iodoacetic acid


Summary: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.

Top Publications

  1. Zapun A, Cooper L, Creighton T. Replacement of the active-site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo. Biochemistry. 1994;33:1907-14 pubmed
    ..This suggests that the thiol groups are involved in interactions that stabilize the folded conformation, which would cause any disulfide bonds, either inter- or intramolecular, that involve these groups to be unstable...
  2. Aromolaran A, Zima A, Blatter L. Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. Am J Physiol Cell Physiol. 2007;293:C106-18 pubmed
    ..2 mM) to glycolytic inhibitors 2-deoxy-D-glucose (2-DG), pyruvate (pyr) + beta-hydroxybutyrate (beta-HB), or iodoacetic acid (IAA) caused an increase of intracellular Ca(2+) concentration ([Ca(2+)](i))...
  3. Maher P, Salgado K, Zivin J, Lapchak P. A novel approach to screening for new neuroprotective compounds for the treatment of stroke. Brain Res. 2007;1173:117-25 pubmed
    ..Fisetin significantly reduced the behavioral deficits following a stroke, providing proof of principle for this novel approach to identifying new compounds for the treatment of stroke. ..
  4. Plewa M, Wagner E, Richardson S, Thruston A, Woo Y, McKague A. Chemical and biological characterization of newly discovered iodoacid drinking water disinfection byproducts. Environ Sci Technol. 2004;38:4713-22 pubmed
    ..The purpose of this paper is to report the analytical chemical identification of iodoacetic acid (IA) and other iodoacids in drinking water samples, to address the cytotoxicity and genotoxicity of IA in ..
  5. Richardson S, Fasano F, Ellington J, Crumley F, Buettner K, Evans J, et al. Occurrence and mammalian cell toxicity of iodinated disinfection byproducts in drinking water. Environ Sci Technol. 2008;42:8330-8 pubmed
    An occurrence study was conducted to measure five iodo-acids (iodoacetic acid, bromoiodoacetic acid, (Z)-3-bromo-3-iodo-propenoic acid, (E)-3-bromo-3-iodo-propenoic acid, and (E)-2-iodo-3-methylbutenedioic acid) and two iodo-..
  6. Noel J, Fernandez de Castro J, DeMarco P, Franco L, Wang W, Vukmanic E, et al. Iodoacetic acid, but not sodium iodate, creates an inducible swine model of photoreceptor damage. Exp Eye Res. 2012;97:137-47 pubmed publisher domestic swine the efficacy of two chemical toxins, known to create photoreceptor damage in other species: Iodoacetic Acid (IAA) and Sodium Iodate (NaIO(3))...
  7. Rogel A, Bromberg Y, Sperling O, Zoref Shani E. Phospholipase C is involved in the adenosine-activated signal transduction pathway conferring protection against iodoacetic acid-induced injury in primary rat neuronal cultures. Neurosci Lett. 2005;373:218-21 pubmed
    We have demonstrated before that exposure of neuronal cultures to poisoning by iodoacetic acid, followed by "reperfusion" (iodoacetate-"reperfusion" insult; IAA-R insult), results in severe cytotoxicity...
  8. Liang L, Katagiri Y, Franco L, Yamauchi Y, Enzmann V, Kaplan H, et al. Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Vis Neurosci. 2008;25:167-77 pubmed publisher
    This study investigated the anatomical consequences of a photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Retinae were examined 2 weeks, 1, 3, and 6 months after systemic IAA injection...
  9. Baragi V, Becher G, Bendele A, Biesinger R, Bluhm H, Boer J, et al. A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. Arthritis Rheum. 2009;60:2008-18 pubmed publisher
    ..This study was undertaken to identify a new class of potent and selective MMP-13 inhibitors that would provide histologic and clinical efficacy without musculoskeletal toxicity...

