clofibrate

Summary

Summary: A fibric acid derivative used in the treatment of HYPERLIPOPROTEINEMIA TYPE III and severe HYPERTRIGLYCERIDEMIA. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986)

Top Publications

  1. Ibabe A, Herrero A, Cajaraville M. Modulation of peroxisome proliferator-activated receptors (PPARs) by PPAR(alpha)- and PPAR(gamma)-specific ligands and by 17beta-estradiol in isolated zebrafish hepatocytes. Toxicol In Vitro. 2005;19:725-35 pubmed
    ..specific ligand (8S-HETE), a PPARgamma specific ligand (PGJ) and a peroxisome proliferator of the fibrate class (clofibrate) were selected...
  2. Cruz A, Rodríguez Gómez I, Pérez Abud R, Vargas M, Wangensteen R, Quesada A, et al. Effects of clofibrate on salt loading-induced hypertension in rats. J Biomed Biotechnol. 2011;2011:469481 pubmed publisher
    The effects of clofibrate on the hemodynamic and renal manifestations of increased saline intake were analyzed...
  3. Luci S, Giemsa B, Kluge H, Eder K. Clofibrate causes an upregulation of PPAR-{alpha} target genes but does not alter expression of SREBP target genes in liver and adipose tissue of pigs. Am J Physiol Regul Integr Comp Physiol. 2007;293:R70-7 pubmed
    This study investigated the effect of clofibrate treatment on expression of target genes of peroxisome proliferator-activated receptor (PPAR)-alpha and various genes of the lipid metabolism in liver and adipose tissue of pigs...
  4. Muzio G, Maggiora M, Trombetta A, Martinasso G, Reffo P, Colombatto S, et al. Mechanisms involved in growth inhibition induced by clofibrate in hepatoma cells. Toxicology. 2003;187:149-59 pubmed
    ..b>Clofibrate chiefly inhibited cell proliferation in these cells...
  5. Sivarajah A, Chatterjee P, Hattori Y, Brown P, Stewart K, Todorovic Z, et al. Agonists of peroxisome-proliferator activated receptor-alpha (clofibrate and WY14643) reduce renal ischemia/reperfusion injury in the rat. Med Sci Monit. 2002;8:BR532-9 pubmed
    ..study was to investigate the effects of peroxisome-proliferator activated receptor-alpha (PPAR-alpha) agonists, clofibrate and WY14643 on the renal dysfunction and injury caused by bilateral ischemia/reperfusion (I/R) of rat kidneys in ..
  6. Zhou Y, Huang H, Chang H, Du J, Wu J, Wang C, et al. Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. J Pharmacol Exp Ther. 2006;317:11-8 pubmed
    ..We also studied the effect of treatment with clofibrate, a CYP4A inducer, on sodium retention and renal function and on CYP4A expression in HF rats...
  7. Penna F, Pin F, Costamagna D, Reffo P, Baccino F, Bonelli G, et al. Caspase 2 activation and ER stress drive rapid Jurkat cell apoptosis by clofibrate. PLoS ONE. 2012;7:e45327 pubmed publisher
    ..action most commonly assigned to peroxisome proliferators (PPs), we demonstrated that some of them, clofibrate (CF) in particular, display clearcut apoptogenic properties on rat hepatoma cell lines...
  8. Sugatani J, Osabe M, Wada T, Yamakawa K, Yamazaki Y, Takahashi T, et al. Comparison of enzymatically synthesized inulin, resistant maltodextrin and clofibrate effects on biomarkers of metabolic disease in rats fed a high-fat and high-sucrose (cafeteria) diet. Eur J Nutr. 2008;47:192-200 pubmed publisher
    ..While naturally occurring inulin has anti-hyperlipidemic effects in animals and humans, health effects of synthetic inulin with different degrees of fructose polymerization remain poorly understood...
  9. Rajaraman G, Wang G, Yan J, Jiang P, Gong Y, Burczynski F. Role of cytosolic liver fatty acid binding protein in hepatocellular oxidative stress: effect of dexamethasone and clofibrate treatment. Mol Cell Biochem. 2007;295:27-34 pubmed
    ..L-FABP expressing 1548-hepatoma cells, treated with dexamethasone or clofibrate, decreased and increased intracellular L-FABP levels, respectively...

