testicular diseases

Summary

Summary: Pathological processes of the TESTIS.

Top Publications

  1. Strom K, Levine L. Microsurgical denervation of the spermatic cord for chronic orchialgia: long-term results from a single center. J Urol. 2008;180:949-53 pubmed publisher
    ..We assessed the long-term efficacy, complications and patient perceptions of microsurgical denervation of the spermatic cord in the treatment of chronic orchialgia...
  2. Atis G, Memis O, Güngör H, Arikan O, Saglican Y, Caskurlu T. Testicular polyarteritis nodosa mimicking testicular neoplasm. ScientificWorldJournal. 2010;10:1915-8 pubmed publisher
    ..We described the case of a 57-year-old patient with isolated testicular PAN who presented with a testicular mass mimicking a primary testicular tumor. ..
  3. van Casteren N, Looijenga L, Dohle G. Testicular microlithiasis and carcinoma in situ overview and proposed clinical guideline. Int J Androl. 2009;32:279-87 pubmed publisher
    ..A long-term active follow-up schedule, including ultrasonography and physical examinations, is not indicated in the remaining patients with TM...
  4. Xu M, Dai D, Zhang Q, Cheng Y, Dai Y. Upregulated NADPH oxidase contributes to diabetic testicular complication and is relieved by strontium fructose 1,6-diphosphate. Exp Clin Endocrinol Diabetes. 2010;118:459-65 pubmed publisher
    ..It is due to its extra-energy supply and an antioxidant activity of FDP-Sr...
  5. Korde L, PremKumar A, Mueller C, Rosenberg P, Soho C, Bratslavsky G, et al. Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives. Br J Cancer. 2008;99:1748-53 pubmed publisher
    ..If proven, this could be clinically important to men in FTGCT families, and may be useful in identifying specific genes involved in FTGCT...
  6. Macleod D, Sharpe R, Welsh M, Fisken M, Scott H, Hutchison G, et al. Androgen action in the masculinization programming window and development of male reproductive organs. Int J Androl. 2010;33:279-87 pubmed publisher
    ..controls. In conclusion, we show that the size of all male reproductive organs is programmed by androgen exposure in the MPW, but that growth towards this size is dependent on androgen action postnatally...
  7. Miller F, Sidhu P. Does testicular microlithiasis matter? A review. Clin Radiol. 2002;57:883-90 pubmed
    ..Similarly, there is limited evidence to support the association with infertility. Not surprisingly, algorithms for the follow-up of patients with TM on ultrasound have been difficult to formulate...
  8. Kim F, Pinto P, Su L, Jarrett T, Rattner L, Montgomery R, et al. Ipsilateral orchialgia after laparoscopic donor nephrectomy. J Endourol. 2003;17:405-9 pubmed
    ..In an effort to assess the incidence of this problem, determine the etiology, and adapt preventive measures, we reviewed our experience...
  9. Wasniewska M, De Luca F, Bertelloni S, Matarazzo P, Weber G, Crisafulli G, et al. Testicular microlithiasis: an unreported feature of McCune-Albright syndrome in males. J Pediatr. 2004;145:670-2 pubmed
    ..To ascertain the incidence of testicular microlithiasis (TM) in boys with McCune-Albright syndrome (MAS)...

More Information

Publications62

  1. Vegni Talluri M, Bigliardi E, Vanni M, Tota G. Testicular microliths: their origin and structure. J Urol. 1980;124:105-7 pubmed
    ..The microliths seem to originate from degenerating intratubular cells and consist of a central calcified core surrounded by concentric layers of connective fibers...
  2. Li M, Fogarty J, Whitney K, Stone P. Repeated testicular infarction in a patient with sickle cell disease: a possible mechanism for testicular failure. Urology. 2003;62:551 pubmed
    ..We propose repeated testicular infarction as a probable mechanism of testicular failure and impaired fertility in patients with sickle cell disease...
