oligospermia

Summary

Summary: A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.

Top Publications

  1. Foresta C, Garolla A, Bartoloni L, Bettella A, Ferlin A. Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. J Clin Endocrinol Metab. 2005;90:152-6 pubmed
    ..Genetic tests and genetic counseling should therefore be considered in oligozoospermic men who are candidates for intracytoplasmic sperm injection...
  2. Chen X, Li Z, Ping P, Dai J, Zhang F, Shang X. [Efficacy of natural vitamin E on oligospermia and asthenospermia: a prospective multi-centered randomized controlled study of 106 cases]. Zhonghua Nan Ke Xue. 2012;18:428-31 pubmed
    To explore the therapeutic effect of natural vitamin E (VitE) on oligospermia and asthenospermia in in- fertile men.
  3. Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, et al. Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR). PLoS ONE. 2010;5:e13884 pubmed publisher
    ..Hypermethylation of the promoter of MTHFR gene in sperms is associated with idiopathic male infertility. The functional relevance of hypermathylation of MTHFR to male fertility warrants further investigation. ..
  4. Krausz C, Chianese C, Giachini C, Guarducci E, Laface I, Forti G. The Y chromosome-linked copy number variations and male fertility. J Endocrinol Invest. 2011;34:376-82 pubmed publisher
    ..While searching for new genetic factors on other chromosomes, our work on the Y chromosome still needs to be completed, with special focus on the biological function of the Y genes...
  5. Tüttelmann F, Simoni M, Kliesch S, Ledig S, Dworniczak B, Wieacker P, et al. Copy number variants in patients with severe oligozoospermia and Sertoli-cell-only syndrome. PLoS ONE. 2011;6:e19426 pubmed publisher
    ..The recurring, patient-specific and private, sex-chromosomal CNVs as well as those associated with SCOS are candidates for further, larger case-control and re-sequencing studies...
  6. Thakur M, Chauhan N, Sharma V, Dixit V, Bhargava S. Effect of Curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. Int J Impot Res. 2012;24:31-7 pubmed publisher
    ..The study validates the use of CO in traditional medicine for curing diabetes-induced sexual dysfunction and compromised sexual potency...
  7. Navarro Costa P, Nogueira P, Carvalho M, Leal F, Cordeiro I, Calhaz Jorge C, et al. Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm. Hum Reprod. 2010;25:2647-54 pubmed publisher
    ..Nevertheless, an association between abnormal spermatogenesis and epigenetic disturbances in germline-specific genes remains to be demonstrated...
  8. Aston K, Krausz C, Laface I, Ruiz Castané E, Carrell D. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. Hum Reprod. 2010;25:1383-97 pubmed publisher
    ..This is an expanded follow-up study of the SNPs identified by the GWAS as well as other SNPs from previously published gene re-sequencing studies...
  9. Aston K, Carrell D. Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia. J Androl. 2009;30:711-25 pubmed publisher

More Information

Publications62

  1. Marques C, Costa P, Vaz B, Carvalho F, Fernandes S, Barros A, et al. Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia. Mol Hum Reprod. 2008;14:67-74 pubmed publisher
    ..Additionally, unmethylation of the CTCF-binding site could lead to inactivation of the paternal IGF2 gene, and be linked to decreased embryo quality and birth weight, often associated with ART...
  2. Baazeem A, Belzile E, Ciampi A, Dohle G, Jarvi K, Salonia A, et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol. 2011;60:796-808 pubmed publisher
    ..Varicocele is a common condition, found in many men who present for infertility evaluation...
  3. Mbah A, Ndukwu G, Ghasi S, Shu E, Ozoemena F, Mbah J, et al. Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. Clin Pharmacol Ther. 2012;91:582-9 pubmed publisher
    ..Thirty-three men with idiopathic oligospermia were randomized to start either daily oral lisinopril 2.5 mg (n = 17) or daily oral placebo (n = 16)...
  4. Paradiso Galatioto G, Gravina G, Angelozzi G, Sacchetti A, Innominato P, Pace G, et al. May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele?. World J Urol. 2008;26:97-102 pubmed
    ..therapy in improve the quality of seminal fluid parameters and the natural pregnancies in men with persistent oligospermia (5-20 million/ml) 6 months after retrograde embolization...
