oxidized cellulose


Summary: A cellulose of varied carboxyl content retaining the fibrous structure. It is commonly used as a local hemostatic and as a matrix for normal blood coagulation.

Top Publications

  1. Gao H, Lin C, Yu C, Yu M, Chen A. Oxidized cellulose (Surgicel) granuloma mimicking a primary ovarian tumor. Int J Gynecol Pathol. 2002;21:422-3 pubmed
    ..Histological examination revealed that the mass consisted of a massive foreign-body granulomatous reaction to oxidized cellulose (Surgicel). To our knowledge, this is only the second report of an ovarian Surgicel granuloma.
  2. Sirlak M, Eryilmaz S, Yazicioglu L, Kiziltepe U, Eyileten Z, Durdu M, et al. Comparative study of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) in high transfusion-risk cardiac surgery. J Thorac Cardiovasc Surg. 2003;126:666-70 pubmed
    The effects of microfibrillar collagen hemostat (Colgel) and oxidized cellulose (Surgicel) on bleeding and allogeneic transfusions were compared in cardiac operations with a predicted high risk of bleeding...
  3. Sabino L, Andreoni C, Faria E, Ferreira P, Paz A, Kalil W, et al. Evaluation of renal defect healing, hemostasis, and urinary fistula after laparoscopic partial nephrectomy with oxidized cellulose. J Endourol. 2007;21:551-6 pubmed
    Laparoscopic partial nephrectomy (LPN) has been performed at several institutions using oxidized cellulose (OC) as a means of bleeding and urinary fistula (UF) prevention...
  4. Yoldemir T, Sagol S, Adakan S, Oztekin K, Ozsener S, Karadadas N. Comparison of the reduction of postoperative adhesions by two barriers, one solution, and two pharmacologic agents in the rat uterine model. Fertil Steril. 2002;78:335-9 pubmed
    ..The sodium hyaluronate solution alone and medroxyprogesterone acetate treatment alone had the least adhesion prevention scores. However, neither monotherapy nor combined therapy proved to be significantly more beneficial. ..
  5. Krizova P, Masova L, Suttnar J, Salaj P, Dyr J, Homola J, et al. The influence of intrinsic coagulation pathway on blood platelets activation by oxidized cellulose. J Biomed Mater Res A. 2007;82:274-80 pubmed
    b>Oxidized cellulose is an effective hemostat that works naturally to aid in blood coagulation. The mechanism of its action is not very well understood...
  6. Al Jaroudi D, Tulandi T. Adhesion prevention in gynecologic surgery. Obstet Gynecol Surv. 2004;59:360-7 pubmed
  7. Hadi H, Maw A, Hay D. A simple technique to control iatrogenic solid organ injury haemorrhage. Surgeon. 2004;2:339-40, 361 pubmed
    ..Haemostasis from iatrogenic solid organ injury can be difficult to achieve. We describe the use of oxidized regenerated cellulose (Surgicel) and a Hanna-Belfast suction diathermy device to control minor solid organ haemorrhage ..
  8. Ruan C, Gustafsson S, Strømme M, Mihranyan A, Lindh J. Cellulose Nanofibers Prepared via Pretreatment Based on Oxone® Oxidation. Molecules. 2017;22: pubmed publisher
    ..UV-vis transmittance of dispersions of oxidized cellulose with different degrees of mechanical treatment was recorded...
  9. Uysal A, Alagoz M, Orbay H, Sensoz O. An alternative dressing material for the split-thickness skin graft donor site: oxidized regenerated cellulose. Ann Plast Surg. 2006;57:60-4 pubmed

More Information


  1. Mastronardi L, Puzzilli F. Packing of intervertebral spaces with oxidized regenerated cellulose to prevent the recurrence of lumbar disc herniation. Neurosurgery. 2003;52:1106-9; discussion 1109-10 pubmed
    ..At the moment, it seems reasonable to assume that this technique should be used only under the auspices of large clinical investigations with prospective and randomized protocols. ..
