Summary: A condition of having no sperm present in the ejaculate (SEMEN).

Top Publications

  1. Tyler Smith C, Krausz C. The will-o'-the-wisp of genetics--hunting for the azoospermia factor gene. N Engl J Med. 2009;360:925-7 pubmed publisher
  2. Tüttelmann F, Damm O, Luetjens C, Baldi M, Zitzmann M, Kliesch S, et al. Intratesticular testosterone is increased in men with Klinefelter syndrome and may not be released into the bloodstream owing to altered testicular vascularization– a preliminary report. Andrology. 2014;2:275-81 pubmed
    ..On the contrary, ITT concentrations are increased, but not because of increased SHBG activity. The data from the mouse model let us speculate that a reduced vascular bed might be involved in lower release of T into the blood stream. ..
  3. Hadziselimovic F, Gegenschatz Schmid K, Verkauskas G, Docampo Garcia M, Demougin P, Bilius V, et al. Gene Expression Changes Underlying Idiopathic Central Hypogonadism in Cryptorchidism with Defective Mini-Puberty. Sex Dev. 2016;10:136-46 pubmed publisher
    ..RNA sequencing was examined to determine a potential causative role of isolated congenital cryptorchidism in azoospermia and/or infertility in the context of our previously published GeneChip data...
  4. Schachter Safrai N, Karavani G, Levitas E, Friger M, Zeadna A, Lunenfeld E, et al. Does cryopreservation of sperm affect fertilization in nonobstructive azoospermia or cryptozoospermia?. Fertil Steril. 2017;107:1148-1152 pubmed publisher
    ..of fresh or frozen-thawed ejaculated or testicular sperm in patients with cryptozoospermia or nonobstructive azoospermia. Retrospective cohort study. Tertiary medical center IVF unit...
  5. Sávio L, Palmer J, Prakash N, Clavijo R, Adamu D, Ramasamy R. Transurethral resection of ejaculatory ducts: a step-by-step guide. Fertil Steril. 2017;107:e20 pubmed publisher
    ..Vesiculography is performed near the end of the procedure to ensure both EDs have been opened as well as to assess for passive drainage of the seminal vesicles through the newly open EDs. ..
  6. Röpke A, Tüttelmann F. MECHANISMS IN ENDOCRINOLOGY: Aberrations of the X chromosome as cause of male infertility. Eur J Endocrinol. 2017;177:R249-R259 pubmed publisher
    ..The most frequent genetic causes of azoospermia (or severe oligozoospermia) are Klinefelter syndrome (47,XXY), structural chromosomal abnormalities and Y-..
  7. Kelsey T, McConville L, Edgar A, Ungurianu A, Mitchell R, Anderson R, et al. Follicle Stimulating Hormone is an accurate predictor of azoospermia in childhood cancer survivors. PLoS ONE. 2017;12:e0181377 pubmed publisher
    The accuracy of Follicle Stimulating Hormone as a predictor of azoospermia in adult survivors of childhood cancer is unclear, with conflicting results in the published literature...
  8. Makoolati Z, Movahedin M, Forouzandeh Moghadam M, Naghdi M, Koruji M. Embryonic stem cell derived germ cells induce spermatogenesis after transplantation into the testes of an adult mouse azoospermia model. Clin Sci (Lond). 2017;131:2381-2395 pubmed publisher
    ..assess the success of transplantation using in vitro differentiated SSCs in a mouse busulfan-treated azoospermia model...
  9. Sermondade N, Faure C, Fezeu L, Levy R, Czernichow S. Obesity and increased risk for oligozoospermia and azoospermia. Arch Intern Med. 2012;172:440-442 pubmed publisher

More Information


  1. Miller N, Biron Shental T, Pasternak Y, Belenky M, Shefi S, Itsykson P, et al. Fertility outcomes after extended searches for ejaculated spermatozoa in men with virtual azoospermia. Fertil Steril. 2017;107:1305-1311 pubmed publisher
    To assess the fertility outcomes of extended searches for ejaculated spermatozoa in men with virtual azoospermia. A retrospective cohort of 242 couples whose male partner suffered from nonobstructive azoospermia and who were treated with ..
  2. Gou L, Kang J, Dai P, Wang X, Li F, Zhao S, et al. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017;169:1090-1104.e13 pubmed publisher
    ..We report germline mutations in human Piwi (Hiwi) in patients with azoospermia that prevent its ubiquitination and degradation...
  3. Alves L, Oliveira F. Should azoospermic patients with varicocele disease undergo surgery to recover fertility?. Rev Assoc Med Bras (1992). 2017;63:332-335 pubmed publisher
    ..The varicocelectomy procedure in patients with non-obstructive azoospermia (NOA) can raise the rates of sperm in the semen analysis...
  4. Boellaard W, Stoop H, Gillis A, Oosterhuis J, Looijenga L. VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract. Medicine (Baltimore). 2017;96:e7489 pubmed publisher informative protein biomarker to be applied on semen to differentiate between obstructive and nonobstructive azoospermia (OA and NOA, respectively)...
  5. Yu W, Zheng H, Lin W, Tajima A, Zhang Y, Zhang X, et al. Estrogen promotes Leydig cell engulfment by macrophages in male infertility. J Clin Invest. 2014;124:2709-21 pubmed publisher
    ..Furthermore, evaluation of molecular markers in the testes of patients with nonobstructive azoospermia (NOA) revealed enhanced expression of CYP19, GAS6, and AXL, which suggests that the AROM+ mouse model reflects ..
  6. Jiang L, Jin J, Wang S, Zhang F, Dai Y, Shi L, et al. CFTR gene mutations and polymorphism are associated with non-obstructive azoospermia: From case-control study. Gene. 2017;626:282-289 pubmed publisher
    ..However, the association between CFTR gene and non-obstructive azoospermia (NOA) disease remained to be a question...
  7. Chu Q, Hua R, Luo C, Chen Q, Wu B, Quan S, et al. Relationship of genetic causes and inhibin B in non obstructive azoospermia spermatogenic failure. BMC Med Genet. 2017;18:98 pubmed publisher
    Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels...