Andreasson U, Blennow K, et al. Reduced cerebrospinal fluid concentration of interleukin-12/23 subunit p40 in patients with cognitive impairment. PLoS ONE. 2017;12:e0176760 pubmed publisher
    ..Further studies are needed to evaluate the role of CSF IL-12/23 p40 in other dementias and SMCI. ..
  45. Lu Y, Bakas T, Yang Z, Weaver M, Austrom M, Haase J. Feasibility and Effect Sizes of the Revised Daily Engagement of Meaningful Activities Intervention for Individuals With Mild Cognitive Impairment and Their Caregivers. J Gerontol Nurs. 2016;42:45-58 pubmed publisher
    ..Although DEMA showed high feasibility and benefits on some health-related outcomes, further testing of DEMA in a larger randomized controlled clinical trial is needed. ..
  46. Miki T, Shimada H, Kim J, Yamamoto Y, Sugino M, Kowa H, et al. Brain uptake and safety of Flutemetamol F 18 injection in Japanese subjects with probable Alzheimer's disease, subjects with amnestic mild cognitive impairment and healthy volunteers. Ann Nucl Med. 2017;31:260-272 pubmed publisher
    ..Visual delineation of abnormal and normal scans was corroborated by quantitative assessment, with low test-retest variability. registration number NCT02813070. ..
  47. Bettio L, Rajendran L, Gil Mohapel J. The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev. 2017;79:66-86 pubmed publisher
    ..Thus, such approaches may have therapeutic value in counteracting the deleterious effects of aging and protecting the brain against age-associated neurodegenerative processes. ..
  48. Yew B, Nation D. Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia. Brain. 2017;140:1987-2001 pubmed publisher
  49. Staplin L, Lococo K, Mastromatto T, Sifrit K, Trazzera K. CE: Can Your Older Patients Drive Safely?. Am J Nurs. 2017;117:34-43 pubmed publisher
    ..They also discuss the importance of connecting older adults to community resources that may help them continue driving safely for a longer period or find alternative transportation options. ..
  50. Haring B, Omidpanah A, Suchy Dicey A, Best L, Verney S, Shibata D, et al. Left Ventricular Mass, Brain Magnetic Resonance Imaging, and Cognitive Performance: Results From the Strong Heart Study. Hypertension. 2017;70:964-971 pubmed publisher
    ..Our findings emphasize the role of cardiovascular health in midlife as a target for the prevention of deleterious cognitive and functional outcomes in later life. ..
  51. . METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research. Alzheimers Dement. 2016;12:1235-1249 pubmed publisher
  52. Wang D, Liu X, Liu Y, Shen G, Zhu X, Li S. Treatment effects of Cardiotrophin-1 (CT-1) on streptozotocin-induced memory deficits in mice. Exp Gerontol. 2017;92:42-45 pubmed publisher
    ..Taken together, these results suggested that CT-1 improves pathological changes and cognitive impairments via AMPK activation in ICV-STZ mice. ..
  53. Chirles T, Reiter K, Weiss L, Alfini A, Nielson K, Smith J. Exercise Training and Functional Connectivity Changes in Mild Cognitive Impairment and Healthy Elders. J Alzheimers Dis. 2017;57:845-856 pubmed publisher
    ..Whether these effects of exercise training may delay further cognitive decline in patients diagnosed with MCI remains to be demonstrated. ..
  54. Park J, Han S, Cho H, Byun M, Yi D, Choe Y, et al. Chemically treated plasma A? is a potential blood-based biomarker for screening cerebral amyloid deposition. Alzheimers Res Ther. 2017;9:20 pubmed publisher
    ..MPP-A? might be one of the potential blood biomarkers for the prediction of PiB-PET positivity in the brain. ..
  55. da Costa M, Bernardi J, Costa L, Fiuza T, Brandão R, Ribeiro M, et al. N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin. Chem Biol Interact. 2017;272:37-46 pubmed publisher
    ..Our results suggest that NAC is a promising therapeutic strategy for the treatment of AD. ..
  56. Muñoz Moreno J, Prats A, Molto J, Garolera M, Perez Alvarez N, Diez Quevedo C, et al. Transdermal rivastigmine for HIV-associated cognitive impairment: A randomized pilot study. PLoS ONE. 2017;12:e0182547 pubmed publisher
    ..Relevant tolerability issues were not observed. ..
  57. Borrie S, Brems H, Legius E, Bagni C. Cognitive Dysfunctions in Intellectual Disabilities: The Contributions of the Ras-MAPK and PI3K-AKT-mTOR Pathways. Annu Rev Genomics Hum Genet. 2017;18:115-142 pubmed publisher
    ..disorders arising from mutations in these pathways exhibit related neurological phenotypes, including cognitive dysfunction, autism, and intellectual disability...
  58. Mu L, Peng L, Zhang Z, Jie J, Jia S, Yuan H. Memory and Executive Screening for the Detection of Cognitive Impairment in Obstructive Sleep Apnea. Am J Med Sci. 2017;354:399-407 pubmed publisher
    Obstructive sleep apnea (OSA) is commonly associated with cognitive dysfunction, which is more apparent in severe OSA and impairs quality of life. However, the clinical screening methods for these impairments in OSA are still limited...
  59. Nho K, Corneveaux J, Kim S, Lin H, Risacher S, Shen L, et al. Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics. Mol Psychiatry. 2013;18:739 pubmed publisher
  60. Zetterberg H, Blennow K. Neurogranin Levels in Cerebrospinal Fluid: A New Addition to the Alzheimer Disease Diagnostic Toolbox. JAMA Neurol. 2015;72:1237-8 pubmed publisher
  61. Moran J, Pedrera Zamorano J. Comments on "Efficacy and safety assessment of acupuncture and nimodipine to treat mild cognitive impairment after cerebral infarction: a randomized controlled trial". BMC Complement Altern Med. 2017;17:119 pubmed publisher
  62. Papma J, Smits M, de Groot M, Mattace Raso F, van der Lugt A, Vrooman H, et al. The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment. Eur Radiol. 2017;27:3716-3724 pubmed publisher
    ..PCC functioning during episodic memory does not relate to hippocampal structure in MCI. • Functional network changes are an important predictor of PCC functioning in MCI. ..
  63. Clark K, Clark C, Rahman A. A critical analysis of the tools to evaluate neuropsychiatric lupus. Lupus. 2017;26:504-509 pubmed publisher
    ..However, formal cognitive testing is seldom carried out in the acute setting. ..
  64. Buckley R, Schultz A, Hedden T, Papp K, Hanseeuw B, Marshall G, et al. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. 2017;89:29-37 pubmed publisher
    ..These results suggest that rs-fcMRI may be a useful predictor of early, AD-related cognitive decline in clinical research settings. ..
  65. Prickaerts J, Heckman P, Blokland A. Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease. Expert Opin Investig Drugs. 2017;26:1033-1048 pubmed publisher
  66. Emerson J, Smith C, Long K, Ransom J, Roberts R, Hass S, et al. Nursing Home Use Across The Spectrum of Cognitive Decline: Merging Mayo Clinic Study of Aging With CMS MDS Assessments. J Am Geriatr Soc. 2017;65:2235-2243 pubmed publisher
  67. Ashford J, Bayley P. Retrogenesis: a model of dementia progression in Alzheimer's disease related to neuroplasticity. J Alzheimers Dis. 2013;33:1191-3 pubmed publisher
  68. Seo J, Lim S, Kim J, Lee K, Kim J. Alantolactone and Isoalantolactone Prevent Amyloid ?25-35 -induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice. Phytother Res. 2017;31:801-811 pubmed publisher
    ..Therefore, AL and IAL deserve further study as potential therapeutic agents for reactive oxygen species-related neurodegenerative diseases. Copyright © 2017 John Wiley & Sons, Ltd. ..
  69. Rooijackers H, Wiegers E, van der Graaf M, Thijssen D, Kessels R, Tack C, et al. A Single Bout of High-Intensity Interval Training Reduces Awareness of Subsequent Hypoglycemia in Patients With Type 1 Diabetes. Diabetes. 2017;66:1990-1998 pubmed publisher
    ..that, in the short term, HIIT reduces awareness of hypoglycemia and attenuates hypoglycemia-induced cognitive dysfunction. In a randomized crossover trial, patients with type 1 diabetes and normal awareness of hypoglycemia (NAH),..
  70. Moszczynska A, Callan S. Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment. J Pharmacol Exp Ther. 2017;362:474-488 pubmed publisher
  71. Jozwiak N, Postuma R, Montplaisir J, Latreille V, Panisset M, Chouinard S, et al. REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson's Disease. Sleep. 2017;40: pubmed publisher
    ..This patient subgroup and their caregivers should receive targeted medical attention to better detect and monitor impairment and to enable the development of management interventions for cognitive decline and its consequences. ..
  72. Yi D, Seo E, Han J, Sohn B, Byun M, Lee J, et al. Development of the Korean Adult Reading Test (KART) to estimate premorbid intelligence in dementia patients. PLoS ONE. 2017;12:e0181523 pubmed publisher
    ..In conclusion, the results support the validity of KART-predicted IQ as an index of premorbid IQ in individuals with AD. ..
  73. Cabral C, Silveira M. Classification of Alzheimer's disease from FDG-PET images using favourite class ensembles. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:2477-80 pubmed publisher
    ..The ensembles systematically outperformed the corresponding single classifier with the best result (66.78%) being obtained by the SVM ensemble. ..
  74. Oyarzun Gonzalez X, Taylor K, Myers S, Muldoon S, Baumgartner R. Cognitive decline and polypharmacy in an elderly population. J Am Geriatr Soc. 2015;63:397-9 pubmed publisher
  75. Oikonomidis L, Santangelo A, Shiba Y, Clarke F, Robbins T, Roberts A. A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey. Dev Neurobiol. 2017;77:328-353 pubmed publisher
    ..circuits and identifying the selective neurochemical modulation (serotonin vs dopamine) that underlie cognitive dysfunction have revealed counterparts in the clinical domain...
  76. Thom R, Grudzinskas A, Saleh F. Sexual Behavior Among Persons With Cognitive Impairments. Curr Psychiatry Rep. 2017;19:25 pubmed publisher
  77. Li W, Tian Y, Deng Y, Feng X, Wang Y, Feng H, et al. [Correlation between serum adiponectin level and cognitive function in patients with Alzheimer's disease]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;37:542-545 pubmed
    ..05). Serum adiponectin level was positively correlated with the MMSE score in the AD patients (r=0.683, P<0.001). Serum adiponectin levels are reduced in AD patients and associated with the degree of cognitive impairment. ..
  78. Comes M, Rosa A, Reinares M, Torrent C, Vieta E. Functional Impairment in Older Adults With Bipolar Disorder. J Nerv Ment Dis. 2017;205:443-447 pubmed publisher
    ..217, p = 0.002). Older patients with bipolar disorder had a greater functional impairment than the healthy control group. Implementation of novel rehabilitation models is critical to help patients manage their illness. ..
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    ..The aim of this study was to examine brain amyloid accumulation in patients with lifetime major depression using (18)F-florbetapir (AV-45/Amyvid) PET imaging in comparison with that in nondepressed subjects...
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