cortactin

Summary

Summary: A microfilament protein that interacts with F-ACTIN and regulates cortical actin assembly and organization. It is also an SH3 DOMAIN containing phosphoprotein, and it mediates tyrosine PHOSPHORYLATION based SIGNAL TRANSDUCTION by PROTO-ONCOGENE PROTEIN PP60(C-SRC).

Top Publications

  1. Han S, Gambin Y, Gomez G, Verma S, Giles N, Michael M, et al. Cortactin scaffolds Arp2/3 and WAVE2 at the epithelial zonula adherens. J Biol Chem. 2014;289:7764-75 pubmed publisher
    ..But how this is coordinated with cadherin adhesion is not known. We now identify cortactin as a key scaffold for actin regulation at the ZA, which localizes to the ZA through influences from both E-..
  2. Lladó A, Timpson P, Vilà de Muga S, Moretó J, Pol A, Grewal T, et al. Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Mol Biol Cell. 2008;19:17-29 pubmed
    ..PKCdelta-induced polymerization of actin is orchestrated by the Arp2/3 complex and requires the interaction of cortactin with PKCdelta...
  3. Xia J, Chen Q, Li B, Zeng X. Amplifications of TAOS1 and EMS1 genes in oral carcinogenesis: association with clinicopathological features. Oral Oncol. 2007;43:508-14 pubmed
    ..Our data suggested potential roles in oral carcinogenesis and that TAOS1 might be involved earlier than EMS1. Both genes might be candidate biomarkers for diagnosis and prognosis in OSCC. ..
  4. Chen L, Wang Z, Zhu J, Zhan X. Roles of cortactin, an actin polymerization mediator, in cell endocytosis. Acta Biochim Biophys Sin (Shanghai). 2006;38:95-103 pubmed
    b>Cortactin, an actin-binding protein and a substrate of Src, is encoded by the EMS1 oncogene...
  5. Huang C, Liu J, Haudenschild C, Zhan X. The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells. J Biol Chem. 1998;273:25770-6 pubmed
    b>Cortactin, a filamentous actin cross-linking protein and a substrate of Src protein tyrosine kinase, is phosphorylated at tyrosine residues upon stimulation by extracellular signals...
  6. Crowley J, Smith T, Fang Z, Takizawa N, Luna E. Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Mol Biol Cell. 2009;20:948-62 pubmed publisher
    ..Overexpressed SV induces redistribution of lamellipodial cortactin and lamellipodin/RAPH1/PREL1 away from the cell periphery to internal sites and concomitantly increases the ..
  7. Siton O, Ideses Y, Albeck S, Unger T, Bershadsky A, Gov N, et al. Cortactin releases the brakes in actin- based motility by enhancing WASP-VCA detachment from Arp2/3 branches. Curr Biol. 2011;21:2092-7 pubmed publisher
    b>Cortactin is involved in invadopodia and podosome formation [1], pathogens and endosome motility [2], and persistent lamellipodia protrusion [3, 4]; its overexpression enhances cellular motility and metastatic activity [5-8]...
  8. Luo C, Pan H, Mines M, Watson K, Zhang J, Fan G. CXCL12 induces tyrosine phosphorylation of cortactin, which plays a role in CXC chemokine receptor 4-mediated extracellular signal-regulated kinase activation and chemotaxis. J Biol Chem. 2006;281:30081-93 pubmed
    ..present study demonstrated that stimulation of CXCR4 by its ligand, CXCL12, induced transient translocation of cortactin from endosomal compartments to the cell periphery where it colocalized with CXCR4 followed by internalization of ..
  9. Cheng L, Yung A, Covarrubias M, Radice G. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. J Biol Chem. 2011;286:20478-89 pubmed publisher
    ..The decreased Kv1.5/Kcne2 expression correlated with disruption of the actin cytoskeleton and reduced cortactin at the sarcolemma. Biochemical experiments revealed that cortactin co-immunoprecipitates with Kv1.5...

More Information

Publications62

  1. Wang W, Chen L, Ding Y, Jin J, Liao K. Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin. J Cell Sci. 2008;121:1334-43 pubmed publisher
    ..From G2-M transition to mitotic anaphase, phosphorylation of Tyr421, Tyr466 and Tyr482 of cortactin, an actin-filament associated protein, is dramatically induced...
  2. Zhan X, Hu X, Hampton B, Burgess W, Friesel R, Maciag T. Murine cortactin is phosphorylated in response to fibroblast growth factor-1 on tyrosine residues late in the G1 phase of the BALB/c 3T3 cell cycle. J Biol Chem. 1993;268:24427-31 pubmed
    ..sequenced, and cloned the cDNA encoding p80/p85 and report that it is the murine homolog of the chicken cortactin gene and a member of the human hematopoietic specific-1 gene family...
