type vi secretion systems


Summary: Multiprotein complexes in GRAM NEGATIVE BACTERIA that deliver effector proteins into eukaryotic or prokaryotic cells by a mechanism similar to the contractile tail of bacteriophages. They are composed of a cell envelope-spanning tube which is surrounded by a contractile sheath and tipped by a cell puncturing complex; a base plate structure that anchors the assembly to the cell envelope; and an ATPase involved in the sheath contraction and disassembly of the complex.

Top Publications

  1. Gueguen E, Durand E, Zhang X, d Amalric Q, Journet L, Cascales E. Expression of a Yersinia pseudotuberculosis Type VI Secretion System Is Responsive to Envelope Stresses through the OmpR Transcriptional Activator. PLoS ONE. 2013;8:e66615 pubmed publisher
    ..Finally, we show that T6SS-4 promotes Y. pseudotuberculosis survival in high osmolarity conditions and resistance to deoxycholate. ..
  2. Journet L, Cascales E. The Type VI Secretion System in Escherichia coli and Related Species. EcoSal Plus. 2016;7: pubmed publisher
    ..In this review we summarize the current knowledge regarding the prevalence, the assembly, the regulation, and the roles of the T6SS in E. coli, Salmonella, and related species. ..
  3. Spidlov√° P, Stulik J. Francisella tularensis type VI secretion system comes of age. Virulence. 2017;8:628-631 pubmed publisher
  4. Tian Y, Zhao Y, Shi L, Cui Z, Hu B, Zhao Y. Type VI Secretion Systems of Erwinia amylovora Contribute to Bacterial Competition, Virulence, and Exopolysaccharide Production. Phytopathology. 2017;107:654-661 pubmed publisher
    ..Interestingly, these 19 mutants also produced less amylovoran or levan or both. These findings suggest that E. amylovora T6SS play a role in bacterial competition and virulence possibly by influencing exopolysaccharide production. ..
  5. Veening J, Blokesch M. Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria. Nat Rev Microbiol. 2017;15:621-629 pubmed publisher
    ..pneumoniae secreting bacteriocins. We argue that the forced release of DNA from killed bacteria and the transfer of non-clonal genetic material have important roles in bacterial evolution. ..
  6. Yang X, Li Z, Gao Z, Wang W, Geng Z, Xu J, et al. Structural and SAXS analysis of Tle5-Tli5 complex reveals a novel inhibition mechanism of H2-T6SS in Pseudomonas aeruginosa. Protein Sci. 2017;26:2083-2091 pubmed publisher
    ..We also distinguished the structural features of Tle5 and Tle5B family immunity proteins. Together, our work provided insights into a novel inhibition mechanism that may enhance our understanding of phospholipase D family proteins. ..
  7. Whiteley L, Meffert T, Haug M, Weidenmaier C, Hopf V, Bitschar K, et al. Entry, Intracellular Survival, and Multinucleated-Giant-Cell-Forming Activity of Burkholderia pseudomallei in Human Primary Phagocytic and Nonphagocytic Cells. Infect Immun. 2017;85: pubmed publisher
    ..In summary, the ability of the bacteria to enter and survive as well as induce MNGC formation in certain host cells may contribute to the pathogenesis observed in B. pseudomallei infection. ..
  8. Hood R, Peterson S, Mougous J. From Striking Out to Striking Gold: Discovering that Type VI Secretion Targets Bacteria. Cell Host Microbe. 2017;21:286-289 pubmed publisher
    ..Our discovery that the type VI secretion system delivers toxins between bacterial cells has broadened our understanding of how both pathogens and non-pathogens interact with one another, whether within or outside of the host. ..
  9. Wan B, Zhang Q, Ni J, Li S, Wen D, Li J, et al. Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS). PLoS Pathog. 2017;13:e1006246 pubmed publisher
    ..Taken together, our findings suggest that EHEC could sense oxidative stress in phagosome and decrease the host cell ROS by secreting catalase KatN to facilitate its survival in the host cells. ..

More Information


  1. McMullen J, McQuade R, Ogier J, Pages S, Gaudriault S, Patricia Stock S. Variable virulence phenotype of Xenorhabdus bovienii (?-Proteobacteria: Enterobacteriaceae) in the absence of their vector hosts. Microbiology. 2017;163:510-522 pubmed publisher
  2. Sana T, Lugo K, Monack D. T6SS: The bacterial "fight club" in the host gut. PLoS Pathog. 2017;13:e1006325 pubmed publisher