More Information

Publications62

  1. Muzio G, Martinasso G, Trombetta A, Di Simone D, Canuto R, Maggiora M. HMG-CoA reductase and PPARalpha are involved in clofibrate-induced apoptosis in human keratinocytes. Apoptosis. 2006;11:265-75 pubmed
    Contrasting data have been reported on the effects of clofibrate, a PPARalpha agonist and hypolipidemic drug...
  2. Gottlicher M, Widmark E, Li Q, Gustafsson J. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci U S A. 1992;89:4653-7 pubmed
    ..In conclusion, the present results indicate that fatty acids can regulate gene expression mediated by a member of the steroid nuclear receptor superfamily...
  3. Nunes B, Carvalho F, Guilhermino L. Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki. Chemosphere. 2004;57:1581-9 pubmed
    The objective of this study was to investigate both acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase (AChE), lactate dehydrogenase (LDH) and catalase (CAT) of the mosquitofish (Gambusia ..
  4. Le Bouquin R, Lugnier A, Frossard N, Pons F. Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Fundam Clin Pharmacol. 2004;18:181-6 pubmed
    ..characterized expression of CYP4A in the lung of BALB/c mice, and studied its regulation by the CYP4A inducer, clofibrate and by the pro-inflammatory and asthma-associated cytokine, interleukin-1beta (IL-1beta)...
  5. Canuto R, Muzio G, Maggiora M, Trombetta A, Martinasso G, Autelli R, et al. Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase. J Lipid Res. 2003;44:56-64 pubmed
    b>Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family. PPs are well-recognized hepatocarcinogens, though only for rodents and not for humans...
  6. Kimura S, Hardwick J, Kozak C, Gonzalez F. The rat clofibrate-inducible CYP4A subfamily. II. cDNA sequence of IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and coordinate and tissue-specific regulation of the CYP4A genes. DNA. 1989;8:517-25 pubmed
    A novel P450 cDNA, designated IVA3, was isolated from a lambda gt11 cDNA library from clofibrate-treated rat liver by screening with the lauric acid omega-hydroxylase, IVA1, cDNA probe...
  7. Rodríguez Gómez I, Cruz A, Moreno J, Soler A, Osuna A, Vargas F. Clofibrate prevents and reverses the hemodynamic manifestations of hyperthyroidism in rats. Am J Hypertens. 2008;21:341-7 pubmed publisher
    This study analyzed the effects of the chronic administration of clofibrate, a peroxisome proliferator-activated receptor-alpha (PPARalpha) agonist, on the development and established hemodynamic, morphologic, metabolic, and renal ..
  8. Jemnitz K, Veres Z, Monostory K, Vereczkey L. Glucuronidation of thyroxine in primary monolayer cultures of rat hepatocytes: in vitro induction of UDP-glucuronosyltranferases by methylcholanthrene, clofibrate, and dexamethasone alone and in combination. Drug Metab Dispos. 2000;28:34-7 pubmed
    ..UGTs) toward thyroxine (T4) and p-nitrophenol (pNP) by 3-methylcholanthrene (MC), dexamethasone (DEX), clofibrate (Cl), and MC combined with DEX or Cl was studied in rat hepatocyte culture...
  9. Hashimoto F, Oguchi Y, Morita M, Matsuoka K, Takeda S, Kimura M, et al. PPARalpha agonists clofibrate and gemfibrozil inhibit cell growth, down-regulate hCG and up-regulate progesterone secretions in immortalized human trophoblast cells. Biochem Pharmacol. 2004;68:313-21 pubmed
    ..These results suggest that gemfibrozil and clofibric acid inhibit the proliferation of trophoblast cells. Cell metabolism is probably affected by both agents. The two agents may down-regulate hCG and up-regulate progesterone secretions...
  10. Penna F, Bonelli G, Baccino F, Costelli P. Cytotoxic properties of clofibrate and other peroxisome proliferators: relevance to cancer progression. Curr Med Chem. 2010;17:309-20 pubmed
    ..The present review will focus on the cytotoxic effects exerted by several PPs, among which clofibrate, on different types of tumor cells, with particular reference to the mechanisms of cell death and to their ..
  11. Brass E. Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of coenzyme A availability. J Nutr. 1992;122:234-40 pubmed
    ..b>Clofibrate-treatment increases hepatic CoA content and carnitine acetyltransferase activity, both of which may modulate ..
