Summary: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.

Top Publications

  1. Yatsushiro S, Akamine R, Yamamura S, Hino M, Kajimoto K, Abe K, et al. Quantitative analysis of serum procollagen type I C-terminal propeptide by immunoassay on microchip. PLoS ONE. 2011;6:e18807 pubmed publisher
    ..For the construction of a sandwich ELISA for procollagen type I C-peptide (PICP), a biomarker for bone formation, we used a piezoelectric inkjet printing system for the ..
  2. Jung K, Miller K, Wirth M, Albrecht M, Lein M. Bone turnover markers as predictors of mortality risk in prostate cancer patients with bone metastases following treatment with zoledronic acid. Eur Urol. 2011;59:604-12 pubmed publisher
    ..Serum levels of total and bone-specific alkaline phosphatase, amino-terminal procollagen propeptides of type I collagen (PINP), cross-linked N-terminal (NTx) and cross-linked C-terminal telopeptides ..
  3. Eastell R, Chen P, Saag K, Burshell A, Wong M, Warner M, et al. Bone formation markers in patients with glucocorticoid-induced osteoporosis treated with teriparatide or alendronate. Bone. 2010;46:929-34 pubmed publisher
    ..GIO), and is reflected by decreased biochemical markers of bone formation, such as serum osteocalcin (OC) and procollagen type I N-terminal propeptide (PINP)...
  4. Bhasin S, He E, Kawakubo M, Schroeder E, Yarasheski K, Opiteck G, et al. N-terminal propeptide of type III procollagen as a biomarker of anabolic response to recombinant human GH and testosterone. J Clin Endocrinol Metab. 2009;94:4224-33 pubmed publisher
    ..During collagen synthesis in soft lean tissue, N-terminal propeptide of type III procollagen (P3NP) is released into circulation...
  5. Parkes J, Guha I, Roderick P, Harris S, Cross R, Manos M, et al. Enhanced Liver Fibrosis (ELF) test accurately identifies liver fibrosis in patients with chronic hepatitis C. J Viral Hepat. 2011;18:23-31 pubmed publisher
    ..Issues of spectrum effect in diagnostic test evaluations are discussed. In chronic hepatitis C a simplified ELF test can detect severe liver fibrosis with good accuracy. ..
  6. Leung A, Wong S, Chan D, Tam P, Cheah K. Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn. 2010;239:2319-29 pubmed publisher
    ..In this study, we show that procollagen IIA (IIA), an isoform of the cartilage extracellular matrix protein encoded by an alternatively spliced ..
  7. Iglesias P, Arrieta F, Piñera M, Botella Carretero J, Balsa J, Zamarrón I, et al. Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance. Clin Endocrinol (Oxf). 2011;75:184-8 pubmed publisher
    To evaluate serum levels of osteocalcin (OC), procollagen type 1 N-terminal propeptide (P1PN) and beta-CrossLaps (beta-CTx) in obese subjects and their relationship with glucose metabolism parameters...
  8. Marin L, Koivula M, Jukkola Vuorinen A, Leino A, Risteli J. Comparison of total and intact aminoterminal propeptide of type I procollagen assays in patients with breast cancer with or without bone metastases. Ann Clin Biochem. 2011;48:447-51 pubmed publisher
    Aminoterminal propeptide of type I procollagen (PINP) reflects bone formation. Two different antigens exist in human serum: intact PINP and a monomeric form...
  9. Koivula M, Risteli L, Risteli J. Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum. Clin Biochem. 2012;45:920-7 pubmed publisher
    The aminoterminal propeptide of type I procollagen (PINP) in serum is a sensitive indicator of the synthesis of type I collagen...

More Information


  1. Gilkes D, Bajpai S, Wong C, Chaturvedi P, Hubbi M, Wirtz D, et al. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Mol Cancer Res. 2013;11:456-66 pubmed publisher
    ..cancer cells, hypoxia-inducible factor 1 (HIF-1) activates transcription of the PLOD1 and PLOD2 genes encoding procollagen lysyl hydroxylases that are required for the biogenesis of collagen, which is a major constituent of the ECM...
  2. Hong M, Ko E, Park S, Chang M. Inhibitory effect of Astragalus membranaceus root on matrix metalloproteinase-1 collagenase expression and procollagen destruction in ultraviolet B-irradiated human dermal fibroblasts by suppressing nuclear factor kappa-B activity. J Pharm Pharmacol. 2013;65:142-8 pubmed publisher
    ..This study has investigated the photo-protective effect of A. membranaceus on UVB radiation-induced activation of nuclear factor kappa-B (NF-?B) activity in human dermal fibroblasts...