  2. Kanko M, Liman T, Topcu S. A low-cost and simple method to stop intraoperative leakage-type bleeding: use of the vancomycin-oxidized regenerated cellulose (ORC) sandwich. J Invest Surg. 2006;19:323-7 pubmed
  3. Toivonen M, Kurki Suonio S, Wagermaier W, Hynninen V, Hietala S, Ikkala O. Interfacial Polyelectrolyte Complex Spinning of Cellulose Nanofibrils for Advanced Bicomponent Fibers. Biomacromolecules. 2017;18:1293-1301 pubmed publisher
    Fiber spinning of anionic TEMPO-oxidized cellulose (TOCN) nanofibrils with polycations by interfacial polyelectrolyte complexation is demonstrated...
  4. Zawaneh P, Putnam D. Materials in surgery: a review of biomaterials in postsurgical tissue adhesion and seroma prevention. Tissue Eng Part B Rev. 2008;14:377-91 pubmed publisher
    ..This paper provides a review of the pathogenesis and treatment of these surgical complications, with a thorough overview of biomaterial-based treatment and prevention methods. ..
  5. Revaux A, Ducarme G, Luton D. [Prevention of intrauterine adhesions after hysteroscopic surgery]. Gynecol Obstet Fertil. 2008;36:311-7 pubmed publisher
    ..Data are still insufficient to evaluate them for clinical use. There is a need for other randomised controlled trials. ..
  6. Elahi M, Jackson I, Moreira Gonzalez A, Yamini D. Nasal augmentation with Surgicel-wrapped diced cartilage: a review of 67 consecutive cases. Plast Reconstr Surg. 2003;111:1309-18; discussion 1319-21 pubmed
    ..Patient satisfaction with the aesthetic results was rated highly, with no reports of graft extrusion or contour irregularities. This technique is recommended for nasal augmentation and contouring for selected rhinoplasty patients. ..
  7. Mizutani E, Nakahara K, Miyanaga S, Seike A, Sakai E. [Usefulness of Oxidization-regenerated Cellulose Sheets in Preventing Postoperative Adhesion Confirmed at Second Surgery for Lung Cancer]. Kyobu Geka. 2017;70:1005-1007 pubmed
    ..At surgery, the plain between the upper and lower lobe was covered with a regenerative oxidized cellulose membrane...
  8. Duncan C, Richardson D, May P, Thiruchelvam J, Shong D, Potter F, et al. Reducing blood loss in synostosis surgery: the Liverpool experience. J Craniofac Surg. 2008;19:1424-30 pubmed publisher
    ..Our findings support the recommendation that all of these cases be carried out in multidisciplinary units where high patient throughput allows both maintenance of skills and completion of audit cycles. ..
  9. Vytrasova J, Tylsova A, Brozkova I, Cervenka L, Pejchalova M, Havelka P. Antimicrobial effect of oxidized cellulose salts. J Ind Microbiol Biotechnol. 2008;35:1247-52 pubmed publisher
    Antimicrobial properties of oxidized cellulose and its salts in linters (-L) and microsphere (-M) form (OKCEL H-L, OKCEL Zn-M, OKCEL ZnNa-L, OKCEL ZnNa-M and OKCEL Ag-L) were tested by a dilution method against a spectrum of microbial ..
  10. McColl R, Hochman D, Sample C. Laparoscopic management of splenic cysts: marsupialization, cavity lining with surgicel and omentopexy to prevent recurrence. Surg Laparosc Endosc Percutan Tech. 2007;17:455-8 pubmed
    ..Laparoscopic marsupialization of splenic cysts in combination with lining the cyst cavity with Surgicel and omentopexy is a safe, feasible, and efficacious method of management with excellent results at 25-month follow-up. ..