  5. Ishikawa T, Kondo Y, Yamaguchi K, Sakamoto Y, Fujisawa M. Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia. BJU Int. 2008;101:216-8 pubmed
    To assess the treatment outcome and benefits after varicocelectomy in men with unobstructive azoospermia (UOA) and severe oligospermia (SO).
  6. Gat Y, Bachar G, Everaert K, Levinger U, Gornish M. Induction of spermatogenesis in azoospermic men after internal spermatic vein embolization for the treatment of varicocele. Hum Reprod. 2005;20:1013-7 pubmed
    ..To evaluate the improvement in semen quality and pregnancy rate after internal spermatic vein (ISV) embolization in men with nonobstructive azoospermia virtual azoospermia, or extremely severe oligoteratoasthenoazoospermia (OTA)...
  7. Singh K, Raman R. Male infertility: Y-chromosome deletion and testicular aetiology in cases of azoo-/oligospermia. Indian J Exp Biol. 2005;43:1088-92 pubmed
    ..Since male infertility is a multifactorial disorder, the contributions of environmental and occupational insults may not be underestimated...
  8. A Z, Yang Y, Zhang S, Li N, Zhang W. Single nucleotide polymorphism C677T in the methylenetetrahydrofolate reductase gene might be a genetic risk factor for infertility for Chinese men with azoospermia or severe oligozoospermia. Asian J Androl. 2007;9:57-62 pubmed
  9. Ferlin A, Arredi B, Speltra E, Cazzadore C, Selice R, Garolla A, et al. Molecular and clinical characterization of Y chromosome microdeletions in infertile men: a 10-year experience in Italy. J Clin Endocrinol Metab. 2007;92:762-70 pubmed
    ..However, despite the progresses in the biology of this chromosome, a number of molecular and clinical concerns are not supported by definitive data...
  10. Barone M, Nazerali H, Cortes M, Chen Mok M, Pollack A, Sokal D. A prospective study of time and number of ejaculations to azoospermia after vasectomy by ligation and excision. J Urol. 2003;170:892-6 pubmed
    ..We obtained detailed information on the time and number of ejaculations to azoospermia after vasectomy by ligation and excision...
  11. Dada R, Shamsi M, Sidhu T, Mitra A, Singh S, Kumar R, et al. Azoospermia factor deletions in varicocele cases with severe oligozoospermia. Indian J Med Sci. 2007;61:505-10 pubmed
    ..However, it is still not understood why some cases improve after varicocelectomy and why some cases show no improvement in semen parameters postoperatively...
  12. Corea M, Campagnone J, Sigman M. The diagnosis of azoospermia depends on the force of centrifugation. Fertil Steril. 2005;83:920-2 pubmed
    ..To determine the centrifugal force required to pellet sperm...
  13. Grangeia A, Niel F, Carvalho F, Fernandes S, Ardalan A, Girodon E, et al. Characterization of cystic fibrosis conductance transmembrane regulator gene mutations and IVS8 poly(T) variants in Portuguese patients with congenital absence of the vas deferens. Hum Reprod. 2004;19:2502-8 pubmed
    ..Cystic fibrosis conductance transmembrane regulator (CFTR) gene mutations and IVS8 poly(T) variants in Portuguese patients with bilateral (CBAVD) and unilateral (CUAVD) congenital absence of the vas deferens remain to be evaluated...
  14. Cakan M, Altug U. Induction of spermatogenesis by inguinal varicocele repair in azoospermic men. Arch Androl. 2004;50:145-50 pubmed
    ..Varicocele repair can result in the induction of spermatogenesis for men with hypospermatogenesis and late maturation arrest. No other related factor could be detected...
  15. Schlegel P, Kaufmann J. Role of varicocelectomy in men with nonobstructive azoospermia. Fertil Steril. 2004;81:1585-8 pubmed
    ..To evaluate the benefits of varicocelectomy in men with nonobstructive azoospermia...
  16. Samli M, Dogan I. An artificial neural network for predicting the presence of spermatozoa in the testes of men with nonobstructive azoospermia. J Urol. 2004;171:2354-7 pubmed
    ..We developed an artificial neural network (ANN) for predicting spermatozoa prior to testicular biopsy in men with nonobstructive azoospermia. The performance of this ANN was compared to that of the standard logistic regression (LR) model...