More Information

Publications101 found, 100 shown here

  1. Yamauchi Y, Agawa T, Tsukahara R, Kimura K, Yamakawa N, Miura M, et al. Correlation between high-resolution optical coherence tomography (OCT) images and histopathology in an iodoacetic acid-induced model of retinal degeneration in rabbits. Br J Ophthalmol. 2011;95:1157-60 pubmed publisher
    ..Because the relationship between optical coherence tomography (OCT) images and histopathology is unclear, we compared these in an iodoacetic acid (IAA)-induced model of photoreceptor degeneration in rabbits.
  2. Orita S, Ishikawa T, Miyagi M, Ochiai N, Inoue G, Eguchi Y, et al. Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain. BMC Musculoskelet Disord. 2011;12:134 pubmed publisher
    ..We aimed to investigate pain-related sensory innervation in a monoiodoacetate (MIA)-induced model of OA...
  3. Scott P, Kaplan H, Sandell J. Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye. Exp Eye Res. 2011;93:513-27 pubmed publisher
    b>Iodoacetic acid (IAA) induces photoreceptor (PR) degeneration in small animal models, however, eye size and anatomic differences detract from the usefulness of these models for studying retinal rescue strategies intended for humans...
  4. Wang W, Fernandez de Castro J, Vukmanic E, Zhou L, Emery D, DeMarco P, et al. Selective rod degeneration and partial cone inactivation characterize an iodoacetic acid model of Swine retinal degeneration. Invest Ophthalmol Vis Sci. 2011;52:7917-23 pubmed publisher
    ..Here, the authors evaluate an iodoacetic acid (IAA) model of photoreceptor degeneration in the pig as an alternative model that shares features of the ..
  5. Ferreira Gomes J, Adães S, Sousa R, Mendonça M, Castro Lopes J. Dose-dependent expression of neuronal injury markers during experimental osteoarthritis induced by monoiodoacetate in the rat. Mol Pain. 2012;8:50 pubmed publisher
    ..3, 1 or 2?mg). Measurements were performed at days 3, 7, 14, 21 and 31 post-MIA injection...
  6. Lukac M, Collier R. Restoration of enzymic activity and cytotoxicity of mutant, E553C, Pseudomonas aeruginosa exotoxin A by reaction with iodoacetic acid. J Biol Chem. 1988;263:6146-9 pubmed
    ..cysteine by site-directed mutagenesis of cloned ETA and then carboxymethylated the cysteine side chain with iodoacetic acid. The E553C mutation reduced ADP-ribosyltransferase and cytotoxic activities greater than 10,000-fold...
  7. Ivanavicius S, Ball A, Heapy C, Westwood F, Murray F, Read S. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. Pain. 2007;128:272-82 pubmed
    ..Collectively, these data suggest that this putative model of OA is associated with an early phase neuropathy in the L5 innervation territory of the knee...
  8. Suna H, Arai M, Tsubotani Y, Hayashi A, Setiawan A, Kobayashi M. Dysideamine, a new sesquiterpene aminoquinone, protects hippocampal neuronal cells against iodoacetic acid-induced cell death. Bioorg Med Chem. 2009;17:3968-72 pubmed publisher
    ..Compounds 1 and 2 showed neuroprotective effect against iodoacetic acid (IAA)-induced cell death at 10 microM concentration in mouse HT22 hippocampal neuronal cells...
  9. Maekawa Y, Yagi K, Nonomura A, Kuraoku R, Nishiura E, Uchibori E, et al. A tetrazolium-based colorimetric assay for metabolic activity of stored blood platelets. Thromb Res. 2003;109:307-14 pubmed
    ..These results indicate that the WST-8 assay can be useful for identifying viable platelets independent of the aggregation response and may contribute to clarifying the mechanism of the loss of function of stored platelets. ..
