thioglycolates

Summary

Summary: Organic esters of thioglycolic acid (HS-CH2COOH).

Top Publications

  1. Lee D, Zhang W, Shirley S, Kong X, Hellermann G, Lockey R, et al. Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene delivery. Pharm Res. 2007;24:157-67 pubmed
    ..Herein, we report on a highly effective gene delivery system utilizing a 33-kDa thiol-modified chitosan derivative...
  2. Chen S, Luetje C. Identification of new agonists and antagonists of the insect odorant receptor co-receptor subunit. PLoS ONE. 2012;7:e36784 pubmed publisher
    ..We have explored the chemical space around the VUAA1 structure in order to identify new Orco ligands...
  3. Trebino C, Eskra J, Wachtmann T, Perez J, Carty T, Audoly L. Redirection of eicosanoid metabolism in mPGES-1-deficient macrophages. J Biol Chem. 2005;280:16579-85 pubmed
    ..The redirection of prostaglandin production in mPGES-1-/- cells provides novel insights into how a cell processes the unstable endoperoxide PGH2 during the inactivation of a major metabolic outlet...
  4. Sirmali M, Uz E, Sirmali R, Kilbas A, Yilmaz H, Agackiran Y, et al. The effects of erdosteine on lung injury induced by the ischemia-reperfusion of the hind-limbs in rats. J Surg Res. 2008;145:303-7 pubmed
    ..corrected] The goal of this experimental study was to investigate whether erdosteine has a protective effect against lung injury as a remote organ after hind-limb ischemia-reperfusion (I/R)...
  5. Jones P, Pask G, Romaine I, Taylor R, Reid P, Waterson A, et al. Allosteric antagonism of insect odorant receptor ion channels. PLoS ONE. 2012;7:e30304 pubmed publisher
    ..In an effort to identify additional Orco modulators, we have investigated the structure/activity relationships around VUAA1...
  6. Dal Negro R, Visconti M, Micheletto C, Tognella S. Changes in blood ROS, e-NO, and some pro-inflammatory mediators in bronchial secretions following erdosteine or placebo: a controlled study in current smokers with mild COPD. Pulm Pharmacol Ther. 2008;21:304-8 pubmed
    ..Anti-oxidant interventions consist in reduction of direct oxidant damage by removing oxidant agents and/or by supplementing reducing agents with anti-oxidant effects...
  7. Jones P, Pask G, Rinker D, Zwiebel L. Functional agonism of insect odorant receptor ion channels. Proc Natl Acad Sci U S A. 2011;108:8821-5 pubmed publisher
  8. Erden E, Kirkil G, Deveci F, Ilhan N, Cobanoglu B, Turgut T, et al. [Effects of erdosteine on inflammation and fibrosis in rats with pulmonary fibrosis induced by bleomycin]. Tuberk Toraks. 2008;56:127-38 pubmed
    ..01). We conclude that erdosteine may prevent the acute lung inflammation and fibrosis by suppressing the accumulation of neutrophils, inhibition of lipid peroxydation, chemokine production, and release...
  9. Keul P, Lucke S, von Wnuck Lipinski K, Bode C, Graler M, Heusch G, et al. Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis. Circ Res. 2011;108:314-23 pubmed publisher
    ..The role of sphingosine-1-phosphate (S1P) and its receptors in the pathogenesis of atherosclerosis has not been investigated...

More Information

Publications93

  1. Hrabak A, Bajor T, Csuka I. The effect of various inflammatory agents on the alternative metabolic pathways of arginine in mouse and rat macrophages. Inflamm Res. 2006;55:23-31 pubmed
    ..The effects of various inflammatory stimuli on the alternative arginine metabolic pathways in mouse and rat peritoneal macrophages were investigated in vitro and compared...
  2. Schenkel A, Chew T, Muller W. Platelet endothelial cell adhesion molecule deficiency or blockade significantly reduces leukocyte emigration in a majority of mouse strains. J Immunol. 2004;173:6403-8 pubmed
    ..Murine models of inflammatory disease that have been studied using C57BL/6 mice should be re-evaluated using FVB/n or other mouse strains to determine whether PECAM plays a role in those models...
  3. Hou S, Zhang L, Wu K, Xia L. Thioglycolic acid inhibits mouse oocyte maturation and affects chromosomal arrangement and spindle configuration. Toxicol Ind Health. 2008;24:227-34 pubmed publisher
    ..Furthermore, it probably interferes with biochemical changes that occur during meiosis, resulting in aberrant development...
