dextran sulfate


Summary: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.

Top Publications

  1. Owen K, Abshire M, Tilghman R, Casanova J, Bouton A. FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing. PLoS ONE. 2011;6:e23123 pubmed publisher
  2. Gabele E, Dostert K, Hofmann C, Wiest R, Scholmerich J, Hellerbrand C, et al. DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH. J Hepatol. 2011;55:1391-9 pubmed publisher
    ..Bacterial endotoxin has been shown to promote NASH progression. Application of dextran sulfate sodium (DSS) is a colitis model in mice characterized by damage of the intestinal barrier...
  3. Jerkic M, Peter M, Ardelean D, Fine M, Konerding M, Letarte M. Dextran sulfate sodium leads to chronic colitis and pathological angiogenesis in Endoglin heterozygous mice. Inflamm Bowel Dis. 2010;16:1859-70 pubmed publisher
    ..C57BL/6 Eng(+/-) and littermate control mice drank water supplemented with 3% dextran sulfate sodium (DSS) for 5 days and were monitored for up to 26 days for clinical signs of colitis...
  4. Donskow Łysoniewska K, Majewski P, Brodaczewska K, Jóźwicka K, Doligalska M. Heligmosmoides polygyrus fourth stages induce protection against DSS-induced colitis and change opioid expression in the intestine. Parasite Immunol. 2012;34:536-46 pubmed publisher
  5. Le Leu R, Young G, Hu Y, Winter J, Conlon M. Dietary red meat aggravates dextran sulfate sodium-induced colitis in mice whereas resistant starch attenuates inflammation. Dig Dis Sci. 2013;58:3475-82 pubmed publisher
    ..was to determine the effects of feeding a red meat diet with and without resistant starch (RS) to mice with dextran sulfate sodium (DSS)-induced colitis. Colonic experimental colitis was induced in Balb/c mice using DSS...
  6. Kim J, Bridle B, Ghia J, Wang H, Syed S, Manocha M, et al. Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. J Immunol. 2013;190:4795-804 pubmed publisher
    ..Colitis was induced with dextran sulfate sodium (DSS) or dinitrobenzene sulfonic acid (DNBS) in mice treated with selective 5-HT7 receptor antagonist ..
  7. Kotagiri N, Lee J, Kim J. Selective pathogen targeting and macrophage evading carbon nanotubes through dextran sulfate coating and PEGylation for photothermal theranostics. J Biomed Nanotechnol. 2013;9:1008-16 pubmed
    ..Here, we demonstrate the stealth character of dextran sulfate (DS) coated SWNTs (DS-SWNTs) towards human macrophages and other biological barriers using Staphylococcus ..
  8. Matos I, Bento A, Marcon R, Claudino R, Calixto J. Preventive and therapeutic oral administration of the pentacyclic triterpene ?,?-amyrin ameliorates dextran sulfate sodium-induced colitis in mice: the relevance of cannabinoid system. Mol Immunol. 2013;54:482-92 pubmed publisher
    ..We assessed the anti-inflammatory effects of the ?,?-amyrin in the dextran sulfate sodium (DSS)-induced colitis in mice and investigated whether its effects were associated with the ..
  9. Rose W, Sakamoto K, Leifer C. Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BMC Immunol. 2012;13:41 pubmed publisher
    ..Oral administration of dextran sulfate sodium (DSS) to mice induces a reproducible experimental colitis that models several intestinal lesions ..

More Information


  1. Tsai Z, Tsai F, Yang W, Wang J, Liu C, Shen C, et al. Preparation and characterization of ferrofluid stabilized with biocompatible chitosan and dextran sulfate hybrid biopolymer as a potential magnetic resonance imaging (MRI) T2 contrast agent. Mar Drugs. 2012;10:2403-14 pubmed publisher
    ..polymer composed of polyelectrolyte complexes (PECs) from chitosan, the positively charged polymer, and dextran sulfate, the negatively charged polymer...
  2. Wende E, Laudeley R, Bleich A, Bleich E, Wetsel R, Glage S, et al. The complement anaphylatoxin C3a receptor (C3aR) contributes to the inflammatory response in dextran sulfate sodium (DSS)-induced colitis in mice. PLoS ONE. 2013;8:e62257 pubmed publisher inflammatory bowel disease, we have investigated the role of the anaphylatoxin C3a receptor in acute dextran sulfate sodium-induced colitis in mice...
