actinin

Summary

Summary: A protein factor that regulates the length of R-actin. It is chemically similar, but immunochemically distinguishable from actin.

Top Publications

  1. Shao H, Wang J, Pollak M, Wells A. ?-actinin-4 is essential for maintaining the spreading, motility and contractility of fibroblasts. PLoS ONE. 2010;5:e13921 pubmed publisher
    ..Most non-muscle cells such as fibroblasts express two isoforms, ?-actinin-1 (ACTN1) and ?-actinin-4 (ACTN4)...
  2. Nakatsuji H, Nishimura N, Yamamura R, Kanayama H, Sasaki T. Involvement of actinin-4 in the recruitment of JRAB/MICAL-L2 to cell-cell junctions and the formation of functional tight junctions. Mol Cell Biol. 2008;28:3324-35 pubmed publisher
    ..We then identified actinin-4, which was originally isolated as an actin-binding protein associated with cell motility and cancer invasion/..
  3. Garatachea N, Fiuza Luces C, Torres Luque G, Yvert T, Santiago C, Gomez Gallego F, et al. Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians. Eur J Appl Physiol. 2012;112:2409-20 pubmed publisher
    ..More studies with larger sample sizes are needed. ..
  4. Eynon N, Ruiz J, Femia P, Pushkarev V, Cieszczyk P, Maciejewska Karlowska A, et al. The ACTN3 R577X polymorphism across three groups of elite male European athletes. PLoS ONE. 2012;7:e43132 pubmed publisher
    ..Our data provide comprehensive support for the influence of the ACTN3 R577X polymorphism on elite athletic performance. ..
  5. Lima R, Leite T, Pereira R, Rabelo H, Roth S, Oliveira R. ACE and ACTN3 genotypes in older women: muscular phenotypes. Int J Sports Med. 2011;32:66-72 pubmed publisher
    ..Of note, the results provide a novel insight that these genetic variations may interact to determine muscle mass in older women. ..
  6. Linnemann A, van der Ven P, Vakeel P, Albinus B, Simonis D, Bendas G, et al. The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin. Eur J Cell Biol. 2010;89:681-92 pubmed publisher
    ..A detailed characterization of the previously described interaction between myopodin and alpha-actinin demonstrates for the first time that myopodin contains three independent alpha-actinin-binding sites...
  7. Bustamante Ara N, Santiago C, Verde Z, Yvert T, Gomez Gallego F, Rodríguez Romo G, et al. ACE and ACTN3 genes and muscle phenotypes in nonagenarians. Int J Sports Med. 2010;31:221-4 pubmed publisher
    ..Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants. ..
  8. Guéguen P, Rouault K, Chen J, Raguenes O, Fichou Y, Hardy E, et al. A missense mutation in the alpha-actinin 1 gene (ACTN1) is the cause of autosomal dominant macrothrombocytopenia in a large French family. PLoS ONE. 2013;8:e74728 pubmed publisher
    ..137GA; p.Arg46Gln) in the alpha-actinin 1 gene (ACTN1) that segregated with macrothrombocytopenia in this large pedigree...
  9. Yu H, Li Z, Ghosh D, Lim T, He Y, Lin Q. ?-Actinin4 nuclear translocation mediates gonadotropin-releasing hormone stimulation of follicle-stimulating hormone ?-subunit gene transcription in L?T2 cells. FEBS Lett. 2012;586:1466-71 pubmed publisher
    ..Our study suggests that ACTN4 nuclear translocation mediates GnRH stimulation of mFsh? gene transcription. ..

More Information

Publications95

  1. Klaavuniemi T, Alho N, Hotulainen P, Kelloniemi A, Havukainen H, Permi P, et al. Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of alpha-actinin. BMC Cell Biol. 2009;10:22 pubmed publisher
    The PDZ-LIM proteins are a family of signalling adaptors that interact with the actin cross-linking protein, alpha-actinin, via their PDZ domains or via internal regions between the PDZ and LIM domains...
  2. Du A, Sanger J, Sanger J. Cardiac myofibrillogenesis inside intact embryonic hearts. Dev Biol. 2008;318:236-46 pubmed publisher
    ..6 mum filaments present in mature A-bands. This supports the proposal that titin may play a role in length determination of myosin filaments...