  17. Hauser R, Yogev L, Paz G, Yavetz H, Azem F, Lessing J, et al. Comparison of efficacy of two techniques for testicular sperm retrieval in nonobstructive azoospermia: multifocal testicular sperm extraction versus multifocal testicular sperm aspiration. J Androl. 2006;27:28-33 pubmed
    ..This comparative prospective clinical study revealed that multifocal TESE is more efficient than multifocal TESA for sperm detection and recovery in men with NOA and should be the procedure of choice for sperm retrieval for them...
  18. Esteves S, Glina S. Recovery of spermatogenesis after microsurgical subinguinal varicocele repair in azoospermic men based on testicular histology. Int Braz J Urol. 2005;31:541-8 pubmed
    ..Analyze whether testicular histologic patterns from a group of azoospermic men with varicocele is predictive of treatment outcome after subinguinal microsurgical varicocele repair...
  19. Cooper T, Hellenkemper B, Jonckheere J, Callewaert N, Grootenhuis A, Kersemaekers W, et al. Azoospermia: virtual reality or possible to quantify?. J Androl. 2006;27:483-90 pubmed
  20. Tsujimura A, Matsumiya K, Miyagawa Y, Takao T, Fujita K, Koga M, et al. Prediction of successful outcome of microdissection testicular sperm extraction in men with idiopathic nonobstructive azoospermia. J Urol. 2004;172:1944-7 pubmed
    ..In this retrospective study we determined the diagnostic and predictive values of noninvasive parameters used in the treatment of patients with NOA...
  21. Just A, Gruber I, Wöber M, Lahodny J, Obruca A, Strohmer H. Novel method for the cryopreservation of testicular sperm and ejaculated spermatozoa from patients with severe oligospermia: a pilot study. Fertil Steril. 2004;82:445-7 pubmed
    ..To investigate Volvox globator as an easy-to-handle vehicle and as a safe alternative for cryopreservation of functional motile sperm cells...
  22. Lin L, Conway G, Hill N, Dattani M, Hindmarsh P, Achermann J. A homozygous R262Q mutation in the gonadotropin-releasing hormone receptor presenting as constitutional delay of growth and puberty with subsequent borderline oligospermia. J Clin Endocrinol Metab. 2006;91:5117-21 pubmed
  23. Hild S, Marshall G, Attardi B, Hess R, Schlatt S, Simorangkir D, et al. Development of l-CDB-4022 as a nonsteroidal male oral contraceptive: induction and recovery from severe oligospermia in the adult male cynomolgus monkey (Macaca fascicularis). Endocrinology. 2007;148:1784-96 pubmed
  24. Liu D, Liu M, Garrett C, Baker H. Comparison of the frequency of defective sperm-zona pellucida (ZP) binding and the ZP-induced acrosome reaction between subfertile men with normal and abnormal semen. Hum Reprod. 2007;22:1878-84 pubmed
    ..e. male partners of infertile couples) with normal and abnormal semen analyses...
  25. Bererhi L, Flamant M, Martinez F, Karras A, Thervet E, Legendre C. Rapamycin-induced oligospermia. Transplantation. 2003;76:885-6 pubmed
  26. Kobayashi H, Sato A, Otsu E, Hiura H, Tomatsu C, Utsunomiya T, et al. Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. Hum Mol Genet. 2007;16:2542-51 pubmed
    ..6%). The majority of these doubly defective samples were in men with moderate or severe oligospermia. These abnormalities were specific to imprinted loci as we found that global DNA methylation was normal in ..
  27. Marques C, Carvalho F, Sousa M, Barros A. Genomic imprinting in disruptive spermatogenesis. Lancet. 2004;363:1700-2 pubmed
    ..002) oligozoospermic patients. Our data suggest an association between abnormal genomic imprinting and hypospermatogenesis, and that spermatozoa from oligozoospermic patients carry a raised risk of transmitting imprinting errors...
  28. Nicopoullos J, Gilling Smith C, Almeida P, Norman Taylor J, Grace I, Ramsay J. Use of surgical sperm retrieval in azoospermic men: a meta-analysis. Fertil Steril. 2004;82:691-701 pubmed
  29. Morel F, Douet Guilbert N, Moerman A, Duban B, Marchetti C, Delobel B, et al. Chromosome aneuploidy in the spermatozoa of two men with globozoospermia. Mol Hum Reprod. 2004;10:835-8 pubmed
    ..293%). In conclusion there seems to be a slightly increased frequency of aneuploidy in round-headed spermatozoa. However, it is unlikely that these aneuploid spermatozoa would be used in assisted reproduction techniques...
  30. Teng Y, Lin Y, Sun H, Hsu P, Chung C, Kuo P. Association of DAZL haplotypes with spermatogenic failure in infertile men. Fertil Steril. 2006;86:129-35 pubmed
    ..To identify novel DAZL single nucleotide polymorphisms (SNPs) and to compare allele/genotype frequencies, linkage disequilibrium (LD) characteristics, and DAZL haplotypes between fertile and infertile men...
  31. Herrler A, Eisner S, Bach V, Weissenborn U, Beier H. Cryopreservation of spermatozoa in alginic acid capsules. Fertil Steril. 2006;85:208-13 pubmed
    ..To develop a method of freezing small amounts of spermatozoa in polymerized alginic acid drops, which can be liquified after thawing for recovery of the spermatozoa...
  32. Dohle G, Colpi G, Hargreave T, Papp G, Jungwirth A, Weidner W. EAU guidelines on male infertility. Eur Urol. 2005;48:703-11 pubmed
  33. Poulakis V, Ferakis N, de Vries R, Witzsch U, Becht E. Induction of spermatogenesis in men with azoospermia or severe oligoteratoasthenospermia after antegrade internal spermatic vein sclerotherapy for the treatment of varicocele. Asian J Androl. 2006;8:613-9 pubmed
    ..To evaluate the treatment outcome of antegrade internal spermatic vein sclerotherapy in men with non-obstructive azoospermia or severe oligoteratoasthenospermia (OTA) as a result of varicocele...
  34. Lin Y, Kuo P, Lin Y, Teng Y, Nan Lin J. Messenger RNA transcripts of the meiotic regulator BOULE in the testis of azoospermic men and their application in predicting the success of sperm retrieval. Hum Reprod. 2005;20:782-8 pubmed
    ..We determined the levels of BOULE transcripts in the testes of azoospermic patients, and evaluated the relationship between BOULE transcript levels and patients' testicular phenotypes, clinical parameters and sperm retrieval results...
  35. Colpi G, Piediferro G, Nerva F, Giacchetta D, Colpi E, Piatti E. Sperm retrieval for intra-cytoplasmic sperm injection in non-obstructive azoospermia. Minerva Urol Nefrol. 2005;57:99-107 pubmed
    ..Abortion rates are significantly higher following ICSI from NOA (11.5%) than from OA (2.5%) (P=0.001). Therefore, the prognostic fertility of a couple with an NOA male is quite lower than for a couple with an OA male...
  36. Pasqualotto F, Sobreiro B, Hallak J, Pasqualotto E, Lucon A. Induction of spermatogenesis in azoospermic men after varicocelectomy repair: an update. Fertil Steril. 2006;85:635-9 pubmed
    ..To assess the treatment outcome after varicocele repair in azoospermic men and to correlate this outcome with the testicular histology patterns...
  37. Casini M, Gerli S, Unfer V. An infertile couple suffering from oligospermia by partial sperm maturation arrest: can phytoestrogens play a therapeutic role? A case report study. Gynecol Endocrinol. 2006;22:399-401 pubmed
    We describe the case of a 30-year-old man with severe oligospermia, caused by partial sperm maturation arrest at spermatidic stage, who was given phytoestrogens. The couple had been trying to conceive for 3 years...
  38. Tahvilzadeh M, Hajimahmoodi M, Toliyat T, Karimi M, Rahimi R. An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine. Andrologia. 2016;48:860-79 pubmed publisher
    ..Further studies are recommended for obtaining more conclusive results about the efficacy and safety of the mentioned medicinal plants. ..
  39. Wu Q, Wang H, Liu Y, Xu Y, Wang P, Shi H, et al. [Sequence tagged sites of AZFc microdeletion in Chinese Han population]. Zhonghua Nan Ke Xue. 2011;17:391-5 pubmed
  40. Adiga S, Ehmcke J, Schlatt S, Kliesch S, Westernströer B, Luetjens C, et al. Reduced expression of DNMT3B in the germ cells of patients with bilateral spermatogenic arrest does not lead to changes in the global methylation status. Mol Hum Reprod. 2011;17:545-9 pubmed publisher
    ..In conclusion, the global methylation status of germ cells is not affected by spermatogenic defects in spite of aberrant DNMT3B expression indicating the necessity of proper methylation for full spermatogenesis...