  11. Smrcka M. [Use of oxicellulose in neurosurgery--technical comments]. Rozhl Chir. 2001;80:12-5 pubmed
    ..e. oxidized cellulose in powder form. Since 1996 the author uses in brain surgery Surgical, extradurally Spongostan...
  12. Rodgers K, Robertson J, Espinoza T, Oppelt W, Cortese S, diZerega G, et al. Reduction of epidural fibrosis in lumbar surgery with Oxiplex adhesion barriers of carboxymethylcellulose and polyethylene oxide. Spine J. 2003;3:277-83; discussion 284 pubmed
    ..In addition, these experiments demonstrated that the gel/film combination provided no additional benefit to that obtained by the gel alone. Gels of CMC/PEO reduced epidural fibrosis and did not impair normal heal ing. ..
  13. Derbyshire A. The use of combination treatments and dressings for a traumatic wound. Br J Nurs. 2004;13:987-93 pubmed
    ..Dressings used in the case study are Promogran, Actisorb Silver 220 and Tielle Plus manufactured by Johnson & Johnson. ..
  14. Lee M, Heo M, Lee H, Kim Y, Shin J. Tunable softening and toughening of individualized cellulose nanofibers-polyurethane urea elastomer composites. Carbohydr Polym. 2017;159:125-135 pubmed publisher
    ..exhibiting softening, was prepared using in situ polymerization by homogeneously dispersing TEMPO-oxidized cellulose individualized nanofibers (TOCNs) in a polyurethane urea (PUU) matrix...
  15. Genc A, Taneli F, Yilmaz O, Turkdogan P, Arslan O, Sencan A, et al. Effect of adhesion barrier (Interceed TC7) on two-stage orchidopexy operation. Scand J Urol Nephrol. 2004;38:401-4 pubmed
    ..0 +/- 30.0 vs 77.1 +/- 21.3 microm, respectively; p < 0.038). The adhesion scores and the biochemical and histopathological examinations showed that an adhesion barrier is not beneficial in two-stage orchidopexy. ..
  16. Dua S, Purandare N, Merchant N, Pramesh C. Oxidised regenerated cellulose: an unusual cause of paraplegia following oesophagectomy. Interact Cardiovasc Thorac Surg. 2010;10:833-5 pubmed publisher
    ..We describe a middle aged woman who developed post-thoracotomy paraplegia following ORC compression on the spinal cord. ..
  17. Ashworth D, Whear N. The haemostatic poultice: an aid to microvascular anastomosis. Br J Oral Maxillofac Surg. 2003;41:353-4 pubmed
  18. Oztürkcan S, Katilmiş H, Ozkul Y, Erdogan N, Başoğlu S, Tayfun M. Surgical treatment of the high jugular bulb by compressing sinus sigmoideus: two cases. Eur Arch Otorhinolaryngol. 2008;265:987-91 pubmed
    ..Venous MR angiographies showed no flow in postoperative controls. Although it is very rarely seen clinically, we present two HJB cases and different treatment perspectives accompanied by literature. ..
  19. Sakuma J, Suzuki K, Sasaki T, Matsumoto M, Oinuma M, Kawakami M, et al. Monitoring and preventing blood flow insufficiency due to clip rotation after the treatment of internal carotid artery aneurysms. J Neurosurg. 2004;100:960-2 pubmed
    ..Motor evoked potential amplitude was maintained until dural closure. Postoperatively, the patient demonstrated no neurological deficit and there was no newly developed low-density area on computerized tomography scans. ..
  20. Kumar V, Kang J, Yang T. Preparation and characterization of spray-dried oxidized cellulose microparticles. Pharm Dev Technol. 2001;6:449-58 pubmed
    The goal of this study was to investigate the feasibility of spray drying to produce microparticles of oxidized cellulose (OC), a biocompatible and bioresorbable polymer...