  12. Kramer J, Blomme E, Bunch R, Davila J, Jackson C, Jones P, et al. Transcription profiling distinguishes dose-dependent effects in the livers of rats treated with clofibrate. Toxicol Pathol. 2003;31:417-31 pubmed
    ..using cDNA microarrays on livers of rats treated for 5 days with 3 doses of the peroxisome proliferator clofibrate. All 3 doses had hepatic effects as assessed by liver to body weight ratio, alanine aminotransferase (ALT) ..
  13. Ammerschlaeger M, Beigel J, Klein K, Mueller S. Characterization of the species-specificity of peroxisome proliferators in rat and human hepatocytes. Toxicol Sci. 2004;78:229-40 pubmed
    ..Nevertheless, our results showed that human hepatocytes limit the extent of peroxisome proliferation regardless of PPARalpha expression...
  14. Ringseis R, Luci S, Spielmann J, Kluge H, Fischer M, Geissler S, et al. Clofibrate treatment up-regulates novel organic cation transporter (OCTN)-2 in tissues of pigs as a model of non-proliferating species. Eur J Pharmacol. 2008;583:11-7 pubmed publisher
    ..An experiment with 18 pigs was performed which were fed a control diet or the same diet supplemented with 5 g clofibrate/kg for 28 days. Pigs treated with clofibrate had higher relative mRNA concentrations of OCTN2 in liver (3...
  15. Ringseis R, Pösel S, Hirche F, Eder K. Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats. Pharmacol Res. 2007;56:175-83 pubmed
    Activation of PPARalpha by clofibrate has recently been shown to cause upregulation of carnitine transporter organic cation transporter (OCTN) 2 and elevated carnitine concentrations in rat liver...
  16. Zahedpasha Y, Ahmadpour Kacho M, Hajiahmadi M, Naderi S. Effect of clofibrate in jaundiced full-term infants:a randomized clinical trial. Arch Iran Med. 2007;10:349-53 pubmed
    ..It can progress to kernicterus in severe forms, unless an intervention is initiated. The objective of this study was to determine the therapeutic effect of clofibrate in full-term neonates with nonhemolytic jaundice.
  17. Manautou J, Silva V, Hennig G, Whiteley H. Repeated dosing with the peroxisome proliferator clofibrate decreases the toxicity of model hepatotoxic agents in male mice. Toxicology. 1998;127:1-10 pubmed
    Pretreatment of mice with clofibrate (CFB) has been shown to protect against acetaminophen (APAP) hepatotoxicity...
  18. Chen C, Hennig G, Whiteley H, Manautou J. Protection against acetaminophen hepatotoxicity by clofibrate pretreatment: role of catalase induction. J Biochem Mol Toxicol. 2002;16:227-34 pubmed
    Mice pretreated with the peroxisome proliferator clofibrate (CFB) are highly resistant to acetaminophen (APAP)-induced hepatotoxicity...
  19. Luci S, Kluge H, Hirche F, Eder K. Clofibrate increases hepatic triiodothyronine (T3)- and thyroxine (T4)-glucuronosyltransferase activities and lowers plasma T3 and T4 concentrations in pigs. Drug Metab Dispos. 2006;34:1887-92 pubmed
    In rats, clofibrate acts as a microsomal enzyme inducer and disrupts the metabolism of thyroid hormones by increasing hepatic glucuronidation of thyroxine. Whether similar effects occur in the pig has not yet been investigated...
  20. Penna F, Reffo P, Muzio G, Canuto R, Baccino F, Bonelli G, et al. Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells. Biochem Pharmacol. 2009;77:169-76 pubmed publisher
    ..PPs, among which clofibrate (CF), have been extensively studied for their hepatocarcinogenic properties in rodents, generally ascribed to ..
  21. Moffit J, Aleksunes L, Kardas M, Slitt A, Klaassen C, Manautou J. Role of NAD(P)H:quinone oxidoreductase 1 in clofibrate-mediated hepatoprotection from acetaminophen. Toxicology. 2007;230:197-206 pubmed
    Mice pretreated with the peroxisome proliferator clofibrate (CFB) are resistant to acetaminophen (APAP) hepatotoxicity...