  3. Dotan Z, Laufer M, Heldenberg E, Langevitz P, Fridman E, Duvdevani M, et al. Isolated testicular polyarteritis nodosa mimicking testicular neoplasm-long-term follow-up. Urology. 2003;62:352 pubmed
    ..The postoperative laboratory evaluation was negative. Long-term follow-up, without systemic treatment, showed no evidence of recurrence in the remainder of the testis or development of systemic vasculitis...
  4. McLachlan R, Rajpert De Meyts E, Hoei Hansen C, de Kretser D, Skakkebaek N. Histological evaluation of the human testis--approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod. 2007;22:2-16 pubmed
    ..We propose a new diagnosis code for testicular biopsies that addresses the needs of ART clinicians and allows data storage and retrieval of value in clinical practice and research...
  5. Joudi F, Austin J, Vogelgesang S, Jensen C. Isolated testicular vasculitis presenting as a tumor-like lesion. J Urol. 2004;171:799 pubmed
  6. Rashid H, Cos L, Weinberg E, Messing E. Testicular microlithiasis: a review and its association with testicular cancer. Urol Oncol. 2004;22:285-9 pubmed
    ..Therefore, follow-up at this time should be dictated based on risk factors for developing testis cancer more than on the presence of TM...
  7. Shamsa A, Kadkhodayan A, Feiz Zadeh B, Rasulian H. Testicular hematocele mimicking a testicular tumor: a case report and review of literature. Transplant Proc. 2002;34:2141-2 pubmed
  8. McGuire B, O Brien M, Akhtar M, Fitzpatrick J. Testicular vasculitis mimicking a testicular neoplasm. Ir Med J. 2006;99:27-8 pubmed
    ..We report the general clinical presentation, methods of investigation and subsequent management. This is the first time it has been described in the elderly population...
  9. Otite U, Webb J, Oliver R, Badenoch D, Nargund V. Testicular microlithiasis: is it a benign condition with malignant potential?. Eur Urol. 2001;40:538-42 pubmed
  10. Peterson A, Bauman J, Light D, McMann L, Costabile R. The prevalence of testicular microlithiasis in an asymptomatic population of men 18 to 35 years old. J Urol. 2001;166:2061-4 pubmed
    ..We report an ultrasound screening study done to establish the prevalence of testicular microlithiasis in an asymptomatic population...
  11. Heidenreich A, Olbert P, Engelmann U. Management of chronic testalgia by microsurgical testicular denervation. Eur Urol. 2002;41:392-7 pubmed
    ..Success rates of conservative and surgical measures including epididymectomy and orchiectomy rarely exceed 55-73% and 10-40%, respectively. We report our experience on microsurgical testicular denervation as therapeutic option in CTP...
  12. Woodward P, Sohaey R, O Donoghue M, Green D. From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation. Radiographics. 2002;22:189-216 pubmed
    ..Other benign lesions that can be suspected on the basis of imaging findings and history include intratesticular cysts, epidermoid cysts, congenital adrenal hyperplasia, and sarcoidosis...
  13. Dagash H, Mackinnon E. Testicular microlithiasis: what does it mean clinically?. BJU Int. 2007;99:157-60 pubmed
  14. Skakkebaek N, Rajpert De Meyts E, Main K. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972-8 pubmed
    ..Otherwise, important biological information may be lost...
  15. Wiesenthal J, Ettler H, Razvi H. Testicular epidermoid cyst: a case report and review of the clinicopathologic features. Can J Urol. 2004;11:2133-5 pubmed
    ..Radical orchidectomy was performed revealing the pathologic diagnosis. The presentation, evaluation and management of epidermoid cysts are discussed...
  16. Gat Y, Gornish M, Navon U, Chakraborty J, Bachar G, Ben Shlomo I. Right varicocele and hypoxia, crucial factors in male infertility: fluid mechanics analysis of the impaired testicular drainage system. Reprod Biomed Online. 2006;13:510-5 pubmed
  17. Backus M, Mack L, Middleton W, King B, Winter T, True L. Testicular microlithiasis: imaging appearances and pathologic correlation. Radiology. 1994;192:781-5 pubmed
    ..To determine the spectrum of sonographic findings, clinical implications, and pathologic correlation in patients with testicular microlithiasis (TM)...