  4. Zhang L, Hou S, Wang D, Wu K, Xia L. Effects of thioglycolic acid on progesterone-induced maturation of Xenopus oocytes. J Toxicol Environ Health A. 2009;72:1123-31 pubmed publisher
    ..Since egg formation is essential to maintain appropriate reproductive capacity, our findings may have certain toxicological implications...
  5. Cook A, Braine E, Hamilton J. The phenotype of inflammatory macrophages is stimulus dependent: implications for the nature of the inflammatory response. J Immunol. 2003;171:4816-23 pubmed
    ..The inflammatory response elicited using the Ag mBSA may be more relevant for studying the inflammatory responses in many diseases, such as those of autoimmune origin and those involving an acquired immune response...
  6. Barthelmes J, Dünnhaupt S, Hombach J, Bernkop Schnurch A. Thiomer nanoparticles: stabilization via covalent cross-linking. Drug Deliv. 2011;18:613-9 pubmed publisher
    ..The method described here might be useful for the preparation of stable nanoparticulate drug delivery systems...
  7. Block H, Herter J, Rossaint J, Stadtmann A, Kliche S, Lowell C, et al. Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med. 2012;209:407-21 pubmed publisher
    ..Thus, SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced AKI in humans...
  8. Gradauer K, Vonach C, Leitinger G, Kolb D, Fröhlich E, Roblegg E, et al. Chemical coupling of thiolated chitosan to preformed liposomes improves mucoadhesive properties. Int J Nanomedicine. 2012;7:2523-34 pubmed publisher
    ..To develop mucoadhesive liposomes by anchoring the polymer chitosan-thioglycolic acid (chitosan-TGA) to the liposomal surface to target intestinal mucosal membranes...
  9. Wiege K, Le D, Syed S, Ali S, Novakovic A, Beer Hammer S, et al. Defective macrophage migration in G?i2- but not G?i3-deficient mice. J Immunol. 2012;189:980-7 pubmed publisher
    ..These results indicate that G?(i2), albeit redundant to G?(i3) in some macrophage activation processes, clearly exhibits a G?(i) isoform-specific role in the regulation of macrophage migration...
  10. Wan H, Coppens J, van Helden Meeuwsen C, Leenen P, Van Rooijen N, Khan N, et al. Chorionic gonadotropin alleviates thioglycollate-induced peritonitis by affecting macrophage function. J Leukoc Biol. 2009;86:361-70 pubmed publisher
    ..Together, these data suggest that hCG contributes to the controlled inflammatory state of pregnancy by regulating Mphi proinflammatory function...
  11. Gan H, Meng X, Song C, Li B. A survey on health effects in a human population exposed to permanent-waving solution containing thioglycolic acid. J Occup Health. 2003;45:400-4 pubmed
    ..Our results suggest that the reproductive function of hairdressers may be affected by long-term exposure to PWS, probably due to the presence of TGA, and more attention should be paid to its potential carcinogenic effects...
  12. Kast C, Frick W, Losert U, Bernkop Schnurch A. Chitosan-thioglycolic acid conjugate: a new scaffold material for tissue engineering?. Int J Pharm. 2003;256:183-9 pubmed
    ..Direct injectable matrices at the site of tissue damage mimicking the tissue being restored may be a future trend on this topic. Hence, chitosan-TGA is a promising candidate as scaffold material in tissue engineering...
  13. Dünnhaupt S, Barthelmes J, Rahmat D, Leithner K, Thurner C, Friedl H, et al. S-protected thiolated chitosan for oral delivery of hydrophilic macromolecules: evaluation of permeation enhancing and efflux pump inhibitory properties. Mol Pharm. 2012;9:1331-41 pubmed publisher
    ..These features approve S-protected thiolated chitosan as a promising excipient for various drug delivery systems providing improved permeation enhancing and efflux inhibition effects...
  14. Moretti M, Marchioni C. An overview of erdosteine antioxidant activity in experimental research. Pharmacol Res. 2007;55:249-54 pubmed
    ..Recent positive clinical trials in humans seem to fulfill the impressive promises that theory and experimental research have put forward...
  15. Coxon A, Rieu P, Barkalow F, Askari S, Sharpe A, von Andrian U, et al. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996;5:653-66 pubmed
    ..Thus, CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils...