  3. McCauley T, Mastana S, Folland J. ACE I/D and ACTN3 R/X polymorphisms and muscle function and muscularity of older Caucasian men. Eur J Appl Physiol. 2010;109:269-77 pubmed publisher
    ..Angiotensin converting enzyme (ACE) I/D and alpha actinin 3 (ACTN3) R/X polymorphisms have been suggested to influence variations in skeletal muscle function and body ..
  4. Greenberg M, Moore J. The molecular basis of frictional loads in the in vitro motility assay with applications to the study of the loaded mechanochemistry of molecular motors. Cytoskeleton (Hoboken). 2010;67:273-85 pubmed publisher
    ..We show computationally and experimentally that the frictional load imposed by alpha-actinin, the most widely employed actin binding protein in frictional loading experiments, behaves as a viscoelastic ..
  5. Druzhevskaya A, Ahmetov I, Astratenkova I, Rogozkin V. Association of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur J Appl Physiol. 2008;103:631-4 pubmed publisher
    The alpha-actinin-3 (ACTN3) gene encodes a Z-disc structural protein which is found only in fast glycolytic muscle fibers...
  6. Rahimzadeh J, Meng F, Sachs F, Wang J, Verma D, Hua S. Real-time observation of flow-induced cytoskeletal stress in living cells. Am J Physiol Cell Physiol. 2011;301:C646-52 pubmed publisher
    ..plate microfluidic chip with a fluorescence resonance energy transfer (FRET)-based mechanical stress sensor in actinin. The sensing cassette was genetically inserted into the cytoskeletal host protein and transfected into Madin-..
  7. Chan S, Seto J, Houweling P, Yang N, North K, Head S. Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female Actn3 knockout mice. Muscle Nerve. 2011;43:37-48 pubmed publisher
    Absence of ?-actinin-3, encoded by the ACTN3 "speed gene," is associated with poorer sprinting performance in athletes and a slowing of relaxation in fast-twitch muscles of Actn3 knockout (KO) mice...
  8. Jevnikar Z, Obermajer N, Pecar Fonović U, Karaoglanovic Carmona A, Kos J. Cathepsin X cleaves the beta2 cytoplasmic tail of LFA-1 inducing the intermediate affinity form of LFA-1 and alpha-actinin-1 binding. Eur J Immunol. 2009;39:3217-27 pubmed publisher
    ..of the beta(2) cytoplasmic tail of LFA-1 is shown to promote binding of the actin-binding protein alpha-actinin-1...
  9. Trulsson M, Yu H, Gisselsson L, Chao Y, Urbano A, Aits S, et al. HAMLET binding to ?-actinin facilitates tumor cell detachment. PLoS ONE. 2011;6:e17179 pubmed publisher
    ..revealed that HAMLET binds to the N-terminal actin-binding domain as well as the integrin-binding domain of ?-actinin-4...
  10. Craig D, Downey C, Basson M. SiRNA-mediated reduction of alpha-actinin-1 inhibits pressure-induced murine tumor cell wound implantation and enhances tumor-free survival. Neoplasia. 2008;10:217-22 pubmed
    ..pressure modulates integrin binding affinity and stimulates colon cancer cell adhesion in vitro through an alpha-actinin-1-dependent signaling pathway...
  11. Rodríguez Romo G, Ruiz J, Santiago C, Fiuza Luces C, Gonzalez Freire M, Gomez Gallego F, et al. Does the ACE I/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults?. Eur J Appl Physiol. 2010;110:1099-106 pubmed publisher
    ..converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism, alone or in combination with the ?-actinin-3 gene (ACTN3) R577X polymorphism, with jumping (vertical squat and counter-movement jump tests) and sprint ..
  12. Manisastry S, Zaal K, Horowits R. Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes. Exp Cell Res. 2009;315:2126-39 pubmed publisher
    N-RAP is a striated muscle-specific scaffolding protein that organizes alpha-actinin and actin into symmetrical I-Z-I structures in developing myofibrils...
  13. Lek M, Quinlan K, North K. The evolution of skeletal muscle performance: gene duplication and divergence of human sarcomeric alpha-actinins. Bioessays. 2010;32:17-25 pubmed publisher
    ..Remarkably, approximately 1 billion people worldwide are deficient in alpha-actinin-3 due to the common ACTN3 R577X polymorphism...
  14. Chiu L, Wu Y, Tang M, Yu H, Hsieh L, Hsieh S. ACTN3 genotype and swimming performance in Taiwan. Int J Sports Med. 2011;32:476-80 pubmed publisher
    Studies have shown that the 577R allele of ?-actinin-3 (ACTN3) is more prevalent in sprint athletes than in the general population or in endurance athletes...