  3. Singh K, Coburn L, Barry D, Asim M, Scull B, Allaman M, et al. Deletion of cationic amino acid transporter 2 exacerbates dextran sulfate sodium colitis and leads to an IL-17-predominant T cell response. Am J Physiol Gastrointest Liver Physiol. 2013;305:G225-40 pubmed publisher
    ..ulcerative colitis (UC), a form of inflammatory bowel disease, and is beneficial in murine colitis induced by dextran sulfate sodium (DSS), a model with similarity to UC...
  4. Huang Y, Wen C, Chen Y, Huang W, Huang L, Lin W, et al. Dietary uptake of Wedelia chinensis extract attenuates dextran sulfate sodium-induced colitis in mice. PLoS ONE. 2013;8:e64152 pubmed publisher
    ..we evaluated the effect of Wedelia chinensis, a medicinal herb commonly used in Asia, on the prevention of dextran sulfate sodium (DSS)-induced acute colitis in mice...
  5. You D, Saravanakumar G, Son S, Han H, Heo R, Kim K, et al. Dextran sulfate-coated superparamagnetic iron oxide nanoparticles as a contrast agent for atherosclerosis imaging. Carbohydr Polym. 2014;101:1225-33 pubmed publisher
    ..In this study, dextran sulfate-coated superparamagnetic iron oxide nanoparticles (DS-SPIONs), as a magnetic resonance (MR) imaging contrast ..
  6. Hou Y, Liu J, Pai M, Tsou S, Yeh S. Alanyl-glutamine administration suppresses Th17 and reduces inflammatory reaction in dextran sulfate sodium-induced acute colitis. Int Immunopharmacol. 2013;17:1-8 pubmed publisher
    ..of alanyl-glutamine (Ala-Gln) on Th cell-associated cytokine expressions and inflammatory reaction in dextran sulfate sodium (DSS)-induced colitis...
  7. Koller F, Dozier E, Nam K, Swee M, Birkland T, Parks W, et al. Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia. Lab Invest. 2012;92:1749-59 pubmed publisher
    ..a single MMP family member, MMP10, and assess its role in a murine model of colonic tissue damage induced by dextran sulfate sodium (DSS) treatment...
  8. Hwang J, Lee S, Kim Y, Kim E, Ahn C, Jeon Y, et al. Purification and characterization of a novel peptide with inhibitory effects on colitis induced mice by dextran sulfate sodium from enzymatic hydrolysates of Crassostrea gigas. Fish Shellfish Immunol. 2012;33:993-9 pubmed publisher
    ..gigas showed decreased serum IgE levels and increased spleen CD4(+)/CD8(+) levels on dextran sulfate sodium (DSS) induced colitis in mice. These results suggest the peptide and hydrolysate from C...
  9. Wen X, Wang C, Yu C, Zhang Z, Calway T, Wang Y, et al. Salvia miltiorrhiza (dan shen) significantly ameliorates colon inflammation in dextran sulfate sodium induced colitis. Am J Chin Med. 2013;41:1097-108 pubmed publisher
    ..05). Colitis histological data supported the pharmacological observations. Thus, Salvia miltiorrhiza could be a promising candidate in preventing and treating colitis and in reducing the risks of inflammation-associated colorectal cancer...
  10. Borniquel S, Jädert C, Lundberg J. Dietary conjugated linoleic acid activates PPAR? and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. J Nutr. 2012;142:2135-40 pubmed publisher
    ..b>Dextran sulfate sodium (2%) was used to induce colitis in mice and they were simultaneously fed with a standard or a CLA-..
  11. Sha T, Igaki K, Yamasaki M, Watanabe T, Tsuchimori N. Establishment and validation of a new semi-chronic dextran sulfate sodium-induced model of colitis in mice. Int Immunopharmacol. 2013;15:23-9 pubmed publisher
    The dextran sulfate sodium (DSS)-induced model of colitis is a commonly used model of inflammatory bowel disease (IBD) in animals...
