mecamylamine

Summary

Summary: A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Top Publications

  1. Bhutada P, Mundhada Y, Ghodki Y, Dixit P, Umathe S, Jain K. Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of exposure to stress and modulation by mecamylamine. J Psychopharmacol. 2012;26:315-23 pubmed publisher
    ..Therefore, the present study investigated the influence of mecamylamine, a nicotinic acetylcholine receptors antagonist on acquisition, expression, and reinstatement of ethanol-..
  2. Levy R, Reyes A, Aoki C. Nicotinic and muscarinic reduction of unitary excitatory postsynaptic potentials in sensory cortex; dual intracellular recording in vitro. J Neurophysiol. 2006;95:2155-66 pubmed
    ..was prevented by the NMDA receptor antagonist D-AP5 (50 microM) and by the nicotinic receptor antagonist mecamylamine (10 microM)...
  3. DeNoble V, Mele P. Intravenous nicotine self-administration in rats: effects of mecamylamine, hexamethonium and naloxone. Psychopharmacology (Berl). 2006;184:266-72 pubmed
    ..Presession injections of mecamylamine (0.75, 1.5, and 3.0 mg/kg, s.c.) decreased the number of infusions in a dose-related manner...
  4. Sacco K, Termine A, Seyal A, Dudas M, Vessicchio J, Krishnan Sarin S, et al. Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms. Arch Gen Psychiatry. 2005;62:649-59 pubmed
    ..weeks during which subjects were pretreated in a counterbalanced manner with the nonselective nAChR antagonist mecamylamine hydrochloride (0, 5, or 10 mg/d). Twenty-five smokers with schizophrenia and 25 control smokers...
  5. Liu X, Caggiula A, Yee S, Nobuta H, Sved A, Pechnick R, et al. Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats. Neuropsychopharmacology. 2007;32:710-8 pubmed
    b>Mecamylamine, a noncompetitive nicotinic cholinergic antagonist, inhibits nicotine self-administration in animals and may attenuate tobacco smoking in humans trying to quit...
  6. Caldarone B, Harrist A, Cleary M, Beech R, King S, Picciotto M. High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biol Psychiatry. 2004;56:657-64 pubmed
    ..Antidepressant properties of the noncompetitive nAChR antagonist mecamylamine in the forced swim test were tested alone and in combination with the tricyclic antidepressant amitriptyline...
  7. Katner S, Davis S, Kirsten A, Taffe M. Effects of nicotine and mecamylamine on cognition in rhesus monkeys. Psychopharmacology (Berl). 2004;175:225-40 pubmed
    ..2-56 microg/kg, i.m.) and the nAChR antagonist mecamylamine (0.32-1.78 mg/kg, i.m.)...
  8. Qiao D, Seidler F, Violin J, Slotkin T. Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. Brain Res Dev Brain Res. 2003;147:183-90 pubmed
    ..The effects were blocked by mecamylamine, indicating mediation by nicotinic acetylcholine receptors...
  9. Kiuchi K, Matsuoka M, Wu J, Lima e Silva R, Kengatharan M, Verghese M, et al. Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization. Invest Ophthalmol Vis Sci. 2008;49:1705-11 pubmed publisher
    ..The effect of the nonselective nAChR antagonist mecamylamine was tested on human retinal and choroidal endothelial cells in vitro and in a murine model of CNV...

More Information

Publications63

  1. Herrero J, Roberts M, Delicato L, Gieselmann M, Dayan P, Thiele A. Acetylcholine contributes through muscarinic receptors to attentional modulation in V1. Nature. 2008;454:1110-4 pubmed publisher
    ..applying the muscarinic antagonist scopolamine reduced attentional modulation, whereas the nicotinic antagonist mecamylamine had no systematic effect...
  2. Arias H, Rosenberg A, Targowska Duda K, Feuerbach D, Jozwiak K, Moaddel R, et al. Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel. Int J Biochem Cell Biol. 2010;42:1007-18 pubmed publisher
    ..receptor in different conformational states was compared with that for the noncompetitive antagonist mecamylamine by using functional and structural approaches...
  3. Lippiello P, Beaver J, Gatto G, James J, Jordan K, Traina V, et al. TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther. 2008;14:266-77 pubmed publisher
    ..examined the potential palliative role of NNR antagonism in these disorders, using TC-5214 (S-(+) enantiomer of mecamylamine), a noncompetitive NNR antagonist...