  10. Miyamoto S, Nakamura J, Ohtori S, Orita S, Omae T, Nakajima T, et al. Intra-articular injection of mono-iodoacetate induces osteoarthritis of the hip in rats. BMC Musculoskelet Disord. 2016;17:132 pubmed publisher
    ..Osteoarthritic (OA) changes became apparent at 42 and 56 days in the MIA group. We established an intra-articular injection technique to the rat hip, creating a hip OA model in the rat by intra-articular injection of MIA. ..
  11. Agalakova N, Lapin A, Gusev G. Differential effects of glycolytic and oxidative metabolism blockers on the Na-K pump in erythrocytes of the frog, Rana temporaria. J Comp Physiol B. 1997;167:576-81 pubmed
    ..These results indicate that about one-half of the Na(+)-K(+)-pump activity in frog erythrocytes is tightly functionally coupled to cytochromes via a separate "membrane-associated" ATP pool. ..
  12. Yep A, Ballicora M, Sivak M, Preiss J. Identification and characterization of a critical region in the glycogen synthase from Escherichia coli. J Biol Chem. 2004;279:8359-67 pubmed
    ..The results of this work indicate that this region is critical for catalysis and substrate binding. ..
  13. Becalski A, Lau B, Schrader T, Seaman S, Sun W. Formation of iodoacetic acids during cooking: interaction of iodized table salt with chlorinated drinking water. Food Addit Contam. 2006;23:957-62 pubmed
    ..b>Iodoacetic acid was recently shown to be a potent cytotoxic and genotoxic agent...
  14. Macrides T, Faktor D, Kalafatis N, Amiet R. Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol. Comp Biochem Physiol Biochem Mol Biol. 1994;107:461-9 pubmed
    ..Isoelectric focusing of the purified material resulted in two major bands with pI values of 5.0 and 5.85. Enzymatic activity was found to be optimal at a pH of 6.5 with little activity recorded at pH 5.0 and 8.0. ..
  15. Lima Catelani A, Ceron C, Bicudo H. Variation of genetic expression during development, revealed by esterase patterns in Aedes aegypti (Diptera, Culicidae). Biochem Genet. 2004;42:69-84 pubmed
    ..Such findings may reflect genetic differences between founders in each population, but the possibility of involvement of the intensive use of insecticides in SJRP is also discussed. ..
  16. Reyes Fermín L, González Reyes S, Tarco Álvarez N, Hernández Nava M, Orozco Ibarra M, Pedraza Chaverri J. Neuroprotective effect of ?-mangostin and curcumin against iodoacetate-induced cell death. Nutr Neurosci. 2012;15:34-41 pubmed publisher
  17. Hou Y, Li X, Dai Z, Wu Z, Bazer F, Wu G. Analysis of Glutathione in Biological Samples by HPLC Involving Pre-Column Derivatization with o-Phthalaldehyde. Methods Mol Biol. 2018;1694:105-115 pubmed publisher
    ..the autosampler: (a) the conversion of GS-SG into GSH by 2-mercaptoethanol; and (b) the oxidation of GSH by iodoacetic acid to yield S-carboxymethyl-glutathione...
  18. Kim J, Yang H, Kim K, Chung Y. Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes. Korean J Parasitol. 2005;43:157-60 pubmed
    ..The enzyme was effectively inhibited by cysteine protease inhibitors, such as iodoacetic acid (IAA) and trans-epoxy-succinyl-L-leucyl-amido (4-guanidino) butane (E-64) while inhibitors acting on serine- ..
  19. Park Y, Goodman W. Analysis and modification of thiols in the hemolymph juvenile hormone binding protein of Manduca sexta. Arch Biochem Biophys. 1993;302:12-8 pubmed
    ..The analyses support the observation that there is a single form of the hemolymph juvenile hormone-binding protein in our strain of M. sexta. ..
  20. Dumond H, Presle N, Pottie P, Pacquelet S, Terlain B, Netter P, et al. Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. Osteoarthritis Cartilage. 2004;12:284-95 pubmed
    ..Increased susceptibility to MIA in weight-bearing areas of cartilage further indicate that MIA-induced experimental OA is a relevant model to study not only metabolical but also biomechanical aspects of human OA. ..