  18. Casella R, Nudell D, Cozzolino D, Wang H, Lipshultz L. Primary testicular amyloidosis mimicking tumor in a cryptorchid testis. Urology. 2002;59:445 pubmed
    ..After radical orchiectomy, the histologic evaluation revealed primary amyloidosis of the testis. The pathogenesis and clinical presentation of testicular amyloidosis are reviewed...
  19. Levine L, Matkov T. Microsurgical denervation of the spermatic cord as primary surgical treatment of chronic orchialgia. J Urol. 2001;165:1927-9 pubmed
    ..We evaluate the effectiveness of microsurgical denervation of the spermatic cord for treatment of chronic orchialgia...
  20. Hutchison G, Sharpe R, Mahood I, Jobling M, Walker M, McKinnell C, et al. The origins and time of appearance of focal testicular dysgenesis in an animal model of testicular dysgenesis syndrome: evidence for delayed testis development?. Int J Androl. 2008;31:103-11 pubmed
    ..5 after DBP exposure, which may be indicative of a wider delay in testis cell development and organisation, and this might account for some of the unexplained findings...
  21. Ketola I, Pentikäinen V, Vaskivuo T, Ilvesmaki V, Herva R, Dunkel L, et al. Expression of transcription factor GATA-4 during human testicular development and disease. J Clin Endocrinol Metab. 2000;85:3925-31 pubmed
    ..GATA-4 protein is abundantly present in Sertoli and Leydig cell tumors, suggesting a relationship to tumorigenesis or tumor progression in somatic cell-derived testicular neoplasms...
  22. Nistal M, Paniagua R, Diez Pardo J. Testicular microlithiasis in 2 children with bilateral cryptorchidism. J Urol. 1979;121:535-7 pubmed
    ..The presence of similar concretion in the nervous system as well as the lung in other reported cases suggests that microlithiasis could be a systemic disease...
  23. Srigley J, Hartwick R. Tumors and cysts of the paratesticular region. Pathol Annu. 1990;25 Pt 2:51-108 pubmed
  24. Fridman E, Skarda J, Ofek Moravsky E, Cordoba M. Complex multilocular cystic lesion of rete testis, accompanied by smooth muscle hyperplasia, mimicking intratesticular Leydig cell neoplasm. Virchows Arch. 2005;447:768-71 pubmed
    ..To the best of our knowledge, no similar complex lesion of the rete testis has yet been reported...
  25. Doherty F, Mullins T, Sant G, Drinkwater M, Ucci A. Testicular microlithiasis. A unique sonographic appearance. J Ultrasound Med. 1987;6:389-92 pubmed
  26. Jahnukainen K, Jahnukainen T, Salmi T, Svechnikov K, Eksborg S, Soder O. Amifostine protects against early but not late toxic effects of doxorubicin in infant rats. Cancer Res. 2001;61:6423-7 pubmed
  27. Drut R, Drut R. Testicular microlithiasis: histologic and immunohistochemical findings in 11 pediatric cases. Pediatr Dev Pathol. 2002;5:544-50 pubmed
    ..It is unclear how this may be related to the development of germ cell tumors. However, the presence of calcospherites in gonadoblastoma may indicate a combined Sertoli cell and germ cell derangement in the genesis of TM...
  28. Holm M, Hoei Hansen C, Rajpert De Meyts E, Skakkebaek N. Increased risk of carcinoma in situ in patients with testicular germ cell cancer with ultrasonic microlithiasis in the contralateral testicle. J Urol. 2003;170:1163-7 pubmed
    ..We compared clinical and histological data regarding the contralateral testicle in a population of men diagnosed with testicular germ cell cancer to find features associated with an increased risk of bilateral neoplasia...
  29. Ringdahl E, Claybrook K, Teague J, Northrup M. Testicular microlithiasis and its relation to testicular cancer on ultrasound findings of symptomatic men. J Urol. 2004;172:1904-6 pubmed
    ..We reviewed testicular microlithiasis (TM) on scrotal ultrasound in relation to the incidence of testicular neoplasm in males 17 to 45 years old with scrotal symptoms...