  22. Venkatachalam A, Lall S, Denovan Wright E, Wright J. Tissue-specific differential induction of duplicated fatty acid-binding protein genes by the peroxisome proliferator, clofibrate, in zebrafish (Danio rerio). BMC Evol Biol. 2012;12:112 pubmed publisher
    ..tested by analyzing the transcriptional induction of the duplicated fatty acid-binding protein (fabp) genes by clofibrate in zebrafish...
  23. Moffit J, Koza Taylor P, Holland R, Thibodeau M, Beger R, Lawton M, et al. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate. Toxicol Appl Pharmacol. 2007;222:169-79 pubmed
    Pretreatment of mice with the peroxisome proliferator clofibrate (CFB) protects against acetaminophen (APAP)-induced hepatotoxicity...
  24. Chen C, Hennig G, Whiteley H, Corton J, Manautou J. Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure. Toxicol Sci. 2000;57:338-44 pubmed
    ..from acetaminophen (APAP) hepatotoxicity produced by repeated administration of the peroxisome proliferator clofibrate (CFB)...
  25. Xu S, Zhu B, Conney A. Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats. Biochem Pharmacol. 2002;63:985-92 pubmed
    Treatment of rats with clofibrate markedly stimulated the liver microsomal esterification of estradiol, testosterone, pregnenolone, dehydroepiandrosterone, and corticosterone by acyl-CoA:steroid acyltransferase...
  26. Colton H, Falls J, Ni H, Kwanyuen P, Creech D, McNeil E, et al. Visualization and quantitation of peroxisomes using fluorescent nanocrystals: treatment of rats and monkeys with fibrates and detection in the liver. Toxicol Sci. 2004;80:183-92 pubmed
  27. Portilla D, Dai G, Peters J, Gonzalez F, Crew M, Proia A. Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. Am J Physiol Renal Physiol. 2000;278:F667-75 pubmed
    ..To examine the role of stimulated FAO during ischemia, Etomoxir (Eto), clofibrate, and WY-14,643 compounds were given 5 days prior to the induction of ischemia/reperfusion (I/R) injury...
  28. Canuto R, Maggiora M, Trombetta A, Martinasso G, Muzio G. Aldehyde dehydrogenase 3 expression is decreased by clofibrate via PPAR gamma induction in JM2 rat hepatoma cell line. Chem Biol Interact. 2003;143-144:29-35 pubmed
    ..In the present study we address the effect of clofibrate, a hypolipidemic drug and synthetic PPAR ligand on ALDH gene expression...
  29. Ibarra Lara L, Hong E, Soria Castro E, Torres Narvaez J, Perez Severiano F, del Valle Mondragon L, et al. Clofibrate PPAR? activation reduces oxidative stress and improves ultrastructure and ventricular hemodynamics in no-flow myocardial ischemia. J Cardiovasc Pharmacol. 2012;60:323-34 pubmed publisher
    ..We assessed the antioxidant effect of clofibrate-induced Peroxisome proliferator-activated receptor alpha (PPAR?) stimulation on ischemic myocardium on ..
  30. Kwon E, Do G, Cho Y, Park Y, Jeon S, Choi M. Anti-atherogenic property of ferulic acid in apolipoprotein E-deficient mice fed Western diet: comparison with clofibrate. Food Chem Toxicol. 2010;48:2298-303 pubmed publisher
    Anti-atherogenic effect of ferulic acid (0.02%, w/w) was investigated in comparison with the clofibrate (0.02%, w/w) in apolipoprotein E-deficient (apo E(-/-)) mice fed Western diet...
  31. Litherland N, Bionaz M, Wallace R, Loor J, Drackley J. Effects of the peroxisome proliferator-activated receptor-alpha agonists clofibrate and fish oil on hepatic fatty acid metabolism in weaned dairy calves. J Dairy Sci. 2010;93:2404-18 pubmed publisher
    ..Holstein calves (7 wk old; n=15) were assigned to 1 of 3 groups for a 5-d treatment period: control (untreated), clofibrate (62.5 mg/kg of BW), or fish oil (250 mg/kg of BW). Calves treated with clofibrate consumed less dry matter...
