lorazepam

Summary

Summary: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.

Top Publications

  1. Manjunatha N, Saddichha S, Khess C. Idiopathic recurrent catatonia needs maintenance lorazepam: case report and review. Aust N Z J Psychiatry. 2007;41:625-7 pubmed
    ..We aim to report a patient who had recurrent catatonia that responded to and required lorazepam for maintenance...
  2. Kahn D, Barnhorst A, Bourgeois J. A case of alcohol withdrawal requiring 1,600 mg of lorazepam in 24 hours. CNS Spectr. 2009;14:385-9 pubmed
    ..The authors present a case of a patient with delirium tremens requiring up to 1,600 mg/day of lorazepam and discuss alternative treatments for alcohol withdrawal.
  3. Carrasco M, Vallejo J, Pardo de Santayana M, Peral D, Martín M, Altimiras J. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009;23:1795-6 pubmed publisher
    ..The case of a patient self-medicated with Valeriana officinalis L. and Passiflora incarnata L. while he was on lorazepam treatment is described...
  4. Kimiskidis V, Papagiannopoulos S, Kazis D, Sotirakoglou K, Vasiliadis G, Zara F, et al. Lorazepam-induced effects on silent period and corticomotor excitability. Exp Brain Res. 2006;173:603-11 pubmed
    ..The objective of this study is to describe the effects of lorazepam on silent period (SP) and corticomotor excitability...
  5. Carson S, Kress J, Rodgers J, Vinayak A, Campbell Bright S, Levitt J, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med. 2006;34:1326-32 pubmed
    To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions of propofol using protocols that include scheduled daily interruption of sedation...
  6. Dominguez K, Crowley M, Coleman D, Katz R, Wilkins D, Kelly H. Withdrawal from lorazepam in critically ill children. Ann Pharmacother. 2006;40:1035-9 pubmed
    ..To document the occurrence of lorazepam withdrawal in critically ill children and identify predictors for the development of withdrawal...
  7. Schunck T, Mathis A, Erb G, Namer I, Hode Y, Demazières A, et al. One milligram of lorazepam does not decrease anxiety induced by CCK-4 in healthy volunteers: investigation of neural correlates with BOLD MRI. J Psychopharmacol. 2011;25:52-9 pubmed publisher
    ..This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in healthy volunteers...
  8. Tsai M, Huang T. Severe neuroleptic malignant syndrome: successful treatment with high-dose lorazepam and diazepam: a case report. Chang Gung Med J. 2010;33:576-80 pubmed
    ..Here, we report a patient with severe NMS who was successfully treated with highdose lorazepam and diazepam. A 61-year-old man with bipolar I disorder was admitted to the hospital because of manic episodes...
  9. de Haas S, de Visser S, van der Post J, De Smet M, Schoemaker R, Rijnbeek B, et al. Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers. J Psychopharmacol. 2007;21:374-83 pubmed
    ..This study investigated the effects of 0.5 and 1.5 mg TPA023 and compared them with placebo and lorazepam 2 mg (therapeutic anxiolytic dose)...

More Information

Publications67

  1. Woelk H, Schlafke S. A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine. 2010;17:94-9 pubmed publisher
    ..In this study, the efficacy of a 6-week-intake of silexan compared to lorazepam was investigated in adults with GAD...
  2. Schunck T, Mathis A, Erb G, Namer I, Demazières A, Luthringer R. Effects of lorazepam on brain activity pattern during an anxiety symptom provocation challenge. J Psychopharmacol. 2010;24:701-8 pubmed publisher
    ..this study was to use functional magnetic resonance imaging (fMRI) to test the hypothesis that a single dose of lorazepam modifies brain activation during an anxiety challenge...
  3. DeCarolis D, Rice K, Ho L, Willenbring M, Cassaro S. Symptom-driven lorazepam protocol for treatment of severe alcohol withdrawal delirium in the intensive care unit. Pharmacotherapy. 2007;27:510-8 pubmed
    ..To compare outcomes of treating alcohol withdrawal delirium (AWD) with a symptom-driven benzodiazepine protocol versus nonprotocol benzodiazepine infusions in the intensive care unit (ICU)...
