pentetic acid

Summary

Summary: An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Top Publications

  1. Ghavami S, Kerkhoff C, Los M, Hashemi M, Sorg C, Karami Tehrani F. Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions. J Leukoc Biol. 2004;76:169-75 pubmed
  2. Brom M, Oyen W, Joosten L, Gotthardt M, Boerman O. 68Ga-labelled exendin-3, a new agent for the detection of insulinomas with PET. Eur J Nucl Med Mol Imaging. 2010;37:1345-55 pubmed publisher
    ..Glucagon-like peptide 1 (GLP-1), the natural ligand of GLP-1R, is rapidly degraded in vivo. A more stable agonist of GLP-1R is exendin-3. We investigated imaging of insulinomas with DOTA-conjugated exendin-3 labelled with (68)Ga...
  3. Nayak T, Regino C, Wong K, Milenic D, Garmestani K, Baidoo K, et al. PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A''-DTPA-cetuximab. Eur J Nucl Med Mol Imaging. 2010;37:1368-76 pubmed publisher
    ..86)Y-CHX-A''-DTPA-cetuximab offers an attractive alternative to previously labeled cetuximab for PET and further investigation for clinical translation is warranted. ..
  4. Nayak T, Garmestani K, Baidoo K, Milenic D, Brechbiel M. PET imaging of tumor angiogenesis in mice with VEGF-A-targeted (86)Y-CHX-A″-DTPA-bevacizumab. Int J Cancer. 2011;128:920-6 pubmed publisher
  5. Nayak T, Garmestani K, Baidoo K, Milenic D, Brechbiel M. Preparation, biological evaluation, and pharmacokinetics of the human anti-HER1 monoclonal antibody panitumumab labeled with 86Y for quantitative PET of carcinoma. J Nucl Med. 2010;51:942-50 pubmed publisher
    ..7-2.8 d). This study demonstrates the potential of (86)Y-CHX-A''-DTPA-panitumumab for quantitative noninvasive PET of HER1-expressing tumors and represents the first step toward clinical translation. ..
  6. Good S, Walter M, Waser B, Wang X, Muller Brand J, Béhé M, et al. Macrocyclic chelator-coupled gastrin-based radiopharmaceuticals for targeting of gastrin receptor-expressing tumours. Eur J Nucl Med Mol Imaging. 2008;35:1868-77 pubmed publisher
    ..We used macrocyclic chelators for coupling to increase complex stability, modified the peptide sequence to enhance radiolytic stability and studied tumour-to-kidney ratio and metabolic stability using (111)In-labelled derivatives...
  7. Wicki A, Wild D, Storch D, Seemayer C, Gotthardt M, Behe M, et al. [Lys40(Ahx-DTPA-111In)NH2]-Exendin-4 is a highly efficient radiotherapeutic for glucagon-like peptide-1 receptor-targeted therapy for insulinoma. Clin Cancer Res. 2007;13:3696-705 pubmed
    ..In this study, we investigated the therapeutic potential of [Lys(40)(Ahx-DTPA-(111)In)NH(2)]-Exendin-4, an (111)In-labeled agonist of GLP-1, in a transgenic mouse model of human insulinoma...
  8. Ruzsics B, SURANYI P, Kiss P, Brott B, Elgavish A, Simor T, et al. Head-to-head comparison between delayed enhancement and percent infarct mapping for assessment of myocardial infarct size in a canine model. J Magn Reson Imaging. 2008;28:1386-92 pubmed publisher
    ..PIM is compared to the DE method using Gd(DTPA), and both to triphenyltetrazolium chloride (TTC) staining histochemistry...
  9. SURANYI P, Kiss P, Ruzsics B, Brott B, Simor T, Elgavish A, et al. In vivo myocardial tissue kinetics of Gd(ABE-DTTA), a tissue-persistent contrast agent. Magn Reson Med. 2007;58:55-64 pubmed
    ..It demonstrates high affinity for infarcted myocardium and induces highlighting of infarcts between 4 hr and 12 days following administration...

More Information

Publications86

  1. Raja C, Graham P, Abbas Rizvi S, Song E, Goldsmith H, Thompson J, et al. Interim analysis of toxicity and response in phase 1 trial of systemic targeted alpha therapy for metastatic melanoma. Cancer Biol Ther. 2007;6:846-52 pubmed
    ..The aim is to assess toxicity and response of systemic alpha therapy for metastatic melanoma...