  15. Hamill K, Hopkinson S, Skalli O, Jones J. Actinin-4 in keratinocytes regulates motility via an effect on lamellipodia stability and matrix adhesions. FASEB J. 2013;27:546-56 pubmed publisher
    ..b>Actinin-4 associates with lamellipodia and has been implicated in regulating lamellipodial structure, function and ..
  16. Ginevičienė V, Pranculis A, Jakaitienė A, Milašius K, Kucinskas V. Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas). 2011;47:284-90 pubmed
    Based on the results of many studies, the angiotensin-converting enzyme (ACE) and the ?-actinin-3 (ACTN3) genes are considered strong candidate genes associated with human physical performance...
  17. Khotin M, Turoverova L, Aksenova V, Barlev N, Borutinskaite V, Vener A, et al. Proteomic analysis of ACTN4-interacting proteins reveals it's a putative involvement in mRNA metabolism. Biochem Biophys Res Commun. 2010;397:192-6 pubmed publisher
    Alpha-actinin 4 (ACTN4) is an actin-binding protein. In the cytoplasm, ACTN4 participates in structural organisation of the cytoskeleton via cross-linking of actin filaments...
  18. Roca Cusachs P, Del Rio A, Puklin Faucher E, Gauthier N, Biais N, Sheetz M. Integrin-dependent force transmission to the extracellular matrix by ?-actinin triggers adhesion maturation. Proc Natl Acad Sci U S A. 2013;110:E1361-70 pubmed publisher
    ..Here, we demonstrate a major mechanosensitive pathway in which ?-actinin triggers adhesion maturation by linking integrins to actin in nascent adhesions...
  19. Yamamoto S, Tsuda H, Honda K, Takano M, Tamai S, Imoto I, et al. ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas. Histopathology. 2012;60:1073-83 pubmed publisher
    b>Actinin-4, encoded by the ACTN4 gene located on chromosome 19q13.2, enhances cell motility by bundling the actin cytoskeleton...
  20. Kunishima S, Okuno Y, Yoshida K, Shiraishi Y, Sanada M, Muramatsu H, et al. ACTN1 mutations cause congenital macrothrombocytopenia. Am J Hum Genet. 2013;92:431-8 pubmed publisher
    ..ACTN1 encodes ?-actinin-1, a member of the actin-crosslinking protein superfamily that participates in the organization of the ..
  21. Smith M, Blankman E, Gardel M, Luettjohann L, Waterman C, Beckerle M. A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell. 2010;19:365-76 pubmed publisher
    ..Zyxin promotes recruitment of the actin regulatory proteins ?-actinin and VASP to compromised stress fiber zones...
  22. Chi R, Simon A, Bienkiewicz E, Felix A, Keller T. Smooth muscle titin Zq domain interaction with the smooth muscle alpha-actinin central rod. J Biol Chem. 2008;283:20959-67 pubmed publisher
    ..in striated muscle, smooth muscle, and nonmuscle cells contain the actin filament-cross-linking protein alpha-actinin. In striated muscle Z-disks, alpha-actinin interacts with N-terminal domains of titin to provide a structural ..
  23. Fraley S, Feng Y, Giri A, Longmore G, Wirtz D. Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun. 2012;3:719 pubmed publisher
    ..depletion shows that these one-dimensional oscillations are uniquely controlled by zyxin and binding partners ?-actinin and p130Cas, but not vasodilator-stimulated phosphoprotein and cysteine-rich protein 1...
  24. Tadokoro S, Nakazawa T, Kamae T, Kiyomizu K, Kashiwagi H, Honda S, et al. A potential role for ?-actinin in inside-out ?IIb?3 signaling. Blood. 2011;117:250-8 pubmed publisher
    ..Here, we describe a new role for ?-actinin in inside-out integrin activation...
  25. Scott R, Irving R, Irwin L, Morrison E, Charlton V, Austin K, et al. ACTN3 and ACE genotypes in elite Jamaican and US sprinters. Med Sci Sports Exerc. 2010;42:107-12 pubmed publisher
    The angiotensin-converting enzyme (ACE) and the alpha-actinin-3 (ACTN3) genes are two of the most studied "performance genes" and both have been associated with sprint/power phenotypes and elite performance...
  26. Agarwal S, Simonds W, Marx S. The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3. Mol Cancer. 2008;7:65 pubmed publisher
    ..Fourteen parafibromin interaction positive preys representing 10 independent clones encoding actinin-2 were isolated...