  4. Barletta J, Devlin J. Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA. 2008;299:1541-2; author reply 1542 pubmed publisher
  5. Misra U, Kalita J, Maurya P. Levetiracetam versus lorazepam in status epilepticus: a randomized, open labeled pilot study. J Neurol. 2012;259:645-8 pubmed publisher
    For the management of status epilepticus (SE), lorazepam (LOR) is recommended as the first and phenytoin or fosphenytoin as the second choice. Both these drugs have significant toxicity...
  6. de Haas S, de Visser S, van der Post J, Schoemaker R, Van Dyck K, Murphy M, et al. Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers. J Psychopharmacol. 2008;22:24-32 pubmed publisher
    ..25 and 0.75 mg) in comparison to placebo and an anxiolytic dose (2 mg) of the non-selective agonist lorazepam. Effects were measured by eye movements, body sway, Visual Analogue scales (VAS) and memory tests...
  7. Inouye S. Delirium in older persons. N Engl J Med. 2006;354:1157-65 pubmed
  8. Finkle W, Der J, Greenland S, Adams J, Ridgeway G, Blaschke T, et al. Risk of fractures requiring hospitalization after an initial prescription for zolpidem, alprazolam, lorazepam, or diazepam in older adults. J Am Geriatr Soc. 2011;59:1883-90 pubmed publisher
    ..organization members with an initial prescription for zolpidem (n = 43,343), alprazolam (n = 103,790), lorazepam (n = 150,858), or diazepam (n = 93,618)...
  9. O Donnell M, Williams J, Weinrieb R, Denysenko L. Catatonic mutism after liver transplant rapidly reversed with lorazepam. Gen Hosp Psychiatry. 2007;29:280-1 pubmed
  10. Pandharipande P, Pun B, Herr D, Maze M, Girard T, Miller R, et al. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007;298:2644-53 pubmed
    b>Lorazepam is currently recommended for sustained sedation of mechanically ventilated intensive care unit (ICU) patients, but this and other benzodiazepine drugs may contribute to acute brain dysfunction, ie, delirium and coma, associated ..
  11. Lin Y, Hsu C, Chu S, Tsai S. Another dangerous combination for hypoglycemic coma: concurrent use of sibutramine and lorazepam. QJM. 2008;101:243-5 pubmed publisher
  12. Wunsch H, Meltzer J. Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA. 2008;299:1540-1; author reply 1542 pubmed publisher
  13. Kumar C, Andrade C, Murthy P. A randomized, double-blind comparison of lorazepam and chlordiazepoxide in patients with uncomplicated alcohol withdrawal. J Stud Alcohol Drugs. 2009;70:467-74 pubmed
    For important reasons, lorazepam (Ativan) and chlordiazepoxide (Librium) are both popular treatments for alcohol-withdrawal syndrome. Nevertheless, there is little literature directly comparing the two drugs...
  14. Zar T, Yusufzai I, Sullivan A, Graeber C. Acute kidney injury, hyperosmolality and metabolic acidosis associated with lorazepam. Nat Clin Pract Nephrol. 2007;3:515-20 pubmed
    ..He received a high-dose lorazepam infusion for alcohol withdrawal during hospitalization and developed severe hyperosmolality, high anion gap ..
  15. Brignell C, Rosenthal J, Curran H. Pharmacological manipulations of arousal and memory for emotional material: effects of a single dose of methylphenidate or lorazepam. J Psychopharmacol. 2007;21:673-83 pubmed
    ..placebo controlled trial with 48 volunteers was used to investigate the effects of methylphenidate (40 mg) and Lorazepam (1.5 mg) on incidental memory for emotional material in Cahill and McGaugh's (1995) slide-story task...
  16. Park S, Bang S, Nam E, Cho E, Shin D, Lee J, et al. A randomized double-blind placebo-controlled study of low-dose intravenous Lorazepam to reduce procedural pain during bone marrow aspiration and biopsy. Pain Med. 2008;9:249-52 pubmed publisher
    To evaluate the efficacy of intravenous lorazepam as premedication for bone marrow aspiration and biopsy (BMAB). Randomized, double-blind, placebo-controlled. One hundred and thirty-eight consenting patients planned to receive BMAB...