  21. Washio T, Kato S, Oikawa T. Molecular cloning and enzymological characterization of pyridoxal 5'-phosphate independent aspartate racemase from hyperthermophilic archaeon Thermococcus litoralis DSM 5473. Extremophiles. 2016;20:711-21 pubmed publisher
    ..acid and L-cysteine sulfinic acid in addition to D- and L-aspartic acids, and was strongly inhibited by iodoacetic acid. The site-directed mutagenesis of the enzyme showed that the essential cysteine residues were conserved as ..
  22. Polliotti B, Abramowsky C, Schwartz D, Keesling S, Lee G, Caba J, et al. Culture of first-trimester and full-term human chorionic villus explants: role of human chorionic gonadotropin and human placental lactogen as a viability index. Early Pregnancy. 1995;1:270-80 pubmed
    ..Only hCG kinetics were significantly different between tissue incubated with and without cycloheximide or iodoacetic acid. Both hCG and hPL immunoreactivity were not significantly different between tissue cultures with, and without,..
  23. Rodrigo G, Lawrence C, Standen N. Dinitrophenol pretreatment of rat ventricular myocytes protects against damage by metabolic inhibition and reperfusion. J Mol Cell Cardiol. 2002;34:555-69 pubmed
    ..uncoupler 2,4-dinitrophenol on the cellular damage induced by metabolic inhibition (with cyanide and iodoacetic acid) and reperfusion in freshly isolated adult rat ventricular myocytes...
  24. Foucher B, Pina G, Desjeux G, Cheminel V, Prevosto J. [Stability of blood glucose collected with or without antiglycolytic agent]. Ann Biol Clin (Paris). 2004;62:601-4 pubmed
    ..It is re-emphasised that glycolysis inhibitor should be used for glucose determination, especially when centrifugation is delayed. ..
  25. Liviac D, Creus A, Marcos R. Genotoxicity testing of three monohaloacetic acids in TK6 cells using the cytokinesis-block micronucleus assay. Mutagenesis. 2010;25:505-9 pubmed publisher
    ..the results obtained in the evaluation of the chromosome damage induced by three monohaloacetic acids, namely iodoacetic acid (IAA), bromoacetic acid (BAA) and chloroacetic acid (CAA)...
  26. Rodriguez S, Stitt B, Ash D. Cysteine 351 is an essential nucleophile in catalysis by Porphyromonas gingivalis peptidylarginine deiminase. Arch Biochem Biophys. 2010;504:190-6 pubmed publisher
    ..However, the C351S PAD variant was catalytically inactive, exhibiting <0.01% wild-type activity. These results indicate that Cys 351 is a nucleophile that initiates the enzymatic reaction. ..
  27. Samgina T, Vorontsov E, Gorshkov V, Artemenko K, Nifant ev I, Kanawati B, et al. Novel cysteine tags for the sequencing of non-tryptic disulfide peptides of anurans: ESI-MS study of fragmentation efficiency. J Am Soc Mass Spectrom. 2011;22:2246-55 pubmed publisher
    ..Some novel tags [N-benzylmaleimide, N-(2,6-dimethylphenyl)maleimide] along with known N-phenylmaleimide and iodoacetic acid showed high total sequence coverage taking into account combined ETD and HCD fragmentation...
  28. Suzuki S, Noda M, Sugita M, Tsubochi H, Fujimura S. Difference in the effect of phloridzin on alveolar fluid absorption in anesthetized rats and in ex vivo rat lungs. Exp Lung Res. 1999;25:393-406 pubmed
    ..the effect of phloridzin on lung metabolism and compared the data with those determined in the presence of iodoacetic acid (IAA) and NaCN. Phloridzin reduced alveolar glucose uptake with no decrease in lung ATP content...