  21. Kumar V, Kang J, Hohl R. Improved dissolution and cytotoxicity of camptothecin incorporated into oxidized-cellulose microspheres prepared by spray drying. Pharm Dev Technol. 2001;6:459-67 pubmed
    ..5 x 10(-2) and 0.75 microg/mL, respectively, against the THP-1 line. The higher activity of OC-20/CPT microspheres compared to that of the free drug is attributed to increased dissolution of CPT from microspheres. ..
  22. Buffa J, Grela M, Aranguren M, Mucci V. EPR spectroscopy applied to the study of the TEMPO mediated oxidation of nanocellulose. Carbohydr Polym. 2016;136:744-9 pubmed publisher
    ..Two different methods of pH control were used in the synthesis of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) oxidized cellulose nanocrystals (CNC) and the reaction kinetics and degree of oxidation were investigated...
  23. Baumann P, Schumacher H, Husing J, Luntz S, Knaebel H. A randomized, controlled, prospective trial to evaluate the haemostatic effect of Lyostypt versus Surgicel in arterial bypass anastomosis: "COBBANA" trial. Trials. 2009;10:91 pubmed publisher
    ..g. different forms of collagen, oxidized cellulose, gelatine sponge, ethylcyanoacrylate glue or fibrin) with various success...
  24. Masova L, Rysavá J, Krizova P, Suttnar J, Salaj P, Dyr J, et al. Hemostyptic effect of oxidized cellulose on blood platelets. Sb Lek. 2003;104:231-6 pubmed
    ..Serotonin release in platelet rich plasma incubated with various concentrations of oxidized cellulose (0.5%-2.0%) started in about 20 min...
  25. Tamasauskas A, Sinkūnas K, Draf W, Deltuva V, Matukevicius A, Rastenyte D, et al. Management of cerebrospinal fluid leak after surgical removal of pituitary adenomas. Medicina (Kaunas). 2008;44:302-7 pubmed
    ..In more resent practice, the regenerated oxidized cellulose (Surgicel) and collagen sponge with human fibrin (TachoSil) were used to cover the sella membrane defect, ..
  26. Jensen O, Brownd C, Baer D. Maxillary molar sinus floor intrusion at the time of dental extraction. J Oral Maxillofac Surg. 2006;64:1415-9 pubmed
    ..Sinus perforation was occluded with oxidized cellulose. After 4 months of healing, implants were placed and later restored successfully...
  27. Ibrahim M, Aps C, Young C. A foreign body reaction to Surgicel mimicking an abscess following cardiac surgery. Eur J Cardiothorac Surg. 2002;22:489-90; author reply 490 pubmed
  28. Verma G, Lyngdoh T, Kaman L, Bala I. Placement of 0.5% bupivacaine-soaked Surgicel in the gallbladder bed is effective for pain after laparoscopic cholecystectomy. Surg Endosc. 2006;20:1560-4 pubmed
    ..Visceral pain is prominent after laparoscopic cholecystectomy and can be effectively controlled by 0.5% bupivacaine-soaked Surgicel in the gallbladder bed alone. Trocar-site infiltration alone is ineffective. ..
  29. Akbas H, Karacaoglan N, Eroglu L, Uysal A, Incesu L, Kandemir B. Radiologic and histological evaluation of otogenic sliced cartilage grafts at the tip of the chin of rabbits: an experimental study. Otolaryngol Head Neck Surg. 2004;130:453-8 pubmed
    ..The use of autologous cartilage is ideal for many reasons. An attempt was made to produce an experimental animal model to test the efficacy of otogenic Surgicel-wrapped sliced cartilage...
  30. Celebi D, Guy R, Edler K, Scott J. Ibuprofen delivery into and through the skin from novel oxidized cellulose-based gels and conventional topical formulations. Int J Pharm. 2016;514:238-243 pubmed publisher
    The delivery of ibuprofen into and through the skin from novel formulations containing TEMPO-oxidized cellulose nanofibril-based (TOCN) gels was compared to that from two conventional and commercially available products...