  2. Forrer F, Valkema R, Kwekkeboom D, de Jong M, Krenning E. Neuroendocrine tumors. Peptide receptor radionuclide therapy. Best Pract Res Clin Endocrinol Metab. 2007;21:111-29 pubmed
    ..Furthermore, clinical issues--including indication and timing of therapy--are discussed. Finally, important directions for future research are mentioned to illustrate new strategies for increasing therapy efficacy...
  3. Hanaoka H, Mukai T, Tamamura H, Mori T, Ishino S, Ogawa K, et al. Development of a 111In-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. Nucl Med Biol. 2006;33:489-94 pubmed
    ..These findings suggested that 111In-DTPA-Ac-TZ14011 would be a potential agent for the imaging of CXCR4 expression in metastatic tumors in vivo...
  4. Hoh C, Wallace A, Vera D. Preclinical studies of [(99m)Tc]DTPA-mannosyl-dextran . Nucl Med Biol. 2003;30:457-64 pubmed
    ..15 mGy/MBq and the effective dose was 1.06 x 10(-2) mSv/MBq. This preclinical study demonstrates that [(99m)Tc]DTPA-mannosyl-dextran has no toxicities and has an acceptable biodistribution and radiation dose...
  5. Breeman W, de Jong M, Erion J, Bugaj J, Srinivasan A, Bernard B, et al. Preclinical comparison of (111)In-labeled DTPA- or DOTA-bombesin analogs for receptor-targeted scintigraphy and radionuclide therapy. J Nucl Med. 2002;43:1650-6 pubmed
    ..Radiometal-labeled diethylenetriaminepentaacetic acid (DTPA)-BN derivatives are potentially useful radioligands for receptor-targeted scintigraphy and radiotherapy of GRP receptor-expressing tumors...
  6. Behe M, Behr T. Cholecystokinin-B (CCK-B)/gastrin receptor targeting peptides for staging and therapy of medullary thyroid cancer and other CCK-B receptor expressing malignancies. Biopolymers. 2002;66:399-418 pubmed
    ..They allow for a sensitive and reliable staging of patients with metastatic MTC. Initial therapeutic results are promising, but nephrotoxicity is a major concern to be solved...
  7. Vera D, Wallace A, Hoh C, Mattrey R. A synthetic macromolecule for sentinel node detection: (99m)Tc-DTPA-mannosyl-dextran. J Nucl Med. 2001;42:951-9 pubmed
    ..We report the synthesis and preliminary biologic testing of a synthetic macromolecule, (99m)Tc-diethylenetriaminepentaacetic acid (DTPA)--mannosyl-dextran, for sentinel node detection...
  8. Yui S, Nakatani Y, Hunter M, Chazin W, Yamazaki M. Implication of extracellular zinc exclusion by recombinant human calprotectin (MRP8 and MRP14) from target cells in its apoptosis-inducing activity. Mediators Inflamm. 2002;11:165-72 pubmed
    ..We previously reported that rat calprotectin purified from inflammatory neutrophils induces apoptosis of various tumor cells or normal fibroblasts in a zinc-reversible manner...
  9. Lin K, Luu A, Baidoo K, Hashemzadeh Gargari H, Chen M, Pili R, et al. A new high affinity technetium analogue of bombesin containing DTPA as a pharmacokinetic modifier. Bioconjug Chem. 2004;15:1416-23 pubmed
    ..Thus, [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN has the potential for imaging BN/GRP receptor-positive lesions...
  10. Milenic D, Garmestani K, Brady E, Albert P, Ma D, Abdulla A, et al. Targeting of HER2 antigen for the treatment of disseminated peritoneal disease. Clin Cancer Res. 2004;10:7834-41 pubmed
    ..The results of this study were not as dramatic as with the former model, and higher doses were required to obtain an increase in survival of the mice (P = 0.001)...
  11. Simor T, Gaszner B, Oshinski J, Waldrop S, Pettigrew R, Horvath I, et al. Gd(ABE-DTTA)-enhanced cardiac MRI for the diagnosis of ischemic events in the heart. J Magn Reson Imaging. 2005;21:536-45 pubmed
    ..To demonstrate that contrast-enhanced MRI (ceMRI) with the aid of Gd(ABE-DTTA) is able to detect ischemic events in the heart in a canine ischemia/reperfusion (30/40 minutes) model...
  12. Capello A, Krenning E, Bernard B, Reubi J, Breeman W, de Jong M. 111In-labelled somatostatin analogues in a rat tumour model: somatostatin receptor status and effects of peptide receptor radionuclide therapy. Eur J Nucl Med Mol Imaging. 2005;32:1288-95 pubmed
    ..We therefore also investigated the somatostatin receptor status of the tumour before and after PRRT...