  3. Su C, Liu Y, Lin J, Chen S, Yang C, Chen J, et al. Increased procollagen type I C-terminal peptide levels indicate diastolic dysfunction in end-stage renal disease patients undergoing maintenance dialysis therapy. J Am Soc Echocardiogr. 2012;25:895-901 pubmed publisher
    ..Blood studies included albumin, cardiac troponin T, and procollagen type I C-terminal peptide (PICP)...
  4. Ghoul B, Squalli T, Servais A, Elie C, Meas Yedid V, Trivint C, et al. Urinary procollagen III aminoterminal propeptide (PIIINP): a fibrotest for the nephrologist. Clin J Am Soc Nephrol. 2010;5:205-10 pubmed publisher
    ..UPIIINP/Cr is a promising fibro-test for the kidney and may alleviate the need for KB in some patients with CKD. Its predictive value for CKD progression deserves evaluation in prospective studies. ..
  5. Harris B, Zhang Y, Card L, Rivera L, Brekken R, Bradshaw A. SPARC regulates collagen interaction with cardiac fibroblast cell surfaces. Am J Physiol Heart Circ Physiol. 2011;301:H841-7 pubmed publisher
    ..isolated from SPARC-null and WT mice were assayed for collagen I synthesis by [(3)H]proline incorporation into procollagen and by immunoblot analysis of procollagen processing...
  6. Gouttenoire J, Bougault C, Aubert Foucher E, Perrier E, Ronzière M, Sandell L, et al. BMP-2 and TGF-beta1 differentially control expression of type II procollagen and alpha 10 and alpha 11 integrins in mouse chondrocytes. Eur J Cell Biol. 2010;89:307-14 pubmed publisher
    ..this study, the expression of alpha 10 and alpha 11 integrin subunits and the IIA/IIB spliced forms of type II procollagen have been monitored for the first time in parallel in the same in vitro model of mouse chondrocyte ..
  7. Pyott S, Schwarze U, Christiansen H, Pepin M, Leistritz D, Dineen R, et al. Mutations in PPIB (cyclophilin B) delay type I procollagen chain association and result in perinatal lethal to moderate osteogenesis imperfecta phenotypes. Hum Mol Genet. 2011;20:1595-609 pubmed publisher the rough endoplasmic reticulum (RER) and can form a complex involved in prolyl 3-hydroxylation in type I procollagen. CYPB, a prolyl cis-trans isomerase, has been thought to drive the prolyl-containing peptide bonds to the trans ..
  8. Kalson N, Holmes D, Kapacee Z, Otermin I, Lu Y, Ennos R, et al. An experimental model for studying the biomechanics of embryonic tendon: Evidence that the development of mechanical properties depends on the actinomyosin machinery. Matrix Biol. 2010;29:678-89 pubmed publisher
    ..labeling showed that blebbistatin inhibited the contraction of the constructs without affecting cell viability, procollagen synthesis, or conversion of procollagen to collagen...
  9. García Ocaña M, Vazquez F, García Pravia C, Fuentes Martínez N, Menendez Rodriguez P, Fresno Forcelledo F, et al. Characterization of a novel mouse monoclonal antibody, clone 1E8.33, highly specific for human procollagen 11A1, a tumor-associated stromal component. Int J Oncol. 2012;40:1447-54 pubmed publisher
    A novel IgG1, ? mouse monoclonal antibody (clone 1E8.33) to human procollagen 11A1 has been generated...
  10. Ishida Y, Nagata K. Autophagy eliminates a specific species of misfolded procollagen and plays a protective role in cell survival against ER stress. Autophagy. 2009;5:1217-9 pubmed
    ..Using two independent cell lines that produce misfolded collagens, we recently demonstrated that procollagen, which is misfolded and accumulated as trimers, is eliminated through the autophagy-lysosomal pathway, not ..
  11. Clarke C, Baghdadi H, Howie A, Mason J, Walker S, Beckett G. Selenium supplementation attenuates procollagen-1 and interleukin-8 production in fat-loaded human C3A hepatoblastoma cells treated with TGFbeta1. Biochim Biophys Acta. 2010;1800:611-8 pubmed publisher
    ..The contributions of individual liver cell types to fibrogenesis remain controversial and the influence of selenium status has not been investigated...