  29. Liu X, Wei X, Zheng W, Jiang S, Templeton M, He G, et al. An optimized analytical method for the simultaneous detection of iodoform, iodoacetic acid, and other trihalomethanes and haloacetic acids in drinking water. PLoS ONE. 2013;8:e60858 pubmed publisher
    An optimized method is presented using liquid-liquid extraction and derivatization for the extraction of iodoacetic acid (IAA) and other haloacetic acids (HAA9) and direct extraction of iodoform (IF) and other trihalomethanes (THM4) from ..
  30. Bersinger N, Marguerat P, Pescia G, Schneider H. Pregnancy-associated plasma protein A (PAPP-A): measurement by highly sensitive and specific enzyme immunoassay, importance of first-trimester serum determinations, and stability studies. Reprod Fertil Dev. 1995;7:1419-23 pubmed
    ..A decrease of 21% was observed after such dry storage for three weeks at room temperature, which can be compensated for by the inclusion of a dried control serum, mailed with the sample(s). ..
  31. Bakken I, White L, Unsgard G, Aasly J, Sonnewald U. [U-13C]glutamate metabolism in astrocytes during hypoglycemia and hypoxia. J Neurosci Res. 1998;51:636-45 pubmed
    ..The present results indicate that glutamate-to-aspartate conversion is preferentially utilized by astrocytes when oxygen is available but glycolysis is impaired. ..
  32. Shivaprasad S, Wetzel R. Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils. J Biol Chem. 2006;281:993-1000 pubmed
    ..In another approach, monomeric Cys mutants, either in the thiol form or modified with iodoacetic acid or methyl iodide, were grown into amyloid fibrils, and the equilibrium position at the end of the amyloid ..
  33. Sugisawa T, Hoshino T. Purification and properties of membrane-bound D-sorbitol dehydrogenase from Gluconobacter suboxydans IFO 3255. Biosci Biotechnol Biochem. 2002;66:57-64 pubmed
    ..The optimum pH of the enzyme activity was 6.0, and the optimum temperature was 30 degrees C. Western blot analysis suggested the occurrence of the enzyme in all the Gluconobacter strains tested. ..
  34. Chumsae C, Gaza Bulseco G, Liu H. Identification and localization of unpaired cysteine residues in monoclonal antibodies by fluorescence labeling and mass spectrometry. Anal Chem. 2009;81:6449-57 pubmed publisher
    ..5-idoacetamidofluorescein (5-IAF), which was followed by reduction of disulfide bonds and alkylation with iodoacetic acid (IAA)...
  35. Alvarez J, Garcia Sancho J, Herreros B. All or none cell responses of Ca2+-dependent K channels elicited by calcium or lead in human red cells can be explained by heterogeneity of agonist distribution. J Membr Biol. 1988;104:129-38 pubmed
    ..This interpretation turns interest from K channels to Ca pumps to explain the heterogeneous behavior of red cells in response to a uniform stimulus. ..
  36. Harrison G, van Wijhe M, de Groot B, Dijk F, Gustafson L, van Beek J. Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase. Am J Physiol Heart Circ Physiol. 2003;285:H883-90 pubmed
    ..4 mM iodoacetamide (IA; n = 6) to block CK (CK activity <3% vs. control), 2) 0.3 mM iodoacetic acid (IAA; n = 5) to inhibit glycolysis (GAPDH activity <3% vs...
  37. Xiong H, Stanley B, Pegg A. Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase. Biochemistry. 1999;38:2462-70 pubmed
    ..b>Iodoacetic acid inhibited wild-type enzyme activity in a time- and pH-dependent manner but did not affect the already reduced ..
  38. Nam J, Perera P, Liu J, Wu L, Rath B, Butterfield T, et al. Transcriptome-wide gene regulation by gentle treadmill walking during the progression of monoiodoacetate-induced arthritis. Arthritis Rheum. 2011;63:1613-25 pubmed publisher
    ..However, the extent of cartilage damage at the initiation of GTW may be an important determinant of the success or failure of such therapies. ..