  13. Tisell L, Ahlman H, Wangberg B, Kolby L, Fjalling M, Forssell Aronsson E, et al. Expression of somatostatin receptors in oncocytic (Hürthle cell) neoplasia of the thyroid. Br J Cancer. 1999;79:1579-82 pubmed
    ..A relatively high uptake of (111)In was also observed in goiter tissue, which may lead to misinterpretations. The main indication for octreotide scintigraphy in patients with Hürthle cell carcinoma is suspicion of metastatic disease...
  14. Breeman W, Hofland L, De Jong M, Bernard B, Srinivasan A, Kwekkeboom D, et al. Evaluation of radiolabelled bombesin analogues for receptor-targeted scintigraphy and radiotherapy. Int J Cancer. 1999;81:658-65 pubmed
    ..We conclude that [(111)In-DTPA-Pro1,Tyr4]BN has promising characteristics for applications in nuclear medicine...
  15. Kiss P, Suranyi P, Simor T, Saab Ismail N, Elgavish A, Hejjel L, et al. In vivo R1-enhancement mapping of canine myocardium using ceMRI with Gd(ABE-DTTA) in an acute ischemia-reperfusion model. J Magn Reson Imaging. 2006;24:571-9 pubmed
    ..To demonstrate the usefulness of normalized DeltaR1 (DeltaR1(n)) mapping in myocardial tissue following the administration of the contrast agent (CA) Gd(ABE-DTTA)...
  16. Gotthardt M, Lalyko G, van Eerd Vismale J, Keil B, Schurrat T, Hower M, et al. A new technique for in vivo imaging of specific GLP-1 binding sites: first results in small rodents. Regul Pept. 2006;137:162-7 pubmed
    ..For in vivo imaging, a high-resolution multi-pinhole SPECT (single photon emission computed tomography) system was used in conjunction with an MRI (magnetic resonance imaging) system for image fusion...
  17. Fisher A, Maxwell S, Naughton D. Superoxide and hydrogen peroxide suppression by metal ions and their EDTA complexes. Biochem Biophys Res Commun. 2004;316:48-51 pubmed
    ..Caution should be employed in bioassays when chelating metal ions. Our results demonstrate that DTPA is preferential to EDTA for inactivating redox-active metal ions in bioassays...
  18. Forssell Aronsson E, Nilsson O, Bejegård S, Kolby L, Bernhardt P, Molne J, et al. 111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors. J Nucl Med. 2000;41:636-42 pubmed
    ..The purpose of this study was to evaluate the potential for therapy of thyroid tumors using the radiolabeled somatostatin (SS) analog octreotide...
  19. Parker G, Suckling J, Tanner S, Padhani A, Revell P, Husband J, et al. Probing tumor microvascularity by measurement, analysis and display of contrast agent uptake kinetics. J Magn Reson Imaging. 1997;7:564-74 pubmed
    ..Quantification of permeability and leakage space provides a method for comparing physiology in patients between visits or for intersite comparisons...
  20. Breeman W, De Jong M, Bernard B, Kwekkeboom D, Srinivasan A, van der Pluijm M, et al. Pre-clinical evaluation of [(111)In-DTPA-Pro(1), Tyr(4)]bombesin, a new radioligand for bombesin-receptor scintigraphy. Int J Cancer. 1999;83:657-63 pubmed
    ..The CA20948 tumour, inoculated in the hindleg, was also visualized scintigraphically. [(111)In-DTPA-Pro(1), Tyr(4)]BN appears to be a promising radioligand for scintigraphy of BNR-expressing tumours...
  21. Gouin S, Winnik F. Quantitative assays of the amount of diethylenetriaminepentaacetic acid conjugated to water-soluble polymers using isothermal titration calorimetry and colorimetry. Bioconjug Chem. 2001;12:372-7 pubmed
    ..The longer relaxation times of protons of the polymer backbone, compared to those of protons attached to the freely moving DTPA side-chains may account for the discrepancy...
  22. Behe M, Becker W, Gotthardt M, Angerstein C, Behr T. Improved kinetic stability of DTPA- dGlu as compared with conventional monofunctional DTPA in chelating indium and yttrium: preclinical and initial clinical evaluation of radiometal labelled minigastrin derivatives. Eur J Nucl Med Mol Imaging. 2003;30:1140-6 pubmed
    ..DTPA- dGlu(1)-minigastrin is preferred to "monofunctional" DTPA-Leu(1)-minigastrin for diagnostic application with (111)In for the in vivo detection of CCK-B receptor-expressing tissues...