  12. Bekhouche M, Kronenberg D, Vadon Le Goff S, Bijakowski C, Lim N, Font B, et al. Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity. J Biol Chem. 2010;285:15950-9 pubmed publisher
    ..The presence of a C-terminal NTR domain in procollagen C-proteinase enhancers (PCPEs), proteins that stimulate the activity of astacin-like tolloid proteinases, ..
  13. Bon J, Zhang Y, Duncan S, Pilewski J, Zaldonis D, Zeevi A, et al. Plasma inflammatory mediators associated with bone metabolism in COPD. COPD. 2010;7:186-91 pubmed publisher
    ..C-telopeptide type I collagen (CTx), a marker of bone resorption, was measured with ELISA, and N-terminal procollagen propeptide (P1NP), a marker of bone formation, was ascertained with a radioimmunoassay...
  14. Venditti R, Scanu T, Santoro M, Di Tullio G, Spaar A, Gaibisso R, et al. Sedlin controls the ER export of procollagen by regulating the Sar1 cycle. Science. 2012;337:1668-72 pubmed
    Newly synthesized proteins exit the endoplasmic reticulum (ER) via coat protein complex II (COPII) vesicles. Procollagen (PC), however, forms prefibrils that are too large to fit into typical COPII vesicles; PC thus needs large transport ..
  15. Pingel J, Langberg H, Skovgård D, Koskinen S, Flyvbjerg A, Frystyk J, et al. Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women. J Appl Physiol (1985). 2012;113:1040-7 pubmed publisher
    ..The collected dialysate was analyzed for procollagen type I NH(2)-terminal propeptide (PINP), insulin-like growth factor I (IGF-I), and interleukin-6 (IL-6)...
  16. Heikkilä H, Krafft E, Jespers P, McEntee K, Rajamäki M, Clercx C. Procollagen type III amino terminal propeptide concentrations in dogs with idiopathic pulmonary fibrosis compared with chronic bronchitis and eosinophilic bronchopneumopathy. Vet J. 2013;196:52-6 pubmed publisher
    ..b>Procollagen type III amino terminal propeptide (PIIINP) is used as a marker of collagen type III synthesis...
  17. Seddon J, Kasprowicz V, Walker N, Yuen H, Sunpath H, Tezera L, et al. Procollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosis. J Infect Dis. 2013;208:1571-9 pubmed publisher
    ..Concentrations of MDPs and MMPs were analyzed by ELISA and Luminex array in 2 patient cohorts. Procollagen III N-terminal propeptide (PIIINP) was 3...
  18. Bradshaw A, Baicu C, Rentz T, Van Laer A, Bonnema D, Zile M. Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2010;298:H614-22 pubmed publisher
    ..that one determinant of age-dependent remodeling is a change in the extent to which newly synthesized procollagen is processed into mature collagen fibrils...
  19. Burshell A, Möricke R, Correa Rotter R, Chen P, Warner M, Dalsky G, et al. Correlations between biochemical markers of bone turnover and bone density responses in patients with glucocorticoid-induced osteoporosis treated with teriparatide or alendronate. Bone. 2010;46:935-9 pubmed publisher
    ..With both therapies, early changes in some bone turnover markers were correlated with 18-month gains in BMD in patients with GIO...
  20. Lee T, Lee S, Lee D, Son Y, Chung D, Baek N, et al. A glycosidic spinasterol from Koreana stewartia promotes procollagen production and inhibits matrix metalloproteinase-1 expression in UVB-irradiated human dermal fibroblasts. Biol Pharm Bull. 2011;34:768-73 pubmed
    ..The effects of spinasteol-Glc on expression of procollagen and matrix metalloproteinase-1 (MMP-1) were further evaluated...
  21. Hochberg M, Silverman S, Barr C, Miller P. The utility of changes in serum levels of C-terminal telopeptide of type I collagen in predicting patient response to oral monthly ibandronate therapy. J Clin Densitom. 2010;13:181-9 pubmed publisher
    ..61, p=0.0007). These data suggest that 3-mo changes in sCTX levels are associated with 1-yr LS BMD increases in postmenopausal women treated with once-monthly oral ibandronate. ..
