dynactin complex

Summary

Summary: A multi-subunit protein of EUKARYOTIC CELLS. It functions in bidirectional intracellular transport of ORGANELLES and CYTOPLASMIC VESICLES by linking them to DYNEIN and KINESIN.

Top Publications

  1. Adames N, Cooper J. Microtubule interactions with the cell cortex causing nuclear movements in Saccharomyces cerevisiae. J Cell Biol. 2000;149:863-74 pubmed
    ..Conversely, microtubule sliding can move the nucleus into the neck even when capture/shrinkage is impaired. ..
  2. Huhn S, Liu J, Ye C, Lu H, Jiang X, Feng X, et al. Regulation of spindle integrity and mitotic fidelity by BCCIP. Oncogene. 2017;36:4750-4766 pubmed publisher
    ..Our study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression. ..
  3. Estrem C, Fees C, Moore J. Dynein is regulated by the stability of its microtubule track. J Cell Biol. 2017;216:2047-2058 pubmed publisher
    ..In contrast, the dynactin complex counteracts dynein and stabilizes microtubules through a mechanism involving the shoulder subcomplex and the ..
  4. GutiƩrrez P, Ackermann B, Vershinin M, McKenney R. Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility. J Biol Chem. 2017;292:12245-12255 pubmed publisher
  5. Zhang K, Foster H, Rondelet A, Lacey S, Bahi Buisson N, Bird A, et al. Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. Cell. 2017;169:1303-1314.e18 pubmed publisher
    ..Our model explains how dynactin binding to the dynein-1 tail directly stimulates its motor activity. ..
  6. Barbosa D, Duro J, Prevo B, Cheerambathur D, Carvalho A, Gassmann R. Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport. PLoS Genet. 2017;13:e1006941 pubmed publisher
  7. Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher
  8. Mishima T, Koga S, Lin W, Kasanuki K, Castanedes Casey M, Wszolek Z, et al. Perry Syndrome: A Distinctive Type of TDP-43 Proteinopathy. J Neuropathol Exp Neurol. 2017;76:676-682 pubmed publisher
    ..Dynactin p50 inclusions were observed in both Perry syndrome and HMN7B, but not in the other conditions. These results suggest that Perry syndrome may be distinctive type of TDP-43 proteinopathy. ..
  9. Liu X, Yang L, Tang L, Chen L, Liu X, Fan D. DCTN1 gene analysis in Chinese patients with sporadic amyotrophic lateral sclerosis. PLoS ONE. 2017;12:e0182572 pubmed publisher
    ..Our results suggested that variants in DCTN1 are not common risk factors for Chinese sporadic ALS and that the frequency of variants of unknown significance in the cohort study was 0.39%. ..

More Information

Publications11

  1. Kobayashi T, Miyashita T, Murayama T, Toyoshima Y. Dynactin has two antagonistic regulatory domains and exerts opposing effects on dynein motility. PLoS ONE. 2017;12:e0183672 pubmed publisher
    ..In DCTN1A, the K-rich domain antagonized these inhibitory effects. Therefore, dynactin has two antagonistic domains and promotes or suppresses dynein motility to accomplish correct localization and functions of dynein within a cell. ..
  2. Huynh W, Vale R. Disease-associated mutations in human BICD2 hyperactivate motility of dynein-dynactin. J Cell Biol. 2017;216:3051-3060 pubmed publisher
    ..Our results reveal that dominant mutations in BICD2 hyperactivate DDB motility and suggest that an imbalance of minus versus plus end-directed microtubule motility in neurons may underlie spinal muscular atrophy. ..