  31. Hao J, Xu S, Xu N, Li D, Linhardt R, Zhang Z. Impact of degree of oxidation on the physicochemical properties of microcrystalline cellulose. Carbohydr Polym. 2017;155:483-490 pubmed publisher
    ..molecular weight and the structures of the resulting oligosaccharide products of selectively oxidized cellulose were investigated using x-ray diffraction, thermogravimetric analysis, gel permeation chromatography-..
  32. Soni B, Hassan E, Schilling M, Mahmoud B. Transparent bionanocomposite films based on chitosan and TEMPO-oxidized cellulose nanofibers with enhanced mechanical and barrier properties. Carbohydr Polym. 2016;151:779-789 pubmed publisher
    ..This was accomplished by incorporating TEMPO-oxidized cellulose nanofibers (2,2,6,6-tetramethylpiperidine-1-oxyl radical) into a chitosan matrix...
  33. Isken T, Alagoz S, Onyedi M, Izmirli H. Use of diced bone grafts wrapped in surgicel in the augmentation of maxillofacial area. J Craniofac Surg. 2008;19:1440-5 pubmed publisher
    ..In the later periods, collagen-enhancing effect of Surgicel not only prevents the bone grafts' being noticed, but also softens its consistency. This in turn facilitates adaptation of bone grafts to the facial area. ..
  34. Sharma J, Malhotra M, Pundir P. Laparoscopic oxidized cellulose (Surgicel) application for small uterine perforations. Int J Gynaecol Obstet. 2003;83:271-5 pubmed
    To test the efficacy and safety of laparoscopic oxidized cellulose application at the uterine perforation site. In a prospective study over a 3...
  35. Motoyama S, Laoag Fernandez J, Mochizuki S, Yamabe S, Maruo T. Vaginoplasty with Interceed absorbable adhesion barrier for complete squamous epithelialization in vaginal agenesis. Am J Obstet Gynecol. 2003;188:1260-4 pubmed
    ..The purpose of this study was to present our experiences of an innovative surgical approach for vaginal agenesis with the use of Interceed absorbable adhesion barrier (Ethicon) to achieve a satisfactory neovagina...
  36. Rajab T, Wallwiener M, Kraemer B, Wallwiener C. Evaluation of cross-linked poly gamma-glutamic acid and Interceed in a rat adhesion model. Surgery. 2008;143:152; author reply 153 pubmed
  37. Aghamir S, Khazaeli M, Meisami A. Use of Surgicel for sealing nephrostomy tract after totally tubeless percutaneous nephrolithotomy. J Endourol. 2006;20:293-5 pubmed
    ..In this study, Surgicel (oxidized cellulose) was used to seal the nephrostomy tract after totally tubeless PNL...
  38. Lagman R, Walsh D, Day K. Oxidized cellulose dressings for persistent bleeding from a superficial malignant tumor. Am J Hosp Palliat Care. 2002;19:417-8 pubmed
    ..We report a case where application of oxidized regenerated cellulose surgical dressing appeared to contribute to successful hemostasis. ..
  39. Tabata T, Kihira T, Shiozaki T, Tanida K, Kondo E, Nagao K, et al. Efficacy of a sodium hyaluronate-carboxycellulose membrane (seprafilm) for reducing the risk of early postoperative small bowel obstruction in patients with gynecologic malignancies. Int J Gynecol Cancer. 2010;20:188-93 pubmed publisher
    ..6%) and the control group (6.7%). Placement of Seprafilm helped to prevent EPSBO and had no significant adverse effect on surgical infections in patients who underwent lymphadenectomy for gynecological malignancy. ..
  40. Ayhan A, Basaran A, Güler T. Effects of oxidized regenerated methylcellulose on lymphocyst formation and peritoneum in gynecologic cancer patients. Int J Gynecol Cancer. 2010;20:23-7 pubmed publisher
    ..The role of oxidized regenerated methylcellulose (ORC) in the lymphocyst formation after systematic lymphadenectomy...