  23. Kim R, Chen E, Lima J, Judd R. Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation. 1996;94:3318-26 pubmed
    ..The precise mechanisms that lead to these altered enhancement patterns are unknown. This study was designed to evaluate possible mechanisms and to relate altered enhancement patterns to myocardial perfusion and viability...
  24. Valkema R, de Jong M, Bakker W, Breeman W, Kooij P, Lugtenburg P, et al. Phase I study of peptide receptor radionuclide therapy with [In-DTPA]octreotide: the Rotterdam experience. Semin Nucl Med. 2002;32:110-22 pubmed
    ..The decrease in serum inhibin B and concomitant increase of serum FSH levels in men indicate that the spermatogenesis was impaired...
  25. Aloj L, Caracò C, Panico M, Zannetti A, Del Vecchio S, Tesauro D, et al. In vitro and in vivo evaluation of 111In-DTPAGlu-G-CCK8 for cholecystokinin-B receptor imaging. J Nucl Med. 2004;45:485-94 pubmed
  26. Ruzsics B, SURANYI P, Kiss P, Brott B, Elgavish A, Saab Ismail N, et al. Gd(ABE-DTTA), a novel contrast agent, at the MRI-effective dose shows absence of deleterious physiological effects in dogs. Pharmacology. 2006;77:188-94 pubmed
    ..Between days 7 and 56 no elevation in ALT was observed. In dogs no substantial short- or long-term effect was observed on the investigated, physiological parameters after Gd(ABE-DTTA) administration at the MRI effective dose...
  27. Kwekkeboom D, Mueller Brand J, Paganelli G, Anthony L, Pauwels S, Kvols L, et al. Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs. J Nucl Med. 2005;46 Suppl 1:62S-6S pubmed
    ..These data compare favorably with those for the limited number of alternative treatment approaches...
  28. Geoghegan J, Corrigan R, Gruszka D, Speziale P, O Gara J, Potts J, et al. Role of surface protein SasG in biofilm formation by Staphylococcus aureus. J Bacteriol. 2010;192:5663-73 pubmed publisher
    ..Extensively purified recombinant B domain protein is very labile, and we propose that cleavage occurs spontaneously at labile peptide bonds and that this is necessary for biofilm formation. ..
  29. Chen Y, Xiong Q, Yang X, Huang Z, He L. Preparation and imaging research on 188Re-DTPA-deoxyglucose in MCF-7 tumor-bearing mice. Cancer Biother Radiopharm. 2007;22:400-2 pubmed
    ..08 mm(3) in the (188)Re-DTPA-DG treated and control groups, respectively (p < 0.01). (188)Re-DTPA-DG showed excellent tumor targeting and tumor-growth-suppressing effects, and holds promise as an internal agent for tumor radiotherapy. ..
  30. Jafarnejadi A, Sayyad G, Homaee M, Davamei A. Spatial variability of soil total and DTPA-extractable cadmium caused by long-term application of phosphate fertilizers, crop rotation, and soil characteristics. Environ Monit Assess. 2013;185:4087-96 pubmed publisher
    ..01), pH, and clay content (p < 0.05). Therefore, consumption rate of the phosphate fertilizers and crop rotation are important factors on solubility and hence spatial variability of Cd content in agricultural soils. ..
  31. Khorrami Moghaddam A, Reza Jalilian A, Hayati V, Shanehsazzadeh S. Determination of human absorbed dose of 201Tl(III)-DTPA-HIgG based on biodistribution data in rats. Radiat Prot Dosimetry. 2010;141:269-74 pubmed publisher
    ..5 (mGy), 58.64 (mGy) and 56.44 (mGy), respectively. Biodistribution of [201Tl](III)-DTPA-HIgG demonstrated significant inflamed tissue uptake and low muscle and blood uptake, allowing for imaging of inflamed tissues. ..
  32. Sabbah E, Kadouche J, Ellison D, Finucane C, Decaudin D, Mather S. In vitro and in vivo comparison of DTPA- and DOTA-conjugated antiferritin monoclonal antibody for imaging and therapy of pancreatic cancer. Nucl Med Biol. 2007;34:293-304 pubmed
    ..Altogether, these results in animal models suggest that (90)Y-Bz-DTPA-AMB8LK is a good candidate for further therapeutic efficacy studies. ..