  3. Luxenburg C, Parsons J, Addadi L, Geiger B. Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts. J Cell Sci. 2006;119:4878-88 pubmed
    ..polarization was inversely related to the local levels of tyrosine phosphorylation of the Src substrate, cortactin. Furthermore, overexpression of cortactin, mutated at its major Src phosphorylation sites, enhanced actin ..
  4. Ren G, Crampton M, Yap A. Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions. Cell Motil Cytoskeleton. 2009;66:865-73 pubmed publisher
    ..We further argue that regulatory proteins, such as cortactin, serve to coordinate the molecular components of this protrusive apparatus into a cohesive module.
  5. Zhou S, Webb B, Eves R, Mak A. Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells. Am J Physiol Cell Physiol. 2006;290:C463-71 pubmed
    b>Cortactin, a predominant substrate of Src family kinases, plays an important role in Arp2/3-dependent actin polymerization in lamellipodia and membrane ruffles and was recently shown to be enriched in podosomes induced by either c-Src or ..
  6. Kelley L, Weed S. Cortactin is a substrate of activated Cdc42-associated kinase 1 (ACK1) during ligand-induced epidermal growth factor receptor downregulation. PLoS ONE. 2012;7:e44363 pubmed publisher
    ..Here we show that ACK1 directly binds and phosphorylates the Arp2/3 regulatory protein cortactin, potentially providing a direct link to Arp2/3-based actin dynamics during EGFR degradation...
  7. Zuo Q, Wu W, Li X, Zhao L, Chen W. HDAC6 and SIRT2 promote bladder cancer cell migration and invasion by targeting cortactin. Oncol Rep. 2012;27:819-24 pubmed publisher
    ..promotes the migration and invasion of bladder cancer cells by targeting the cytoskeletal protein cortactin. Furthermore, a colony formation assay as well as in vitro migration and invasion assays ..
  8. Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, et al. GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS ONE. 2011;6:e23359 pubmed publisher
    ..AMAP1 functions by binding to cortactin in cancer invasion and metastasis...
  9. Selbach M, Moese S, Hurwitz R, Hauck C, Meyer T, Backert S. The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J. 2003;22:515-28 pubmed
    ..c-Src inactivation leads to tyrosine dephosphorylation of the actin binding protein cortactin. Concomitantly, cortactin is specifically redistributed to actin-rich cellular protrusions...
  10. Zhang X, Yuan Z, Zhang Y, Yong S, Salas Burgos A, Koomen J, et al. HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell. 2007;27:197-213 pubmed
    ..In this study, we identify the F-actin-binding protein cortactin as a HDAC6 substrate...
  11. Campbell D, Sutherland R, Daly R. Signaling pathways and structural domains required for phosphorylation of EMS1/cortactin. Cancer Res. 1999;59:5376-85 pubmed
    The structural characteristics of EMS1 (human cortactin) suggest that it may link signaling events to reorganization of the actin cytoskeleton...
  12. Folio C, Zalacain M, Zandueta C, Ormazábal C, Sierrasesumaga L, San Julian M, et al. Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival. Cancer Biomark. 2011;10:35-41 pubmed publisher
    The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma...
  13. Grigera P, Ma L, Borgman C, Pinto A, Sherman N, Parsons J, et al. Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells. J Proteomics. 2012;75:2153-9 pubmed publisher
    b>Cortactin is an F-actin binding protein that functions as a scaffold to regulate Arp2/3 mediated actin polymerization in lamellipodia and invadopodia formation as well as functioning in cell migration and endocytosis of many different ..
  14. Yamada S, Yanamoto S, Kawasaki G, Mizuno A, Nemoto T. Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma. Pathol Oncol Res. 2010;16:523-31 pubmed publisher
    b>Cortactin, an F-actin binding protein, stabilizes F-actin networks and promotes actin polymerization by activating the Arp2/3 complex. Overexpression of cortactin has been reported in several human cancers...
  15. Artym V, Matsumoto K, Mueller S, Yamada K. Dynamic membrane remodeling at invadopodia differentiates invadopodia from podosomes. Eur J Cell Biol. 2011;90:172-80 pubmed publisher
    ..the cell membrane adherent to the matrix, fluorescence microscopy studies have focused on invadopodia as actin-cortactin aggregates localized to areas of ECM degradation...
  16. Yang L, Kowalski J, Zhan X, Thomas S, Luscinskas F. Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res. 2006;98:394-402 pubmed
    ..b>Cortactin is a substrate of Src tyrosine kinases and a regulator of cytoskeletal dynamics...