  4. Andreasen J, Redrobe J. Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. Behav Pharmacol. 2009;20:286-95 pubmed publisher
    ..In humans, both nicotine and the nonselective nicotinic acetylcholine receptor antagonist mecamylamine ameliorate depressive symptoms. Similarly, both drugs produce antidepressant-like effects in rodents...
  5. O Dell L, Chen S, Smith R, Specio S, Balster R, Paterson N, et al. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. J Pharmacol Exp Ther. 2007;320:180-93 pubmed
    ..Somatic signs of nicotine withdrawal were examined following saline or mecamylamine administration (1.5 mg/kg i.p.), and extinction of nicotine-seeking behavior was assessed...
  6. Young E, Mahler S, Chi H, de Wit H. Mecamylamine and ethanol preference in healthy volunteers. Alcohol Clin Exp Res. 2005;29:58-65 pubmed
    ..b>Mecamylamine, a nicotinic acetylcholine receptor antagonist, reduces alcohol preference and consumption in alcohol-..
  7. McKee S, Weinberger A, Harrison E, Coppola S, George T. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: a preliminary study. Schizophr Res. 2009;115:317-24 pubmed publisher
    ..This difference may be related to how intensely cigarettes are smoked but this has not been well studied. Mecamylamine (MEC), a non-competitive nicotinic acetylcholine receptor (nAChR) antagonist, which has been shown to increase ..
  8. Olson M, Olson E, Qualls J, Stratton J, Harding J, Wright J. Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficits. Peptides. 2004;25:233-41 pubmed
    ..We initially established that intracerebroventricular administration of the nAChR-antagonist mecamylamine (mec) interfered with spatial memory performance in male Sprague-Dawley rats...
  9. Farook J, Lewis B, Gaddis J, Littleton J, Barron S. Effects of mecamylamine on alcohol consumption and preference in male C57BL/6J mice. Pharmacology. 2009;83:379-84 pubmed publisher
    ..In the present study, using C57BL/6J mice, we investigated the ability of mecamylamine (a nicotinic antagonist) to reduce alcohol consumption and alcohol preference with free 24-hour access using a ..
  10. Park D, Kim H, Jung W, Shin M, Kim K. Mecamylamine attenuates dexamethasone-induced anxiety-like behavior in association with brain derived neurotrophic factor upregulation in rat brains. Neuropharmacology. 2011;61:276-82 pubmed publisher
    b>Mecamylamine (MEC), which was initially developed as a ganglionic blocker for the treatment of hypertension has been investigated as a potent antagonist for most types of nicotinic acetylcholine receptors (nAChRs)...
  11. Rabenstein R, Caldarone B, Picciotto M. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006;189:395-401 pubmed
    ..We determined whether the noncompetitive nAChR antagonist mecamylamine had antidepressant-like effects in the forced swim test (FST) and tail suspension test (TST)...
  12. Glover E, Laflin M, Schuh K, Schuh L, Nides M, Christen A, et al. A randomized, controlled trial to assess the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers. Addiction. 2007;102:795-802 pubmed
    ..determine the efficacy and safety of nicotine transdermal therapy co-administered with the nicotine antagonist, mecamylamine, compared to a nicotine transdermal patch alone (21 mg nicotine + 6 mg mecamylamine, 21 mg nicotine + 3 mg ..
  13. Levin E, Caldwell D. Low-dose mecamylamine improves learning of rats in the radial-arm maze repeated acquisition procedure. Neurobiol Learn Mem. 2006;86:117-22 pubmed
    The nicotinic antagonist mecamylamine has been widely shown to cause cognitive impairment. However, these effects are mainly seen with high doses...
  14. George T, Sacco K, Vessicchio J, Weinberger A, Shytle R. Nicotinic antagonist augmentation of selective serotonin reuptake inhibitor-refractory major depressive disorder: a preliminary study. J Clin Psychopharmacol. 2008;28:340-4 pubmed publisher
    ..We compared the nicotinic antagonist, mecamylamine hydrochloride (MEC), with placebo as an augmentation strategy for patients with MDD who were refractory to ..
  15. Andreasen J, Redrobe J. Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests. Behav Brain Res. 2009;197:150-6 pubmed publisher
    ..In rodents, antidepressant-like effects of both nicotine and the non-selective nAChR antagonist mecamylamine have been reported...
  16. Fedorov N, Benson L, Graef J, Lippiello P, Bencherif M. Differential pharmacologies of mecamylamine enantiomers: positive allosteric modulation and noncompetitive inhibition. J Pharmacol Exp Ther. 2009;328:525-32 pubmed publisher
    b>Mecamylamine is a racemic mixture of a widely used brain-permeant noncompetitive inhibitor of muscle-type and neuronal nicotinic receptors (NNRs)...
