type v secretion systems


Summary: Secretion systems of GRAM-NEGATIVE BACTERIA (single membrane proteins or multiprotein complexes) that carry out secretion of proteins from the PERIPLASMIC SPACE to the EXTRACELLULAR SPACE via a beta-barrel transmembrane pore. There are several T5SS subtypes: T5aSS monomeric autotransporters, T5bSS two-partner secretions systems (TPSS), T5cSS trimeric autotransporters, T5dSS fused two-partner secretion systems, and T5eSS autotransporters with inverted domains.

Top Publications

  1. McWilliams B, Torres A. Enterohemorrhagic Escherichia coli Adhesins. Microbiol Spectr. 2014;2: pubmed publisher
  2. Fan E, Chauhan N, Udatha D, Leo J, Linke D. Type V Secretion Systems in Bacteria. Microbiol Spectr. 2016;4: pubmed publisher
    ..In this chapter, we review the structure and function of these transporters and review recent findings on additional factors involved in the secretion process, which have put the term "autotransporter" to debate. ..
  3. Chen X, Cheng H, Zhou J, Chan C, Lau K, Tsui S, et al. Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis. J Biol Chem. 2017;292:16880-16890 pubmed publisher
    ..Moreover, homology-modeling and mutagenesis studies further delineated the molecular determinants of the specific PE-PPE interactions. These findings help develop an atomic algorithm of ESX-5 substrate recognition and PE-PPE pairing. ..