  17. Bañón Rodríguez I, Monypenny J, Ragazzini C, Franco A, Calle Y, Jones G, et al. The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cells. Eur J Cell Biol. 2011;90:213-23 pubmed publisher
    ..A second weaker Arp2/3 activator, cortactin, is also found at podosomes where it has been proposed to participate in matrix metalloproteinase (MMP) ..
  18. Kaluza D, Kroll J, Gesierich S, Yao T, Boon R, Hergenreider E, et al. Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. EMBO J. 2011;30:4142-56 pubmed publisher
    ..Instead, we found that HDAC6 interacts with and deacetylates the actin-remodelling protein cortactin in ECs, which is essential for zebrafish vessel formation and which mediates the angiogenic effect of HDAC6...
  19. van Rossum A, de Graaf J, Schuuring Scholtes E, Kluin P, Fan Y, Zhan X, et al. Alternative splicing of the actin binding domain of human cortactin affects cell migration. J Biol Chem. 2003;278:45672-9 pubmed
    b>Cortactin is a filamentous actin (F-actin)-binding protein that regulates cytoskeletal dynamics by activating the Arp2/3 complex; it binds to F-actin by means of six N-terminal "cortactin repeats"...
  20. Bryce N, Clark E, Leysath J, Currie J, Webb D, Weaver A. Cortactin promotes cell motility by enhancing lamellipodial persistence. Curr Biol. 2005;15:1276-85 pubmed
    ..Cells deficient in cortactin have impaired cell migration and invasion...
  21. Agerer F, Lux S, Michel A, Rohde M, Ohlsen K, Hauck C. Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation. J Cell Sci. 2005;118:2189-200 pubmed
    ..of several host proteins associated with bacterial attachment sites, including FAK and the Src substrate cortactin. In FAK-deficient cells, local recruitment of cortactin still occurred, whereas the integrin- and Src-dependent ..
  22. Katsube T, Togashi S, Hashimoto N, Ogiu T, Tsuji H. Filamentous actin binding ability of cortactin isoforms is responsible for their cell-cell junctional localization in epithelial cells. Arch Biochem Biophys. 2004;427:79-90 pubmed
    b>Cortactin is an F-actin binding protein that contributes to cytoskeleton remodelling. We identified five isoforms of mouse cortactin that differ in the number of tandem 37-amino acid repeats, named cortactin repeats...
  23. Miyaso H, Nakamura N, Matsuno Y, Kawashiro Y, Komiyama M, Mori C. Postnatal exposure to low-dose decabromodiphenyl ether adversely affects mouse testes by increasing thyrosine phosphorylation level of cortactin. J Toxicol Sci. 2012;37:987-99 pubmed
    ..We hypothesized that decaBDE affects mouse testes by altering the expression and phosphorylation level of cortactin (CTTN), an F-actin-binding protein that is similar to flutamide, and we performed western blot analyses on ..
  24. Pollard T. Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct. 2007;36:451-77 pubmed
    ..Formins nucleate and support the elongation of unbranched actin filaments for cytokinesis and various types of actin filament bundles. Formins associate processively with the fast-growing ends of filaments and protect them from capping. ..
  25. Ohashi E, Tanabe K, Henmi Y, Mesaki K, Kobayashi Y, Takei K. Receptor sorting within endosomal trafficking pathway is facilitated by dynamic actin filaments. PLoS ONE. 2011;6:e19942 pubmed publisher
    ..We further elucidated that cortactin, an actin-nucleating factor, was required for transporting contents from within EEs...
  26. Tegtmeyer N, Wittelsberger R, Hartig R, Wessler S, Martinez Quiles N, Backert S. Serine phosphorylation of cortactin controls focal adhesion kinase activity and cell scattering induced by Helicobacter pylori. Cell Host Microbe. 2011;9:520-31 pubmed publisher
    ..regulation of cytoskeletal architectural changes by signaling factors, including the actin-binding protein cortactin. Bacterial and viral pathogens subvert these signaling factors to promote their uptake, spread and dissemination...
  27. Hofman P, Butori C, Havet K, Hofman V, Selva E, Guevara N, et al. Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status. Br J Cancer. 2008;98:956-64 pubmed publisher
    b>Cortactin is an actin-binding Src substrate involved in cell motility and invasion. In this study, we sought to examine the prognostic importance of cortactin protein expression in head and neck squamous cell carcinoma (HNSCC)...