  22. Wang Z, Bryan J, Franz C, Havlioglu N, Sandell L. Type IIB procollagen NH(2)-propeptide induces death of tumor cells via interaction with integrins alpha(V)beta(3) and alpha(V)beta(5). J Biol Chem. 2010;285:20806-17 pubmed publisher
    ..In an assay for invasion, PIIBNP reduced the number of cells crossing the membrane. In vivo, in a tumor model for breast cancer, PIIBNP was consistently able to reduce the size of the tumor. ..
  23. Ueno T, Tanaka K, Kaneko K, Taga Y, Sata T, Irie S, et al. Enhancement of procollagen biosynthesis by p180 through augmented ribosome association on the endoplasmic reticulum in response to stimulated secretion. J Biol Chem. 2010;285:29941-50 pubmed publisher
    ..Here, we show that p180 plays a key role in procollagen biosynthesis and secretion in diploid fibroblasts...
  24. Blumsohn A, Marin F, Nickelsen T, Brixen K, Sigurdsson G, Gonzalez de la Vera J, et al. Early changes in biochemical markers of bone turnover and their relationship with bone mineral density changes after 24 months of treatment with teriparatide. Osteoporos Int. 2011;22:1935-46 pubmed publisher
    ..Teriparatide (20 ?g/day) was administered for up to 24 months. We measured procollagen type I N-terminal propeptide (PINP), bone-specific alkaline phosphatase (b-ALP), and total alkaline phosphatase ..
  25. Baicu C, Li J, Zhang Y, Kasiganesan H, Cooper G, Zile M, et al. Time course of right ventricular pressure-overload induced myocardial fibrosis: relationship to changes in fibroblast postsynthetic procollagen processing. Am J Physiol Heart Circ Physiol. 2012;303:H1128-34 pubmed publisher
    ..insoluble collagen, and levels of SPARC (secreted protein acidic and rich in cysteine), a protein that affects procollagen processing. RV hypertrophic growth was complete 2 wk after PAB...
  26. Eastell R, Christiansen C, Grauer A, Kutilek S, Libanati C, McClung M, et al. Effects of denosumab on bone turnover markers in postmenopausal osteoporosis. J Bone Miner Res. 2011;26:530-7 pubmed publisher
    ..of type I collagen [CTX] and tartrate-resistant acid phosphatise [TRACP-5b]) and bone formation (serum procollagen type I N-terminal propeptide [PINP] and bone alkaline phosphatase [BALP]) were measured at baseline and at 1, 6,..
  27. McClung M, Miller P, Recknor C, Mesenbrink P, Bucci Rechtweg C, Benhamou C. Zoledronic acid for the prevention of bone loss in postmenopausal women with low bone mass: a randomized controlled trial. Obstet Gynecol. 2009;114:999-1007 pubmed publisher,, NCT00132808. I. ..
  28. Kwon Y, Kim D, Kim J, Hwang J. Effects of licarin E on expression of matrix metalloproteinase-1 and type-1 procollagen in UVB-irradiated human skin fibroblasts. Phytother Res. 2011;25:1891-4 pubmed publisher
    ..on MMP-1 and type-1 procollagen levels in UVB-irradiated human skin fibroblasts...
  29. Zhao H, Han K, Wang Z, Chen Y, Li H, Zeng J, et al. Value of C-telopeptide-cross-linked Type I collagen, osteocalcin, bone-specific alkaline phosphatase and procollagen Type I N-terminal propeptide in the diagnosis and prognosis of bone metastasis in patients with malignant tumors. Med Sci Monit. 2011;17:CR626-633 pubmed
    ..The serum levels of C-Telopeptide-Cross-Linked Type I Collagen (CTx), Procollagen Type I N-Terminal Propeptide (PINP), Bone-Specific Alkaline Phosphatase (B-ALP) and Osteocalcin (OST) in ..
  30. Kim S, Pahuja K, Ravazzola M, Yoon J, Boyadjiev S, Hammamoto S, et al. The [corrected] SEC23-SEC31 [corrected] interface plays critical role for export of procollagen from the endoplasmic reticulum. J Biol Chem. 2012;287:10134-44 pubmed publisher
    ..size, and packaging of cargo molecules into COPII vesicles that we have tested but induces accumulation of procollagen in the endoplasmic reticulum when expressed in normal fibroblasts...