  27. Yoshii H, Ito K, Asano T, Horiguchi A, Hayakawa M, Asano T. Increased expression of ?-actinin-4 is associated with unfavorable pathological features and invasiveness of bladder cancer. Oncol Rep. 2013;30:1073-80 pubmed publisher
    In the present study, the association between clinicopathological parameters and ?-actinin-4 (ACTN4) expression in bladder cancer specimens was evaluated, and the functional role of ACTN4 in bladder cancer cells was investigated...
  28. Meng F, Sachs F. Visualizing dynamic cytoplasmic forces with a compliance-matched FRET sensor. J Cell Sci. 2011;124:261-9 pubmed publisher
    ..To measure cytoskeletal stress in vivo we inserted sstFRET into ?-actinin and expressed it in HEK and BAEC cells...
  29. Yamamoto S, Tsuda H, Honda K, Onozato K, Takano M, Tamai S, et al. Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance. Mod Pathol. 2009;22:499-507 pubmed publisher
    b>Actinin-4, an isoform of non-muscular alpha-actinin, enhances cell motility by bundling the actin cytoskeleton...
  30. Shams H, Golji J, Mofrad M. A molecular trajectory of ?-actinin activation. Biophys J. 2012;103:2050-9 pubmed publisher
    ..b>Actinin is an actin cross-linker and may act as a mechanosensor in adhesion sites...
  31. Massidda M, Vona G, Calò C. Association between the ACTN3 R577X polymorphism and artistic gymnastic performance in Italy. Genet Test Mol Biomarkers. 2009;13:377-80 pubmed publisher
    ..Homozygosis (577XX) for the stop codon in the ACTN3 polymorphism results in alpha-actinin-3 complete deficiency...
  32. Koizumi T, Nakatsuji H, Fukawa T, Avirmed S, Fukumori T, Takahashi M, et al. The role of actinin-4 in bladder cancer invasion. Urology. 2010;75:357-64 pubmed publisher
    To examine actinin-4 expression levels in bladder cancer, in particular its levels during cellular growth and invasion. Actinin-4 is an actin-binding protein that is associated with cell motility and cancer metastasis...
  33. Kovac B, Teo J, Makela T, Vallenius T. Assembly of non-contractile dorsal stress fibers requires ?-actinin-1 and Rac1 in migrating and spreading cells. J Cell Sci. 2013;126:263-73 pubmed publisher
    ..Actin stress fibers are considered to contain ?-actinin crosslinkers and nonmuscle myosin II motors...
  34. Park S, Kim M, Yun S, Ryu J, Park J, Seo B, et al. C(16)-Ceramide-induced F-actin regulation stimulates mouse embryonic stem cell migration: involvement of N-WASP/Cdc42/Arp2/3 complex and cofilin-1/?-actinin. Biochim Biophys Acta. 2013;1831:350-60 pubmed publisher
    ..Indeed, C(16)-Cer increased cofilin-1/F-actin interaction or F-actin/?-actinin-1 and ?-actinin-4 interactions in the cytoskeleton compartment, which was reversed by Cdc42-specific siRNA...
  35. Welsch T, Keleg S, Bergmann F, Bauer S, Hinz U, Schmidt J. Actinin-4 expression in primary and metastasized pancreatic ductal adenocarcinoma. Pancreas. 2009;38:968-76 pubmed publisher
    b>Actinin-4 is an actin-bundling protein that probably has a tumor-promoting potential in several solid tumors...
  36. Yang N, Schindeler A, McDonald M, Seto J, Houweling P, Lek M, et al. ?-Actinin-3 deficiency is associated with reduced bone mass in human and mouse. Bone. 2011;49:790-8 pubmed publisher
    ..b>Actinin-3 (ACTN3) is highly expressed in fast skeletal muscle fibres...
  37. Aratyn Schaus Y, Oakes P, Gardel M. Dynamic and structural signatures of lamellar actomyosin force generation. Mol Biol Cell. 2011;22:1330-9 pubmed publisher
    ..As stress fibers build and tension increases, myosin band spacing decreases and ?-actinin bands form...
  38. Mishra S, Chander V, Banerjee P, Oh J, Lifirsu E, Park W, et al. Interaction of annexin A6 with alpha actinin in cardiomyocytes. BMC Cell Biol. 2011;12:7 pubmed publisher
    ..length annexin A6 as well as GST-C terminus deleted annexin A6 when immunoblotted with anti sarcomeric alpha (?)-actinin antibody showed the presence of ?-actinin in the immunoblot which was absent when GST-N terminus deleted annexin ..