  28. Du Y, Weed S, Xiong W, Marshall T, Parsons J. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Mol Cell Biol. 1998;18:5838-51 pubmed
    b>Cortactin is an actin-binding protein that contains several potential signaling motifs including a Src homology 3 (SH3) domain at the distal C terminus...
  29. Naisbitt S, Kim E, Tu J, Xiao B, Sala C, Valtschanoff J, et al. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin. Neuron. 1999;23:569-82 pubmed
    ..In addition to its PDZ domain, Shank contains a proline-rich region that binds to cortactin and a SAM domain that mediates multimerization...
  30. Higgs H, Pollard T. Regulation of actin filament network formation through ARP2/3 complex: activation by a diverse array of proteins. Annu Rev Biochem. 2001;70:649-76 pubmed
    ..These interactions provide a final common pathway for many signaling inputs to regulate actin polymerization. Microorganisms either activate Arp2/3 complex directly or usurp N-WASP to initiate actin polymerization. ..
  31. Schafer D, Weed S, Binns D, Karginov A, Parsons J, Cooper J. Dynamin2 and cortactin regulate actin assembly and filament organization. Curr Biol. 2002;12:1852-7 pubmed
    ..Through interactions via its proline-rich domain (PRD), dynamin binds several proteins, including cortactin, profilin, syndapin, and murine Abp1, that regulate the actin cytoskeleton...
  32. Vidal C, Geny B, Melle J, Jandrot Perrus M, Fontenay Roupie M. Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood. 2002;100:4462-9 pubmed
    ..The cortical-actin binding protein, p80/85 cortactin, is constitutively associated with PAK in resting platelets and dissociates from PAK after thrombin stimulation...
  33. Iki J, Inoue A, Bito H, Okabe S. Bi-directional regulation of postsynaptic cortactin distribution by BDNF and NMDA receptor activity. Eur J Neurosci. 2005;22:2985-94 pubmed
    Abstract Cortactin is an F-actin-associated protein which interacts with the postsynaptic scaffolding protein Shank at the SH3 domain and is localized within the dendritic spine in the mouse neuron...
  34. Anahara R, Toyama Y, Maekawa M, Kai M, Ishino F, Toshimori K, et al. Flutamide depresses expression of cortactin in the ectoplasmic specialization between the Sertoli cells and spermatids in the mouse testis. Food Chem Toxicol. 2006;44:1050-6 pubmed
    ..The apical ES is an actin-based junctional structure between the Sertoli cells and germ cells. Cortactin, an actin-binding protein, is found in the actin layer of ES...
  35. Cowieson N, King G, Cookson D, Ross I, Huber T, Hume D, et al. Cortactin adopts a globular conformation and bundles actin into sheets. J Biol Chem. 2008;283:16187-93 pubmed publisher
    b>Cortactin is a filamentous actin-binding protein that plays a pivotal role in translating environmental signals into coordinated rearrangement of the cytoskeleton...
  36. Rodrigo J, Garcia Carracedo D, Garcia L, Menéndez S, Allonca E, Gonzalez M, et al. Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas. J Pathol. 2009;217:516-23 pubmed publisher
    ..We investigated the clinical significance of cortactin (CTTN) and cyclin D1 (CCND1) amplification in both malignant transformation and tumour progression...
  37. Buday L, Downward J. Roles of cortactin in tumor pathogenesis. Biochim Biophys Acta. 2007;1775:263-73 pubmed
    b>Cortactin is a ubiquitous actin-binding protein that was originally identified as a substrate for the protein kinase Src...
  38. Perrin B, Amann K, Huttenlocher A. Proteolysis of cortactin by calpain regulates membrane protrusion during cell migration. Mol Biol Cell. 2006;17:239-50 pubmed
    ..One potential candidate substrate is the actin binding protein cortactin. Cortactin is a Src substrate that drives actin polymerization by activating the Arp2/3 complex and also ..
  39. Selbach M, Backert S. Cortactin: an Achilles' heel of the actin cytoskeleton targeted by pathogens. Trends Microbiol. 2005;13:181-9 pubmed
    b>Cortactin is an actin-binding protein and a central regulator of the actin cytoskeleton. Importantly, cortactin is also a common target exploited by microbes during infection...
  40. Kinley A, Weed S, Weaver A, Karginov A, Bissonette E, Cooper J, et al. Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Curr Biol. 2003;13:384-93 pubmed
    ..A key regulator of actin polymerization is Arp2/3 complex. Cortactin, an F-actin binding protein that localizes to membrane ruffles, is an activator of Arp2/3 complex...