  17. Skwara A, Karwoski T, Czambel R, Rubin R, Rhodes M. Influence of environmental enrichment on hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine by osmotic mini-pumps, and nicotine withdrawal by mecamylamine in male and female rats. Behav Brain Res. 2012;234:1-10 pubmed publisher
    ..NIC), single-dose NIC following continuous NIC administration for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) in male and female rats...
  18. Gentile N, Andrekanic J, Karwoski T, Czambel R, Rubin R, Rhodes M. Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats. Brain Res Bull. 2011;85:145-52 pubmed publisher
    ..NIC, a single-dose of NIC immediately following continuous NIC for two weeks, and NIC withdrawal by single-dose mecamylamine (MEC) following continuous NIC infusion for two weeks...
  19. Ford M, Fretwell A, Nickel J, Mark G, Strong M, Yoneyama N, et al. The influence of mecamylamine on ethanol and sucrose self-administration. Neuropharmacology. 2009;57:250-8 pubmed publisher
    ..The current studies examined the influence of the nAChR antagonist mecamylamine (MEC) on operant ethanol self-administration using a procedure that independently assessed appetitive and ..
  20. Chen H, Su C. Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro. Neuropharmacology. 2006;51:1120-8 pubmed
    ..Application of mecamylamine, an open-channel nicotinic receptor blocker, reduced SND in a progressive manner...
  21. Shram M, Siu E, Li Z, Tyndale R, Le A. Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats. Psychopharmacology (Berl). 2008;198:181-90 pubmed publisher
    ..The present study investigated age differences in the motivational effects of mecamylamine-precipitated and spontaneous nicotine withdrawal in adolescent and adult rats using the conditioned place ..
  22. Coolon R, Cain M. Effects of mecamylamine on nicotine-induced conditioned hyperactivity and sensitization in differentially reared rats. Pharmacol Biochem Behav. 2009;93:59-66 pubmed publisher
    ..This study also examined the effects of mecamylamine on conditioned hyperactivity and sensitization...
  23. Biala G, Weglinska B. Blockade of the expression of mecamylamine-precipitated nicotine withdrawal by calcium channel antagonists. Pharmacol Res. 2005;51:483-8 pubmed
    ..four times daily for 7 days. In attempt to precipitate nicotine abstinence, mice were given one injection of mecamylamine (3 mgkg(-1), intraperitoneally (i.p...
  24. Thuerauf N, Markovic K, Braun G, Bleich S, Reulbach U, Kornhuber J, et al. The influence of mecamylamine on trigeminal and olfactory chemoreception of nicotine. Neuropsychopharmacology. 2006;31:450-61 pubmed
    ..b>Mecamylamine, a nicotinic acetylcholine-receptor-(nAch-R) antagonist, was able to block painful responses following chemical ..
  25. Gacar N, Mutlu O, Utkan T, Komsuoglu Celikyurt I, Göçmez S, Ulak G. Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and Morris water maze tests in rats. Pharmacol Biochem Behav. 2011;99:316-23 pubmed publisher
    ..the effect of resveratrol on emotional and spatial memory in naive rats, as well as on scopolamine- and mecamylamine-induced memory impairment in the passive avoidance and Morris water maze (MWM) tests. Resveratrol (12...
  26. Weinberger A, Sacco K, Creeden C, Vessicchio J, Jatlow P, George T. Effects of acute abstinence, reinstatement, and mecamylamine on biochemical and behavioral measures of cigarette smoking in schizophrenia. Schizophr Res. 2007;91:217-25 pubmed
    ..and reinstatement, and with pre-treatment using the nicotinic acetylcholine receptor (nAChR) antagonist mecamylamine (MEC) in a human laboratory setting. Biochemical (e.g., plasma nicotine) and behavioral (e.g...
  27. Jackson K, Chen Q, Chen J, Aggen S, Kendler K, Chen X. Association of the histidine-triad nucleotide-binding protein-1 (HINT1) gene variants with nicotine dependence. Pharmacogenomics J. 2011;11:251-7 pubmed publisher
    ..This increase was reduced after treatment with the nicotinic-receptor antagonist mecamylamine, and 24 and 72?h after cessation of nicotine treatment...