  41. Song S, Chiba K, Ramasamy R, Lamb D. Recent advances in the genetics of testicular failure. Asian J Androl. 2016;18:350-5 pubmed publisher
    ..In this review, we focus on the genetics of testicular failure and provide an update on the advances in the study of genetics of male infertility. ..
  42. Zedan H, El Mekhlafi A, El Noweihi A, Abd El Azim N, Mostafa T. Soluble Fas and gonadal hormones in infertile men with varicocele. Fertil Steril. 2009;91:420-4 pubmed publisher
    ..To assess gonadal hormones in serum and semen as well as seminal antiapoptotic factor; soluble fibroblast associated (sFas) in infertile men associated with scrotal varicocele...
  43. Almeida C, Correia S, Rocha E, Alves A, Ferráz L, Silva J, et al. Caspase signalling pathways in human spermatogenesis. J Assist Reprod Genet. 2013;30:487-95 pubmed publisher
    ..Little is known about the apoptotic mechanisms involved in abnormal spermatogenesis. In order to describe the significance of apoptosis in azoospermia, testicular tissue from abnormal spermatogenesis was analysed...
  44. Liu D, Liu M. Clinical value of sperm DNA damage should be assessed in motile sperm fraction rather than whole ejaculated sperm. Fertil Steril. 2013;99:367-71 pubmed publisher
    ..To determine differences and frequency of excessive (?50%) sperm DNA damage between ejaculated and motile sperm...
  45. Sa R, Cremades N, Malheiro I, Sousa M. Cryopreservation of human testicular diploid germ cell suspensions. Andrologia. 2012;44:366-72 pubmed publisher
    ..The vitrification of isolated human diploid germ cells is innovative and constitutes valuable information for cryopreservation in cases of transplants or in vitro maturation...
  46. Sha Y, Ding L, Song Y, Ge Y, Zeng H, Li P. [Ring 22 chromosome syndrome induced azoospermia: a case report and literature review]. Zhonghua Nan Ke Xue. 2012;18:1111-4 pubmed
    ..To investigate the clinical phenotype and genetic characteristics of an azoospermia patient with ring 22 chromosome syndrome...
  47. O Donnell L, Rhodes D, Smith S, Merriner D, Clark B, Borg C, et al. An essential role for katanin p80 and microtubule severing in male gamete production. PLoS Genet. 2012;8:e1002698 pubmed publisher
    ..Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development...
  48. Mahajan G, Mahajan A, Mahajan R. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med. 2012;9:Article 6 pubmed publisher
    ..No side effects were noticed during the entire duration of the trial...
  49. Lazaros L, Xita N, Hatzi E, Kaponis A, Stefos T, Plachouras N, et al. Association of paraoxonase gene polymorphisms with sperm parameters. J Androl. 2011;32:394-401 pubmed publisher
    ..001). In our series, the PON1 55M and PON1 192R alleles were associated with decreased sperm motility whereas the PON2 311C allele was associated with decreased concentration, supporting the significance of PON genes in semen quality...
  50. Sermondade N, Faure C, Fezeu L, Levy R, Czernichow S. Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med. 2012;172:440-442 pubmed publisher
  51. Pasqualotto F, Fonseca G, Pasqualotto E. Azoospermia after treatment with clomiphene citrate in patients with oligospermia. Fertil Steril. 2008;90:2014.e11-2 pubmed publisher
    To describe three cases of azoospermia in patients with oligospermia after clomiphene citrate (CC) intake.
  52. Henckel A, Feil R. [Differential epigenetic marking on imprinted genes and consequences in human diseases]. Med Sci (Paris). 2008;24:747-52 pubmed publisher
    ..Alteration of imprints is thought to occur early in carcinogenesis and shows similarities with the acquisition of aberrant DNA methylation at tumour suppressor genes. This suggests that similar underlying mechanisms could be involved...
  53. Yu J, Chen Z, Zhang T, Li Z, Ni Y, Li Z. Association of genetic variants in CFTR gene, IVS8 c.1210-12T[5_9] and c.1210-35_1210-12GT[8_12], with spermatogenetic failure: case-control study and meta-analysis. Mol Hum Reprod. 2011;17:594-603 pubmed publisher
    ..case-control study in Chinese Han population that consisted of 126 non-obstructive azoospermia, 169 severe oligospermia and 213 fertile male controls, and subsequently performed a meta-analysis of the available data, including our ..