  39. Hsu K, Kao H. Alpha-actinin 4 and tumorigenesis of breast cancer. Vitam Horm. 2013;93:323-51 pubmed publisher
    ..Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression ..
  40. Grooman B, Fujiwara I, Otey C, Upadhyaya A. Morphology and viscoelasticity of actin networks formed with the mutually interacting crosslinkers: palladin and alpha-actinin. PLoS ONE. 2012;7:e42773 pubmed publisher
    ..Palladin coexists with ?-actinin in stress fibers and focal adhesions and binds to both actin and ?-actinin...
  41. Hirooka S, Akashi T, Ando N, Suzuki Y, Ishida N, Kurata M, et al. Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas. Pathobiology. 2011;78:10-23 pubmed publisher
    ..We investigated an alteration of subcellular localization of invadopodia-related actin-associated proteins, actinin-1 and cortactin, in lung adenocarcinomas, its clinical significance, and its possible regulatory factors...
  42. Oikonomou K, Zachou K, Dalekos G. Alpha-actinin: a multidisciplinary protein with important role in B-cell driven autoimmunity. Autoimmun Rev. 2011;10:389-96 pubmed publisher
    Alpha-actinin (?-actinin) is a ubiquitous cytoskeletal protein, which belongs to the superfamily of filamentous actin (F-actin) crosslinking proteins...
  43. Ngan E, Northey J, Brown C, Ursini Siegel J, Siegel P. A complex containing LPP and ?-actinin mediates TGF?-induced migration and invasion of ErbB2-expressing breast cancer cells. J Cell Sci. 2013;126:1981-91 pubmed publisher
    ..Finally, we have determined that the interaction between LPP and ?-actinin, an actin cross-linking protein, is necessary for TGF?-induced migration and invasion of ErbB2-expressing breast ..
  44. Barbolina M, Adley B, Kelly D, Fought A, Scholtens D, Shea L, et al. Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. Lab Invest. 2008;88:602-14 pubmed publisher
    ..Three-dimensional collagen I culture led to differential expression of several genes. The role of actinin alpha-4 (ACTN4), a cytoskeleton-associated protein implicated in the regulation of cell motility, was examined in ..
  45. Miyazaki K, Ohno K, Tamura N, Sasaki T, Sato K. CLP36 and RIL recruit ?-actinin-1 to stress fibers and differentially regulate stress fiber dynamics in F2408 fibroblasts. Exp Cell Res. 2012;318:1716-25 pubmed publisher
    ..CLP36 and RIL form a complex with ?-actinin-1 and palladin...
  46. Shang X, Huang C, Chang Q, Zhang L, Huang T. Association between the ACTN3 R577X polymorphism and female endurance athletes in China. Int J Sports Med. 2010;31:913-6 pubmed publisher
    The ?-actinin 3 ( ACTN3) gene is absent in 18% of healthy white individuals owing to homozygosity for a premature stop codon polymorphism (rs1815739) and is only expressed in the Z line of fast glycolytic muscle fibres...
  47. Ahmetov I, Druzhevskaya A, Astratenkova I, Popov D, Vinogradova O, Rogozkin V. The ACTN3 R577X polymorphism in Russian endurance athletes. Br J Sports Med. 2010;44:649-52 pubmed publisher
    The functional 577R allele of the alpha-actinin-3 (ACTN3) gene has been reported to be associated with elite power athlete status, while the nonfunctional 577XX genotype (predicts an alpha-actinin-3 deficient phenotype) has been ..
  48. Wang J, Hu H, Wang S, Shi J, Chen S, Wei H, et al. The important role of actinin-like protein (AcnA) in cytokinesis and apical dominance of hyphal cells in Aspergillus nidulans. Microbiology. 2009;155:2714-25 pubmed publisher
    ..Here, we report the identification and characterization of an actinin-like protein (AcnA) from the filamentous fungus Aspergillus nidulans...
  49. Kimura M, Murakami T, Kizaka Kondoh S, Itoh M, Yamamoto K, Hojo Y, et al. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin. J Cell Sci. 2010;123:747-55 pubmed publisher
  50. Kumeta M, Yoshimura S, Harata M, Takeyasu K. Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4. J Cell Sci. 2010;123:1020-30 pubmed publisher
    In addition to its well-known role as a crosslinker of actin filaments at focal-adhesion sites, actinin-4 is known to be localized to the nucleus...