  16. Segal B, Kuhns D, Ding L, Gallin J, Holland S. Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol. 2002;71:410-6 pubmed
    ..These data suggest that LTB(4) and C5a have separate but overlapping roles in thioglycollate-elicited peritonitis, and at least the leukotriene component is, in turn, regulated by reactive oxidants...
  17. Kast C, Bernkop Schnurch A. Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates. Biomaterials. 2001;22:2345-52 pubmed
    ..According to these results. chitosan-TGA conjugates represent a promising tool for the development of mucoadhesive drug delivery systems...
  18. Hartwell D, Mayadas T, Berger G, Frenette P, Rayburn H, Hynes R, et al. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol. 1998;143:1129-41 pubmed
    ..Our results suggest that different sorting mechanisms for P-selectin are used in platelets and endothelial cells and that the storage pool of P-selectin in endothelial cells is functionally important during early stages of inflammation...
  19. Lu H, Smith C, Perrard J, Bullard D, Tang L, Shappell S, et al. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J Clin Invest. 1997;99:1340-50 pubmed
    ..Our results demonstrate that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophil emigration, which is more dependent upon LFA-1...
  20. Lagasse E, Weissman I. Flow cytometric identification of murine neutrophils and monocytes. J Immunol Methods. 1996;197:139-50 pubmed
    ..The method described in this paper is simple to perform and can be applied to characterize myeloid cells from blood, spleen, bone marrow and after an induced inflammation. ..
  21. Navratil T, Kohlíková E, Petr M, Pelclova D, Heyrovský M, Pristoupilova K. Supplemented creatine induces changes in human metabolism of thiocompounds and one- and two-carbon units. Physiol Res. 2010;59:431-42 pubmed
    ..Differences between initial and terminal TDGA levels indicate that creatine affects equilibria of redox processes. Creatinine excretion into urine changed in the dependence on the extent of metabolic disturbances. ..
  22. Fujikawa T, Fujita R, Iwaki Y, Matsumura S, Fushiki T, Inoue K. Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity. Physiol Behav. 2010;101:370-5 pubmed publisher
    ..p. MA administration were eliminated by vagotomy. Our data suggest that TGF-beta in the CSF is activated by the inhibition of FA oxidation via the vagus nerve and that this subsequently induces depression of SMA. ..
  23. Arica V, Tutanc M, Ozturk O, Arica S, Basarslan F, Erden E, et al. Dual effects of erdosteine on hemostasis via its different metabolites in young rats. Hum Exp Toxicol. 2011;30:1644-8 pubmed publisher
    ..We have concluded erdosteine may disrupt hemostasis parameters by its different metabolites in patients. Erdosteine has dual effects on hemostasis via its different metabolites, which occur in different doses. ..
  24. Blum A, Moore M, Ratna B. Quantum dot fluorescence as a function of alkyl chain length in aqueous environments. Langmuir. 2008;24:9194-7 pubmed publisher
    ..Our results show that the quantum yield of CdSe/ZnS quantum dots is highest for the longest alkyl chain length, suggesting that a more hydrophobic environment is beneficial for generating bright, water-soluble quantum dots. ..
  25. Boyaci H, Maral H, Turan G, Basyigit I, Dillioglugil M, Yildiz F, et al. Effects of erdosteine on bleomycin-induced lung fibrosis in rats. Mol Cell Biochem. 2006;281:129-37 pubmed
  26. Ayna G, Krysko D, Kaczmarek A, Petrovski G, Vandenabeele P, Fesus L. ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages. PLoS ONE. 2012;7:e40069 pubmed publisher
    ..These findings demonstrate that NALP3 performs key upstream functions in inflammasome activation in mouse macrophages engulfing dying autophagic cells, and that these functions lead to pro-inflammatory responses. ..
  27. Terzi A, Iraz M, Sahin S, Ilhan A, Idiz N, Fadillioglu E. Protective effects of erdosteine on rotenone-induced oxidant injury in liver tissue. Toxicol Ind Health. 2004;20:141-7 pubmed
    ..833, P < 0.05). In the light of these findings, erdosteine may be a protective agent for rotenone-induced liver oxidative injury in rats. ..
  28. Demiralay R, Gursan N, Erdem H. Regulation of sepsis-induced apoptosis of pulmonary cells by posttreatment of erdosteine and N-aceylcysteine. Toxicology. 2006;228:151-61 pubmed
    ..This finding suggests that the effects of erdosteine at the administered dose on apoptosis regulation are stronger than that of NAC. ..
  29. Dal Negro R, Visconti M, Trevisan F, Bertacco S, Micheletto C, Tognella S. Erdosteine enhances airway response to salbutamol in patients with mild-to-moderate COPD. Ther Adv Respir Dis. 2008;2:271-7 pubmed publisher
    ..E provides a sort of indirect bronchodilation through 're-sensitisation' of beta( 2)-adrenoceptors. Once confirmed in further controlled studies, it may be useful in long-term treatment of COPD. ..
  30. Bushek D, Landau B, Scarpa E. Perkinsus chesapeaki in stout razor clams Tagelus plebeius from Delaware Bay. Dis Aquat Organ. 2008;78:243-7 pubmed publisher
    ..Investigators are further cautioned to use care when applying and interpreting diagnostic assays when used with novel species. ..
  31. Yildirim Z, Turkoz Y, Kotuk M, Armutcu F, Gurel A, Iraz M, et al. Effects of aminoguanidine and antioxidant erdosteine on bleomycin-induced lung fibrosis in rats. Nitric Oxide. 2004;11:156-65 pubmed
    ..Also our data suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitric oxide generation in this model. ..
  32. Steventon G, Mitchell S. Thiodiglycolic acid and dermatological reactions following S-carboxymethyl-L-cysteine administration. Br J Dermatol. 2006;154:386-7 pubmed
  33. Xia J, Wei W, Hu Y, Tao H, Wu L. A novel voltammetric method for the direct determination of copper in complex environmental samples. Anal Sci. 2004;20:1037-41 pubmed
    ..Copper in a real environmental sample was successfully detected. ..
  34. Jongstra Bilen J, Zhang C, Wisnicki T, Li M, White Alfred S, Ilaalagan R, et al. Oxidized Low-Density Lipoprotein Loading of Macrophages Downregulates TLR-Induced Proinflammatory Responses in a Gene-Specific and Temporal Manner through Transcriptional Control. J Immunol. 2017;199:2149-2157 pubmed publisher
    ..This study revealed that oxLDL loading of M?s negatively regulates transcription at late stages of TLR-induced proinflammatory gene expression and implicates epigenetic mechanisms such as histone deacetylase activity. ..
  35. Mei F, He X, Li W, Zhang Y. Effects of the grafting on the fluorescence properties of CdTe nanocrystals. Luminescence. 2009;24:379-85 pubmed publisher
    ..The fluorescence intensity of the carboxyl-grafted TGA-CdTe was more stable than that of the amino-grafted TGA-CdTe at wide pH ranges (pH 5.1-10.0). ..
  36. Nowak N, Fischer O, Gust T, Fuhrmann U, Habenicht U, Schmidt A. Intraperitoneal inflammation decreases endometriosis in a mouse model. Hum Reprod. 2008;23:2466-74 pubmed publisher
    ..An intraperitoneal inflammation decreases endometriosis establishment in this mouse model. Thus, a pre-existing peritoneal inflammation might not be a factor favouring the development of endometriosis. ..
  37. Dal Negro R. Erdosteine: antitussive and anti-inflammatory effects. Lung. 2008;186 Suppl 1:S70-3 pubmed publisher
  38. Zabashta Y, Kasprova A, Senchurov S, Grabovskii Y. The location of the thioglycolic acid molecules in intrafibrillar unordered areas of the human hair keratin structure. Int J Cosmet Sci. 2012;34:223-5 pubmed publisher
    ..Based on this fact it has been concluded that the redistribution of disulphide bonds of hair occurs mainly in the mentioned above areas when treated with thioglycolic acid solution. ..
  39. Seal A, Pratley J, Haig T, An M. Identification and quantitation of compounds in a series of allelopathic and non-allelopathic rice root exudates. J Chem Ecol. 2004;30:1647-62 pubmed
    ..Greater amounts of trans-ferulic acid, p-hydroxybenzoic acid, and caffeic acid were detected in the exudates of allelopathic cultivars. The seventh compound, abietic acid, was significantly higher in the non-allelopathic cultivars. ..
  40. Sun G, Anderson V. Prevention of artifactual protein oxidation generated during sodium dodecyl sulfate-gel electrophoresis. Electrophoresis. 2004;25:959-65 pubmed
  41. Zhang L, Zhu K, Ding T, Hu X, Sun Q, Xu C. Quantum dot-phenanthroline dyads: detection of double-stranded DNA using a photoinduced hole transfer mechanism. Analyst. 2013;138:887-93 pubmed publisher
    ..Therefore, the QD-molecule direct conjugation based fluorescent probe could provide an effective alternative to those based on QD-bioconjugation and QD-ionic conjugation. ..
  42. Zhao W, Hu Z, Chen G, Ito R, Hu Z. Contributions of IMP-10 metallo-beta-lactamase, the outer membrane barrier and the MexAB-OprM efflux system to high-level carbapenem resistance in Pseudomonas aeruginosa. Chemotherapy. 2009;55:168-74 pubmed publisher
    ..The acquired IMP-10 MBL is a crucial factor in the high-level resistance to carbapenems in P. aeruginosa clinical isolates, while the outer membrane barrier and the MexAB-OprM efflux system play a basic and minor role, respectively. ..
  43. Franz N, Menin L, Klok H. A post-modification approach to peptide foldamers. Org Biomol Chem. 2009;7:5207-18 pubmed publisher
  44. Kandov Y, Israel Y, Kest A, Dostova I, Verasammy J, Bernal S, et al. GABA receptor subtype antagonists in the nucleus accumbens shell and ventral tegmental area differentially alter feeding responses induced by deprivation, glucoprivation and lipoprivation in rats. Brain Res. 2006;1082:86-97 pubmed
  45. Yoshimatsu Y, Yamazaki T, Mihira H, Itoh T, Suehiro J, Yuki K, et al. Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1. J Cell Sci. 2011;124:2753-62 pubmed publisher
    ..Furthermore, we found that both Prox1 and Ets-2 bind to the VEGFR3 promoter in intact chromatin. These findings suggest that Ets family members function as transcriptional cofactors that enhance Prox1-induced lymphangiogenesis. ..
  46. Gurel A, Armutcu F, Cihan A, Numanoglu K, Unalacak M. Erdosteine improves oxidative damage in a rat model of renal ischemia-reperfusion injury. Eur Surg Res. 2004;36:206-9 pubmed
    ..Our data support a role for erdosteine in attenuation in renal damage after I/R injury of the kidney, in part at least by inhibition of neutrophil sequestration and XO activity. ..
  47. Wang S, Wei M, Huang Y. Biosorption of multifold toxic heavy metal ions from aqueous water onto food residue eggshell membrane functionalized with ammonium thioglycolate. J Agric Food Chem. 2013;61:4988-96 pubmed publisher
    ..The effects of solution pH, coexisting substances, and natural water matrices were studied. The thiol-functionalized eggshell membrane can be used as column packing to fabricate a column for real wastewater purification. ..
  48. Lai J. Biodegradable in situ gelling delivery systems containing pilocarpine as new antiglaucoma formulations: effect of a mercaptoacetic acid/N-isopropylacrylamide molar ratio. Drug Des Devel Ther. 2013;7:1273-85 pubmed publisher
  49. Cicek E, Sutcu R, Gokalp O, Yilmaz H, Ozer M, Uz E, et al. The effects of isoniazid on hippocampal NMDA receptors: protective role of erdosteine. Mol Cell Biochem. 2005;277:131-5 pubmed
  50. Sener G, Sehirli A, Toklu H, Yuksel M, Ercan F, Gedik N. Erdosteine treatment attenuates oxidative stress and fibrosis in experimental biliary obstruction. Pediatr Surg Int. 2007;23:233-41 pubmed
  51. Umarova B, Lelekova T, Kopylova G, Goncharova E, Bakaeva Z, Samonina G. The role of protective effects of proline-containing peptides (PGP, PG, and GP) in contractile dysfunction of mesenteric lymphatic vessels in rats with experimental acute peritonitis. Bull Exp Biol Med. 2006;142:279-82 pubmed
    ..Our results attest to the possibility of using peptides for the correction of mesenteric microcirculatory disturbances during inflammation. ..
  52. Yesildag A, Ozden A, Yilmaz H, Uz E, Agackiran Y, Yesildağ M, et al. Erdosteine modulates radiocontrast-induced hepatotoxicity in rat. Cell Biochem Funct. 2009;27:142-7 pubmed publisher
    ..Erdosteine seems to be protective agent on the radiocontrast media-induced liver toxicity by inhibiting the production of ROS via the enzymatic antioxidant system...
  53. Simšíková M, Antalik M, Kaňuchová M, Skvarla J. Cytochrome c conjugated to ZnO-MAA nanoparticles: the study of interaction and influence on protein structure. Int J Biol Macromol. 2013;59:235-41 pubmed publisher
    ..Our observations from UV-vis spectroscopy and circular dichroism performed preserved protein structure after the interaction with modified nanoparticles...
  54. Sunay M, Dadalı M, Emir L, Karabulut A, Erol D. Effect of thioglycolic acid instillation to stop hair growth on the urethral mucosa after urethroplasty with hairy skin in a rat model. Urol Int. 2010;84:282-5 pubmed publisher
    ..The aim of this study was to investigate the impact of thioglycolic acid on normal urethral mucosa...
  55. Bondue B, De Henau O, Luangsay S, Devosse T, de Nadai P, Springael J, et al. The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLoS ONE. 2012;7:e40043 pubmed publisher
    ..In conclusion, our results rule out the direct anti-inflammatory effect of chemerin on macrophages ex vivo, described previously in the literature, despite the expression of a functional ChemR23 receptor in these cells...
  56. Wachino J, Yamaguchi Y, Mori S, Kurosaki H, Arakawa Y, Shibayama K. Structural insights into the subclass B3 metallo-?-lactamase SMB-1 and the mode of inhibition by the common metallo-?-lactamase inhibitor mercaptoacetate. Antimicrob Agents Chemother. 2013;57:101-9 pubmed publisher
    ..Our results demonstrate the possibility that MCR could be a potent inhibitor for subclass B3 MBLs and that the screening technique using MCR as an inhibitor would be effective for detecting subclass B3 MBL producers...
  57. Cook A, Braine E, Hamilton J. Stimulus-dependent requirement for granulocyte-macrophage colony-stimulating factor in inflammation. J Immunol. 2004;173:4643-51 pubmed
    ..Of general significance, the findings also indicate that the nature of the stimulus is quite critical in determining whether a particular inflammatory mediator, such as GM-CSF, plays a role in an ensuing inflammatory reaction...
  58. Waissbluth S, Dupuis I, Daniel S. Protective effect of erdosteine against cisplatin-induced ototoxicity in a guinea pig model. Otolaryngol Head Neck Surg. 2012;146:627-32 pubmed publisher
    ..No treatment has yet been approved for this condition. The objective of this study was to determine the potential protective effect of a systemic administration of erdosteine against cisplatin-induced ototoxicity...
  59. Stanojevic S, Kustrimović N, Mitić K, Vujić V, Aleksić I, Dimitrijević M. Peritoneal mast cell degranulation differently affected thioglycollate-induced macrophage phenotype and activity in Dark Agouti and Albino Oxford rats. Life Sci. 2013;93:564-72 pubmed publisher
    ..The objective of the study was to explore macrophage effector functions during different inflammatory conditions in two rat strains...
  60. Jeong H, Chung H, An H, Kim J, Lee E, Park E, et al. Immune-enhancement effect of the herbal combination Allergina. Clin Chim Acta. 2003;337:77-84 pubmed
    ..We investigated the effect of Allergina on the proliferation of T cell and production of cytokines in human T-cell line, MOLT-4 cells, and mouse peritoneal macrophages...
  61. Guma M, Ronacher L, Firestein G, Karin M, Corr M. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis Rheum. 2011;63:1603-12 pubmed publisher
    ..To elucidate the nonredundant roles of JNK-1 and JNK-2 in antigen-induced arthritis (AIA)...
  62. Sahin M, Cam H, Olgar S, Tunc S, Arslan C, Uz E, et al. Protective role of erdosteine on vancomycin-induced oxidative stress in rat liver. Mol Cell Biochem. 2006;291:155-60 pubmed
    ..01) and catalase (p < 0.001) activities in liver tissue when compared with VCM alone. It can be concluded that erdosteine may prevent VCM-induced oxidative changes in liver by reducing reactive oxygen species...