  17. Spiegel D, Ramdath N. A failed case of weaning from a mechanical ventilator with lorazepam successfully accomplished by ziprasidone. Gen Hosp Psychiatry. 2009;31:494-6 pubmed publisher
    ..exacerbation requiring intubation who failed extubation multiple times while concurrently being treated with lorazepam, for agitation...
  18. Malcolm R, Myrick L, Veatch L, Boyle E, Randall P. Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin. J Clin Sleep Med. 2007;3:24-32 pubmed
    ..The primary objective of this study was to compare the efficacy of gabapentin to lorazepam in alleviating sleep disturbances and daytime sleepiness during an episode of alcohol withdrawal...
  19. Fahey J, Pritchard G, Reddi J, Pratt J, Grassi J, Shader R, et al. The effect of chronic lorazepam administration in aging mice. Brain Res. 2006;1118:13-24 pubmed
    To assess benzodiazepine tolerance in aged animals, lorazepam or vehicle was administered chronically to male Crl: CD-1(ICR)BR mice. Pharmacodynamic and neurochemical endpoints were examined on days 1 and 14 of drug administration...
  20. Arce E, Miller D, Feinstein J, Stein M, Paulus M. Lorazepam dose-dependently decreases risk-taking related activation in limbic areas. Psychopharmacology (Berl). 2006;189:105-16 pubmed
    ..This investigation was aimed to determine whether the benzodiazepine lorazepam dose-dependently alters risk-taking behavior and underlying neural substrates...
  21. Pandharipande P, Shintani A, Peterson J, Pun B, Wilkinson G, Dittus R, et al. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006;104:21-6 pubmed
    ..b>Lorazepam was an independent risk factor for daily transition to delirium (odds ratio, 1.2 [95% confidence interval, 1.1-1...
  22. Mintzer M, Griffiths R. Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine. Exp Clin Psychopharmacol. 2005;13:336-47 pubmed
    This experiment was designed to use the graded dose-related amnesia produced by the benzodiazepine lorazepam (1.0, 2.0 mg/70 kg, oral) and the anticholinergic scopolamine (0.3, 0...
  23. Anderson M, Tambe P, Sammons H, Mulla H, Cole R, Choonara I. Pharmacokinetics of buccal and intranasal lorazepam in healthy adult volunteers. Eur J Clin Pharmacol. 2012;68:155-9 pubmed publisher
    To investigate the plasma-concentration profile of lorazepam when administered by the intranasal and buccal routes to determine their utility for the treatment of prolonged seizures...
  24. Perkins A, Ettinger U, Davis R, Foster R, Williams S, Corr P. Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety. J Neurosci. 2009;29:12617-24 pubmed publisher
    ..used a within-subjects, placebo-controlled, design to test this theory, measuring the effects of citalopram and lorazepam on the defensive behavior of 30 healthy adult male humans...
  25. Ahmad S, Ellis J, Kamwendo H, Molyneux E. Efficacy and safety of intranasal lorazepam versus intramuscular paraldehyde for protracted convulsions in children: an open randomised trial. Lancet. 2006;367:1591-7 pubmed
    ..These treatments can be expensive and sometimes toxic. We aimed to assess a drug and delivery system that is potentially more effective, safer, and easier to administer than those presently in use...
  26. Giersch A, Speeg Schatz C, Tondre M, Gottenkiene S. Impairment of contrast sensitivity in long-term lorazepam users. Psychopharmacology (Berl). 2006;186:594-600 pubmed
    Oculomotor balance and contrast sensitivity are known to be impaired after an intake of a single dose of lorazepam. To the best of our knowledge, these effects have not been explored in long-term users of lorazepam, despite the potential ..