  41. Valentine R, Wormald P, Sindwani R. Advances in absorbable biomaterials and nasal packing. Otolaryngol Clin North Am. 2009;42:813-28, ix pubmed publisher
    ..The selection of packing material used in any given sinus procedure should be based on surgeon preference and the details of the specific case. ..
  42. Chen Y, Chen F, Xie P, Qiu P, Zhou J, Deng Y. Combined oxidized cellulose and cyanoacrylate glue in the management of severe presacral bleeding. Surg Today. 2009;39:1016-7 pubmed publisher
    Massive presacral bleeding is a severe complication during a resection of the rectum. The combination of oxidized cellulose and cyanoacrylate glue can quickly control presacral bleeding...
  43. Baysal B. Comparison of the resorbable barrier interceed (TC7) and preoperative use of medroxyprogesterone acetate in postoperative adhesion prevention. Clin Exp Obstet Gynecol. 2001;28:126-7 pubmed
    ..It seems that there are some other mechanisms responsible for this effect rather than anti-inflammation and/or immunosuppression. It may be that the hypoestrogenic milieu depends on the use of progesterone. ..
  44. Brodbelt A, Miles J, Foy P, Broome J. Intraspinal oxidised cellulose (Surgicel) causing delayed paraplegia after thoracotomy--a report of three cases. Ann R Coll Surg Engl. 2002;84:97-9 pubmed
    ..In all intraspinal and perispinal procedures, the over-liberal use of Surgicel should be avoided, and attempts made to remove all excess Surgicel once adequate haemostasis is obtained. ..
  45. Bassetto F, Vindigni V, Scarpa C, Botti C, Botti G. Use of oxidized regenerated cellulose to stop bleeding after a facelift procedure. Aesthetic Plast Surg. 2008;32:807-9 pubmed publisher
    ..In the weeks after the operation no local pain or skin damage was observed. We believe that oxidized regenerated cellulose could be a good ancillary therapy for controlling local bleeding associated with this kind of surgery. ..
  46. Arslan E, Majka C, Polat A. The fate of diced cartilage grafts of traumatized versus nontraumatized origin. Aesthetic Plast Surg. 2007;31:365-71 pubmed
  47. Soares L, Oliveira M, Pinheiro A, Fronza B, Maciel M. Effects of laser therapy on experimental wound healing using oxidized regenerated cellulose hemostat. Photomed Laser Surg. 2008;26:10-3 pubmed publisher
    ..These results suggest that laser therapy at 685 nm could improve the healing process, even when the inflammatory process has been stimulated by oxidized regenerated cellulose hemostat. ..
  48. Alkan A, Inal S, Yildirim M, Bas B, Agar E. The effects of hemostatic agents on peripheral nerve function: an experimental study. J Oral Maxillofac Surg. 2007;65:630-4 pubmed
    ..The present study shows that bovine collagen is the most suitable hemostatic agent applicable for peripheral nerves. ..
  49. Omugha N, Jones A. The management of hard-to-heal necrobiosis with PROMOGRAN. Br J Nurs. 2003;12:S14-20 pubmed
    ..Treatment with a new protease modulating matrix resulted in complete healing of the ulcer after 8 weeks, where other dressing regimens had failed to affect healing over a period of 2.5 years. ..
  50. Prepageran N, Raman R. The use of surgicel to stop epistaxis in children secondary to coagulopathies. Med J Malaysia. 2007;62:87 pubmed
  51. Veves A, Sheehan P, Pham H. A randomized, controlled trial of Promogran (a collagen/oxidized regenerated cellulose dressing) vs standard treatment in the management of diabetic foot ulcers. Arch Surg. 2002;137:822-7 pubmed
    ..Therefore, Promogran may be a useful adjunct in the management of diabetic foot ulceration, especially in ulcers of less than 6 months' duration. ..
  52. Sabel M, Stummer W. The use of local agents: Surgicel and Surgifoam. Eur Spine J. 2004;13 Suppl 1:S97-101 pubmed