Summary: Dyneins that are responsible for intracellular transport, MITOSIS, cell polarization, and movement within the cell.
Yang M, Shin J, Kearns C, Langworthy M, Snell H, Walker M, et al
. CNS myelination requires cytoplasmic dynein function. Dev Dyn. 2015;244:134-45 pubmed
..In addition to its well known roles in axon transport and neuronal migration, cytoplasmic dynein contributes to neural development by promoting myelination. ..
Laquerriere A, Maillard C, Cavallin M, Chapon F, Marguet F, Molin A, et al
. Neuropathological Hallmarks of Brain Malformations in Extreme Phenotypes Related to DYNC1H1 Mutations. J Neuropathol Exp Neurol. 2017;76:195-205 pubmed publisher
Lehti M, Zhang F, Kotaja N, Sironen A. SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation. Development. 2017;144:2683-2693 pubmed publisher
..These data indicate a possible novel role of SPEF2 as a linker protein for dynein 1-mediated cargo transport along microtubules. ..
Schmidt R, Fielmich L, Grigoriev I, Katrukha E, Akhmanova A, van den Heuvel S. Two populations of cytoplasmic dynein contribute to spindle positioning in C. elegans embryos. J Cell Biol. 2017;216:2777-2793 pubmed publisher
Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al
. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher
Morgan J, Jensen M, Ozenne V, Blackledge M, Barbar E. The LC8 Recognition Motif Preferentially Samples Polyproline II Structure in Its Free State. Biochemistry. 2017;56:4656-4666 pubmed publisher
Zhang K, Foster H, Rondelet A, Lacey S, Bahi Buisson N, Bird A, et al
. Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Cell. 2017;169:1303-1314.e18 pubmed publisher
..Our model explains how dynactin binding to the dynein-1 tail directly stimulates its motor activity. ..
Kubo S, Li W, Takada S. Allosteric conformational change cascade in cytoplasmic dynein revealed by structure-based molecular simulations. PLoS Comput Biol. 2017;13:e1005748 pubmed publisher
..In both processes, the MTBD conformational change was regulated by the AAA4 module and the AAA5/Strut module. ..