  31. Koivula M, Ruotsalainen V, Bjorkman M, Nurmenniemi S, Ikäheimo R, Savolainen K, et al. Difference between total and intact assays for N-terminal propeptide of type I procollagen reflects degradation of pN-collagen rather than denaturation of intact propeptide. Ann Clin Biochem. 2010;47:67-71 pubmed publisher
    The concentration of N-terminal propeptide of type I procollagen (PINP) in the serum reflects the rate of type I collagen formation...
  32. Bruyere O, Collette J, Rizzoli R, Decock C, Ortolani S, Cormier C, et al. Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years. Osteoporos Int. 2010;21:1031-6 pubmed publisher
    ..biochemical markers of bone formation (bone-specific alkaline phosphatase and C-terminal propeptide of type I procollagen) were associated with 3-year bone mineral density (BMD) changes, but not fracture incidence in patients treated ..
  33. Kronenberg D, Vadon Le Goff S, Bourhis J, Font B, Eichenberger D, Hulmes D, et al. Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity. J Biol Chem. 2009;284:33437-46 pubmed publisher
    b>Procollagen C-proteinase enhancers (PCPE-1 and -2) specifically activate bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family during C-terminal processing of fibrillar collagen precursors...
  34. Delmas P, Munoz F, Black D, Cosman F, Boonen S, Watts N, et al. Effects of yearly zoledronic acid 5 mg on bone turnover markers and relation of PINP with fracture reduction in postmenopausal women with osteoporosis. J Bone Miner Res. 2009;24:1544-51 pubmed publisher
    ..telopeptides of type 1 collagen (beta-CTX), 30% for bone alkaline phosphatase (ALP), and 56% for procollagen type 1 amino-terminal propeptide (PINP)...
  35. Boonen S, Marin F, Obermayer Pietsch B, Simões M, Barker C, Glass E, et al. Effects of previous antiresorptive therapy on the bone mineral density response to two years of teriparatide treatment in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2008;93:852-60 pubmed
    ..Teriparatide induces positive effects on BMD and markers of bone formation in postmenopausal women with established osteoporosis, regardless of previous long-term exposure to antiresorptive therapies. ..
  36. Aslam M, Lansky E, Varani J. Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells. J Ethnopharmacol. 2006;103:311-8 pubmed
    ..peel extract (and to a lesser extent, both the fermented juice and seed cake extracts) stimulated type I procollagen synthesis and inhibited matrix metalloproteinase-1 (MMP-1; interstitial collagenase) production by dermal ..
  37. Koopmans N, de Jong I, Breeuwsma A, van der Veer E. Serum bone turnover markers (PINP and ICTP) for the early detection of bone metastases in patients with prostate cancer: a longitudinal approach. J Urol. 2007;178:849-53; discussion 853; quiz 1129 pubmed
    ..The bone formation marker is the most indicative. ..
  38. Bradshaw A, Baicu C, Rentz T, Van Laer A, Boggs J, Lacy J, et al. Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing. Circulation. 2009;119:269-80 pubmed publisher determinant of these pressure overload-induced changes is the extracellular processing of newly synthesized procollagen into mature collagen fibrils...
  39. Klepzig M, Jonas D, Oremek G. Procollagen type 1 amino-terminal propeptide: a marker for bone metastases in prostate carcinoma. Anticancer Res. 2009;29:671-3 pubmed
    The objective of this study was to assess the utility of the bone formation marker procollagen type 1 amino-terminal propeptide (P1NP) in indicating bone metastases in patients with prostate carcinoma...
  40. Palmieri D, Astigiano S, Barbieri O, Ferrari N, Marchisio S, Ulivi V, et al. Procollagen I COOH-terminal fragment induces VEGF-A and CXCR4 expression in breast carcinoma cells. Exp Cell Res. 2008;314:2289-98 pubmed publisher
    The COOH-terminal fragment of procollagen type I (C3) is produced in tissues with high synthesis of collagen I, such as in breast cancer stroma and in bone...
  41. Schuller S, Valentin S, Remy B, Jespers P, Foulon S, Van Israël N, et al. Analytical, physiologic, and clinical validation of a radioimmunoassay for measurement of procollagen type III amino terminal propeptide in serum and bronchoalveolar lavage fluid obtained from dogs. Am J Vet Res. 2006;67:749-55 pubmed
    To validate a radioimmunoassay for measurement of procollagen type III amino terminal propeptide (PIIINP) concentrations in canine serum and bronchoalveolar lavage fluid (BALF) and investigate the effects of physiologic and pathologic ..