  12. Araki A, Nara H, Rahman M, Onoda T, Li J, Juliana F, et al. Role of interleukin-21 isoform in dextran sulfate sodium (DSS)-induced colitis. Cytokine. 2013;62:262-71 pubmed publisher
    ..These results indicate that besides IL-21, IL-21iso may be another regulator of gut inflammation. ..
  13. Yamamoto A, Itoh T, Nasu R, Nishida R. Effect of sodium alginate on dextran sulfate sodium- and 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis in mice. Pharmacology. 2013;92:108-16 pubmed publisher
    We evaluated the effects of sodium alginate (AL-Na) on dextran sulfate sodium (DSS)- and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. DSS was added to the drinking water for 7 days...
  14. Snider A, Wu B, Jenkins R, Sticca J, Kawamori T, Hannun Y, et al. Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. Prostaglandins Other Lipid Mediat. 2012;99:124-30 pubmed publisher
    ..To this end, we established nCDase expression is increased in patients with ulcerative colitis. Using the dextran sulfate sodium (DSS)-induced colitis model, we determined nCDase activity increased in colon epithelium, but not ..
  15. Kang C, Ban M, Choi E, Moon H, Jeon J, Kim D, et al. Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis. PLoS ONE. 2013;8:e76520 pubmed publisher
    ..Experimental IBD model was established by oral application of dextran sulfate sodium (DSS) to C57BL/6 mice...
  16. Chang H, Miaw S, Tseng W, Sun Y, Liu C, Tsao H, et al. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol. 2013;191:2134-43 pubmed publisher
    ..PTPN22-deficient mice develop severe colitis induced by dextran sulfate sodium, and their intestinal macrophages express higher levels of M1 genes but lower levels of M2-associated ..
  17. Sánchez Fidalgo S, Cárdeno A, Sanchez Hidalgo M, Aparicio Soto M, de la Lastra C. Dietary extra virgin olive oil polyphenols supplementation modulates DSS-induced chronic colitis in mice. J Nutr Biochem. 2013;24:1401-13 pubmed publisher
    ..We concluded that PE-enriched EVOO diet could be a beneficial functional food on ulcerative colitis. ..
  18. Kleiveland C, Hult L, Spetalen S, Kaldhusdal M, Christofferesen T, Bengtsson O, et al. The noncommensal bacterium Methylococcus capsulatus (Bath) ameliorates dextran sulfate (Sodium Salt)-Induced Ulcerative Colitis by influencing mechanisms essential for maintenance of the colonic barrier function. Appl Environ Microbiol. 2013;79:48-56 pubmed publisher
    ..Brevibacillus agri, and Aneurinibacillus sp. At day 8, colitis was induced by 3.5% dextran sulfate sodium (DSS) ad libitum in the drinking water for 6 days...
  19. Araki Y, Bamba T, Mukaisho K, Kanauchi O, Ban H, Bamba S, et al. Dextran sulfate sodium administered orally is depolymerized in the stomach and induces cell cycle arrest plus apoptosis in the colon in early mouse colitis. Oncol Rep. 2012;28:1597-605 pubmed publisher
    ..The pathogenic factors for dextran sulfate sodium (DSS)-induced colitis, one of the experimental animal colitis models, also remain unknown...
  20. Ding S, Walton K, Blue R, McNaughton K, Macnaughton K, Magness S, et al. Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen ?1(I)-promoter-GFP reporter mice. PLoS ONE. 2012;7:e42568 pubmed publisher
    ..The procollagen ?1(I)-GFP transgenic provides a useful model to study activation of a gene encoding a major extracellular matrix protein during acute or chronic experimental intestinal inflammation and fibrosis. ..
  21. Hou Y, Chu C, Ko T, Yeh C, Yeh S. Effects of alanyl-glutamine dipeptide on the expression of colon-inflammatory mediators during the recovery phase of colitis induced by dextran sulfate sodium. Eur J Nutr. 2013;52:1089-98 pubmed publisher
    ..investigated the effects of Gln on colonic-inflammatory-mediator expression and mucosal repair in mice with dextran sulfate sodium (DSS)-induced colitis...
  22. Song J, Qian Y, Li G, Zhao X. Anti-inflammatory effects of kudingcha methanol extract (Ilex kudingcha C.J. Tseng) in dextran sulfate sodium-induced ulcerative colitis. Mol Med Rep. 2013;8:1256-62 pubmed publisher
    ..J. Tseng methanol extracts (KME) on 3% dextran sulfate sodium (DSS)?induced ulcerative colitis (UC) in mice (C57BL/6J strain)...
