male infertility


Summary: The inability of the male to effect FERTILIZATION of an OVUM after a specified period of unprotected intercourse. Male sterility is permanent infertility.

Top Publications

  1. Stouffs K, Vandermaelen D, Tournaye H, Liebaers I, Van Steirteghem A, Lissens W. [Genetics and male infertility]. Verh K Acad Geneeskd Belg. 2009;71:115-39 pubmed
    ..and the Centre for Medical Genetics of UZ Brussel in order to gain more insight into the genetic causes of male infertility. The studies, focusing on men with fertility problems, can be subdivided into three groups: studies on ..
  2. Ding X, Zhang J, Fei J, Bian Z, Li Y, Xia Y, et al. Variants of the EPPIN gene affect the risk of idiopathic male infertility in the Han-Chinese population. Hum Reprod. 2010;25:1657-65 pubmed publisher
    ..The aim of this study was to determine whether variants of the EPPIN gene are risk factors for idiopathic male infertility.
  3. Nalam R, Matzuk M. Local signalling environments and human male infertility: what we can learn from mouse models. Expert Rev Mol Med. 2010;12:e15 pubmed publisher
    ..and to identify proteins essential for this process, which in turn are candidate genes for human male infertility. Successful spermatogenesis depends on a delicate balance of local signalling factors, and this review ..
  4. Navarro Costa P, Goncalves J, Plancha C. The AZFc region of the Y chromosome: at the crossroads between genetic diversity and male infertility. Hum Reprod Update. 2010;16:525-42 pubmed publisher
    ..Yet, the most distal region, AZFc, is a major generator of large-scale variation in the human genome. Determining to what extent this variability affects spermatogenesis is a highly contentious topic in human reproduction...
  5. Reis A, Araújo F, Pereira V, Dos Reis A, Santos R, Reis F. Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility. J Mol Histol. 2010;41:75-80 pubmed publisher
    ..This shows, for the first time, the immunolocalization of Ang-(1-7) and its receptor Mas in testes of fertile and infertile men, and suggests that this system may be altered when spermatogenesis is severely impaired...
  6. Dimitriadis F, Tsounapi P, Saito M, Watanabe T, Sylakos A, Tsabalas S, et al. Is there a role for PDE5 inhibitors in the management of male infertility due to defects in testicular or epididymal function?. Curr Pharm Des. 2009;15:3506-20 pubmed
    ..refers to the possibility to employ PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest that PDE5 inhibitors enhance the Leydig cell secretory function and play a ..
  7. Droździk M, Stefankiewicz J, Kurzawa R, Górnik W, Baczkowski T, Kurzawski M. Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility. Pharmacol Rep. 2009;61:690-6 pubmed
    ..MDR1 (ABCB1) gene, may be a link between genetic and environmental factors contributing to the development of male infertility because pesticides (P-gp substrates) are well established factors of male infertility...
  8. Lanzafame F, La Vignera S, Vicari E, Calogero A. Oxidative stress and medical antioxidant treatment in male infertility. Reprod Biomed Online. 2009;19:638-59 pubmed
    Oxidative stress (OS) has been recognized as one of the most important cause of male infertility. Despite the antioxidant activity of seminal plasma, epididymis and spermatozoa, OS damages sperm function and DNA integrity...
  9. Lend A, Belousova A, Haller Kikkatalo K, Punab M, Poolamets O, Peters M, et al. Follicle-stimulating hormone receptor gene haplotypes and male infertility in estonian population and meta-analysis. Syst Biol Reprod Med. 2010;56:84-90 pubmed publisher
    ..In conclusion, we suggest that FSHR haplotypes are not considerable risk factors for spermatogenic failure. The protective nature of G-29-A919-A2039 haplotype cannot be concluded without additional studies...

Scientific Experts

More Information


  1. Schulte R, Ohl D, Sigman M, Smith G. Sperm DNA damage in male infertility: etiologies, assays, and outcomes. J Assist Reprod Genet. 2010;27:3-12 pubmed publisher
    ..15% of patients with male factor infertility have a normal semen analysis and a definitive diagnosis of male infertility often cannot be made as a result of routine semen analysis...
  2. Makker K, Agarwal A, Sharma R. Oxidative stress & male infertility. Indian J Med Res. 2009;129:357-67 pubmed
    ..Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a ..