  27. Kale A, Patravale V. Development and evaluation of lorazepam microemulsions for parenteral delivery. AAPS PharmSciTech. 2008;9:966-71 pubmed publisher
    The objective of this investigation was to develop lorazepam (LZM) microemulsions as an alternative to the conventional cosolvent based formulation. Solubility of LZM in various oils and Tween 80 was determined...
  28. Chung J, Cho J, Yu K, Kim J, Lim K, Sohn D, et al. Pharmacokinetic and pharmacodynamic interaction of lorazepam and valproic acid in relation to UGT2B7 genetic polymorphism in healthy subjects. Clin Pharmacol Ther. 2008;83:595-600 pubmed
    Pharmacokinetic and pharmacodynamic profiles of lorazepam and valproate were analyzed according to uridine 5'-diphosphate-glucuronosyltransferase (UGT)2B7 genotype in 14 healthy subjects with UGT2B15*2/*2 genotype...
  29. Pruett J, Rizvi S. A16-year-old girl with excited catatonia treated with low-dose oral Lorazepam. J Child Adolesc Psychopharmacol. 2005;15:1005-10 pubmed
    ..Her catatonic symptoms responded to low-dose oral lorazepam (higher doses led to worsening of her clinical status)...
  30. Pomara N, Belzer K, Silva R, Cooper T, Sidtis J. The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge. Psychopharmacology (Berl). 2008;201:125-35 pubmed publisher
    ..This allele has also been associated with increased memory impairment following oral lorazepam challenge in healthy elderly...
  31. Nelsen J, Haas C, Habtemariam B, Kaufman D, Partridge A, Welle S, et al. A prospective evaluation of propylene glycol clearance and accumulation during continuous-infusion lorazepam in critically ill patients. J Intensive Care Med. 2008;23:184-94 pubmed
    Propylene glycol is a commonly used diluent in several pharmaceutical preparations, including the sedative lorazepam. Fifty critically ill patients receiving continuous-infusion lorazepam for a minimum of 36 hours were prospectively ..
  32. Dotson B, Peeters M. Sedation with dexmedetomidine vs lorazepam in mechanically ventilated patients. JAMA. 2008;299:1540; author reply 1542 pubmed publisher
  33. de Haas S, Franson K, Schmitt J, Cohen A, Fau J, Dubruc C, et al. The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A alpha2,3 selective agonist, in comparison with lorazepam in healthy volunteers. J Psychopharmacol. 2009;23:625-32 pubmed publisher
    ..1498 in comparison with placebo and lorazepam 2 mg in healthy volunteers...
  34. Elliott M, Giersch A, Seifert D. Some facilitatory effects of lorazepam on dynamic visual binding. Psychopharmacology (Berl). 2006;184:229-38 pubmed
    The benzodiazepine lorazepam enhances the potential for inhibitory gamma-aminobutyric acid (GABAA) synapses in the cortex to stabilize postsynaptic, excitatory activity by synchronizing discharge rates at frequencies of around 40 Hz...
  35. Muchohi S, Obiero K, Newton C, Ogutu B, Edwards G, Kokwaro G. Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions. Br J Clin Pharmacol. 2008;65:12-21 pubmed
    To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions...
  36. Pietrzak R, Fredrickson A, Snyder P, Maruff P. A comparison of statistical approaches used to evaluate change in cognitive function following pharmacologic challenge: an example with lorazepam. Hum Psychopharmacol. 2010;25:335-41 pubmed publisher
    ..Data from a randomized, placebo-controlled, crossover study of the effect of an acute dose of lorazepam on cognitive function in healthy adults were analyzed using five statistical approaches (paired sample t-test, ..
  37. Ilechukwu S, Henry T. Amytal interview using intravenous lorazepam in a patient with dissociative fugue. Gen Hosp Psychiatry. 2006;28:544-5 pubmed
  38. Yahwak J, Riker R, Fraser G, Subak Sharpe S. Determination of a lorazepam dose threshold for using the osmol gap to monitor for propylene glycol toxicity. Pharmacotherapy. 2008;28:984-91 pubmed publisher
    To determine a threshold dose for parenteral lorazepam when screening for propylene glycol toxicity with the osmol gap, and to characterize which osmol gap values are more predictive of toxic propylene glycol concentrations and resultant ..