  42. Takeyama N, Sakai H, Ohtake H, Mashitori H, Tamai K, Saotome K. Effects of hyperbaric oxygen on gene expressions of procollagen, matrix metalloproteinase and tissue inhibitor of metalloproteinase in injured medial collateral ligament and anterior cruciate ligament. Knee Surg Sports Traumatol Arthrosc. 2007;15:443-52 pubmed
    ..Gene expression of type I procollagen was significantly greater in Group MH than in Group MC at 7 days postoperatively and was also significantly ..
  43. Adami S, Bianchi G, Brandi M, Giannini S, Ortolani S, DiMunno O, et al. Determinants of bone turnover markers in healthy premenopausal women. Calcif Tissue Int. 2008;82:341-7 pubmed publisher
    ..serum BTMs (serum C-telopeptide of type I collagen [CTX], osteocalcin [OC], and N-terminal propeptide of type I procollagen [P1NP]), serum calcium, creatinine, phosphate, magnesium, and follicle-stimulating hormone (FSH) were measured ..
  44. Shim J, Kwon Y, Hwang J. The effects of panduratin A isolated from Kaempferia pandurata on the expression of matrix metalloproteinase-1 and type-1 procollagen in human skin fibroblasts. Planta Med. 2008;74:239-44 pubmed publisher
    ..on the expression of matrix metalloproteinase-1 (MMP-1) and type-1 procollagen in UV-irradiated human skin fibroblasts...
  45. Jacobs J, de Nijs R, Lems W, Geusens P, Laan R, Huisman A, et al. Prevention of glucocorticoid induced osteoporosis with alendronate or alfacalcidol: relations of change in bone mineral density, bone markers, and calcium homeostasis. J Rheumatol. 2007;34:1051-7 pubmed
    ..Associations between changes in serum procollagen type I C-propeptide (P1CP), fasting urine N-terminal telopeptide of type I collagen (NTx), serum calcium, ..
  46. McAlinden A, Havlioglu N, Liang L, Davies S, Sandell L. Alternative splicing of type II procollagen exon 2 is regulated by the combination of a weak 5' splice site and an adjacent intronic stem-loop cis element. J Biol Chem. 2005;280:32700-11 pubmed
    Alternative splicing of the type II procollagen gene (COL2A1) is developmentally regulated during chondrogenesis...
  47. Carter R, Jain K, Sykes V, Lanning D. Differential expression of procollagen genes between mid- and late-gestational fetal fibroblasts. J Surg Res. 2009;156:90-4 pubmed publisher
    ..we have shown that cutaneous wounds in mid-gestational (E15) mice heal in a scarless manner with decreased procollagen 1 and increased procollagen 3 production compared with wounds in late-gestational (E18) mice, which heal with ..
  48. Veitch S, Findlay S, Hamer A, Blumsohn A, Eastell R, Ingle B. Changes in bone mass and bone turnover following tibial shaft fracture. Osteoporos Int. 2006;17:364-72 pubmed
    ..We measured three bone formation markers, bone alkaline phosphatase (bone ALP), osteocalcin (OC) and procollagen type 1 N-terminal peptide (PINP), a marker of bone resorption, serum C-telopeptides of type 1 collagen (beta-..
  49. Takahashi S. [Evaluation of cancer-induced bone diseases by bone metabolic marker]. Clin Calcium. 2006;16:581- 90 pubmed
    ..These findings suggest that bone metabolic markers would be useful to detect, to monitor, and to predict prognosis of bone metastases. ..
  50. Sharif M, Kirwan J, Charni N, Sandell L, Whittles C, Garnero P. A 5-yr longitudinal study of type IIA collagen synthesis and total type II collagen degradation in patients with knee osteoarthritis--association with disease progression. Rheumatology (Oxford). 2007;46:938-43 pubmed
    ..The data also suggest that the combined measurement of serum PIIANP and urinary CTX-II may be useful to identify patients with knee OA at increased risk of disease progression. ..
  51. Lu X, Li M, Weng M. [Inhibition effects of constituents of Radix Salviae Miltiorrhizae on proliferation and procollagen transcription of dermal fibroblasts in systemic sclerosis]. Zhonghua Yi Xue Za Zhi. 2007;87:2426-8 pubmed
    To study the effects of tanshinone IIA, danshensu, lithospermate, and protocatechualdehyde on proliferation and procollagen mRNA synthesis of dermal fibroblasts from patients with systemic sclerosis (SSc)...