  28. George O, Ghozland S, Azar M, Cottone P, Zorrilla E, Parsons L, et al. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proc Natl Acad Sci U S A. 2007;104:17198-203 pubmed
    ..Overactivation of the CRF-CRF(1) system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction. ..
  29. Campochiaro P, Shah S, Hafiz G, Heier J, Lit E, Zimmer Galler I, et al. Topical mecamylamine for diabetic macular edema. Am J Ophthalmol. 2010;149:839-51.e1 pubmed publisher
    ..The safety and bioactivity of topical mecamylamine, an antagonist of nACh receptors, was tested in patients with diabetic macular edema...
  30. Bacher I, Wu B, Shytle D, George T. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009;10:2709-21 pubmed publisher
    b>Mecamylamine (Inversine), the first orally available antihypertensive agent launched in the 1950s, is rarely used today for hypertension because of its widespread ganglionic side effects at antihypertensive doses (25 - 90 mg/day)...
  31. Hendrickson L, Zhao Shea R, Tapper A. Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice. Psychopharmacology (Berl). 2009;204:563-72 pubmed publisher
    ..Adult male C57Bl/6J mice were injected i.p. with nicotinic receptor antagonists including mecamylamine, hexamethonium, dihydro-beta-erythroidine, and methyllycaconitine...
  32. Phillips J, Ehrlichman R, Siegel S. Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma. Neuroscience. 2007;144:1314-23 pubmed
    ..conducted to examine the effect of acute administration of nicotine and the non-specific nicotinic antagonist mecamylamine on the P20 and N40 components of the ERP and evoked gamma oscillations in mice...
  33. Mineur Y, Somenzi O, Picciotto M. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology. 2007;52:1256-62 pubmed
    ..These studies also suggest that both antagonists and partial agonists of alpha4/beta2*nAChRs would be interesting targets for the development of novel antidepressant drugs. ..
  34. Mansbach R, Chambers L, Rovetti C. Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine. Psychopharmacology (Berl). 2000;148:234-42 pubmed
    ..study compared the effects of the competitive nACHR antagonist erysodine and the noncompetitive antagonist mecamylamine in rats trained to discriminate or self-administer nicotine. Adult male rats were trained to discriminate 0...
  35. Corrigall W, Coen K. Nicotine maintains robust self-administration in rats on a limited-access schedule. Psychopharmacology (Berl). 1989;99:473-8 pubmed
    ..pharmacological sensitivity; it was dose-dependently reduced by pre-session treatment with either nicotine or mecamylamine but not with hexamethonium...
  36. Rose J, Behm F, Westman E. Acute effects of nicotine and mecamylamine on tobacco withdrawal symptoms, cigarette reward and ad lib smoking. Pharmacol Biochem Behav. 2001;68:187-97 pubmed
    Separate and combined effects of nicotine and the nicotinic antagonist mecamylamine were studied in 32 healthy volunteer smokers after overnight abstinence from smoking...
  37. Rada P, Jensen K, Hoebel B. Effects of nicotine and mecamylamine-induced withdrawal on extracellular dopamine and acetylcholine in the rat nucleus accumbens. Psychopharmacology (Berl). 2001;157:105-10 pubmed
    ..After chronic nicotine administration for 7 days, the nicotinic antagonist mecamylamine (1.0 mg/kg, s.c...
  38. Heeschen C, Weis M, Aicher A, Dimmeler S, Cooke J. A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest. 2002;110:527-36 pubmed
    ..In an in vitro angiogenesis model, increasing concentrations of the nonselective nAChR antagonist mecamylamine completely and reversibly inhibited endothelial network formation...
  39. Rose J, Behm F, Westman E, Bates J. Mecamylamine acutely increases human intravenous nicotine self-administration. Pharmacol Biochem Behav. 2003;76:307-13 pubmed
    ..of human cigarette smoking have shown that administration of the nicotinic acetylcholine receptor antagonist mecamylamine produces acute increases in smoking behavior...
  40. Woodruff Pak D. Mecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits tested with delay eyeblink classical conditioning. Behav Brain Res. 2003;143:159-67 pubmed
    ..nAChR partial agonist that antagonizes alpha4beta2 nAChRs) and the relatively nonselective nAChR antagonist, mecamylamine. Groups of young rabbits were injected with 0...
  41. Hsieh M, Kuo L, Tsai F, Wang W, Wu C. Effects of puerarin on scopolamine-, mecamylamine-, p-chloroamphetamine- and dizocilpine-induced inhibitory avoidance performance impairment in rats. Planta Med. 2002;68:901-5 pubmed
    Puerarin at 10-50 mg/kg attenuated the mecamylamine- but not scopolamine-induced acquisition impairment of inhibitory avoidance performance in an inverse U-shape manner...