  39. Prochazkova M, Zanvit P, Dolezal T, Prokesova L, Krsiak M. Increased gene expression and production of spinal cyclooxygenase 1 and 2 during experimental osteoarthritis pain. Physiol Res. 2009;58:419-25 pubmed
    ..Thus, in contrast to inflammatory pain, the upregulation of spinal COX-1 may be important in osteoarthritis pain. ..
  40. Reshef A, Sperling O, Zoref Shani E. Preconditioning of primary rat neuronal cultures against ischemic injury: characterization of the "time window of protection'. Brain Res. 1996;741:252-7 pubmed
    ..Preconditioning by short exposure (5 min) of the cultures to iodoacetic acid (simulating sublethal ischemia), or to adenosine (1 mM) and the A1 adenosine receptor agonist N6-(R)-..
  41. Boja E, Fales H. Overalkylation of a protein digest with iodoacetamide. Anal Chem. 2001;73:3576-82 pubmed
    ..After reduction, the sulfhydryls are usually reacted with iodoacetamide (IAM), iodoacetic acid (IAA), or another electrophile to prevent reformation of disulfide linkages in a random manner...
  42. Parkinson F, Xiong W. Stimulus- and cell-type-specific release of purines in cultured rat forebrain astrocytes and neurons. J Neurochem. 2004;88:1305-12 pubmed
    ..In summary, the metabolic pathways for adenosine formation and release were cell-type dependent whereas the pathways for inosine formation were stimulus dependent. ..
  43. Blanco M, Vetman T, Chandrasekhar S, Fisher M, Harvey A, Kuklish S, et al. Identification and biological activity of 6-alkyl-substituted 3-methyl-pyridine-2-carbonyl amino dimethyl-benzoic acid EP4 antagonists. Bioorg Med Chem Lett. 2016;26:2303-7 pubmed publisher
    ..Pharmacokinetic profile, selectivity and in vivo efficacy comparing 4f to NSAID diclofenac in the monoiodoacetic acid (MIA) pain model and adjuvant induced arthritis (AIA) inflammatory model are included. ..
  44. Seymour C, Mothersill C. The effect of glycolysis inhibitors on the recovery of CHO-K1 cells from split-dose irradiation. Acta Oncol. 1987;26:367-71 pubmed
  45. Mut P, Espelt M, Krumschnabel G, Schwarzbaum P. Potassium transmembrane fluxes in anoxic hepatocytes from goldfish (Carassius auratus L.). Comp Biochem Physiol C Toxicol Pharmacol. 2006;142:205-11 pubmed
    ..This uncoupling was not observed when glycolytic ATP production was inhibited with iodoacetic acid. Although the CN-induced decrease of K(+) influx was fully reversible upon washout of the inhibitor, it could ..
  46. Lee J, Hong Y, Jeong J, Yang E, Jhun J, Park M, et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS ONE. 2013;8:e69362 pubmed publisher
    ..CoQ10 exerts a therapeutic effect on OA via pain suppression and cartilage degeneration by inhibiting inflammatory mediators, which play a vital role in OA pathogenesis. ..
  47. Buttle D, Dando P, Coe P, Sharp S, Shepherd S, Barrett A. The preparation of fully active chymopapain free of contaminating proteinases. Biol Chem Hoppe Seyler. 1990;371:1083-8 pubmed
    ..The rate of alkylation of the active site cysteine of chymopapain by iodoacetate was found to be sufficiently rapid and selective for this reagent to be used as an active-site titrant...
  48. Han Z, Malik N, Carter T, Reeves W, Wyche J, Hendrickson E. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J Biol Chem. 1996;271:25035-40 pubmed
    ..Finally, our results demonstrated that the cleavage of DNA-PKcs in vitro proceeded in the presence of Bcl-2, indicating that the function provided by Bcl-2 lies upstream the proteolysis of DNA-PKcs...
  49. Prakash O, Bhushan G. A study of inhibition of urease from seeds of the water melon (Citrullus vulgaris). J Enzyme Inhib. 1998;13:69-77 pubmed
    ..Time-dependent inactivation of urease with iodoacetic acid, N-ethylmaleimide and p-hydroxymercuribenzoate exhibited biphasic kinetics in which half of the initial ..
  50. Shimada H, Funakoshi T, Inoue T, Kojima S. The effects of sulfhydryl blockers and metal ions on nickel accumulation by rat primary hepatocyte cultures. Toxicol Lett. 2000;118:87-92 pubmed
  51. Wang X, Sun M, Zhao D, Wang M. Kinetics of inactivation of phytase (phy A) during modification of histidine residue by IAA and DEP. Protein Pept Lett. 2006;13:565-70 pubmed
    Chemical probing of histidine residues using specific modifiers, iodoacetic acid (IAA) and diethylpyrocarbonate (DEP) resulted in the inactivation of phytase (phy A)...
  52. Walsh B, Stary C, Howlett R, Kelley K, Hogan M. Glycolytic activation at the onset of contractions in isolated Xenopus laevis single myofibres. Exp Physiol. 2008;93:1076-84 pubmed publisher
    ..67 Hz in anoxia in the absence (control condition; CON) and presence of a glycolytic inhibitor (1 mM iodoacetic acid; IAA)...
  53. Rao Y, McCooeye M, Windust A, Bramanti E, D Ulivo A, Mester Z. Mapping of selenium metabolic pathway in yeast by liquid chromatography-Orbitrap mass spectrometry. Anal Chem. 2010;82:8121-30 pubmed publisher
    ..b>Iodoacetic acid (IAA) was used as the derivatizing reagent to stabilize the selenols...
  54. Furukawa N, Sugie H, Tsurui S, Ito M, Igarashi Y. [A biochemical study of an animal model with defective muscle glycolysis, induced by iodoacetate administration]. No To Hattatsu. 1992;24:342-6 pubmed
    ..This study indicates that this model will be useful to study the pathophysiology of human muscle glycogen storage diseases...
  55. Miyata S, Yoshida Y, Kihara H. Purification and characterization of a protease from Xenopus embryos. Eur J Biochem. 1989;186:49-54 pubmed
    ..0. This proteolytic activity was inhibited by antipain, leupeptin and iodoacetic acid; it was not affected by phenylmethylsulfonyl fluoride and pepstatin; and it was enhanced by dithiothreitol...
  56. Staswick P, Hermodson M, Nielsen N. Identification of the cystines which link the acidic and basic components of the glycinin subunits. J Biol Chem. 1984;259:13431-5 pubmed
    ..Residues involved in the disulfides were further identified by labeling them with [3H] iodoacetic acid. Only 1 cystine was found to be involved in linking the acidic and basic components of each subunit, and they ..
  57. Oda Y, Osaka H, Urakami T, Tonomura K. Purification and properties of poly(3-hydroxybutyrate) depolymerase from the fungus Paecilomyces lilacinus D218. Curr Microbiol. 1997;34:230-2 pubmed
    ..0 and 45 degrees C. The Km and Vmax values for PHB were 0.13(mg/ml) and 3750 (U/mg protein), respectively. The enzyme hydrolyzed PHB and p-nitrophenyl fatty acids but not polycaprolactone and triglycerides...
  58. VanPutte C, MacKenzie D, Eales J. Characterization of hepatic low-K(m) outer-ring deiodination in red drum (Sciaenops ocellatus). Comp Biochem Physiol B Biochem Mol Biol. 2001;128:413-23 pubmed
    ..ORD was not inhibited by propylthiouracil but was 50% inhibited by 90 microM of iodoacetic acid and 7 microM of gold thioglucose...