  33. Lin C, Song Y, Lou B, Zhao P. Dextranation of bioreducible cationic polyamide for systemic gene delivery. Biomed Mater Eng. 2014;24:673-82 pubmed publisher
    ..Dextranated, bioreducible cationic polyamide holds high potential as a non-viral vector for gene delivery. ..
  34. Ferone D, Pivonello R, Kwekkeboom D, Gatto F, Ameri P, Colao A, et al. Immunohistochemical localization and quantitative expression of somatostatin receptors in normal human spleen and thymus: Implications for the in vivo visualization during somatostatin receptor scintigraphy. J Endocrinol Invest. 2012;35:528-34 pubmed publisher
    ..These observations might have an important impact when interpretating in vivo visualization of SSR-positive lesions, and when treatment with novel SRIF analogs is considered. ..
  35. Spreckelmeyer S, Ramogida C, Rousseau J, Arane K, Bratanovic I, Colpo N, et al. p-NO2-Bn-H4neunpa and H4neunpa-Trastuzumab: Bifunctional Chelator for Radiometalpharmaceuticals and 111In Immuno-Single Photon Emission Computed Tomography Imaging. Bioconjug Chem. 2017;28:2145-2159 pubmed publisher
  36. Jia B, Liu Z, Shi J, Yu Z, Yang Z, Zhao H, et al. Linker effects on biological properties of 111In-labeled DTPA conjugates of a cyclic RGDfK dimer. Bioconjug Chem. 2008;19:201-10 pubmed
    ..It is concluded that using a glutamic acid linker can significantly improve excretion kinetics of the 111 In-labeled E[c(RGDfK)] 2 from liver and kidneys. ..
  37. Laverman P, Meeuwissen S, van Berkel S, Oyen W, van Delft F, Rutjes F, et al. In-depth evaluation of the cycloaddition--retro-Diels--Alder reaction for in vivo targeting with [(111)In]-DTPA-RGD conjugates. Nucl Med Biol. 2009;36:749-57 pubmed publisher
    ..Since there is no information on the stability and reaction rate of the tandem crDA reaction in biological media, we set out to characterize these reaction parameters...
  38. Josan J, De Silva C, Yoo B, Lynch R, Pagel M, Vagner J, et al. Fluorescent and lanthanide labeling for ligand screens, assays, and imaging. Methods Mol Biol. 2011;716:89-126 pubmed publisher
    ..In this context, we also illustrate the syntheses and use of heteromultivalent ligands as targeted imaging agents. ..
  39. Zhou S, Zhang B, Sturm E, Teagarden D, SCHONEICH C, Kolhe P, et al. Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody. J Pharm Sci. 2010;99:4239-50 pubmed publisher
    ..These destabilization effects were not observed when the chelators were present at stoichiometric ratios highlighting the feasibility of using DTPA as an alternate trace metal chelator to Na(2)EDTA in biologic protein formulations. ..
  40. Park D, Don A, Massamiri T, Karwa A, Warner B, Macdonald J, et al. Noninvasive imaging of cell death using an Hsp90 ligand. J Am Chem Soc. 2011;133:2832-5 pubmed publisher
    ..Tumor cell death in mice was noninvasively imaged by SPECT/CT using an (111)In-tagged compound. This versatile compound should enable the imaging of cell death in most experimental settings...
  41. D Huyvetter M, Aerts A, Xavier C, Vaneycken I, Devoogdt N, Gijs M, et al. Development of 177Lu-nanobodies for radioimmunotherapy of HER2-positive breast cancer: evaluation of different bifunctional chelators. Contrast Media Mol Imaging. 2012;7:254-64 pubmed publisher
    ..Both macrocyclic and acyclic chelators show high stability in time. High specific tumor uptake combined with the lowest background uptake was measured using the 1B4M-DTPA-based conjugate. ..
  42. Xiao X, Chen T, An Z, Lei M, Huang Z, Liao X, et al. Potential of Pteris vittata L. for phytoremediation of sites co-contaminated with cadmium and arsenic: the tolerance and accumulation. J Environ Sci (China). 2008;20:62-7 pubmed
    ..The results suggested that the Cd-tolerant ecotype of P. vittata extracted effectively As and Cd from the site co-contaminated with Cd and As, and might be used to remediate and revegetate this type of site. ..
  43. Ware R, Rees R, Sarnaik S, Iyer R, Alvarez O, Casella J, et al. Renal function in infants with sickle cell anemia: baseline data from the BABY HUG trial. J Pediatr. 2010;156:66-70.e1 pubmed publisher
    ..Schwartz GFR estimates are not highly correlated with quantitative DTPA GFR values. Baseline GFR measurements suggest that renal dysfunction in SCA, evidenced by glomerular hyperfiltration, begins during infancy. ..
  44. Aupiais J, Bonin L, Den Auwer C, Moisy P, Siberchicot B, Topin S. On the use of speciation techniques and ab initio modelling to understand tetravalent actinide behavior in a biological medium: An(IV)DTPA case. Dalton Trans. 2016;45:3759-70 pubmed publisher
    ..This results in the capability to evaluate the stability constants for the formation of Pa(IV)DTPA(-), Am(IV)DTPA(-) or Bk(IV)DTPA(-). ..
  45. Hasegawa H, Rahman I, Kinoshita S, Maki T, Furusho Y. Non-destructive separation of metal ions from wastewater containing excess aminopolycarboxylate chelant in solution with an ion-selective immobilized macrocyclic material. Chemosphere. 2010;79:193-8 pubmed publisher
    ..Compared to the conventional treatment options for such waste solutions, our proposed technique has the advantage of non-destructive separation of both metal ions and chelants. ..
  46. Hughes D, Afsar A, Harwood L, Jiang T, Laventine D, Shaw L, et al. Adsorption of Pb and Zn from binary metal solutions and in the presence of dissolved organic carbon by DTPA-functionalised, silica-coated magnetic nanoparticles. Chemosphere. 2017;183:519-527 pubmed publisher
    ..The nanoparticles have the potential to perform effectively as metal adsorbents in systems containing more than one metal and dissolved organic carbon at a range of pH values. ..
  47. Singh S, Fulzele D, Kaushik C. Potential of Vetiveria zizanoides L. Nash for phytoremediation of plutonium ((239)Pu): Chelate assisted uptake and translocation. Ecotoxicol Environ Saf. 2016;132:140-4 pubmed publisher
    ..The present study demonstrates that V. zizanoides plant is a potential plant for phytoremediation of (239)Pu. ..
  48. Dehshahri A, Sadeghpour H, Keykhaee M, Khalvati B, Sheikhsaran F. Enhanced Delivery of Plasmid Encoding Interleukin-12 Gene by Diethylene Triamine Penta-Acetic Acid (DTPA)-Conjugated PEI Nanoparticles. Appl Biochem Biotechnol. 2016;179:251-69 pubmed publisher
  49. Snow B, Gatti J, Renschler T, Corneli H, Cartwright P. Variation in diethylenetriamine pentaacetic acid and mercaptoacetyltriglycine renal scans: clinical implications of interobserver and intraobserver differences. J Urol. 2008;179:1132-6; discussion 1137 pubmed publisher
    ..6% differential function for a clinician to be 95% confident that a real change in kidney function has occurred. This uncertainty is substantial and is likely larger than is currently allowed for in clinical practice. ..
  50. Chan C, Cai Z, Su R, Reilly R. 111In- or 99mTc-labeled recombinant VEGF bioconjugates: in vitro evaluation of their cytotoxicity on porcine aortic endothelial cells overexpressing Flt-1 receptors. Nucl Med Biol. 2010;37:105-15 pubmed publisher
    ..111)In is a more cytotoxic radionuclide than (99m)Tc, unless DNA delivery can be achieved, due to the short range of the electrons emitted. ..
  51. Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse D, et al. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorg Med Chem Lett. 2010;20:2489-92 pubmed publisher
    ..While results from the latter assay reflected only statistical effects, results from the former assay reflected a mixture of statistical, proximity, and/or cooperative binding effects. ..
  52. Melis M, Krenning E, Bernard B, de Visser M, Rolleman E, de Jong M. Renal uptake and retention of radiolabeled somatostatin, bombesin, neurotensin, minigastrin and CCK analogues: species and gender differences. Nucl Med Biol. 2007;34:633-41 pubmed
    ..Newly developed peptides are evaluated preclinically in different animal models before their application in humans. In this study, the renal retention of several radiolabeled peptides was compared in male and female rats and mice...
  53. Tokin C, Cope F, Metz W, Blue M, Potter B, Abbruzzese B, et al. The efficacy of Tilmanocept in sentinel lymph mode mapping and identification in breast cancer patients: a comparative review and meta-analysis of the ??mTc-labeled nanocolloid human serum albumin standard of care. Clin Exp Metastasis. 2012;29:681-6 pubmed publisher
    ..99 % (CI 0.9977-1.0000) localization rate and degree of localization of 2.16 (CI 1.964-2.3600). Tilmanocept was superior to the Nanocoll SOC for both endpoints (P < 0.0001)...
  54. Warsi M, Chechik V. Strategies for increasing relaxivity of gold nanoparticle based MRI contrast agents. Phys Chem Chem Phys. 2011;13:9812-7 pubmed publisher
    ..The restricted motion of Gd(3+) chelates coated by 2-4 polymer layers led to increased relaxivity which was dramatically reduced for thicker layers, presumably due to restricted diffusion of water molecules...
  55. Ogawa Y, Traina J, Zimmermann E, Yu T, Schneider D, Pungor E. Quantification of bifunctional diethylenetriaminepentaacetic acid derivative conjugation to monoclonal antibodies by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal Biochem. 2007;368:214-21 pubmed
    ..The standard deviation, expressed as coefficient of variation for samples with 2 to 4 mol of DTPA attached per mole of IgG, was 8 to 9%...
  56. Churin A, Karpova G, Fomina T, Vetoshkina T, Dubskaia T, Voronova O, et al. [Preclinical toxicological evaluation of Pentamang and Mangascan]. Eksp Klin Farmakol. 2008;71:49-52 pubmed
    ..No pathological changes were observed in the functional activity and morphology of the internal organs and systems. The results showed that both Mangascan and Pentamang belong to the class of low toxicity substances...
  57. Melis M, Vegt E, Konijnenberg M, de Visser M, Bijster M, Vermeij M, et al. Nephrotoxicity in mice after repeated imaging using 111In-labeled peptides. J Nucl Med. 2010;51:973-7 pubmed publisher
    ..We determined the renal radiation dose of a series of (111)In-labeled peptides using animal SPECT. Because the animals' health deteriorated, renal toxicity was assessed...
  58. Melis M, de Swart J, de Visser M, Berndsen S, Koelewijn S, Valkema R, et al. Dynamic and static small-animal SPECT in rats for monitoring renal function after 177Lu-labeled Tyr3-octreotate radionuclide therapy. J Nucl Med. 2010;51:1962-8 pubmed publisher
    ..99m)Tc-MAG3 renography, especially, appears to be a more sensitive marker of tubular function after PRRT than serum chemistry or (99m)Tc-DMSA scintigraphy. ..
  59. He Q, Han H, Xu F, Yan J, Zeng J, Li X, et al. [Imaging and quantitative measurement of brain extracellular space using MRI Gd-DTPA tracer method]. Beijing Da Xue Xue Bao Yi Xue Ban. 2010;42:188-91 pubmed
    ..To observe the diffusion of Gd-DTPA in brain extracellular space (ECS) by magnetic resonance imaging(MRI) and investigate the feasibility of ECS measurement by using MRI tracer method in vivo...
  60. Wang W, Barger S. Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species. J Neurosci Res. 2012;90:1218-29 pubmed publisher
    ..These findings suggest a compensatory feedback in which the consequences of neuroinflammation might dampen D-serine production to limit excitotoxic stimulation of NMDA receptors...
  61. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio M, et al. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011;589:135-48 pubmed publisher
    ..These findings reveal a novel mechanism of interaction between N2O and ion channels, furthering our understanding of this widely used analgesic in pain processing...
  62. Garg M, Singh V, Sinha R, Sankhwar S. Prospective randomized comparison of retroperitoneoscopic vs open pyeloplasty with minimal incision: subjective and objective assessment in adults. Urology. 2014;83:805-11 pubmed publisher
    ..To determine the subjective and objective outcomes of retroperitoneoscopic vs open pyeloplasty with minimal incision in a prospective randomized comparison study...
  63. Carbaugh E, Lynch T, Cannon C, Lewis L. Case study: three acute 241Am inhalation exposures with DTPA therapy. Health Phys. 2010;99:539-46 pubmed publisher
    ..The three subjects underwent slightly different therapy regimens, with therapy effectiveness factors (defined as the ratio of the reference doses without therapy relative to the final assessed doses) of 4.5, 1.9, and 1.7, respectively...
  64. Liberman A, Wu Z, Barback C, Viveros R, Blair S, Ellies L, et al. Color Doppler ultrasound and gamma imaging of intratumorally injected 500 nm iron-silica nanoshells. ACS Nano. 2013;7:6367-77 pubmed publisher
  65. Peat D, Horsewill A, Kockenberger W, Perez Linde A, Gadian D, Owers Bradley J. Achievement of high nuclear spin polarization using lanthanides as low-temperature NMR relaxation agents. Phys Chem Chem Phys. 2013;15:7586-91 pubmed publisher
  66. Leguay S, Vercouter T, Topin S, Aupiais J, Guillaumont D, Miguirditchian M, et al. New insights into formation of trivalent actinides complexes with DTPA. Inorg Chem. 2012;51:12638-49 pubmed publisher
    ..DFT calculations indicate that the lowest energy structures correspond to protonation on oxygen that is not involved in An-DTPA bonds and that the structures with two water molecules are not stable...