  3. Poplinski A, Tüttelmann F, Kanber D, Horsthemke B, Gromoll J. Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. Int J Androl. 2010;33:642-9 pubmed publisher
    ..We conclude that idiopathic male infertility is strongly associated with imprinting defects at IGF2/H19 ICR1 and MEST, with aberrant MEST methylation ..
  4. Tambi M, Imran M. Eurycoma longifolia Jack in managing idiopathic male infertility. Asian J Androl. 2010;12:376-80 pubmed publisher
    ..The proprietary extract of Eurycoma longifolia Jack significantly improved the sperm quality in these patients, allowing for 11 (14.7%) spontaneous pregnancies...
  5. Volle D, Decourteix M, Garo E, McNeilly J, Fenichel P, Auwerx J, et al. The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. J Clin Invest. 2009;119:3752-64 pubmed publisher
    ..Together, these data demonstrate that Nr0b2 plays a critical role in the pathophysiological changes induced by DES in the mouse testis...
  6. Tamowski S, Aston K, Carrell D. The use of transgenic mouse models in the study of male infertility. Syst Biol Reprod Med. 2010;56:260-73 pubmed publisher
    ..mouse models have emerged as a powerful tool for the study of gene function and complex diseases including male infertility. In this review we give a brief history of the development of tools for the production of transgenic mouse ..
  7. Ross C, Morriss A, Khairy M, Khalaf Y, Braude P, Coomarasamy A, et al. A systematic review of the effect of oral antioxidants on male infertility. Reprod Biomed Online. 2010;20:711-23 pubmed publisher
    ..The use of oral antioxidants in infertile men could improve sperm quality and pregnancy rates. Adequately powered robust trials of individual and combinations of antioxidants are needed to guide clinical practice...
  8. Xu K, Lu T, Zhou H, Bai L, Xiang Y. The role of MSH5 C85T and MLH3 C2531T polymorphisms in the risk of male infertility with azoospermia or severe oligozoospermia. Clin Chim Acta. 2010;411:49-52 pubmed publisher
    The mismatch repair proteins MSH5 and MLH3 play a crucial role in spermatogenesis. We tested this hypothesis by examining the contribution of functional polymorphisms in MSH5 C85T and MLH3 C2531T to the risk of male infertility.
  9. Imai H, Hakkaku N, Iwamoto R, Suzuki J, Suzuki T, Tajima Y, et al. Depletion of selenoprotein GPx4 in spermatocytes causes male infertility in mice. J Biol Chem. 2009;284:32522-32 pubmed publisher
    ..2001) Biol. Reprod. 64, 674-683). To clarify whether defective GPx4 in spermatocytes causes male infertility, we established spermatocyte-specific GPx4 knock-out mice using a Cre-loxP system...
  10. Lee T, Liu C, Huang C, Hsieh K, Lin P, Lee M. Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles. Reprod Biol Endocrinol. 2009;7:100 pubmed publisher
  11. Safarinejad M, Shafiei N, Safarinejad S. Association of polymorphisms in the estrogen receptors alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and semen parameters. J Steroid Biochem Mol Biol. 2010;122:193-203 pubmed publisher
    b>Male infertility is a multifactorial condition with a strong genetic component. In the last decade a large number of investigations focused on the identification of gene variants affecting spermatogenesis in human...
  12. du Plessis S, Cabler S, McAlister D, Sabanegh E, Agarwal A. The effect of obesity on sperm disorders and male infertility. Nat Rev Urol. 2010;7:153-61 pubmed publisher
    ..Several mechanisms might account for the effect of obesity on male infertility, both directly and indirectly, by inducing sleep apnea, alterations in hormonal profiles (reduced inhibin B ..
  13. Safarinejad M, Shafiei N, Safarinejad S. The role of endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms in the risk of idiopathic male infertility. Mol Reprod Dev. 2010;77:720-7 pubmed publisher
    ..between endothelial nitric oxide synthase (eNOS) T-786C, G894T, and 4a/b gene polymorphisms and idiopathic male infertility. Three hundred fifty-two men with idiopathic infertility (mean age 32.4 +/- 11...
  14. Imken L, Rouba H, El Houate B, Louanjli N, Barakat A, Chafik A, et al. Mutations in the protamine locus: association with spermatogenic failure?. Mol Hum Reprod. 2009;15:733-8 pubmed publisher
    ..Several studies indicate an abnormal expression pattern of protamine genes associated with male infertility, although the molecular mechanism underlying this observation is unclear...
  15. Lee J, Park H, Kim H, Yun Y, Lee D, Lee S. Functional polymorphism in H2BFWT-5'UTR is associated with susceptibility to male infertility. J Cell Mol Med. 2009;13:1942-51 pubmed publisher
    ..A male infertility-associated single nucleotide polymorphism (-9C > T) within the 5' untranslated region (5'UTR) of the ..
  16. Dohle G. Male infertility in cancer patients: Review of the literature. Int J Urol. 2010;17:327-31 pubmed publisher
  17. Ji G, Gu A, Zhu P, Xia Y, Zhou Y, Hu F, et al. Joint effects of XRCC1 polymorphisms and polycyclic aromatic hydrocarbons exposure on sperm DNA damage and male infertility. Toxicol Sci. 2010;116:92-8 pubmed publisher
    ..on a case-control study revealed the joint effect of XRCC1-399 polymorphism and PAHs exposure on the risk of male infertility (p interaction = 0.041)...
  18. Moskovtsev S, Mullen J, Lecker I, Jarvi K, White J, Roberts M, et al. Frequency and severity of sperm DNA damage in patients with confirmed cases of male infertility of different aetiologies. Reprod Biomed Online. 2010;20:759-63 pubmed publisher
    ..flow cytometry-based sperm DNA damage assessment and results were correlated with the major aetiologies of male infertility: varicocele, bacteriospermia and idiopathic infertility...
  19. Tiwari A. Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. IDrugs. 2009;12:381-93 pubmed
    ..all further clinical development of elocalcitol, including an uncompleted phase IIa trial in patients with male infertility. Given the novel mechanism of action, efficacy profile and improved tolerability of elocalcitol over existing ..
  20. Saalu L. The incriminating role of reactive oxygen species in idiopathic male infertility: an evidence based evaluation. Pak J Biol Sci. 2010;13:413-22 pubmed
    ..Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma and tumours, a ..
  21. Hsu C, Hou M, Hong J, Wu J, Her G. Inducible male infertility by targeted cell ablation in zebrafish testis. Mar Biotechnol (NY). 2010;12:466-78 pubmed publisher
  22. Melo C, Danin A, Silva D, Tacon J, Moura K, Costa E, et al. Association between male infertility and androgen receptor mutations in Brazilian patients. Genet Mol Res. 2010;9:128-33 pubmed publisher
    ..Our objective was to evaluate a possible association between male infertility and mutations in the androgen receptor gene based on the presence or absence of exons 1 and 4 of this gene...
  23. Vangompel M, Xu E. A novel requirement in mammalian spermatid differentiation for the DAZ-family protein Boule. Hum Mol Genet. 2010;19:2360-9 pubmed publisher
    ..Expression of key regulators of spermiogenesis was unaffected in Boule(-/-) mice, suggesting that Boule regulates germ-cell differentiation through a novel pathway...
  24. Bashamboo A, Ferraz de Souza B, Lourenço D, Lin L, Sebire N, Montjean D, et al. Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. Am J Hum Genet. 2010;87:505-12 pubmed publisher
    ..To test the hypothesis that mutations in NR5A1 cause male infertility, we sequenced NR5A1 in 315 men with idiopathic spermatogenic failure...
  25. Singh K, Singh S, Raman R. MTHFR A1298C polymorphism and idiopathic male infertility. J Postgrad Med. 2010;56:267-9 pubmed publisher
    ..We have already shown that homozygosity for 677 (C ®T) mutation in the MTHFR gene, is a risk factor for idiopathic male infertility in an Indian population.
  26. Parekattil S, Cohen M. Robotic surgery in male infertility and chronic orchialgia. Curr Opin Urol. 2010;20:75-9 pubmed publisher
    The use of robotic assistance during microsurgical procedures is currently being explored in the treatment of male infertility and patients with chronic testicular pain...
  27. Borg C, Wolski K, Gibbs G, O Bryan M. Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update. 2010;16:205-24 pubmed publisher
    ..A breakdown at any of these phases can result in male infertility. The production of mutant mouse models often yields an unexpected male infertility phenotype...
  28. Schlegel P. Evaluation of male infertility. Minerva Ginecol. 2009;61:261-83 pubmed
    ..problems associated with the symptom of infertility, as well as genetic conditions associated with male infertility that could be transmitted to offspring with assisted reproduction...
  29. Desai N, Sabanegh E, Kim T, Agarwal A. Free radical theory of aging: implications in male infertility. Urology. 2010;75:14-9 pubmed publisher
    ..Excessive ROS can also damage mitochondrial deoxyribonucleic acid and sperm nuclear DNA, contributing to paternally transmitted diseases. ROS generation has a central role in the pathophysiology of age-related decrease in male fertility...
  30. Shimoda C, Koh E, Yamamoto K, Matsui F, Sugimoto K, Sin H, et al. Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene. Endocr J. 2009;56:859-65 pubmed
    Dysfunction of the FSH receptor (FSHR) may be involved in some form of male infertility with azoospermia or oligozoospermia. We assessed the discrete codon combination with homo/heterozygous variation of the exon 10 in the FSHR gene.
  31. Jha R, Sayami G. Testicular fine needle aspiration in evaluation of male infertility. JNMA J Nepal Med Assoc. 2009;48:78-84 pubmed
    ..Recently it has also gained popularity for its diagnostic and therapeutic role in male infertility. The purpose of this article was to review various studies published on role of testicular fine needle ..
  32. Ahmed A, Bello A, Mbibu N, Maitama H, Kalayi G. Epidemiological and aetiological factors of male infertility in northern Nigeria. Niger J Clin Pract. 2010;13:205-9 pubmed
    To evaluate some epidemiologic and aetiologic factors for male infertility in our patients.
  33. Sun F, Palmer K, Handel M. Mutation of Eif4g3, encoding a eukaryotic translation initiation factor, causes male infertility and meiotic arrest of mouse spermatocytes. Development. 2010;137:1699-707 pubmed publisher
    ..Thus, EIF4G3 is required for HSPA2 translation in spermatocytes, a finding that provides the first genetic evidence for selective translational control of meiotic exit in mammalian spermatocytes...
  34. Balercia G, Mancini A, Paggi F, Tiano L, Pontecorvi A, Boscaro M, et al. Coenzyme Q10 and male infertility. J Endocrinol Invest. 2009;32:626-32 pubmed publisher
    ..Alterations of CoQ10 content were also shown in conditions associated with male infertility, such as asthenozoospermia and varicocele (VAR)...
  35. Stouffs K, Tournaye H, Liebaers I, Lissens W. Male infertility and the involvement of the X chromosome. Hum Reprod Update. 2009;15:623-37 pubmed publisher
    b>Male infertility is a worldwide problem, keeping many researchers puzzled. Besides environmental factors, much attention is paid to single gene defects...
  36. Hotaling J, Walsh T. Male infertility: a risk factor for testicular cancer. Nat Rev Urol. 2009;6:550-6 pubmed publisher
    b>Male infertility lies at the crossroads of genetic determinants and environmental effects...
  37. Graham B, Li Z, Alesii E, Versteken P, Lee C, Wang J, et al. Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease. J Biol Chem. 2010;285:11143-53 pubmed publisher
    ..defects of mitochondrial respiration, abnormal muscle mitochondrial morphology, synaptic dysfunction, and male infertility, which are features often observed in human mitochondrial disorders...
  38. Walters E, Bauer B, Franklin C, Evans T, Bryda E, Riley L, et al. Mutational insertion of a ROSA26-EGFP transgene leads to defects in spermiogenesis and male infertility in mice. Comp Med. 2009;59:545-52 pubmed
    ..Although the males are always infertile, the severity of the histologic and sperm morphologic defects appeared to be age-related...
  39. Vani G, Mukesh N, Siva Prasad B, Rama Devi P, Hema Prasad M, Usha Rani P, et al. Association of CYP1A1*2A polymorphism with male infertility in Indian population. Clin Chim Acta. 2009;410:43-7 pubmed publisher
    ..Lipophilic compounds undergo metabolic activation by phase I enzymes, which introduce a reactive center into the molecule, followed by phase II conjugation reaction resulting in a water soluble product...
  40. Okada Y, Tateishi K, Zhang Y. Histone demethylase JHDM2A is involved in male infertility and obesity. J Androl. 2010;31:75-8 pubmed publisher
    ..Thus, JHDM2A possesses organ/tissue-specific target genes, and impairment of this molecule cannot be compensated by other JmjC-containing histone demethylases, suggesting the importance of this molecule in vivo...
  41. Rajender S, Rahul P, Mahdi A. Mitochondria, spermatogenesis and male infertility. Mitochondrion. 2010;10:419-28 pubmed publisher
    Mitochondria and its role in male reproduction has remained an enigma since long. Similarly, etiology of male infertility in a large percentage of individuals, mainly primary infertility, has evaded concrete conclusions...
  42. Madhukar D, Rajender S. Hormonal treatment of male infertility: promises and pitfalls. J Androl. 2009;30:95-112 pubmed publisher
    ..Not only is the etiology of male infertility difficult to understand, but it is equally challenging to treat male infertility because of its etiological ..
  43. Sadeghi Nejad H, Oates R. The Y chromosome and male infertility. Curr Opin Urol. 2008;18:628-32 pubmed publisher
    ..An intact Y chromosome is necessary for optimal spermatogenesis. It is imperative for the clinician to understand the molecular basis and clinical implications of anomalies that might afflict the Y chromosome...
  44. Runkel F, Aubin I, Simon Chazottes D, Bussow H, Stingl R, Miething A, et al. Alopecia and male infertility in oligotriche mutant mice are caused by a deletion on distal chromosome 9. Mamm Genome. 2008;19:691-702 pubmed publisher
    ..We also suggest that the oligotriche locus be named Del(9Ctdspl-Slc22a14)1Pas...
  45. Tavares R, Martins F, Oliveira P, Ramalho Santos J, Peixoto F. Parabens in male infertility-is there a mitochondrial connection?. Reprod Toxicol. 2009;27:1-7 pubmed publisher
    ..It is known that a significant number of cases of male infertility results from exposure to xenobiotics, and also that testis mitochondria are particularly affected by drug-..
  46. Alonso V, Linares V, Belles M, Albina M, Sirvent J, Domingo J, et al. Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol. 2009;27:35-40 pubmed publisher
    The mechanism of action of sulfasalazine (SASP) in male infertility is not well elucidated. For it, an oxidative stress-like mechanism inductor of infertility was hypothesized...
  47. Shefi S, Levron J, Nadu A, Raviv G. Male infertility associated with adult dominant polycystic kidney disease: a case series. Arch Gynecol Obstet. 2009;280:457-60 pubmed publisher
    Although described earlier, the association of male infertility with adult dominant polycystic kidney disease (ADPKD) is quite rare and unfamiliar to some of the multidisciplinary team members caring for affected men.
  48. Geyer C, Inselman A, Sunman J, Bornstein S, Handel M, Eddy E. A missense mutation in the Capza3 gene and disruption of F-actin organization in spermatids of repro32 infertile male mice. Dev Biol. 2009;330:142-52 pubmed publisher
  49. Avenarius M, Hildebrand M, Zhang Y, Meyer N, Smith L, Kahrizi K, et al. Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet. 2009;84:505-10 pubmed publisher
    b>Male infertility, a common barrier that prevents successful conception, is a reproductive difficulty affecting 15% of couples...
  50. Vinci G, Brauner R, Tar A, Rouba H, Sheth J, Sheth F, et al. Mutations in the TSPYL1 gene associated with 46,XY disorder of sex development and male infertility. Fertil Steril. 2009;92:1347-50 pubmed publisher
    ..R89H mutation, and this data supports the hypothesis that mutations in TSPYL1 may contribute to anomalies of testicular development/function...
  51. Wang Z, Huang Y, Liang B. [Clinical observation on electroacupuncture and Chinese drug for treatment of oligospermia and asthenospermia of the male infertility patient]. Zhongguo Zhen Jiu. 2008;28:805-7 pubmed
    To compare therapeutic effects of acupuncture and Chinese drug on oligospermia and asthenospermia in the male infertility.
  52. Hasson O, Stone L. Male infertility, female fertility and extrapair copulations. Biol Rev Camb Philos Soc. 2009;84:225-44 pubmed publisher
    ..increases female reproductive success only if certain specific conditions are upheld in the nature of male infertility. In particular, these conditions require both (i) that fertile sperm precedence (FSP) is absent or incomplete ..
  53. Khazamipour N, Noruzinia M, Fatehmanesh P, Keyhanee M, Pujol P. MTHFR promoter hypermethylation in testicular biopsies of patients with non-obstructive azoospermia: the role of epigenetics in male infertility. Hum Reprod. 2009;24:2361-4 pubmed publisher
    The causative mechanisms of male infertility are still poorly understood...