  42. Woodruff Pak D, Vogel R, Wenk G. Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors. Neuroscience. 2003;117:439-47 pubmed
    ..demonstrated that donepezil, but not galantamine, could be blocked by the nicotinic cholinergic antagonist mecamylamine, suggesting that galantamine acted at a separate (allosteric) site...
  43. Shytle R, Penny E, Silver A, Goldman J, Sanberg P. Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002;16:453-7 pubmed
    b>Mecamylamine (Inversine), the first orally available antihypertensive agent, is now rarely used...
  44. Chadman K, Woods J. Cardiovascular effects of nicotine, chlorisondamine, and mecamylamine in the pigeon. J Pharmacol Exp Ther. 2004;308:73-8 pubmed
    Chlorisondamine and mecamylamine are nicotinic antagonists that produce both ganglionic and central blockade. Chlorisondamine, when administered as a large systemic dose, produces a persistent central block, despite being charged...
  45. Thompson J, Stough C, Ames D, Ritchie C, Nathan P. Effects of the nicotinic antagonist mecamylamine on inspection time. Psychopharmacology (Berl). 2000;150:117-9 pubmed
    ..The present study sought to examine the effects of the nAchR antagonist mecamylamine on inspection time...
  46. Damaj M, Meyer E, Martin B. The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model. Neuropharmacology. 2000;39:2785-91 pubmed
    ..Dihydro-beta-erythroidine and mecamylamine failed to block choline-induced antinociception...
  47. Daniel J, Winsauer P, Moerschbaecher J. Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine. Psychopharmacology (Berl). 2003;170:294-300 pubmed publisher
    ..assessed the interactive effects of castration and scopolamine, a muscarinic receptor antagonist, as well as mecamylamine, a nicotinic receptor antagonist, on behavior. Young adult male rats were castrated or underwent sham surgeries...
  48. Debruyne D, Sobrio F, Hinschberger A, Camsonne R, Coquerel A, Barre L. Short-term pharmacokinetics and brain distribution of mecamylamine as a preliminary to carbon-11 labeling for nicotinic receptor investigation. J Pharm Sci. 2003;92:1051-7 pubmed
    As a preliminary to development and evaluation of labeled mecamylamine as a potential in vivo imaging ligand for human central nicotinic receptors (nAchRs), this work was intended to determine whether the pharmacokinetic properties of ..
  49. Young J, Shytle R, Sanberg P, George T. Mecamylamine: new therapeutic uses and toxicity/risk profile. Clin Ther. 2001;23:532-65 pubmed
    b>Mecamylamine hydrochloride was initially developed for its ganglion-blocking activity and has been marketed as an antihypertensive agent in the United States for >40 years...
  50. Harrison A, Liem Y, Markou A. Fluoxetine combined with a serotonin-1A receptor antagonist reversed reward deficits observed during nicotine and amphetamine withdrawal in rats. Neuropsychopharmacology. 2001;25:55-71 pubmed
  51. Newman M, Manresa J, Sanberg P, Shytle R. Nicotine induced seizures blocked by mecamylamine and its stereoisomers. Life Sci. 2001;69:2583-91 pubmed
    ..These receptors are also involved with the induction of nicotine-induced seizures. (+/-)-Mecamylamine (Inversine), a classic nAChR antagonist, potently inhibits nicotine-induced seizures...
  52. Blomqvist O, Hernandez Avila C, Van Kirk J, Rose J, Kranzler H. Mecamylamine modifies the pharmacokinetics and reinforcing effects of alcohol. Alcohol Clin Exp Res. 2002;26:326-31 pubmed
    ..Consistent with this model, acute administration to rats of the tertiary nicotinic receptor antagonist mecamylamine blocks both alcohol consumption and alcohol-induced dopamine release in the nucleus accumbens...
  53. Brown R, Beale K, Jay Frye G. Mecamylamine blocks enhancement of reference memory but not working memory produced by post-training injection of nicotine in rats tested on the radial arm maze. Behav Brain Res. 2002;134:259-65 pubmed
    ..b>Mecamylamine, a nicotine antagonist, was used to attempt to block the enhancement of memory consolidation...
  54. Shytle R, Silver A, Sheehan K, Sheehan D, Sanberg P. Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine. Depress Anxiety. 2002;16:89-92 pubmed