  67. Gupta A, Sinha S. Decontamination and/or revegetation of fly ash dykes through naturally growing plants. J Hazard Mater. 2008;153:1078-87 pubmed
    ..All examined plants are suitable for revegetation (naturally grows on fly ash dykes) and S. cardifolia and C. album may be used for decontamination purposes...
  68. Guan T, He H, Zhang X, Bai Z. Cu fractions, mobility and bioavailability in soil-wheat system after Cu-enriched livestock manure applications. Chemosphere. 2011;82:215-22 pubmed publisher
    ..7 mg kg?¹, indicating the more sensitivity of roots to the Cu toxicity. The Cu concentrations in grains after 3% manure application did not approach the threshold for Cu toxicity (< 20mg kg?¹) even at higher Cu addition rates...
  69. Satchell L, Leake D. Oxidation of low-density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. Biochemistry. 2012;51:3767-75 pubmed publisher
    ..The presence of oxidized and highly aggregated lipid within lysosomes has the potential to perturb the function of these organelles and to promote atherosclerosis...
  70. Ohba S, Ushioda T, Nakagawa T, Shimizu K, Murakami H. Diffusion magnetic resonance imaging for enhanced visualization of malignant cerebral tumors and abscesses. Neurol India. 2011;59:674-8 pubmed publisher
    ..Recently, diffusion-weighted imaging (DWI) and calculation of apparent diffusion coefficients (ADCs) have been reported to be useful to differentiate between the two disorders...
  71. Yulikov M, Lueders P, Warsi M, Chechik V, Jeschke G. Distance measurements in Au nanoparticles functionalized with nitroxide radicals and Gd(3+)-DTPA chelate complexes. Phys Chem Chem Phys. 2012;14:10732-46 pubmed publisher
  72. Leprince B, Fritsch P, Bérard P, Roméo P. Design and functionalities of the MADOR® software suite for dose-reduction management after DTPA therapy. Radiat Prot Dosimetry. 2016;168:350-7 pubmed publisher
    ..The release 1.0 addresses the effect of DTPA treatments on Pu/Am biokinetics and the dose benefit. The forensic results of the MADOR(®) suite were validated by comparison with reference data. ..
  73. Pujatti P, Massicano A, Mengatti J, de Araujo E. Preparation of [In-111]-labeled-DTPA-bombesin conjugates at high specific activity and stability: evaluation of labeling parameters and potential stabilizers. Appl Radiat Isot. 2012;70:856-63 pubmed publisher
    ..A SA of 174 GBq/?mol was achieved with high radiochemical purity, but the labeled compounds exhibited low stability. The addition of stabilizers avoided their radiolysis and significantly increased their stability...
  74. Tica D, Udovic M, Lestan D. Immobilization of potentially toxic metals using different soil amendments. Chemosphere. 2011;85:577-83 pubmed publisher
    ..The efficiency of stabilization was reflected in the soil respiration rate and in enzymatic activity. The ?-glucosidase activity assay was the most responsive of them...
  75. Repo E, Kurniawan T, Warchol J, Sillanpää M. Removal of Co(II) and Ni(II) ions from contaminated water using silica gel functionalized with EDTA and/or DTPA as chelating agents. J Hazard Mater. 2009;171:1071-80 pubmed publisher
    ..The two-site Langmuir model was representative to simulate adsorption isotherms. The kinetics of Co(II) and Ni(II) adsorption by modified silica gels followed pseudo-second-order...
  76. Ishikawa S, Yokoyama M, Mizobuchi S, Hashimoto H, Moriyama E, Morita K. Epidural blood patch therapy for chronic whiplash-associated disorder. Anesth Analg. 2007;105:809-14 pubmed
    ..We investigated the relation between chronic WAD and CSF leak by RI cisternography and evaluated whether epidural blood patch (EBP) administration is effective in the treatment of chronic WAD...
  77. Koh G, Lee D, Woo J. 2-Deoxy-D-ribose induces cellular damage by increasing oxidative stress and protein glycation in a pancreatic beta-cell line. Metabolism. 2010;59:325-32 pubmed publisher
    ..These results suggest that both oxidative stress and protein glycation are important mechanisms of dRib-induced damage in a pancreatic beta-cell line...