  23. Wada S, Sato K, Ohta R, Wada E, Bou Y, Fujiwara M, et al. Ingestion of low dose pyroglutamyl leucine improves dextran sulfate sodium-induced colitis and intestinal microbiota in mice. J Agric Food Chem. 2013;61:8807-13 pubmed publisher
    ..Acute colitis was induced by dextran sulfate sodium (DSS), and various concentrations of pyroGlu-Leu were administrated by oral gavage for 7 days...
  24. Boehm F, Martin M, Kesselring R, Schiechl G, Geissler E, Schlitt H, et al. Deletion of Foxp3+ regulatory T cells in genetically targeted mice supports development of intestinal inflammation. BMC Gastroenterol. 2012;12:97 pubmed
    ..Intermittent depletion of Foxp3+ Treg aggravates intestinal inflammatory responses demonstrating the importance of Foxp3+ Treg for the balance at the mucosal surface of the intestine. ..
  25. Zhang R, Ito S, Nishio N, Cheng Z, Suzuki H, Isobe K. Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation. Clin Exp Immunol. 2011;164:417-27 pubmed publisher
    ..Further, transplantation of Gr-1(+)CD11b(+) cells greatly suppressed the increase of the same population, especially during the late phase of DSS colitis both in spleen and bone marrow. ..
  26. Bauer C, Duewell P, Mayer C, Lehr H, Fitzgerald K, Dauer M, et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 2010;59:1192-9 pubmed publisher
    ..The NLRP3 inflammasome was identified as a critical mechanism of intestinal inflammation in the DSS colitis model. The NLRP3 inflammasome may serve as a potential target for the development of novel therapeutics for patients with IBD. ..
  27. Chiou Y, Ma N, Sang S, Ho C, Wang Y, Pan M. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012;60:3441-51 pubmed publisher
    ..chemopreventive effects and underlying molecular mechanisms of dietary administration of AcEGCG and EGCG in dextran sulfate sodium (DSS)-induced colitis in mice...
  28. Li N, Ghia J, Wang H, McClemens J, Cote F, Suehiro Y, et al. Serotonin activates dendritic cell function in the context of gut inflammation. Am J Pathol. 2011;178:662-71 pubmed publisher
    ..TPH1(-/-)) mice, which have reduced serotonin in the gut, and wild-type (TPH1(+/+)) mice with or without dextran sulfate sodium (DSS)-induced colitis were stimulated with lipopolysaccharide to assess interleukin-12 (IL-12) ..
  29. Koch S, Nava P, Addis C, Kim W, Denning T, Li L, et al. The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology. 2011;141:259-68, 268.e1-8 pubmed publisher
    ..Intestinal inflammation was induced with dextran sulfate sodium (DSS), followed by a recovery period in which mice were given regular drinking water...
  30. Guri A, Mohapatra S, Horne W, Hontecillas R, Bassaganya Riera J. The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol. 2010;10:60 pubmed publisher
  31. Takagi T, Naito Y, Uchiyama K, Suzuki T, Hirata I, Mizushima K, et al. Carbon monoxide liberated from carbon monoxide-releasing molecule exerts an anti-inflammatory effect on dextran sulfate sodium-induced colitis in mice. Dig Dis Sci. 2011;56:1663-71 pubmed publisher
    ..These results suggest that CO could become a new therapeutic molecule for inflammatory bowel disease. ..
  32. Murphy C, Moloney G, Macsharry J, Haynes A, Faivre E, Quinlan A, et al. Technical Advance: Function and efficacy of an {alpha}4-integrin antagonist using bioluminescence imaging to detect leukocyte trafficking in murine experimental colitis. J Leukoc Biol. 2010;88:1271-8 pubmed publisher
    ..Furthermore, in vivo bioluminescence imaging is a valuable strategy for preclinical evaluation of potential therapeutics that target leukocyte trafficking in inflammatory diseases. ..