  32. Ringseis R, Lüdi S, Hirche F, Eder K. Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate increases intestinal carnitine absorption in rats. Pharmacol Res. 2008;58:58-64 pubmed publisher
    Activation of PPARalpha by clofibrate has recently been shown to cause upregulation of the high-affinity carnitine transporter novel organic cation transporter (OCTN) 2 in small intestine...
  33. Raucy J, Lasker J, Ozaki K, Zoleta V. Regulation of CYP2E1 by ethanol and palmitic acid and CYP4A11 by clofibrate in primary cultures of human hepatocytes. Toxicol Sci. 2004;79:233-41 pubmed
    ..In addition, the xenochemical clofibrate has been reported to induce both rodent CYP2E1 and CYP4A. These findings suggest similar modes of regulation...
  34. Akbiyik F, Cinar K, Demirpence E, Ozsullu T, Tunca R, Haziroglu R, et al. Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver. Eur J Clin Invest. 2004;34:429-35 pubmed
    ..The aim of this study was to assess the PPARalpha expression pattern and mitochondrial/peroxisomal enzyme activities in response to high fat diet (HFD) and clofibrate, a well known PPARalpha ligand.
  35. Konig B, Kluge H, Haase K, Brandsch C, Stangl G, Eder K. Effects of clofibrate treatment in laying hens. Poult Sci. 2007;86:1187-95 pubmed
    ..In this study, laying hens were treated with clofibrate, a synthetic PPARalpha agonist, to investigate the effects of PPARalpha activation on liver lipid metabolism...
  36. Mohammadzadeh A, Farhat A, Iranpour R. Effect of clofibrate in jaundiced term newborns. Indian J Pediatr. 2005;72:123-6 pubmed
    b>Clofibrate is a glucuronosyl transferase inducer that has been proposed to increase the elimination of bilirubin in neonates with hyperbilirubinemia...
  37. Newaz M, Blanton A, Fidelis P, Oyekan A. NAD(P)H oxidase/nitric oxide interactions in peroxisome proliferator activated receptor (PPAR)alpha-mediated cardiovascular effects. Mutat Res. 2005;579:163-71 pubmed
    ..b>Clofibrate, a PPARalpha ligand, increased NOS activity in WT but not KO mice...
  38. Leonard J, Courcol M, Mariet C, Charbonnier A, Boitier E, Duchesne M, et al. Proteomic characterization of the effects of clofibrate on protein expression in rat liver. Proteomics. 2006;6:1915-33 pubmed
    b>Clofibrate is a peroxisome proliferator known to induce liver tumours in rats. A proteomics study was conducted to provide new insights into the molecular mechanisms of clofibrate-induced non-genotoxic hepatocarcinogenesis...
  39. Nakamura M, Kuroiwa N, Kono Y, Takatsuki A. Characterization of clofibrate-induced retrograde Golgi membrane movement to the endoplasmic reticulum: clofibrate distinguishes the Golgi from the trans Golgi network. Biosci Biotechnol Biochem. 2001;65:1812-23 pubmed
    b>Clofibrate-induced retrograde Golgi membrane movement was blocked or retarded when NRK cells were treated with sodium azide/2-deoxyglucose, nocodazole, taxol, and destruxin B, indicating that it depends on energy, and the dynamic state of ..
  40. Lei Z, Chen W, Zhang M, Napoli J. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Biochemistry. 2003;42:4190-6 pubmed
    ..Feeding mice for 2 weeks with a diet containing clofibrate (0...
  41. Tian Q, Grzemski F, Panagiotopoulos S, Ahokas J. Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. Chem Biol Interact. 2006;160:241-51 pubmed
    ..In this study, male Sprague-Dawley rats were treated with either vehicle (olive oil, 1 ml/kg) or clofibrate (300 mg/kgday i.p.) for 1-14 days...
  42. Lundgren B, Bergstrand A, Karlsson K, DePierre J. Effects of dietary treatment with clofibrate, nafenopin or WY-14.643 on mitochondria and DNA in mouse liver. Biochim Biophys Acta. 1990;1035:132-8 pubmed
    Male C57bl/6 mice were administered clofibrate (0.5%, w/w), nafenopin (0.125%, w/w) or WY-14.643 (0.125%, w/w) in their diet for 4 days. Assay of eight mitochondrial marker enzymes, -i.e...