  51. Golji J, Collins R, Mofrad M. Molecular mechanics of the alpha-actinin rod domain: bending, torsional, and extensional behavior. PLoS Comput Biol. 2009;5:e1000389 pubmed publisher
    alpha-Actinin is an actin crosslinking molecule that can serve as a scaffold and maintain dynamic actin filament networks. As a crosslinker in the stressed cytoskeleton, alpha-actinin can retain conformation, function, and strength...
  52. Courson D, Rock R. Actin cross-link assembly and disassembly mechanics for alpha-Actinin and fascin. J Biol Chem. 2010;285:26350-7 pubmed publisher
    ..an optical trapping assay to investigate the behaviors of two actin cross-linking proteins, fascin and alpha-actinin, during the first steps of structure assembly...
  53. Ogura Y, Naito H, Kakigi R, Akema T, Sugiura T, Katamoto S, et al. Different adaptations of alpha-actinin isoforms to exercise training in rat skeletal muscles. Acta Physiol (Oxf). 2009;196:341-9 pubmed publisher
    ..Mammalian skeletal muscle has two isoforms: alpha-actinin-2 and alpha-actinin-3. However, the response of alpha-actinin to exercise training is little understood...
  54. Chan S, Seto J, MacArthur D, Yang N, North K, Head S. A gene for speed: contractile properties of isolated whole EDL muscle from an alpha-actinin-3 knockout mouse. Am J Physiol Cell Physiol. 2008;295:C897-904 pubmed publisher
    The actin-binding protein alpha-actinin-3 is one of the two isoforms of alpha-actinin that are found in the Z-discs of skeletal muscle. alpha-Actinin-3 is exclusively expressed in fast glycolytic muscle fibers...
  55. Han H, Beckerle M. The ALP-Enigma protein ALP-1 functions in actin filament organization to promote muscle structural integrity in Caenorhabditis elegans. Mol Biol Cell. 2009;20:2361-70 pubmed publisher
    ..elegans. We show that ALP-1 and alpha-actinin colocalize at dense bodies where actin filaments are anchored and that the proper localization of ALP-1 at dense ..
  56. Delmonico M, Zmuda J, Taylor B, Cauley J, Harris T, Manini T, et al. Association of the ACTN3 genotype and physical functioning with age in older adults. J Gerontol A Biol Sci Med Sci. 2008;63:1227-34 pubmed
    The purpose of this study was to examine the association of the alpha-actinin-3 (ACTN3) R577X polymorphism on muscle function and physical performance in older adults...
  57. Collin G, Marshall J, King B, Milan G, Maffei P, Jagger D, et al. The Alström syndrome protein, ALMS1, interacts with ?-actinin and components of the endosome recycling pathway. PLoS ONE. 2012;7:e37925 pubmed publisher
    ..The majority of proteins found to interact with the murine carboxy-terminal end (19/32) of ALMS1 were ?-actinin isoforms...
  58. Beck M, Otey C, Campbell S. Structural characterization of the interactions between palladin and ?-actinin. J Mol Biol. 2011;413:712-25 pubmed publisher
    The interaction between ?-actinin and palladin, two actin-cross-linking proteins, is essential for proper bidirectional targeting of these proteins...
  59. Falzone T, Lenz M, Kovar D, Gardel M. Assembly kinetics determine the architecture of ?-actinin crosslinked F-actin networks. Nat Commun. 2012;3:861 pubmed publisher
    ..filament entanglements and crosslinking determine the architecture of reconstituted actin networks formed with ?-actinin crosslinks. Crosslink-mediated bundle formation only occurs in dilute solutions of highly mobile actin filaments...
  60. Chiu C, Bagnall R, Ingles J, Yeates L, Kennerson M, Donald J, et al. Mutations in alpha-actinin-2 cause hypertrophic cardiomyopathy: a genome-wide analysis. J Am Coll Cardiol. 2010;55:1127-35 pubmed publisher
    ..82, theta = 0). A missense mutation, Ala119Thr, in the alpha-actinin-2 (ACTN2) gene was identified that segregated with disease in the family...