  59. Aiedeh K, Taha M, Al Hiari Y, Bustanji Y, Alkhatib H. Effect of ionic crosslinking on the drug release properties of chitosan diacetate matrices. J Pharm Sci. 2007;96:38-43 pubmed
    Chitosan diacetate (CDA) was prepared by alkylating the amino moieties of chitosan with mono-iodoacetic acid. Subsequently, CDA was cross-linked with Al3+, Zn2+, and Ca2+ ions to yield three ionotropically crosslinked polymeric matrices...
  60. Kawase N, Kishi J, Nakamura H, Hayakawa T. Collagenolytic activity in sonic extracts of Tannerella forsythia. Arch Oral Biol. 2010;55:545-9 pubmed publisher
    ..The purpose of the present study was to characterize the collagenolytic activity in a sonicated extract of Tannerella forsythia and to investigate the activation of proMMMP-2 and -9 by the T. forsythia extract...
  61. Kohanski R, Heinrikson R. Primary structure of avian hepatic rhodanese. J Protein Chem. 1990;9:369-77 pubmed
    ..Reaction of the enzyme with a 1.4-fold molar excess of [2-14C]iodoacetate led to inactivation of the enzyme and carboxymethylation of Cys-244; this modification was blocked by the substrate thiosulfate...
  62. Graupe K, Trommer W, Bisswanger H. Interaction between catalytic and regulatory sites of the pyruvate dehydrogenase from Escherichia coli studied by the ESR technique. Biochim Biophys Acta. 1989;999:176-82 pubmed
    ..The implications of these results for the allosteric regulation of the pyruvate dehydrogenase complex are discussed...
  63. Song J, Chai Y, Pang Y, Zuo K, Fei J, Liu X, et al. Isolation and characterization of an IAA-responsive gene from Gossypium barbadense L. DNA Seq. 2004;15:71-6 pubmed
    ..Semi-quantitative PCR analysis indicated that the expression of Gbiaa-Re gene was inducible by IAA. Our studies suggested that Gbiaa-Re was a new member of plant AUX/IAA gene family...
  64. Li S, Kang H, Choi M, Hong S. Long-term storage of Clonorchis sinensis metacercariae in vitro. Parasitol Res. 2006;100:25-9 pubmed
    ..e., PBS (phosphate buffered saline), PBS + antibiotics, PBS + iodoacetic acid (IAA), and PBS + antibiotics + IAA...
  65. Nagarathnam R, Rengasamy A, Balasubramanian R. Purification and properties of cysteine protease from rhizomes of Curcuma longa (Linn.). J Sci Food Agric. 2010;90:97-105 pubmed publisher
    ..Curcumin from turmeric rhizomes has been used for healing many ailments, including cancer. The purpose of this study was to purify turmeric protease and to research their biochemical characteristics [corrected]...
  66. Ondricek A, Kashyap A, Thamake S, Vishwanatha J. A comparative study of phytoestrogen action in mitigating apoptosis induced by oxidative stress. In Vivo. 2012;26:765-75 pubmed
    The phytoestrogens kaempferol, genistein and genistin were characterized using in vitro assays utilizing iodoacetic acid (IAA)-induced oxidative stress and mitochondrial dysfunction...
  67. Abaei M, Sagar D, Stockley E, Spicer C, Prior M, Chapman V, et al. Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Mol Pain. 2016;12: pubmed publisher
    ..Taken together, our data support altered neural pain processing as a result of peripheral and central pain sensitization in this model. ..
  68. Decottignies P, Schmitter J, Miginiac Maslow M, Le Marechal P, Jacquot J, Gadal P. Primary structure of the light-dependent regulatory site of corn NADP-malate dehydrogenase. J Biol Chem. 1988;263:11780-5 pubmed
    ..These results indicate that activation (by light or by dithiothreitol) proceeds on each subunit by reduction of a disulfide bridge located at the amino terminus of the enzyme between Cys10 and Cys15...
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