  43. Ishiguro H, Katano Y, Nakano I, Ishigami M, Hayashi K, Honda T, et al. Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver. Life Sci. 2006;79:737-43 pubmed
    ..Clofibric acid (an active metabolite of clofibrate) is known to promote the BCAA catabolism by activation of branched-chain alpha-keto acid dehydrogenase complex (..
  44. Yakubu M, Nsaif R, Oyekan A. Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate. Bratisl Lek Listy. 2010;111:258-64 pubmed
  45. Seo K, Kim K, Kim Y, Choi J, Lee K, Choi K. Comparison of oxidative stress and changes of xenobiotic metabolizing enzymes induced by phthalates in rats. Food Chem Toxicol. 2004;42:107-14 pubmed
    ..Peroxisome proliferators (PPs), such as di-2-ethylhexyl phthalate (DEHP) and clofibrate (CF) are known to have a hepatocarcinogenic potential in rodents...
  46. Abe I, Okumoto K, Tamura S, Fujiki Y. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11. FEBS Lett. 1998;431:468-72 pubmed
    ..comigrated in SDS-PAGE with a 28-kDa peroxisomal integral membrane protein (PMP28) isolated from the liver of clofibrate-treated rats and was crossreactive to anti-PMP28 antibody, thereby indicating PEX11 to encode PMP28...
  47. Luci S, Giemsa B, Hause G, Kluge H, Eder K. Clofibrate treatment in pigs: effects on parameters critical with respect to peroxisome proliferator-induced hepatocarcinogenesis in rodents. BMC Pharmacol. 2007;7:6 pubmed
    ..In this study the effect of clofibrate treatment on peroxisome proliferation, production of oxidative stress, gene expression of pro- and anti-..
  48. Khodadadi I, Griffin B, Thumser A. Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes. Arch Iran Med. 2008;11:42-9 pubmed
    ..The aim of this study was to investigate the effects of long-chain fatty acids and clofibrate on mRNA levels of specific lipid metabolism-related genes and to determine their effects on global transcriptome ..
  49. Bogdanska J, Todorova B, Labudovic D, Atanasovska E. Effect of clofibrate on the enzymes associated with oxidative stress in Wistar rat liver. Bratisl Lek Listy. 2007;108:56-64 pubmed
    ..The aim of our study was to see the effect of clofibrate on the enzymes associated with oxidative stress.
  50. Tomiyama N, Yasuda N, Iwano C, Matzno S, Matsuyama K. Flow cytometric evaluation of synergistic pro-apoptotic effects of statins and clofibrates in IM-9 human lymphoblasts. Clin Exp Pharmacol Physiol. 2007;34:876-80 pubmed
    ..3. Incubation of IM-9 cells with both 0.1 micromol/L cerivastatin and 200 micromol/L clofibrate had a synergistic effect compared with 0.1 micromol/L cerivastatin alone or 200 micromol/L clofibrate alone...
  51. Gustafson L, Kuipers F, Wiegman C, Sauerwein H, Romijn J, Meijer A. Clofibrate improves glucose tolerance in fat-fed rats but decreases hepatic glucose consumption capacity. J Hepatol. 2002;37:425-31 pubmed
    ..High-fat (HF) diets cause glucose intolerance. Fibrates improve glucose tolerance. We have tried to obtain information on possible hepatic mechanisms contributing to this effect...
  52. Baker V, Harries H, Waring J, Duggan C, Ni H, Jolly R, et al. Clofibrate-induced gene expression changes in rat liver: a cross-laboratory analysis using membrane cDNA arrays. Environ Health Perspect. 2004;112:428-38 pubmed
    ..Application of Genomics to Mechanism-Based Risk Assessment, the biological response in rats to the hepatotoxin clofibrate was investigated...
  53. Do G, Kwon E, Ha T, Park Y, Kim H, Jeon S, et al. Tannic acid is more effective than clofibrate for the elevation of hepatic ?-oxidation and the inhibition of 3-hydroxy-3-methyl-glutaryl-CoA reductase and aortic lesion formation in apo E-deficient mice. Br J Nutr. 2011;106:1855-63 pubmed publisher
    The effects of tannic acid (TA) supplementation (0·02 %, wt/wt) were compared with the effects of clofibrate (CF) supplementation (0·02 %, wt/wt) in apo E-deficient (apo E(- / -)) mice fed a AIN-76 semi-synthetic diet (normal diet) over ..