  33. Fiorotto R, Scirpo R, Trauner M, Fabris L, Hoque R, Spirli C, et al. Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-?B-mediated inflammatory response in mice. Gastroenterology. 2011;141:1498-508, 1508.e1-5 pubmed publisher
    ..These findings might be used to develop therapies for CF-associated cholangiopathy. ..
  34. Bento A, Marcon R, Dutra R, Claudino R, Cola M, Leite D, et al. ?-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPAR? pathway. Am J Pathol. 2011;178:1153-66 pubmed publisher
    ..In this study, we examined the anti-inflammatory effect of BCP in dextran sulfate sodium (DSS)-induced colitis and analyzed whether this effect was mediated by CB2 and PPAR?...
  35. Cai J, Zhang N, Zheng Y, de Wilde R, Maitra A, Pan D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 2010;24:2383-8 pubmed publisher
    ..Thus, the YAP oncoprotein must be exquisitely controlled in tissue regeneration to allow compensatory proliferation and prevent the intrinsic oncogenic potential of a tissue regeneration program. ..
  36. Haselberg R, de Jong G, Somsen G. Capillary electrophoresis-mass spectrometry of intact basic proteins using Polybrene-dextran sulfate-Polybrene-coated capillaries: system optimization and performance. Anal Chim Acta. 2010;678:128-34 pubmed publisher
    ..Capillaries were coated by subsequent rinsing with solutions of Polybrene, dextran sulfate and Polybrene...
  37. Dong L, Li J, Liu Y, Yue W, Luo X. Toll-like receptor 2 monoclonal antibody or/and Toll-like receptor 4 monoclonal antibody increase counts of Lactobacilli and Bifidobacteria in dextran sulfate sodium-induced colitis in mice. J Gastroenterol Hepatol. 2012;27:110-9 pubmed publisher
    ..This study was to evaluate the effect of TLR2 and TLR4 monoclonal antibodies on gut microbial flora in dextran sulfate sodium (DSS)-induced colitis in a mouse model...
  38. Sydora B, Albert E, Foshaug R, Doyle J, Churchill T, Fedorak R. Intravenous injection of endogenous microbial components abrogates DSS-induced colitis. Dig Dis Sci. 2012;57:345-54 pubmed publisher
    ..Pretreatment with high amount of endogenous bacterial components has a profound tolerogenic effect on the systemic and mucosal immune responses resulting in reduced intestinal inflammation and abrogates colitis-induced weight loss. ..
  39. Hall L, Faivre E, Quinlan A, Shanahan F, Nally K, Melgar S. Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis. Dig Dis Sci. 2011;56:79-89 pubmed publisher
    ..This will facilitate a more informed and sophisticated use of this model both for investigating basic mechanisms of intestinal inflammation and for the evaluation of potential new therapeutic agents for IBD. ..
  40. Okada Y, Maeda N, Takakura S, Miyata K, Koshiba M. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-? and interleukin-1? suppression. Biol Pharm Bull. 2011;34:1823-7 pubmed
    We investigated the effect of tacrolimus, a calcineurin inhibitor, on dextran sulfate sodium (DSS)-induced colitis...
  41. Qiu W, Wu B, Wang X, Buchanan M, Regueiro M, Hartman D, et al. PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest. 2011;121:1722-32 pubmed publisher
    ..In mice, PUMA was markedly induced in colonic epithelial cells following induction of colitis by either dextran sulfate sodium salt (DSS) or 2,4,6-trinitrobenzene sulfonic acid (TNBS)...
  42. Yao J, Wang J, Liu L, Li Y, Xun A, Zeng W, et al. Anti-oxidant effects of resveratrol on mice with DSS-induced ulcerative colitis. Arch Med Res. 2010;41:288-94 pubmed publisher
    ..Oral administration of Res exerts marked inhibitory effects on UC in mice. Resveratrol may play an important role in preventing DSS-induced oxidative damage. ..
  43. Yao J, Wang J, Lai M, Li Y, Zhu H, Shi R, et al. Treatment of mice with dextran sulfate sodium-induced colitis with human interleukin 10 secreted by transformed Bifidobacterium longum. Mol Pharm. 2011;8:488-97 pubmed publisher
    ..longum (BL-hIL-10) and investigated its effects on 5% dextran sulfate sodium (DSS)-induced ulcerative colitis in mice and the possible underlying mechanism...
