actin related protein 3


Summary: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.

Top Publications

  1. Maisch J, Fiserova J, Fischer L, Nick P. Tobacco Arp3 is localized to actin-nucleating sites in vivo. J Exp Bot. 2009;60:603-14 pubmed publisher
    ..These findings are interpreted in terms of position-dependent differences of actin organization. ..
  2. Balcer H, Daugherty Clarke K, Goode B. The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation. J Biol Chem. 2010;285:8481-91 pubmed publisher
  3. Tang D, Zhang W, Gunst S. The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle. J Biol Chem. 2005;280:23380-9 pubmed
    ..These studies suggest a novel signaling pathway for the regulation of N-WASp activation and active contraction in smooth muscle tissues. ..
  4. Iwasa J, Mullins R. Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol. 2007;17:395-406 pubmed
    ..Cofilin, twinfilin, and tropomyosin appear to play no role in lamellipodial network assembly but function to limit its size. ..
  5. Nolen B, Tomasevic N, Russell A, Pierce D, Jia Z, McCormick C, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009;460:1031-4 pubmed publisher
    ..Two inhibitors with different mechanisms of action provide a powerful approach for studying the Arp2/3 complex in living cells. ..
  6. Zahradka P, Storie B, Wright B. IGF-1 receptor transactivation mediates Src-dependent cortactin phosphorylation in response to angiotensin II. Can J Physiol Pharmacol. 2009;87:805-12 pubmed publisher
    ..These data establish that IGF-1 receptor transactivation is required for Src kinase-mediated cortactin phosphorylation and cytoskeletal reorganization in response to Ang II. ..
  7. Goley E, Rammohan A, Znameroski E, Firat Karalar E, Sept D, Welch M. An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability. Proc Natl Acad Sci U S A. 2010;107:8159-64 pubmed publisher
  8. Grassart A, Meas Yedid V, Dufour A, Olivo Marin J, Dautry Varsat A, Sauvonnet N. Pak1 phosphorylation enhances cortactin-N-WASP interaction in clathrin-caveolin-independent endocytosis. Traffic. 2010;11:1079-91 pubmed publisher
    ..Thus, Pak1, by controlling the interaction between cortactin and N-WASP, could regulate the polymerization of actin during clathrin-independent endocytosis. ..
  9. Lie P, Chan A, Mruk D, Lee W, Cheng C. Restricted Arp3 expression in the testis prevents blood-testis barrier disruption during junction restructuring at spermatogenesis. Proc Natl Acad Sci U S A. 2010;107:11411-6 pubmed publisher

More Information


  1. D Souza R, Pathak S, Upadhyay R, Gaonkar R, D Souza S, Sonawane S, et al. Disruption of tubulobulbar complex by high intratesticular estrogens leading to failed spermiation. Endocrinology. 2009;150:1861-9 pubmed publisher
    ..In conclusion, the present study reports the role of 17beta-estradiol in inhibiting the formation of tubulobulbar complex, which could be one of the mechanism by which environmental estrogens influence male fertility...
  2. Insall R, Machesky L. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell. 2009;17:310-22 pubmed publisher
    ..Future progress depends on connecting these processes and components to the dynamic behavior of the whole cell in three dimensions. ..
  3. Roh Johnson M, Goldstein B. In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation. J Cell Sci. 2009;122:3983-93 pubmed publisher
    ..elegans gastrulation: in addition to apical constriction, internalization of the endoderm might involve dynamic Arp2/3-dependent F-actin-rich extensions on one side of a ring of cells. ..
  4. Derivery E, Sousa C, Gautier J, Lombard B, Loew D, Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009;17:712-23 pubmed publisher
    ..Together, these data suggest that the WASH molecular machine, integrating CP with a NPF, controls the fission of endosomes through an interplay between the forces generated by microtubule motors and actin polymerization. ..