  61. Zachou K, Oikonomou K, Renaudineau Y, Chauveau A, Gatselis N, Youinou P, et al. Anti-? actinin antibodies as new predictors of response to treatment in autoimmune hepatitis type 1. Aliment Pharmacol Ther. 2012;35:116-25 pubmed publisher
    We reported that combined presence of autoantibodies (Abs) against filamentous-actin (AFA) and ?-actinin are specific for autoimmune hepatitis type 1 (AIH-1) diagnosis...
  62. Jayadev R, Kuk C, Low S, Murata Hori M. Calcium sensitivity of ?-actinin is required for equatorial actin assembly during cytokinesis. Cell Cycle. 2012;11:1929-37 pubmed publisher
    The actin cross-linking protein, ?-actinin, plays a crucial role in mediating furrow ingression during cytokinesis. However, the mechanism by which its dynamics are regulated during this process is poorly understood...
  63. Seto J, Chan S, Turner N, MacArthur D, Raftery J, Berman Y, et al. The effect of ?-actinin-3 deficiency on muscle aging. Exp Gerontol. 2011;46:292-302 pubmed publisher
    Deficiency of the fast-twitch muscle protein ?-actinin-3 due to homozygosity for a nonsense polymorphism (R577X) in the ACTN3 gene is common in humans...
  64. Michaud J, Stitt Cavanaugh E, Endlich N, Endlich K, De Repentigny Y, Kothary R, et al. Mice with podocyte-specific overexpression of wild type alpha-actinin-4 are healthy controls for K256E-alpha-actinin-4 mutant transgenic mice. Transgenic Res. 2010;19:285-9 pubmed publisher
    Mutations in the gene ACTN4 encoding the actin bundling protein-alpha-actinin-4 underlie an inherited form of kidney lesions known as focal segmental glomerulosclerosis (FSGS)...
  65. Döring F, Onur S, Geisen U, Boulay M, Perusse L, Rankinen T, et al. ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sports Sci. 2010;28:1355-9 pubmed publisher
    Homozygosity for a premature stop codon at amino acid position 577 in the alpha-actinin-3 (ACTN3) gene leads to ?-actinin-3 deficiency. This genotype is observed in approximately 18% of Caucasians...
  66. Berman Y, North K. A gene for speed: the emerging role of alpha-actinin-3 in muscle metabolism. Physiology (Bethesda). 2010;25:250-9 pubmed publisher
    A common polymorphism (R577X) in the ACTN3 gene results in complete deficiency of alpha-actinin-3 protein in approximately 16% of humans worldwide...
  67. Boyer O, Benoit G, Gribouval O, Nevo F, Tete M, Dantal J, et al. Mutations in INF2 are a major cause of autosomal dominant focal segmental glomerulosclerosis. J Am Soc Nephrol. 2011;22:239-45 pubmed publisher
  68. Fukuda K, Gupta S, Chen K, Wu C, Qin J. The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions. Mol Cell. 2009;36:819-30 pubmed publisher
    ..They also highlight functional diversity of the kinase fold and its "active" site in mediating many biological processes. ..
  69. Ando Akatsuka Y, Shimizu T, Numata T, Okada Y. Involvements of the ABC protein ABCF2 and ?-actinin-4 in regulation of cell volume and anion channels in human epithelial cells. J Cell Physiol. 2012;227:3498-510 pubmed publisher
    ..In the present study, an involvement of an actin-binding protein, ?-actinin-4 (ACTN4), in RVD was examined in human epithelial HEK293T cells...
  70. Steiner Champliaud M, Schneider Y, Favre B, Paulhe F, Praetzel Wunder S, Faulkner G, et al. BPAG1 isoform-b: complex distribution pattern in striated and heart muscle and association with plectin and alpha-actinin. Exp Cell Res. 2010;316:297-313 pubmed publisher
    ..molecular mass protein in striated and heart muscle cells, co-localizing with the sarcomeric Z-disc protein alpha-actinin-2 and partially with the cytolinker plectin as well as with the intermediate filament protein desmin...
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    ..Homozygosity for the R577X null-allele results in the absence of alpha-actinin-3 in fast muscle fibers with frequencies that vary from < 1% in Africans to approximately 18% in Caucasians...
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    Sarcomeric ?-actinins (?-actinin-2 and -3) are a major component of the Z-disk in skeletal muscle, where they crosslink actin and other structural proteins to maintain an ordered myofibrillar array...
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    ..We aimed to investigate whether alpha-actinin-3 (ACTN3) gene R577X polymorphism affects muscle mass in older Japanese women...