  52. Han B, Copeland M, Geiser A, Hale L, Harvey A, Ma Y, et al. Development of a highly sensitive, high-throughput, mass spectrometry-based assay for rat procollagen type-I N-terminal propeptide (PINP) to measure bone formation activity. J Proteome Res. 2007;6:4218-29 pubmed
    Type-I procollagen aminoterminal propeptide (PINP) is a useful biomarker for bone formation activity that is used to monitor treatment of bone disorders including osteoporosis...
  53. Fontana R, Goodman Z, Dienstag J, Bonkovsky H, Naishadham D, Sterling R, et al. Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C. Hepatology. 2008;47:789-98 pubmed publisher
    ..Serum tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), amino-terminal peptide of type III procollagen (PIIINP), hyaluronic acid (HA), and YKL-40 levels were determined using commercially available assays...
  54. Zissimopoulos A, Bantis A, Stellos K, Petrakis G, Matthaios D. Association between bone scintigraphy and serum levels of procollagen (I) and PSA in the detection of bone disease in prostate cancer patients. J BUON. 2008;13:69-74 pubmed
    To evaluate the clinical usefulness of serum procollagen I carboxyterminal propeptide (PICP) and prostate specific antigen (PSA) in relation to bone scan results in Greek patients with prostate cancer (PC). 108 patients (mean age 58+/-4...
  55. Lin Y, Ho Y, Wang T, Liu C, Kao H, Chao C, et al. The relation of amino-terminal propeptide of type III procollagen and severity of coronary artery disease in patients without myocardial infarction or hibernation. Clin Biochem. 2006;39:861-6 pubmed
    ..We investigated the relationship between serum concentrations of procollagen propeptides and severity of CAD in such patients...
  56. Fujii T, Wakaizumi M, Ikami T, Saito M. Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. J Ethnopharmacol. 2008;119:53-7 pubmed publisher
    ..In this study, we investigated the effects of amla extract on human skin fibroblasts, especially for production of procollagen and matrix metalloproteinases (MMPs), in vitro.
  57. Klepzig M, Sauer Eppel H, Jonas D, Oremek G. Value of procollagen type 1 amino-terminal propeptide in patients with renal cell carcinoma. Anticancer Res. 2008;28:2443-6 pubmed
    The aim of the study was to investigate whether the bone turnover marker procollagen type 1 amino-terminal propeptide (P1NP) could be useful for the early detection of bone metastases in patients with renal cell carcinoma (RCC) and if ..
  58. Steiglitz B, Kreider J, Frankenburg E, Pappano W, Hoffman G, Meganck J, et al. Procollagen C proteinase enhancer 1 genes are important determinants of the mechanical properties and geometry of bone and the ultrastructure of connective tissues. Mol Cell Biol. 2006;26:238-49 pubmed
    b>Procollagen C proteinases (pCPs) cleave type I to III procollagen C propeptides as a necessary step in assembling the major fibrous components of vertebrate extracellular matrix...
  59. Wada S, Fukawa T, Kamiya S. [Biochemical markers of bone turnover. New aspect. Bone metabolic markers available in daily practice]. Clin Calcium. 2009;19:1075-82 pubmed publisher
    ..These laboratory tests offer lots of advantages for the diagnosis of bone metabolic disorders and for the evaluation of clinical states of primary osteoporosis and other metabolic skeletal diseases. ..
  60. Makareeva E, Leikin S. Procollagen triple helix assembly: an unconventional chaperone-assisted folding paradigm. PLoS ONE. 2007;2:e1029 pubmed
    ..We find that human procollagen triple helix spontaneously folds into its native conformation at 30-34 degrees C but not at higher temperatures,..
  61. Elkareh J, Periyasamy S, Shidyak A, Vetteth S, Schroeder J, Raju V, et al. Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy. Am J Physiol Renal Physiol. 2009;296:F1219-26 pubmed publisher
    ..There was a strong inverse relationship between the expressions of Fli-1 and procollagen in primary culture of rat cardiac and human dermal fibroblasts as well as a cell line derived from renal ..
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    ..b>Procollagen 1 (PC1) and CD10 represent recently developed immunoperoxidase reagents that have been forwarded as useful in ..
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    ..Teriparatide significantly increased markers of bone turnover that peaked at 6 months (serum procollagen type I N-terminal propeptide, 218%, and urinary N-telopeptide corrected for creatinine, 58%; P<...