  44. Shaker A, Swietlicki E, Wang L, Jiang S, Onal B, Bala S, et al. Epimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion. J Clin Invest. 2010;120:2081-93 pubmed publisher
    ..Furthermore, we believe that modulation of epimorphin expression may have therapeutic benefits in appropriate clinical settings...
  45. Imaeda H, Andoh A, Aomatsu T, Uchiyama K, Bamba S, Tsujikawa T, et al. Interleukin-33 suppresses Notch ligand expression and prevents goblet cell depletion in dextran sulfate sodium-induced colitis. Int J Mol Med. 2011;28:573-8 pubmed publisher
    ..IL-33-induced goblet cell hyperplasia, we investigated how IL-33 modulates the Notch signaling pathway in dextran sulfate sodium (DSS)-induced experimental colitis...
  46. Singh N, Singh U, Singh B, Price R, Nagarkatti M, Nagarkatti P. Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis. PLoS ONE. 2011;6:e23522 pubmed publisher
    ..These studies demonstrate for the first time that AhR activation promotes epigenetic regulation thereby influencing reciprocal differentiation of Tregs and Th17 cells, and amelioration of inflammation. ..
  47. Park M, Ji G, Sung M. Dietary kaempferol suppresses inflammation of dextran sulfate sodium-induced colitis in mice. Dig Dis Sci. 2012;57:355-63 pubmed publisher
    ..The aim of this study was to determine whether kaempferol alleviates the inflammatory responses of dextran sulfate sodium (DSS)-induced colitis in mice...
  48. Liu Y, Su Y, Ong W, Cheng T, Tsai Y. Oral administration of Lactobacillus plantarum K68 ameliorates DSS-induced ulcerative colitis in BALB/c mice via the anti-inflammatory and immunomodulatory activities. Int Immunopharmacol. 2011;11:2159-66 pubmed publisher
    ..Additionally, orally administered K68 ameliorated dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in BALB/c mice...
  49. Zhao Z, Xiang J, Liu L, Huang X, Gan H. Parthenolide, an inhibitor of the nuclear factor-?B pathway, ameliorates dextran sulfate sodium-induced colitis in mice. Int Immunopharmacol. 2012;12:169-74 pubmed publisher
    ..Experimental colitis was induced by dextran sulfate sodium (DSS), and mice were divided into 3 groups: normal control, DSS+saline, and DSS+parthenolide...
  50. Amrouche Mekkioui I, Djerdjouri B. N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice. Eur J Pharmacol. 2012;691:209-17 pubmed publisher
    ..Male NMRI mice were given 5% dextran sulfate sodium (DSS) in drinking water for 5 days followed by 10 days of water, three times...
  51. Iwaya H, Kashiwaya M, Shinoki A, Lee J, Hayashi K, Hara H, et al. Marginal zinc deficiency exacerbates experimental colitis induced by dextran sulfate sodium in rats. J Nutr. 2011;141:1077-82 pubmed publisher
    ..We then evaluated whether MZD modulated dextran sulfate sodium (DSS)-induced colonic inflammation by administering 2% DSS to the MZD and ZA groups for 7 d...
  52. Weisser S, Brugger H, Voglmaier N, McLarren K, Van Rooijen N, Sly L. SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis. J Leukoc Biol. 2011;90:483-92 pubmed publisher
    ..Adoptive transfer of M2a m? to patients with IBDs offers a promising, new strategy for treatment that may be particularly useful in patients who are otherwise refractory to conventional therapies. ..
  53. Yoshino T, Nakase H, Honzawa Y, Matsumura K, Yamamoto S, Takeda Y, et al. Immunosuppressive effects of tacrolimus on macrophages ameliorate experimental colitis. Inflamm Bowel Dis. 2010;16:2022-33 pubmed publisher
    ..evaluated the effect of the rectal administration of tacrolimus on colonic inflammation in IL-10-KO mice and dextran sulfate sodium (DSS)-induced colitis in CB.17/SCID mice...
  54. Skyberg J, Robison A, Golden S, Rollins M, Callis G, Huarte E, et al. Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression. J Leukoc Biol. 2011;90:1043-54 pubmed publisher
    ..Collectively, these results show that oral administration of APP protects against experimental colitis and diminishes proinflammatory cytokine expression via T cells. ..