axin protein


Summary: A scaffolding protein that is a critical component of the axin signaling complex which binds to ADENOMATOUS POLYPOSIS COLI PROTEIN; GLYCOGEN SYNTHASE KINASE 3; and CASEIN KINASE I.

Top Publications

  1. Machado R, de Freitas E, de Aquino S, Martelli D, Swerts M, Reis S, et al. Clinical relevance of breast and gastric cancer-associated polymorphisms as potential susceptibility markers for oral clefts in the Brazilian population. BMC Med Genet. 2017;18:39 pubmed publisher
    ..008) from parents to the children with NSCL?±?P. The results suggest that polymorphic variants in AXIN2 and CDH1 may be associated with NSCL?±?P susceptibility, and reinforce the putative link between cancer and oral clefts. ..
  2. Lo Y, Noah T, Chen M, ZOU W, Borràs E, Vilar E, et al. SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin. Gastroenterology. 2017;153:205-218.e8 pubmed publisher
    ..In this model, β-catenin activity determines the proliferation or quiescence of CRC cells based on the absence or presence of SPDEF. ..
  3. Ji L, Jiang B, Jiang X, Charlat O, Chen A, Mickanin C, et al. The SIAH E3 ubiquitin ligases promote Wnt/?-catenin signaling through mediating Wnt-induced Axin degradation. Genes Dev. 2017;31:904-915 pubmed publisher
  4. Xu D, Liu J, Fu T, Shan B, Qian L, Pan L, et al. USP25 regulates Wnt signaling by controlling the stability of tankyrases. Genes Dev. 2017;31:1024-1035 pubmed publisher
  5. Pecina Slaus N, Kafka A, Bukovac A, Vladusić T, Tomas D, Hrascan R. Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma. Tumour Biol. 2017;39:1010428317705791 pubmed publisher
    ..14; p?=?0.01). Our study contributes to better understanding of the genetic profile of human intracranial meningiomas and suggests that meningiomas harbor defective cellular DNA mismatch repair mechanisms. ..
  6. Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale T, et al. Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling that Targets ?-Catenin Protein-Protein Interactions. Cell Chem Biol. 2017;24:958-968.e5 pubmed publisher
    ..We expect that this type of integrative strategy that endows stapled peptides with CPP features will be generally useful for developing inhibitors of intracellular PPIs. ..
  7. Farr G, Ferkey D, Yost C, Pierce S, Weaver C, Kimelman D. Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification. J Cell Biol. 2000;148:691-702 pubmed
    ..These results contribute to our growing understanding of how GSK-3 regulation in the early embryo leads to regional differences in beta-catenin levels and establishment of the dorsal axis. ..
  8. Higgins C, Richardson G, Ferdinando D, Westgate G, Jahoda C. Modelling the hair follicle dermal papilla using spheroid cell cultures. Exp Dermatol. 2010;19:546-8 pubmed publisher
    ..This method of DP cell culture may provide us with a tool to elucidate our understanding of signalling within the DP as it relates to induction, maintenance or even inhibition of hair growth. ..
  9. Cui H, Zhao B, Li Y, Guo Y, Hu H, Liu L, et al. Design of stapled ?-helical peptides to specifically activate Wnt/?-catenin signaling. Cell Res. 2013;23:581-4 pubmed publisher

More Information


  1. Matsumoto Y, La Rose J, Lim M, Adissu H, Law N, Mao X, et al. Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism. J Clin Invest. 2017;127:2612-2625 pubmed publisher
    ..These findings indicate that RNF146 is required to coordinate ?-catenin signaling within the osteoblast lineage during embryonic and postnatal bone development. ..
  2. Tan S, Nusse R. In vivo lineage tracing reveals Axin2-expressing, long-lived cortical thymic epithelial progenitors in the postnatal thymus. PLoS ONE. 2017;12:e0184582 pubmed publisher
    ..The identification of cTEC progenitors and their regulation by Wnt signaling have important implications for our understanding of thymus physiology during homeostasis and TEC-related disorders. ..
  3. Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, et al. Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/?-catenin signaling. PLoS ONE. 2017;12:e0184388 pubmed publisher
    ..Fluoxetine suppressed LiCl-induced ?-catenin accumulation in human OA chondrocytes. Intraarticular injection of fluoxetine in a rat OA model ameliorated OA progression and suppressed ?-catenin accumulation. ..