  63. Jang Y, Song J, Shin Y, Han E, Lee C. Depressant effects of ambroxol and erdosteine on cytokine synthesis, granule enzyme release, and free radical production in rat alveolar macrophages activated by lipopolysaccharide. Pharmacol Toxicol. 2003;92:173-9 pubmed
  64. Rosenblat M, Volkova N, Aviram M. Injection of paraoxonase 1 (PON1) to mice stimulates their HDL and macrophage antiatherogenicity. Biofactors. 2011;37:462-7 pubmed publisher
    ..We conclude that rePON1 injection to mice improved the mice HDL and MPM antiatherogenic properties, and these effects could probably lead to attenuation of atherosclerosis development...
  65. Yildirim Z, Sogut S, Odaci E, Iraz M, Ozyurt H, Kotuk M, et al. Oral erdosteine administration attenuates cisplatin-induced renal tubular damage in rats. Pharmacol Res. 2003;47:149-56 pubmed
    ..These results show that erdosteine may be a promising drug for protection against cisplatin-induced nephrotoxicity. However, further studies with different doses of erdosteine are warranted for clarifying the issue...
  66. Pomel V, Klicic J, Covini D, Church D, Shaw J, Roulin K, et al. Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. J Med Chem. 2006;49:3857-71 pubmed
    ..Oral administration of 26 in a mouse model of acute peritonitis led to a significant reduction of leukocyte recruitment...
  67. Duvoisin R, Pfankuch T, Wilson J, Grabell J, Chhajlani V, Brown D, et al. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res. 2010;212:168-73 pubmed publisher
    ..The effects of mGluR8 positive allosteric modulators, which only affect neurotransmission in the presence of extracellular glutamate, seem particularly promising for patients with anxiety disorders showing benzodiazepine insensitivity...
  68. Honda T, Favaloro F, Janosik T, Honda Y, Suh N, Sporn M, et al. Efficient synthesis of (-)- and (+)-tricyclic compounds with enone functionalities in rings A and C. A novel class of orally active anti-inflammatory and cancer chemopreventive agents. Org Biomol Chem. 2003;1:4384-91 pubmed
    ..In contrast, (-)-3 inhibits proliferation of MCF-7 breast cancer cells, whereas (+)-3 does not...
  69. Ghosn E, Cassado A, Govoni G, Fukuhara T, Yang Y, Monack D, et al. Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc Natl Acad Sci U S A. 2010;107:2568-73 pubmed publisher
    ..Thus, they introduce a new context for interpreting (and reinterpreting) data from ex vivo studies with PerC MØ...
  70. Bravo Osuna I, Ponchel G, Vauthier C. Tuning of shell and core characteristics of chitosan-decorated acrylic nanoparticles. Eur J Pharm Sci. 2007;30:143-54 pubmed
    ..Positive surface charge values were obtained in all cases. In addition, evidences of the presence of thiol groups were obtained (0.03-0.16 x 10(-3)micromol/cm(2) of nanoparticle)...
  71. Jin J, Chen X, Zhang Y, Ma Z, Zhong D. [Simultaneous determination of erdosteine and its active metabolite in human plasma by liquid chromatography-tandem mass spectrometry with pre-column derivatization]. Yao Xue Xue Bao. 2013;48:395-400 pubmed
    ..51 +/- 0.788) h, which provided a pharmacokinetic basis for the rational dosage regimen...
  72. Park Y, Yoo S, Kim W, Cho C, Woo J, Yoon C. Anti-inflammatory effects of essential oils extracted from Chamaecyparis obtusa on murine models of inflammation and RAW 264.7 cells. Mol Med Rep. 2016;13:3335-41 pubmed publisher
    ..Therefore, EOCO may be considered an effective therapeutic agent for the treatment of inflammatory diseases...
  73. Hamaoki M, Nagata A. Host macrophages produce diacetylspermine related with tumorigenesis. Cancer Lett. 2006;243:128-34 pubmed
    ..2 x 10(8). The mechanism and productivity studied in this work support the superiority of DAM as a tumor related marker. Diacetylation may relate to the depression of macrophage function by spermine...
  74. Teoh H, Quan A, Bang K, Wang G, Lovren F, Vu V, et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab. 2008;295:E658-64 pubmed publisher
    ..These data suggest a critical role of adiponectin as a modulator of survival and endothelial inflammation in experimental sepsis and a potential mechanistic link between adiposity and increased sepsis...
  75. Talaei F, Azizi E, Dinarvand R, Atyabi F. Thiolated chitosan nanoparticles as a delivery system for antisense therapy: evaluation against EGFR in T47D breast cancer cells. Int J Nanomedicine. 2011;6:1963-75 pubmed publisher
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