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    ..Using differential amino acid labeling and mass spectrometry, we observed insulin-dependent co-precipitation of actinin-4 (ACTN4) with GLUT4 (Foster, L. J., Rudich, A., Talior, I., Patel, N., Huang, X., Furtado, L. M., Bilan, P. J...
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    ..Here we show that the F-actin-binding protein ?-actinin targets CaMKII? to F-actin in cells by binding to the CaMKII regulatory domain, mimicking CaM...
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    The R577X polymorphism in the alpha-actinin-3 encoding gene (ACTN3) has been associated with elite athletic performance, and recently with differences in isometric and dynamic muscle strength and power in the general population...
  77. Shao H, Wu C, Wells A. Phosphorylation of alpha-actinin 4 upon epidermal growth factor exposure regulates its interaction with actin. J Biol Chem. 2010;285:2591-600 pubmed publisher
    ..We expressed the two isoforms of human alpha-actinin in murine fibroblasts that express human epidermal growth factor receptor (EGFR) and found that both alpha-..
  78. Broos S, Malisoux L, Theisen D, Francaux M, Deldicque L, Thomis M. Role of alpha-actinin-3 in contractile properties of human single muscle fibers: a case series study in paraplegics. PLoS ONE. 2012;7:e49281 pubmed publisher
    A common nonsense polymorphism in the ACTN3 gene results in the absence of ?-actinin-3 in XX individuals...
  79. Gomez Gallego F, Santiago C, Gonzalez Freire M, Muniesa C, Fernández Del Valle M, Perez M, et al. Endurance performance: genes or gene combinations?. Int J Sports Med. 2009;30:66-72 pubmed publisher
    ..association between variants of the genes encoding for the angiotensin-converting enzyme ( ACE) and alpha-actinin-3 ( ACTN3) (both individually and combined) and several endurance phenotypic traits, e.g...
  80. Sa E Cunha C, Griffiths N, Murillo I, Virji M. Neisseria meningitidis Opc invasin binds to the cytoskeletal protein alpha-actinin. Cell Microbiol. 2009;11:389-405 pubmed publisher
    ..The identity of the protein was established as alpha-actinin by mass spectrometry...
  81. McCauley T, Mastana S, Hossack J, Macdonald M, Folland J. Human angiotensin-converting enzyme I/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties. Exp Physiol. 2009;94:81-9 pubmed publisher
    The angiotensin-converting enzyme (ACE) I/D and alpha-actinin 3 (ACTN3) R/X polymorphisms have been suggested to influence variations in skeletal muscle function...
  82. Ruiz J, Arteta D, Buxens A, Artieda M, Gomez Gallego F, Santiago C, et al. Can we identify a power-oriented polygenic profile?. J Appl Physiol (1985). 2010;108:561-6 pubmed publisher
    ..e., approximately 0.2% (or 1 in 500 Spanish individuals). We have identified a polygenic profile that allows us, at least partly, to distinguish elite power athletes from both endurance athletes and nonathletic population. ..
  83. Eynon N, Alves A, Meckel Y, Yamin C, Ayalon M, Sagiv M, et al. Is the interaction between HIF1A P582S and ACTN3 R577X determinant for power/sprint performance?. Metabolism. 2010;59:861-5 pubmed publisher
    ..However, sprinter performance is determined by the interaction between the wild-type HIF1A Pro/Pro genotype and ACTN3 RR genotype. ..
  84. Khurana S, Chakraborty S, Lam M, Liu Y, Su Y, Zhao X, et al. Familial focal segmental glomerulosclerosis (FSGS)-linked ?-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors. J Biol Chem. 2012;287:12027-35 pubmed publisher
    Mutations in ?-actinin 4 (ACTN4) are linked to familial forms of focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria due to podocyte injury...
  85. Eynon N, Alves A, Yamin C, Duarte J, Oliveira J, Ayalon M, et al. Is there an ACE ID - ACTN3 R577X polymorphisms interaction that influences sprint performance?. Int J Sports Med. 2009;30:888-91 pubmed publisher
    Functional R577X (rs.1815739) and ID (rs.5186) polymorphisms in the alpha-actinin-3 ( ACTN3) and the angiotensin converting enzyme (ACE) genes, respectively, have been associated with sprint performance...
  86. Sen S, Dong M, Kumar S. Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS ONE. 2009;4:e8427 pubmed publisher
    ..Expression of the actin binding protein alpha-actinin has been strongly correlated with the invasive phenotype of GBM in vivo...