  41. Rothschild B, Shim A, Ammer A, Kelley L, Irby K, Head J, et al. Cortactin overexpression regulates actin-related protein 2/3 complex activity, motility, and invasion in carcinomas with chromosome 11q13 amplification. Cancer Res. 2006;66:8017-25 pubmed
    ..b>Cortactin is an actin-related protein 2/3 (Arp2/3) complex-activating and filamentous (F)-actin-binding protein that is ..
  42. Crostella L, Lidder S, Williams R, Skouteris G. Hepatocyte Growth Factor/scatter factor-induces phosphorylation of cortactin in A431 cells in a Src kinase-independent manner. Oncogene. 2001;20:3735-45 pubmed
    ..b>Cortactin, a p80/85 F-actin binding protein, was found phosphorylated on tyrosine in response to HGF-SF in A431 human ..
  43. Jaworski J, Kapitein L, Gouveia S, Dortland B, Wulf P, Grigoriev I, et al. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Neuron. 2009;61:85-100 pubmed publisher
    ..In addition, we found that p140Cap interacts with Src substrate and F-actin-binding protein cortactin. We propose that EB3-labeled growing microtubule ends regulate the localization of p140Cap, control cortactin ..
  44. Tomar A, Lawson C, Ghassemian M, Schlaepfer D. Cortactin as a target for FAK in the regulation of focal adhesion dynamics. PLoS ONE. 2012;7:e44041 pubmed publisher
    ..b>Cortactin is an actin binding adaptor protein that can influence FA dynamics...
  45. Birukov K, Birukova A, Dudek S, Verin A, Crow M, Zhan X, et al. Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. Am J Respir Cell Mol Biol. 2002;26:453-64 pubmed
    ..the cortical actin ring, junctional protein tyrosine phosphorylation, and transient peripheral translocation of cortactin, an actin-binding protein involved in the regulation of actin polymerization...
  46. Higgs H. Actin nucleation: cortactin caught in the act. Curr Biol. 2002;12:R593-5 pubmed
    A variety of activators stimulate Arp2/3 complex to nucleate branched actin filament structures. New results provide important biochemical and structural information for activation by the proteins cortactin and N-WASP.
  47. Hashimoto S, Hirose M, Hashimoto A, Morishige M, Yamada A, Hosaka H, et al. Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2006;103:7036-41 pubmed
    ..We also have shown that AMAP1 functions by forming a trimeric protein complex with cortactin and paxillin...
  48. Zhu J, Zhou K, Hao J, Liu J, Smith N, Zhan X. Regulation of cortactin/dynamin interaction by actin polymerization during the fission of clathrin-coated pits. J Cell Sci. 2005;118:807-17 pubmed
    ..RNA interference-mediated suppression of cortactin, an F-actin binding protein that promotes Arp2/3 complex-mediated actin polymerization, effectively blocked ..
  49. Kirkbride K, Sung B, Sinha S, Weaver A. Cortactin: a multifunctional regulator of cellular invasiveness. Cell Adh Migr. 2011;5:187-98 pubmed
    ..signaling, cytoskeletal and membrane trafficking proteins is the Src kinase substrate and Arp2/3 binding protein cortactin. Due to its frequent overexpression in advanced, invasive cancers and its general role in regulating branched ..
  50. Mooren O, Kotova T, Moore A, Schafer D. Dynamin2 GTPase and cortactin remodel actin filaments. J Biol Chem. 2009;284:23995-4005 pubmed publisher
    ..actin filaments in vitro via a mechanism that depends on the binding partner and F-actin-binding protein, cortactin. Tightly associated actin filaments cross-linked by dynamin2 and cortactin became loosely associated after GTP ..
  51. Brown M, Adyshev D, Bindokas V, Moitra J, Garcia J, Dudek S. Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium. Microvasc Res. 2010;80:75-88 pubmed publisher
    ..light chain kinase variants (nmMLCK1- and -2), as well as association of nmMLCK with the actin-binding protein, cortactin. As these associations have proven difficult to quantify in a spatially specific manner, we now describe the ..
  52. Belleudi F, Scrofani C, Torrisi M, Mancini P. Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin. PLoS ONE. 2011;6:e29159 pubmed publisher
    ..Here we analyzed the possible role of cortactin, an F-actin binding protein which is tyrosine phosphorylated by Src and is involved in KGFR-mediated cell ..
  53. Rosales E, Aguilera M, Salinas R, Carminati S, Colombo M, Martinez Quiles N, et al. Cortactin is involved in the entry of Coxiella burnetii into non-phagocytic cells. PLoS ONE. 2012;7:e39348 pubmed publisher
    b>Cortactin is a key regulator of the actin cytoskeleton and is involved in pathogen-host cell interactions. Numerous pathogens exploit the phagocytic process and actin cytoskeleton to infect host cells...