  39. Pandharipande P, Sanders R, Girard T, McGrane S, Thompson J, Shintani A, et al. Effect of dexmedetomidine versus lorazepam on outcome in patients with sepsis: an a priori-designed analysis of the MENDS randomized controlled trial. Crit Care. 2010;14:R38 pubmed publisher
    ..We hypothesized that sedation with dexmedetomidine (an alpha2 adrenoceptor agonist), as compared with lorazepam (a benzodiazepine), would provide greater improvements in clinical outcomes among septic patients than among non-..
  40. Seethalakshmi R, Dhavale S, Suggu K, Dewan M. Catatonic syndrome: importance of detection and treatment with lorazepam. Ann Clin Psychiatry. 2008;20:5-8 pubmed publisher
    ..Patients with two or more signs on the Instrument were subsequently administered intravenous lorazepam and their response was rated on the Bush Francis Catatonia Rating Scale...
  41. Cox C, Reed S, Govert J, Rodgers J, Campbell Bright S, Kress J, et al. Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation. Crit Care Med. 2008;36:706-14 pubmed publisher
    ..a hospital, we developed a probabilistic decision model to determine whether continuous propofol or intermittent lorazepam was associated with greater value when combined with daily awakenings...
  42. Nguyen N, Fakra E, Pradel V, Jouve E, Alquier C, Le Guern M, et al. Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. Hum Psychopharmacol. 2006;21:139-49 pubmed
    ..was to compare (non-inferiority test) the efficacies of etifoxine, a non-benzodiazepine anxiolytic drug, and lorazepam, a benzodiazepine, for ADWA outpatients followed by general practitioners...
  43. Skelton K, Gutman D, Thrivikraman K, Nemeroff C, Owens M. The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal. Psychopharmacology (Berl). 2007;192:385-96 pubmed
    ..as measured by CRF heteronuclear RNA, which occurs after flumazenil-precipitation of withdrawal from the BZ, lorazepam. These results indicate that the activation of CRF neuronal systems may be a common neurobiological mechanism in ..
  44. Bailey J, Kendrick A, Diaper A, Potokar J, Nutt D. A validation of the 7.5% CO2 model of GAD using paroxetine and lorazepam in healthy volunteers. J Psychopharmacol. 2007;21:42-9 pubmed
    ..healthy volunteers are described; study one is a double-blind, placebo-controlled study of a single dose of 2 mg lorazepam and study two describes the effects of 21 days of treatment with paroxetine. Gas challenges were air and 7...
  45. Rickels K, Fox I, Greenblatt D, Sandler K, Schless A. Clorazepate and lorazepam: clinical improvement and rebound anxiety. Am J Psychiatry. 1988;145:312-7 pubmed
    Sixty-two anxious patients were treated under double-blind conditions for 4 weeks with either clorazepate or lorazepam. Two-thirds of each treatment group were then switched abruptly to placebo for 2 weeks, while one-third continued to ..
  46. Al Khafaji A, Dewhirst W, Manning H. Propylene glycol toxicity associated with lorazepam infusion in a patient receiving continuous veno-venous hemofiltration with dialysis. Anesth Analg. 2002;94:1583-5, table of contents pubmed
    We report a case of toxicity from the drug solvent propylene glycol resulting from prolonged, large-dose lorazepam infusion...
  47. Agelink M, Majewski T, Andrich J, Mueck Weymann M. Short-term effects of intravenous benzodiazepines on autonomic neurocardiac regulation in humans: a comparison between midazolam, diazepam, and lorazepam. Crit Care Med. 2002;30:997-1006 pubmed
    To evaluate the effects of intravenously applied diazepam, lorazepam, and midazolam on autonomic neurocardiac regulation assessed by standardized measurements of heart rate variability. Prospective, randomized clinical study...
  48. Cigada M, Pezzi A, Di Mauro P, Marzorati S, Noto A, Valdambrini F, et al. Sedation in the critically ill ventilated patient: possible role of enteral drugs. Intensive Care Med. 2005;31:482-6 pubmed
    ..At admission, sedation was induced with propofol or midazolam. Enteral hydroxyzine (+/- enteral lorazepam) was added in all patients within the second day...