  30. Kocak I, Dundar M, Culhaci N, Unsal A. Relapse of brucellosis simulating testis tumor. Int J Urol. 2004;11:683-5 pubmed
    ..Even in the absence of systemic symptoms, the possible relapse of brucellosis as an abscess formation in the testis should be considered as a rare cause of testicular mass in patients who live in endemic regions...
  31. Zastrow S, Hakenberg O, Wirth M. Significance of testicular microlithiasis. Urol Int. 2005;75:3-7 pubmed
    ..Testicular microlithiasis is an uncommon condition characterized by calcifications within the seminiferous tubules. The true prevalence in a normal population has not been defined...
  32. De Gouveia Brazao C, Pierik F, Oosterhuis J, Dohle G, Looijenga L, Weber R. Bilateral testicular microlithiasis predicts the presence of the precursor of testicular germ cell tumors in subfertile men. J Urol. 2004;171:158-60 pubmed
    ..We determined the predictive value of unilateral and bilateral testicular microlithiasis for CIS in subfertile men, a known risk population for TGCTs (approximately 1%)...
  33. Lam D, Gerscovich E, Kuo M, McGahan J. Testicular microlithiasis: our experience of 10 years. J Ultrasound Med. 2007;26:867-73 pubmed
    ..The correlation between TM and testicular malignancies is variable. The purpose of this study was to review our 10-year experience regarding the prevalence of TM and its association with testicular malignancies...
  34. Fisher J, MacPherson S, Marchetti N, Sharpe R. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod. 2003;18:1383-94 pubmed
    ..The disorders comprising human 'testicular dysgenesis syndrome' (TDS) may be increasing in incidence. TDS originates in fetal life but the mechanisms are not known, and discerning them requires an animal model...
  35. Serter S, Gumus B, Unlu M, Tuncyurek O, Tarhan S, Ayyildiz V, et al. Prevalence of testicular microlithiasis in an asymptomatic population. Scand J Urol Nephrol. 2006;40:212-4 pubmed
    ..The aim of this prospective study was to determine the true prevalence of testicular microlithiasis in an asymptomatic population by means of ultrasound screening...
  36. Shergill I, Thwaini A, Kapasi F, Potluri B, Barber C. Management of simple intratesticular cysts: a single-institution 11-year experience. Urology. 2006;67:1266-8 pubmed
    ..To evaluate the clinicoradiologic findings and outcomes of management of simple intratesticular cysts, by review of an 11-year experience...
  37. Sundaram S, Smith D. Giant cell arteritis mimicking a testicular tumour. Rheumatol Int. 2001;20:215-6 pubmed
    ..Giant cell arteritis involving the bladder, prostate, uterus, and adnexa have been described before. To our knowledge, this is the first described case of giant cell arteritis affecting the testis...
  38. Bach A, Hann L, Hadar O, Shi W, Yoo H, Giess C, et al. Testicular microlithiasis: what is its association with testicular cancer?. Radiology. 2001;220:70-5 pubmed
    ..To determine the prevalence of testicular microlithiasis in patients who were referred for scrotal ultrasonography (US) at a tertiary care cancer center and to evaluate the association between microlithiasis and cancer...
  39. Shagirtha K, Pari L. Hesperetin, a citrus flavonone, protects potentially cadmium induced oxidative testicular dysfunction in rats. Ecotoxicol Environ Saf. 2011;74:2105-11 pubmed publisher
    ..Thus, the results suggest that Hp acts as a potent antioxidative agent against Cd induced testicular toxicity in rats...
  40. Chevallier D, Carette D, Gilleron J, Segretain D, Pointis G. The emerging role of connexin 43 in testis pathogenesis. Curr Mol Med. 2013;13:1331-44 pubmed
    ..the emerging role of connexins in testis pathogenesis, specifically in two intimately interconnected human testicular diseases: azoospermia with impaired spermatogenesis and testicular germ cell tumors, whose incidence increased ..
  41. Ramanjaneyulu S, Trivedi P, Kushwaha S, Vikram A, Jena G. Protective role of atorvastatin against doxorubicin-induced cardiotoxicity and testicular toxicity in mice. J Physiol Biochem. 2013;69:513-25 pubmed publisher
    ..The present study clearly indicates that ATV offers a significant protection against DOX-induced oxidative stress and DNA damage in the heart and testes of mice. ..
