Genomes and Genes
actin related protein 3
Summary: A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. It is expressed at higher levels than ARP2 PROTEIN and does not contain a PROFILIN binding domain.
- D Souza R, Pathak S, Upadhyay R, Gaonkar R, D Souza S, Sonawane S, et al. Disruption of tubulobulbar complex by high intratesticular estrogens leading to failed spermiation. Endocrinology. 2009;150:1861-9 pubmed publisher..In conclusion, the present study reports the role of 17beta-estradiol in inhibiting the formation of tubulobulbar complex, which could be one of the mechanism by which environmental estrogens influence male fertility...
- Insall R, Machesky L. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell. 2009;17:310-22 pubmed publisher..Future progress depends on connecting these processes and components to the dynamic behavior of the whole cell in three dimensions. ..
- Roh Johnson M, Goldstein B. In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation. J Cell Sci. 2009;122:3983-93 pubmed publisher..elegans gastrulation: in addition to apical constriction, internalization of the endoderm might involve dynamic Arp2/3-dependent F-actin-rich extensions on one side of a ring of cells. ..
- Derivery E, Sousa C, Gautier J, Lombard B, Loew D, Gautreau A. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Dev Cell. 2009;17:712-23 pubmed publisher..Together, these data suggest that the WASH molecular machine, integrating CP with a NPF, controls the fission of endosomes through an interplay between the forces generated by microtubule motors and actin polymerization. ..