  49. Becker H, Veatch L. Effects of lorazepam treatment for multiple ethanol withdrawals in mice. Alcohol Clin Exp Res. 2002;26:371-80 pubmed
    ..The purpose of this study was to evaluate the ability of lorazepam treatment for multiple withdrawals to prevent or blunt the development/expression of sensitized central nervous ..
  50. Schmider J, Standhart H, Deuschle M, Drancoli J, Heuser I. A double-blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. Biol Psychiatry. 1999;46:437-41 pubmed
    ..such as severe psychomotor disturbance and mutism, associated with psychiatric disorder to the benzodiazepine lorazepam (LO)...
  51. Currier G, Simpson G. Risperidone liquid concentrate and oral lorazepam versus intramuscular haloperidol and intramuscular lorazepam for treatment of psychotic agitation. J Clin Psychiatry. 2001;62:153-7 pubmed
    ..safety, and tolerability of oral risperidone versus intramuscular haloperidol, both in combination with lorazepam, for the emergency treatment of psychotic agitation in patients who are able to accept oral medications...
  52. Nobay F, Simon B, Levitt M, Dresden G. A prospective, double-blind, randomized trial of midazolam versus haloperidol versus lorazepam in the chemical restraint of violent and severely agitated patients. Acad Emerg Med. 2004;11:744-9 pubmed
    To determine if midazolam is superior to lorazepam or haloperidol in the management of violent and severely agitated patients in the emergency department...
  53. Elia J, Dell M, Friedman D, Zimmerman R, Balamuth N, Ahmed A, et al. PANDAS with catatonia: a case report. Therapeutic response to lorazepam and plasmapheresis. J Am Acad Child Adolesc Psychiatry. 2005;44:1145-50 pubmed
    ..Hyperactivity, impulsivity, and inattention improved with lorazepam, suggesting that the attention-deficit/hyperactivity disorder symptoms could be manifestations of catatonia.
  54. Giersch A, Herzog M. Lorazepam strongly prolongs visual information processing. Neuropsychopharmacology. 2004;29:1386-94 pubmed
    b>Lorazepam is a drug that has been widely used for over 30 years...
  55. Rosburg T, Marinou V, Haueisen J, Smesny S, Sauer H. Effects of lorazepam on the neuromagnetic mismatch negativity (MMNm) and auditory evoked field component N100m. Neuropsychopharmacology. 2004;29:1723-33 pubmed
    ..We investigated the impact of the benzodiazepine lorazepam as a GABA agonist on the neuromagnetic MMN (MMNm) and auditory evoked field component N100m...
  56. Schreckenberger M, Lange Asschenfeldt C, Lange Asschenfeld C, Lochmann M, Mann K, Siessmeier T, et al. The thalamus as the generator and modulator of EEG alpha rhythm: a combined PET/EEG study with lorazepam challenge in humans. Neuroimage. 2004;22:637-44 pubmed
    ..EEG) alpha power and cerebral glucose metabolism before and after pharmacological alpha suppression by lorazepam. Ten healthy male volunteers were examined undergoing two F18-fluorodeoxyglucose (18-FDG) positron emission ..
  57. Marill K, Walsh M, Nelson B. Intravenous Lorazepam versus dimenhydrinate for treatment of vertigo in the emergency department: a randomized clinical trial. Ann Emerg Med. 2000;36:310-9 pubmed
    To determine whether lorazepam is more effective than dimenhydrinate in relieving the symptom of vertigo in the emergency department setting.
  58. Northoff G, Pfennig A, Krug M, Danos P, Leschinger A, Schwarz A, et al. Delayed onset of late movement-related cortical potentials and abnormal response to lorazepam in catatonia. Schizophr Res. 2000;44:193-211 pubmed
    ..e. gaba-potentiators like lorazepam. However, pathophysiological mechanisms of cortical motor and gaba-ergic dysfunction remain unclear...