  42. Demers V, Pelsser V. "BCGitis": A rare case of tuberculous epididymo-orchitis following intravesical Bacillus Calmette-Guérin therapy. J Radiol Case Rep. 2012;6:16-21 pubmed publisher
    ..Adequate knowledge of tuberculous epididymo-orchitis is of capital importance in order to ensure a proper diagnosis and treatment...
  43. Tasdemir C, Tuygun U. Perineal ectopic testis: a case report. Eur Rev Med Pharmacol Sci. 2011;15:1318-9 pubmed
    ..The ectopic testis is relatively rare but is easily recognized and treated by orchiopexy. We report a 8 years old male with empty scrotum. He was diagnosed to PET and was treated with orchiopexy...
  44. Clemente M, Caracseghi F, Gussinyer M, Yeste D, Albisu M, Vazquez E, et al. Macroorchidism and panhypopituitarism: two different forms of presentation of FSH-secreting pituitary adenomas in adolescence. Horm Res Paediatr. 2011;75:225-30 pubmed publisher
    ..FSH-secreting pituitary adenomas are extremely rare in children and are seldom associated with clinical manifestations of high serum gonadotrophin levels. Thus, most patients have a late presentation, usually as macroadenomas...
  45. John M, Menon S, Shah N, Menon P. Congenital adrenal hyperplasia 11beta-hydroxylase deficiency: two cases managed with bilateral adrenalectomy. Singapore Med J. 2009;50:e68-70 pubmed
    ..The association of myelolipoma and testicular rests with this condition is also discussed...
  46. Negri L, Benaglia R, Fiamengo B, Pizzocaro A, Albani E, Levi Setti P. Cancer risk in male factor-infertility. Placenta. 2008;29 Suppl B:178-83 pubmed publisher
    ..These men should be aware of the existence of higher risk of testicular cancer and trained in testicular self-examination...
  47. Ou S, Lee S, Tang S, Wu S, Wu C, Cha T, et al. Testicular microlithiasis in Taiwanese men. Arch Androl. 2007;53:339-44 pubmed
    ..We suggest monthly self-examination, annual scrotal ultrasonography and tumor markers screening between the age of 20 and 30 years of patients with TM...
  48. Meissner A, Mamoulakis C, de la Rosette J, Pes M. Clinical update on testicular microlithiasis. Curr Opin Urol. 2009;19:615-8 pubmed publisher
    ..The aim of this review is to present an overview of the current dilemma and summarize management trends based on the most recent data...
  49. Hadadi A, Pourmand G, Mehdipour Aghabagher B. Unilateral testicular tuberculosis: case report. Andrologia. 2012;44:70-2 pubmed publisher
    ..Although testicular TB is uncommon, we report 2 patients with unilateral testicular TB. The main treatment of urogenital tuberculosis is anti-tuberculosis pharmacotherapy, sometimes combined with surgery...
  50. Mihmanli I, Kantarci F. Sonography of scrotal abnormalities in adults: an update. Diagn Interv Radiol. 2009;15:64-73 pubmed
    ..Familiarity with the ultrasonography features of both common and newly described entities is important for the management of scrotal abnormalities...
  51. van den Driesche S, Kolovos P, Platts S, Drake A, Sharpe R. Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat. PLoS ONE. 2012;7:e30111 pubmed publisher
    ..The findings provide strong validation of the TDS hypothesis...
  52. Krawczuk Rybak M, Solarz E, Wysocka J, Wojtkowska M, Matysiak M, Gadomski A, et al. [Testicular function in young men treated in prepubertal period for childhood malignancy]. Pediatr Endocrinol Diabetes Metab. 2008;14:93-8 pubmed
    ..A complex anticancer treatment leads to different late effects e.g. gonadal damage in adulthood. The information about gonadal function (steroido- and spermatogenesis) after the treatment in prepubertal period are ambiguous...
  53. Levine L. Microsurgical denervation of the spermatic cord. J Sex Med. 2008;5:526-9 pubmed publisher